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A Substantial Proportion of Apparently Heterozygous TP53 Pathogenic Variants Detected with a Next-Generation Sequencing Hereditary Pan-Cancer Panel Are Acquired Somatically.

Coffee B, Cox HC, Bernhisel R, Manley S, Bowles K, Roa BB, Mancini-DiNardo D.

Hum Mutat. 2019 Sep 6. doi: 10.1002/humu.23910. [Epub ahead of print]


Integrating behaviour change counselling into chronic disease management: a square peg in a round hole? A system-level exploration in primary health care.

Vallis M, Lee-Baggley D, Sampalli T, Shepard D, McIssaac L, Ryer A, Ryan-Carson S, Manley S.

Public Health. 2019 Aug 2;175:43-53. doi: 10.1016/j.puhe.2019.06.009. [Epub ahead of print]


Strategies for increasing the throughput of super-resolution microscopies.

Mahecic D, Testa I, Griffié J, Manley S.

Curr Opin Chem Biol. 2019 Aug;51:84-91. doi: 10.1016/j.cbpa.2019.05.012. Epub 2019 Jun 15. Review.


Complications Arise.

Manley S.

Anesthesiology. 2019 Jul;131(1):210. doi: 10.1097/ALN.0000000000002778. No abstract available.


Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size.

Gerganova V, Floderer C, Archetti A, Michon L, Carlini L, Reichler T, Manley S, Martin SG.

Elife. 2019 May 3;8. pii: e45983. doi: 10.7554/eLife.45983.


Waveguide-PAINT offers an open platform for large field-of-view super-resolution imaging.

Archetti A, Glushkov E, Sieben C, Stroganov A, Radenovic A, Manley S.

Nat Commun. 2019 Mar 20;10(1):1267. doi: 10.1038/s41467-019-09247-1.


Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes.

Goujon A, Colom A, Straková K, Mercier V, Mahecic D, Manley S, Sakai N, Roux A, Matile S.

J Am Chem Soc. 2019 Feb 27;141(8):3380-3384. doi: 10.1021/jacs.8b13189. Epub 2019 Feb 12.


EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains.

Donaldson-Collier MC, Sungalee S, Zufferey M, Tavernari D, Katanayeva N, Battistello E, Mina M, Douglass KM, Rey T, Raynaud F, Manley S, Ciriello G, Oricchio E.

Nat Genet. 2019 Mar;51(3):517-528. doi: 10.1038/s41588-018-0338-y. Epub 2019 Jan 28.


Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation.

Callegari A, Sieben C, Benke A, Suter DM, Fierz B, Mazza D, Manley S.

PLoS Genet. 2019 Jan 17;15(1):e1007891. doi: 10.1371/journal.pgen.1007891. eCollection 2019 Jan.


Utility of HbA1c assessment in people with diabetes awaiting liver transplantation.

Bhattacharjee D, Vracar S, Round RA, Nightingale PG, Williams JA, Gkoutos GV, Stratton IM, Parker R, Luzio SD, Webber J, Manley SE, Roberts GA, Ghosh S.

Diabet Med. 2018 Nov 26. doi: 10.1111/dme.13870. [Epub ahead of print]


Autonomous illumination control for localization microscopy.

Štefko M, Ottino B, Douglass KM, Manley S.

Opt Express. 2018 Nov 12;26(23):30882-30900. doi: 10.1364/OE.26.030882.


Multicolor single-particle reconstruction of protein complexes.

Sieben C, Banterle N, Douglass KM, Gönczy P, Manley S.

Nat Methods. 2018 Oct;15(10):777-780. doi: 10.1038/s41592-018-0140-x. Epub 2018 Oct 1.


Prevalence of Variant Reclassification Following Hereditary Cancer Genetic Testing.

Mersch J, Brown N, Pirzadeh-Miller S, Mundt E, Cox HC, Brown K, Aston M, Esterling L, Manley S, Ross T.

JAMA. 2018 Sep 25;320(12):1266-1274. doi: 10.1001/jama.2018.13152.


Constriction Rate Modulation Can Drive Cell Size Control and Homeostasis in C. crescentus.

Lambert A, Vanhecke A, Archetti A, Holden S, Schaber F, Pincus Z, Laub MT, Goley E, Manley S.

iScience. 2018 Jun 29;4:180-189. doi: 10.1016/j.isci.2018.05.020. Epub 2018 May 30.


A human touch.

Manley S.

J Gen Intern Med. 2018 Oct;33(10):1822-1823. doi: 10.1007/s11606-018-4549-9. No abstract available.


Optimization of quality assurance to increase clinical utility and cost effectiveness of hereditary cancer testing.

Smith S, Marino I, Schaller J, Arnell C, Moyes K, Manley S.

Per Med. 2017 May;14(3):213-220. doi: 10.2217/pme-2016-0091. Epub 2017 Mar 29.


Application of an incident taxonomy for radiation therapy: Analysis of five years of data from three integrated cancer centres.

Greenham S, Manley S, Turnbull K, Hoffmann M, Fonseca A, Westhuyzen J, Last A, Aherne NJ, Shakespeare TP.

Rep Pract Oncol Radiother. 2018 May-Jun;23(3):220-227. doi: 10.1016/j.rpor.2018.04.002. Epub 2018 May 10.


One Day the Emails Will End.

Manley S.

J Am Geriatr Soc. 2018 Sep;66(9):1845-1846. doi: 10.1111/jgs.15404. Epub 2018 May 9. No abstract available.


Super-resolution microscopy to decipher multi-molecular assemblies.

Sieben C, Douglass KM, Guichard P, Manley S.

Curr Opin Struct Biol. 2018 Apr;49:169-176. doi: 10.1016/ Epub 2018 Apr 2. Review.


Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories.

Rosenthal ET, Bernhisel R, Brown K, Kidd J, Manley S.

Cancer Genet. 2017 Dec;218-219:58-68. doi: 10.1016/j.cancergen.2017.09.003. Epub 2017 Sep 25.


Complexities of Variant Classification in Clinical Hereditary Cancer Genetic Testing.

Mundt E, Nix P, Brown K, Bowles KR, Manley S.

J Clin Oncol. 2017 Dec 1;35(34):3796-3799. doi: 10.1200/JCO.2017.74.5182. Epub 2017 Oct 5. No abstract available.


TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.

Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R.

Nature. 2017 Oct 12;550(7675):265-269. doi: 10.1038/nature24021. Epub 2017 Oct 4.


In Reply.

Gradishar W, Brown K, Mundt E, Manley S.

Oncologist. 2017 Dec;22(12):1540. doi: 10.1634/theoncologist.2017-0320. Epub 2017 Aug 29. No abstract available.


Predicting inpatient hypoglycaemia in hospitalized patients with diabetes: a retrospective analysis of 9584 admissions with diabetes.

Stuart K, Adderley NJ, Marshall T, Rayman G, Sitch A, Manley S, Ghosh S, Toulis KA, Nirantharakumar K.

Diabet Med. 2017 Oct;34(10):1385-1391. doi: 10.1111/dme.13409. Epub 2017 Jul 12.


The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidation.

Manley SJ, Liu W, Welch DR.

J Mol Med (Berl). 2017 Sep;95(9):951-963. doi: 10.1007/s00109-017-1552-2. Epub 2017 Jun 8.


Clinical Variant Classification: A Comparison of Public Databases and a Commercial Testing Laboratory.

Gradishar W, Johnson K, Brown K, Mundt E, Manley S.

Oncologist. 2017 Jul;22(7):797-803. doi: 10.1634/theoncologist.2016-0431. Epub 2017 Apr 13.


The telomeric DNA damage response occurs in the absence of chromatin decompaction.

Vancevska A, Douglass KM, Pfeiffer V, Manley S, Lingner J.

Genes Dev. 2017 Mar 15;31(6):567-577. doi: 10.1101/gad.294082.116. Epub 2017 Apr 5.


Detection of somatic variants in peripheral blood lymphocytes using a next generation sequencing multigene pan cancer panel.

Coffee B, Cox HC, Kidd J, Sizemore S, Brown K, Manley S, Mancini-DiNardo D.

Cancer Genet. 2017 Feb;211:5-8. doi: 10.1016/j.cancergen.2017.01.002. Epub 2017 Jan 16.


Single particle maximum likelihood reconstruction from superresolution microscopy images.

Verdier T, Gunzenhauser J, Manley S, Castelnovo M.

PLoS One. 2017 Mar 2;12(3):e0172943. doi: 10.1371/journal.pone.0172943. eCollection 2017.


Prevalence of undiagnosed type 2 diabetes in patients admitted with acute coronary syndrome: the utility of easily reproducible screening methods.

Karamat MA, Raja UY, Manley SE, Jones A, Hanif W, Tahrani AA.

BMC Endocr Disord. 2017 Jan 23;17(1):3. doi: 10.1186/s12902-017-0153-y.


Increased Identification of Candidates for High-Risk Breast Cancer Screening Through Expanded Genetic Testing.

Rosenthal ET, Evans B, Kidd J, Brown K, Gorringe H, van Orman M, Manley S.

J Am Coll Radiol. 2017 Apr;14(4):561-568. doi: 10.1016/j.jacr.2016.10.003. Epub 2016 Dec 20.


Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria.

Bergé M, Campagne S, Mignolet J, Holden S, Théraulaz L, Manley S, Allain FH, Viollier PH.

Elife. 2016 Dec 23;5. pii: e20640. doi: 10.7554/eLife.20640.


Functional dichotomy and distinct nanoscale assemblies of a cell cycle-controlled bipolar zinc-finger regulator.

Mignolet J, Holden S, Bergé M, Panis G, Eroglu E, Théraulaz L, Manley S, Viollier PH.

Elife. 2016 Dec 23;5. pii: e18647. doi: 10.7554/eLife.18647.


A role for mitotic bookmarking of SOX2 in pluripotency and differentiation.

Deluz C, Friman ET, Strebinger D, Benke A, Raccaud M, Callegari A, Leleu M, Manley S, Suter DM.

Genes Dev. 2016 Nov 15;30(22):2538-2550. Epub 2016 Dec 5.


Super-resolution imaging of multiple cells by optimised flat-field epi-illumination.

Douglass KM, Sieben C, Archetti A, Lambert A, Manley S.

Nat Photonics. 2016 Nov;10(11):705-708. Epub 2016 Oct 17. No abstract available.


In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy.

Nasu Y, Benke A, Arakawa S, Yoshida GJ, Kawamura G, Manley S, Shimizu S, Ozawa T.

Sci Rep. 2016 Jun 13;6:27505. doi: 10.1038/srep27505.


Can HbA1c detect undiagnosed diabetes in acute medical hospital admissions?

Manley SE, O'Brien KT, Quinlan D, Round RA, Nightingale PG, Ali F, Durrani BK, Liew A, Luzio SD, Stratton IM, Roberts GA.

Diabetes Res Clin Pract. 2016 May;115:106-14. doi: 10.1016/j.diabres.2016.01.023. Epub 2016 Jan 21.


Visualizing the HoxD Gene Cluster at the Nanoscale Level.

Fabre PJ, Benke A, Manley S, Duboule D.

Cold Spring Harb Symp Quant Biol. 2015;80:9-16. doi: 10.1101/sqb.2015.80.027177. Epub 2016 Jan 14. Review.


Correction of a Depth-Dependent Lateral Distortion in 3D Super-Resolution Imaging.

Carlini L, Holden SJ, Douglass KM, Manley S.

PLoS One. 2015 Nov 23;10(11):e0142949. doi: 10.1371/journal.pone.0142949. eCollection 2015.


Role of farnesoid X receptor and bile acids in alcoholic liver disease.

Manley S, Ding W.

Acta Pharm Sin B. 2015 Mar;5(2):158-67. doi: 10.1016/j.apsb.2014.12.011. Epub 2015 Mar 9. Review.


3D high-density localization microscopy using hybrid astigmatic/ biplane imaging and sparse image reconstruction.

Min J, Holden SJ, Carlini L, Unser M, Manley S, Ye JC.

Biomed Opt Express. 2014 Oct 14;5(11):3935-48. doi: 10.1364/BOE.5.003935. eCollection 2014 Nov 1.


Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states.

Fabre PJ, Benke A, Joye E, Nguyen Huynh TH, Manley S, Duboule D.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9. doi: 10.1073/pnas.1517972112. Epub 2015 Oct 26.


Regional cancer centre demonstrates voluntary conformity with the national Radiation Oncology Practice Standards.

Manley S, Last A, Fu K, Greenham S, Kovendy A, Shakespeare TP.

J Med Radiat Sci. 2015 Jun;62(2):152-9. doi: 10.1002/jmrs.102. Epub 2015 Apr 8.


Quantitative evaluation of software packages for single-molecule localization microscopy.

Sage D, Kirshner H, Pengo T, Stuurman N, Min J, Manley S, Unser M.

Nat Methods. 2015 Aug;12(8):717-24. doi: 10.1038/nmeth.3442. Epub 2015 Jun 15.


Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.

Williams JA, Ni HM, Haynes A, Manley S, Li Y, Jaeschke H, Ding WX.

J Biol Chem. 2015 Apr 24;290(17):10934-46. doi: 10.1074/jbc.M114.602284. Epub 2015 Mar 9.


Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.

Ni HM, Bhakta A, Wang S, Li Z, Manley S, Huang H, Copple B, Ding WX.

PLoS One. 2014 Dec 23;9(12):e115849. doi: 10.1371/journal.pone.0115849. eCollection 2014.


A Quantitative Approach to Evaluate the Impact of Fluorescent Labeling on Membrane-Bound HIV-Gag Assembly by Titration of Unlabeled Proteins.

Gunzenhäuser J, Wyss R, Manley S.

PLoS One. 2014 Dec 10;9(12):e115095. doi: 10.1371/journal.pone.0115095. eCollection 2014.


Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity.

Manley S, Ni HM, Williams JA, Kong B, DiTacchio L, Guo G, Ding WX.

Redox Biol. 2014;2:991-1002. doi: 10.1016/j.redox.2014.08.007. Epub 2014 Aug 28.


PALMsiever: a tool to turn raw data into results for single-molecule localization microscopy.

Pengo T, Holden SJ, Manley S.

Bioinformatics. 2015 Mar 1;31(5):797-8. doi: 10.1093/bioinformatics/btu720. Epub 2014 Oct 31.

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