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Items: 1 to 50 of 80


Survival after Prehospital Traumatic Cardiac Arrest: A Comparison of Isolated Head and Non-Head-Penetrating Injuries.

Manley NR, Holley JE, Martin LJC, Stavely TC, Croce MA, Fischer PE.

Am Surg. 2019 Mar 1;85(3):e123-e125. No abstract available.


Evolution of Firearm Violence over 20 Years: Integrating Law Enforcement and Clinical Data.

Manley NR, Croce MA, Fischer PE, Crowe DE, Goines JH, Sharpe JP, Fabian TC, Magnotti LJ.

J Am Coll Surg. 2019 Apr;228(4):427-434. doi: 10.1016/j.jamcollsurg.2018.12.033. Epub 2019 Jan 28.


Analysis of over 2 decades of colon injuries identifies optimal method of diversion: Does an end justify the means?

Manley NR, Sharpe JP, Lewis RH, Iltis MS, Chaudhuri R, Fabian TC, Croce MA, Magnotti LJ.

J Trauma Acute Care Surg. 2019 Feb;86(2):214-219. doi: 10.1097/TA.0000000000002135.


Embryology of the Parathyroid Glands.

Peissig K, Condie BG, Manley NR.

Endocrinol Metab Clin North Am. 2018 Dec;47(4):733-742. doi: 10.1016/j.ecl.2018.07.002. Review.


Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment.

Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Yi S, Xie H, Orkin SH, Manley NR, Ehrlich LIR, Jiang N, Richie ER.

Sci Rep. 2018 Sep 25;8(1):14335. doi: 10.1038/s41598-018-32729-z.


Factors Contributing to Morbidity after Combined Arterial and Venous Lower Extremity Trauma.

Manley NR, Magnotti LJ, Fabian TC, Cutshall MB, Croce MA, Sharpe JP.

Am Surg. 2018 Jul 1;84(7):1217-1222.


Predicted miRNA-mRNA-mediated posttranscriptional control associated with differences in cervical and thoracic thymus function.

Assis AF, Li J, Donate PB, Dernowsek JA, Manley NR, Passos GA.

Mol Immunol. 2018 Jul;99:39-52. doi: 10.1016/j.molimm.2018.04.003. Epub 2018 May 26.


Thymic B cell development is controlled by the B potential of progenitors via both hematopoietic-intrinsic and thymic microenvironment-intrinsic regulatory mechanisms.

Xiao S, Zhang W, Manley NR.

PLoS One. 2018 Feb 20;13(2):e0193189. doi: 10.1371/journal.pone.0193189. eCollection 2018.


Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a.

Xiao S, Zhang W, Manley NR.

PLoS One. 2018 Feb 20;13(2):e0193188. doi: 10.1371/journal.pone.0193188. eCollection 2018.


Impact of venorrhaphy and vein ligation in isolated lower-extremity venous injuries on venous thromboembolism and edema.

Manley NR, Magnotti LJ, Fabian TC, Croce MA, Sharpe JP.

J Trauma Acute Care Surg. 2018 Feb;84(2):325-329. doi: 10.1097/TA.0000000000001746.


The changing role of endovascular stenting for blunt cerebrovascular injuries.

Shahan CP, Sharpe JP, Stickley SM, Manley NR, Filiberto DM, Fabian TC, Croce MA, Magnotti LJ.

J Trauma Acute Care Surg. 2018 Feb;84(2):308-311. doi: 10.1097/TA.0000000000001740.


Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration.

Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM.

Sci Immunol. 2018 Jan 12;3(19). pii: eaal2736. doi: 10.1126/sciimmunol.aal2736.


Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.

Xiao S, Shterev ID, Zhang W, Young L, Shieh JH, Moore M, van den Brink M, Sempowski GD, Manley NR.

J Immunol. 2017 Oct 15;199(8):2701-2712. doi: 10.4049/jimmunol.1600934. Epub 2017 Sep 20.


Good news, bad news: An analysis of 11,294 gunshot wounds (GSWs) over two decades in a single center.

Manley NR, Fabian TC, Sharpe JP, Magnotti LJ, Croce MA.

J Trauma Acute Care Surg. 2018 Jan;84(1):58-65. doi: 10.1097/TA.0000000000001635.


MiCASA is a new method for quantifying cellular organization.

Sornborger A, Li J, Timmons C, Lupu F, Eggenschwiler J, Takahama Y, Manley NR.

Nat Commun. 2017 May 30;8:15619. doi: 10.1038/ncomms15619.


Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.

Ito R, Hale LP, Geyer SM, Li J, Sornborger A, Kajimura J, Kusunoki Y, Yoshida K, van den Brink MRM, Kyoizumi S, Manley NR, Nakachi K, Sempowski GD.

Radiat Res. 2017 May;187(5):589-598. doi: 10.1667/RR4554.1. Epub 2017 Mar 20.


Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate.

Bain VE, Gordon J, O'Neil JD, Ramos I, Richie ER, Manley NR.

Development. 2016 Nov 1;143(21):4027-4037. Epub 2016 Sep 15.


Temporal and spatial requirements for Hoxa3 in mouse embryonic development.

Chojnowski JL, Trau HA, Masuda K, Manley NR.

Dev Biol. 2016 Jul 1;415(1):33-45. doi: 10.1016/j.ydbio.2016.05.010. Epub 2016 May 10.


Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues.

Kajimura J, Ito R, Manley NR, Hale LP.

J Histochem Cytochem. 2016 Feb;64(2):112-24. doi: 10.1369/0022155415610792. Epub 2015 Sep 21.


Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance.

Bredenkamp N, Jin X, Liu D, O'Neill KE, Manley NR, Blackburn CC.

Regen Med. 2015;10(3):317-29. doi: 10.2217/rme.15.8. Review.


Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.

Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR.

Development. 2014 Oct;141(19):3697-708. doi: 10.1242/dev.110833. Epub 2014 Sep 5.


An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts.

Bredenkamp N, Ulyanchenko S, O'Neill KE, Manley NR, Vaidya HJ, Blackburn CC.

Nat Cell Biol. 2014 Sep;16(9):902-8. doi: 10.1038/ncb3023. Epub 2014 Aug 24.


Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.

Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER.

Development. 2014 Aug;141(15):2950-8. doi: 10.1242/dev.111641.


Histone deacetylation critically determines T cell subset radiosensitivity.

Pugh JL, Sukhina AS, Seed TM, Manley NR, Sempowski GD, van den Brink MR, Smithey MJ, Nikolich-Žugich J.

J Immunol. 2014 Aug 1;193(3):1451-8. doi: 10.4049/jimmunol.1400434. Epub 2014 Jul 2.


Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T-cell development.

Li J, Liu Z, Xiao S, Manley NR.

Nat Commun. 2013;4:2959. doi: 10.1038/ncomms3959.


Serum-free culture of mid-gestation mouse embryos: a tool for the study of endoderm-derived organs.

Gordon J, Moore BA, Blackburn CC, Manley NR.

Methods Mol Biol. 2014;1092:183-94. doi: 10.1007/978-1-60327-292-6_12.


Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.

Bryson JL, Griffith AV, Hughes B 3rd, Saito F, Takahama Y, Richie ER, Manley NR.

PLoS One. 2013 Jun 4;8(6):e65196. doi: 10.1371/journal.pone.0065196. Print 2013.


Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.

Garfin PM, Min D, Bryson JL, Serwold T, Edris B, Blackburn CC, Richie ER, Weinberg KI, Manley NR, Sage J, Viatour P.

J Exp Med. 2013 Jun 3;210(6):1087-97. doi: 10.1084/jem.20121716. Epub 2013 May 13.


Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis.

Gardiner JR, Jackson AL, Gordon J, Lickert H, Manley NR, Basson MA.

Development. 2012 Sep;139(18):3456-66. doi: 10.1242/dev.079400.


Changes in primary lymphoid organs with aging.

Chinn IK, Blackburn CC, Manley NR, Sempowski GD.

Semin Immunol. 2012 Oct;24(5):309-20. doi: 10.1016/j.smim.2012.04.005. Epub 2012 May 2. Review.


Whole mount in situ hybridization of E8.5 to E11.5 mouse embryos.

Wei Q, Manley NR, Condie BG.

J Vis Exp. 2011 Oct 10;(56). pii: 2797. doi: 10.3791/2797.


A method for labeling vasculature in embryonic mice.

Bryson JL, Coles MC, Manley NR.

J Vis Exp. 2011 Oct 7;(56). pii: 3267. doi: 10.3791/3267.


Mechanisms of thymus organogenesis and morphogenesis.

Gordon J, Manley NR.

Development. 2011 Sep;138(18):3865-78. doi: 10.1242/dev.059998. Review.


Structure and function of the thymic microenvironment.

Manley NR, Richie ER, Blackburn CC, Condie BG, Sage J.

Front Biosci (Landmark Ed). 2011 Jun 1;16:2461-77. Review.


Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions.

Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, Blackburn CC, Manley NR.

PLoS Genet. 2010 Dec 23;6(12):e1001251. doi: 10.1371/journal.pgen.1001251.


Impaired thymic selection and abnormal antigen-specific T cell responses in Foxn1(Δ/Δ) mutant mice.

Xiao S, Manley NR.

PLoS One. 2010 Nov 4;5(11):e15396. doi: 10.1371/journal.pone.0015396.


Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation.

Manley NR, Condie BG.

Prog Mol Biol Transl Sci. 2010;92:103-20. doi: 10.1016/S1877-1173(10)92005-X. Review.


EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13414-9. doi: 10.1073/pnas.1003747107. Epub 2010 Jul 8.


Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function.

Chen L, Zhao P, Wells L, Amemiya CT, Condie BG, Manley NR.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10555-60. doi: 10.1073/pnas.1005129107. Epub 2010 May 24.


Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.

Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR.

J Clin Invest. 2010 Mar;120(3):840-9. doi: 10.1172/JCI40728. Epub 2010 Feb 8.


Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis.

Gordon J, Patel SR, Mishina Y, Manley NR.

Dev Biol. 2010 Mar 1;339(1):141-54. doi: 10.1016/j.ydbio.2009.12.026. Epub 2010 Jan 4.


An evolutionary perspective on the mechanisms of immunosenescence.

Shanley DP, Aw D, Manley NR, Palmer DB.

Trends Immunol. 2009 Jul;30(7):374-81. doi: 10.1016/ Epub 2009 Jun 21. Review.


An ancient gene network is co-opted for teeth on old and new jaws.

Fraser GJ, Hulsey CD, Bloomquist RF, Uyesugi K, Manley NR, Streelman JT.

PLoS Biol. 2009 Feb 10;7(2):e31. doi: 10.1371/journal.pbio.1000031.


Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos.

Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER.

Dev Biol. 2009 Mar 1;327(1):216-27. doi: 10.1016/j.ydbio.2008.12.019. Epub 2008 Dec 25.


Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity.

Youm YH, Yang H, Sun Y, Smith RG, Manley NR, Vandanmagsar B, Dixit VD.

J Biol Chem. 2009 Mar 13;284(11):7068-77. doi: 10.1074/jbc.M808302200. Epub 2008 Dec 2.


Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner.

Chen L, Xiao S, Manley NR.

Blood. 2009 Jan 15;113(3):567-74. doi: 10.1182/blood-2008-05-156265. Epub 2008 Oct 31.


Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, Pierres M, Manley NR, Duarte A, Macdonald HR, Radtke F.

J Exp Med. 2008 Oct 27;205(11):2515-23. doi: 10.1084/jem.20080829. Epub 2008 Sep 29.


Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis.

Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C.

Dev Biol. 2008 Oct 1;322(1):145-55. doi: 10.1016/j.ydbio.2008.07.021. Epub 2008 Jul 26.


T cell development from kit-negative progenitors in the Foxn1Delta/Delta mutant thymus.

Xiao S, Su DM, Manley NR.

J Immunol. 2008 Jan 15;180(2):914-21.

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