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Items: 35


Chikungunya virus requires cellular chloride channels for efficient genome replication.

Müller M, Slivinski N, Todd EJAA, Khalid H, Li R, Karwatka M, Merits A, Mankouri J, Tuplin A.

PLoS Negl Trop Dis. 2019 Sep 4;13(9):e0007703. doi: 10.1371/journal.pntd.0007703. eCollection 2019 Sep.


Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis.

Davies K, Afrough B, Mankouri J, Hewson R, Edwards TA, Barr JN.

J Gen Virol. 2019 Aug;100(8):1208-1221. doi: 10.1099/jgv.0.001291. Epub 2019 Jul 3.


Rescue of Infectious Recombinant Hazara Nairovirus from cDNA Reveals the Nucleocapsid Protein DQVD Caspase Cleavage Motif Performs an Essential Role other than Cleavage.

Fuller J, Surtees RA, Slack GS, Mankouri J, Hewson R, Barr JN.

J Virol. 2019 Jul 17;93(15). pii: e00616-19. doi: 10.1128/JVI.00616-19. Print 2019 Aug 1.


Cellular cholesterol abundance regulates potassium accumulation within endosomes and is an important determinant in bunyavirus entry.

Charlton FW, Hover S, Fuller J, Hewson R, Fontana J, Barr JN, Mankouri J.

J Biol Chem. 2019 May 3;294(18):7335-7347. doi: 10.1074/jbc.RA119.007618. Epub 2019 Feb 25.


Correction: Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus.

Punch EK, Hover S, Blest HTW, Fuller J, Hewson R, Fontana J, Mankouri J, Barr JN.

J Biol Chem. 2019 Feb 15;294(7):2579. doi: 10.1074/jbc.AAC119.007718. No abstract available.


Hazara nairovirus elicits differential induction of apoptosis and nucleocapsid protein cleavage in mammalian and tick cells.

Fuller J, Surtees RA, Shaw AB, Álvarez-Rodríguez B, Slack GS, Bell-Sakyi L, Mankouri J, Edwards TA, Hewson R, Barr JN.

J Gen Virol. 2019 Mar;100(3):392-402. doi: 10.1099/jgv.0.001211. Epub 2019 Feb 5.


The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.

Selvaraj M, Yegambaram K, Todd EJAA, Richard CA, Dods RL, Pangratiou GM, Trinh CH, Moul SL, Murphy JC, Mankouri J, Éléouët JF, Barr JN, Edwards TA.

MBio. 2018 Nov 13;9(6). pii: e01554-18. doi: 10.1128/mBio.01554-18.


Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness.

Nwogu N, Boyne JR, Dobson SJ, Poterlowicz K, Blair GE, Macdonald A, Mankouri J, Whitehouse A.

PLoS Pathog. 2018 Sep 6;14(9):e1007276. doi: 10.1371/journal.ppat.1007276. eCollection 2018 Sep.


Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus.

Punch EK, Hover S, Blest HTW, Fuller J, Hewson R, Fontana J, Mankouri J, Barr JN.

J Biol Chem. 2018 Jun 29;293(26):9937-9944. doi: 10.1074/jbc.RA118.002494. Epub 2018 Apr 20. Erratum in: J Biol Chem. 2019 Feb 15;294(7):2579.


The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility.

Stakaitytė G, Nwogu N, Lippiat JD, Blair GE, Poterlowicz K, Boyne JR, Macdonald A, Mankouri J, Whitehouse A.

J Biol Chem. 2018 Mar 23;293(12):4582-4590. doi: 10.1074/jbc.RA117.001343. Epub 2018 Feb 8.


Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection.

Hover S, Foster B, Fontana J, Kohl A, Goldstein SAN, Barr JN, Mankouri J.

PLoS Pathog. 2018 Jan 19;14(1):e1006845. doi: 10.1371/journal.ppat.1006845. eCollection 2018 Jan.


Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation.

Stakaitytė G, Nwogu N, Dobson SJ, Knight LM, Wasson CW, Salguero FJ, Blackbourn DJ, Blair GE, Mankouri J, Macdonald A, Whitehouse A.

J Virol. 2018 Jan 2;92(2). pii: e00940-17. doi: 10.1128/JVI.00940-17. Print 2018 Jan 15.


Viral dependence on cellular ion channels - an emerging anti-viral target?

Hover S, Foster B, Barr JN, Mankouri J.

J Gen Virol. 2017 Mar;98(3):345-351. doi: 10.1099/jgv.0.000712. Epub 2017 Apr 1. Review.


Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle.

Surtees R, Dowall SD, Shaw A, Armstrong S, Hewson R, Carroll MW, Mankouri J, Edwards TA, Hiscox JA, Barr JN.

J Virol. 2016 Sep 29;90(20):9305-16. doi: 10.1128/JVI.00661-16. Print 2016 Oct 15.


Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion.

Mankouri J, Walter C, Stewart H, Bentham M, Park WS, Heo WD, Fukuda M, Griffin S, Harris M.

J Virol. 2016 Jul 27;90(16):7159-70. doi: 10.1128/JVI.00826-16. Print 2016 Aug 15.


Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication.

Mohl BP, Bartlett C, Mankouri J, Harris M.

J Gen Virol. 2016 Mar;97(3):680-93. doi: 10.1099/jgv.0.000387. Epub 2016 Jan 4.


Modulation of Potassium Channels Inhibits Bunyavirus Infection.

Hover S, King B, Hall B, Loundras EA, Taqi H, Daly J, Dallas M, Peers C, Schnettler E, McKimmie C, Kohl A, Barr JN, Mankouri J.

J Biol Chem. 2016 Feb 12;291(7):3411-22. doi: 10.1074/jbc.M115.692673. Epub 2015 Dec 16.


The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers.

Cesur Ö, Nicol C, Groves H, Mankouri J, Blair GE, Stonehouse NJ.

Viruses. 2015 Jun 26;7(7):3443-61. doi: 10.3390/v7072780.


Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction.

Igloi Z, Kazlauskas A, Saksela K, Macdonald A, Mankouri J, Harris M.

J Gen Virol. 2015 Aug;96(8):2133-44. doi: 10.1099/vir.0.000145. Epub 2015 Apr 13.


Requirement for chloride channel function during the hepatitis C virus life cycle.

Igloi Z, Mohl BP, Lippiat JD, Harris M, Mankouri J.

J Virol. 2015 Apr;89(7):4023-9. doi: 10.1128/JVI.02946-14. Epub 2015 Jan 21.


Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes.

Ross-Thriepland D, Mankouri J, Harris M.

J Virol. 2015 Mar;89(6):3123-35. doi: 10.1128/JVI.02995-14. Epub 2014 Dec 31.


Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M.

J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15.


Viruses and the fuel sensor: the emerging link between AMPK and virus replication.

Mankouri J, Harris M.

Rev Med Virol. 2011 Jul;21(4):205-12. doi: 10.1002/rmv.687. Epub 2011 Apr 28. Review.


Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1.

Dallas ML, Boyle JP, Milligan CJ, Sayer R, Kerrigan TL, McKinstry C, Lu P, Mankouri J, Harris M, Scragg JL, Pearson HA, Peers C.

FASEB J. 2011 May;25(5):1519-30. doi: 10.1096/fj.10-173450. Epub 2011 Jan 19.


Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase.

Mankouri J, Tedbury PR, Gretton S, Hughes ME, Griffin SD, Dallas ML, Green KA, Hardie DG, Peers C, Harris M.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11549-54. doi: 10.1073/pnas.0912426107. Epub 2010 Jun 7.


Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.

Mankouri J, Fragkoudis R, Richards KH, Wetherill LF, Harris M, Kohl A, Elliott RM, Macdonald A.

PLoS Pathog. 2010 Feb 19;6(2):e1000778. doi: 10.1371/journal.ppat.1000778.


Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion.

Milward A, Mankouri J, Harris M.

J Gen Virol. 2010 Feb;91(Pt 2):373-81. doi: 10.1099/vir.0.015305-0. Epub 2009 Oct 21.


Expression of the NS3 protease of cytopathogenic bovine viral diarrhea virus results in the induction of apoptosis but does not block activation of the beta interferon promoter.

Gamlen T, Richards KH, Mankouri J, Hudson L, McCauley J, Harris M, Macdonald A.

J Gen Virol. 2010 Jan;91(Pt 1):133-44. doi: 10.1099/vir.0.016170-0. Epub 2009 Sep 30.


Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence.

Mankouri J, Dallas ML, Hughes ME, Griffin SD, Macdonald A, Peers C, Harris M.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15903-8. doi: 10.1073/pnas.0906798106. Epub 2009 Aug 26.


Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism.

Taneja TK, Mankouri J, Karnik R, Kannan S, Smith AJ, Munsey T, Christesen HB, Beech DJ, Sivaprasadarao A.

Hum Mol Genet. 2009 Jul 1;18(13):2400-13. doi: 10.1093/hmg/ddp179. Epub 2009 Apr 8.


A comparative cell biological analysis reveals only limited functional homology between the NS5A proteins of hepatitis C virus and GB virus B.

Mankouri J, Milward A, Pryde KR, Warter L, Martin A, Harris M.

J Gen Virol. 2008 Aug;89(Pt 8):1911-20. doi: 10.1099/vir.0.2008/001131-0.


The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor.

Mankouri J, Griffin S, Harris M.

Traffic. 2008 Sep;9(9):1497-509. doi: 10.1111/j.1600-0854.2008.00779.x. Epub 2008 Jun 9.


Trafficking of ATP-sensitive potassium channels in health and disease.

Sivaprasadarao A, Taneja TK, Mankouri J, Smith AJ.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1055-9. Review.


Molecular cell biology of KATP channels: implications for neonatal diabetes.

Smith AJ, Taneja TK, Mankouri J, Sivaprasadarao A.

Expert Rev Mol Med. 2007 Aug 1;9(21):1-17. Review.


Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels.

Mankouri J, Taneja TK, Smith AJ, Ponnambalam S, Sivaprasadarao A.

EMBO J. 2006 Sep 6;25(17):4142-51. Epub 2006 Aug 10.

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