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Items: 1 to 50 of 133

1.

Engineered ribosomes with tethered subunits for expanding biological function.

Carlson ED, d'Aquino AE, Kim DS, Fulk EM, Hoang K, Szal T, Mankin AS, Jewett MC.

Nat Commun. 2019 Sep 2;10(1):3920. doi: 10.1038/s41467-019-11427-y.

2.

Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome.

Meydan S, Marks J, Klepacki D, Sharma V, Baranov PV, Firth AE, Margus T, Kefi A, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2019 May 2;74(3):481-493.e6. doi: 10.1016/j.molcel.2019.02.017. Epub 2019 Mar 20.

PMID:
30904393
3.

Assembly and functionality of the ribosome with tethered subunits.

Aleksashin NA, Leppik M, Hockenberry AJ, Klepacki D, Vázquez-Laslop N, Jewett MC, Remme J, Mankin AS.

Nat Commun. 2019 Feb 25;10(1):930. doi: 10.1038/s41467-019-08892-w.

4.

How Macrolide Antibiotics Work.

Vázquez-Laslop N, Mankin AS.

Trends Biochem Sci. 2018 Sep;43(9):668-684. doi: 10.1016/j.tibs.2018.06.011. Epub 2018 Jul 24. Review.

5.

Genes within Genes in Bacterial Genomes.

Meydan S, Vázquez-Laslop N, Mankin AS.

Microbiol Spectr. 2018 Jul;6(4). doi: 10.1128/microbiolspec.RWR-0020-2018. Review.

PMID:
30003865
6.

Context-Specific Action of Ribosomal Antibiotics.

Vázquez-Laslop N, Mankin AS.

Annu Rev Microbiol. 2018 Sep 8;72:185-207. doi: 10.1146/annurev-micro-090817-062329. Epub 2018 Jun 15. Review.

PMID:
29906204
7.

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.

Pantel L, Florin T, Dobosz-Bartoszek M, Racine E, Sarciaux M, Serri M, Houard J, Campagne JM, de Figueiredo RM, Midrier C, Gaudriault S, Givaudan A, Lanois A, Forst S, Aumelas A, Cotteaux-Lautard C, Bolla JM, Vingsbo Lundberg C, Huseby DL, Hughes D, Villain-Guillot P, Mankin AS, Polikanov YS, Gualtieri M.

Mol Cell. 2018 Apr 5;70(1):83-94.e7. doi: 10.1016/j.molcel.2018.03.001.

8.

Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.

Tereshchenkov AG, Dobosz-Bartoszek M, Osterman IA, Marks J, Sergeeva VA, Kasatsky P, Komarova ES, Stavrianidi AN, Rodin IA, Konevega AL, Sergiev PV, Sumbatyan NV, Mankin AS, Bogdanov AA, Polikanov YS.

J Mol Biol. 2018 Mar 16;430(6):842-852. doi: 10.1016/j.jmb.2018.01.016. Epub 2018 Feb 2.

9.

Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics.

Svetlov MS, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13673-13678. doi: 10.1073/pnas.1717168115. Epub 2017 Dec 11.

10.

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.

Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS.

Nucleic Acids Res. 2017 Sep 19;45(16):9573-9582. doi: 10.1093/nar/gkx673.

11.

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.

Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.

Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439. Epub 2017 Jul 24.

12.

Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene.

Meydan S, Klepacki D, Karthikeyan S, Margus T, Thomas P, Jones JE, Khan Y, Briggs J, Dinman JD, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2017 Jan 19;65(2):207-219. doi: 10.1016/j.molcel.2016.12.008.

13.

Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center.

Marks J, Kannan K, Roncase EJ, Klepacki D, Kefi A, Orelle C, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12150-12155. Epub 2016 Oct 10.

14.

Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.

Sothiselvam S, Neuner S, Rigger L, Klepacki D, Micura R, Vázquez-Laslop N, Mankin AS.

Cell Rep. 2016 Aug 16;16(7):1789-99. doi: 10.1016/j.celrep.2016.07.018. Epub 2016 Aug 4.

15.

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.

Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA.

Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi: 10.1093/nar/gkw018. Epub 2016 Jan 24.

16.

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.

Gupta P, Liu B, Klepacki D, Gupta V, Schulten K, Mankin AS, Vázquez-Laslop N.

Nat Chem Biol. 2016 Mar;12(3):153-8. doi: 10.1038/nchembio.1998. Epub 2016 Jan 4.

17.

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

Almutairi MM, Park SR, Rose S, Hansen DA, Vázquez-Laslop N, Douthwaite S, Sherman DH, Mankin AS.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12956-61. doi: 10.1073/pnas.1512090112. Epub 2015 Oct 5.

18.

Protein synthesis by ribosomes with tethered subunits.

Orelle C, Carlson ED, Szal T, Florin T, Jewett MC, Mankin AS.

Nature. 2015 Aug 6;524(7563):119-24. doi: 10.1038/nature14862. Epub 2015 Jul 29.

PMID:
26222032
19.

The general mode of translation inhibition by macrolide antibiotics.

Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman JS, Mankin AS.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15958-63. doi: 10.1073/pnas.1417334111. Epub 2014 Oct 27.

20.

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.

Polikanov YS, Szal T, Jiang F, Gupta P, Matsuda R, Shiozuka M, Steitz TA, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2014 Nov 20;56(4):541-50. doi: 10.1016/j.molcel.2014.09.021. Epub 2014 Oct 9.

21.

Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.

Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV.

Mol Cell. 2014 Nov 20;56(4):531-40. doi: 10.1016/j.molcel.2014.09.020. Epub 2014 Oct 9.

22.

Macrolide antibiotics allosterically predispose the ribosome for translation arrest.

Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9804-9. doi: 10.1073/pnas.1403586111. Epub 2014 Jun 24.

23.

Protein accounting in the cellular economy.

Vázquez-Laslop N, Mankin AS.

Cell. 2014 Apr 24;157(3):529-31. doi: 10.1016/j.cell.2014.04.002.

24.

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.

Arenz S, Ramu H, Gupta P, Berninghausen O, Beckmann R, Vázquez-Laslop N, Mankin AS, Wilson DN.

Nat Commun. 2014 Mar 24;5:3501. doi: 10.1038/ncomms4501.

25.

Regulation of gene expression by macrolide-induced ribosomal frameshifting.

Gupta P, Kannan K, Mankin AS, Vázquez-Laslop N.

Mol Cell. 2013 Dec 12;52(5):629-42. doi: 10.1016/j.molcel.2013.10.013. Epub 2013 Nov 14.

26.

Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.

Martínez AK, Gordon E, Sengupta A, Shirole N, Klepacki D, Martinez-Garriga B, Brown LM, Benedik MJ, Yanofsky C, Mankin AS, Vazquez-Laslop N, Sachs MS, Cruz-Vera LR.

Nucleic Acids Res. 2014 Jan;42(2):1245-56. doi: 10.1093/nar/gkt923. Epub 2013 Oct 16.

27.

Tools for characterizing bacterial protein synthesis inhibitors.

Orelle C, Carlson S, Kaushal B, Almutairi MM, Liu H, Ochabowicz A, Quan S, Pham VC, Squires CL, Murphy BT, Mankin AS.

Antimicrob Agents Chemother. 2013 Dec;57(12):5994-6004. doi: 10.1128/AAC.01673-13. Epub 2013 Sep 16.

28.

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.

Orelle C, Szal T, Klepacki D, Shaw KJ, Vázquez-Laslop N, Mankin AS.

Nucleic Acids Res. 2013 Aug;41(14):e144. doi: 10.1093/nar/gkt526. Epub 2013 Jun 12.

29.

Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible.

Gupta P, Sothiselvam S, Vázquez-Laslop N, Mankin AS.

Nat Commun. 2013;4:1984. doi: 10.1038/ncomms2984.

PMID:
23749080
30.

The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.

LaMarre J, Mendes RE, Szal T, Schwarz S, Jones RN, Mankin AS.

Antimicrob Agents Chemother. 2013 Mar;57(3):1173-9. doi: 10.1128/AAC.02047-12. Epub 2012 Dec 17.

31.

Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel.

Kannan K, Vázquez-Laslop N, Mankin AS.

Cell. 2012 Oct 26;151(3):508-20. doi: 10.1016/j.cell.2012.09.018.

32.

Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.

LeTourneau N, Vimal P, Klepacki D, Mankin A, Melman A.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4575-8. doi: 10.1016/j.bmcl.2012.05.110. Epub 2012 Jun 6.

PMID:
22738632
33.

Major families of multiresistant plasmids from geographically and epidemiologically diverse staphylococci.

Shearer JE, Wireman J, Hostetler J, Forberger H, Borman J, Gill J, Sanchez S, Mankin A, Lamarre J, Lindsay JA, Bayles K, Nicholson A, O'Brien F, Jensen SO, Firth N, Skurray RA, Summers AO.

G3 (Bethesda). 2011 Dec;1(7):581-91. doi: 10.1534/g3.111.000760. Epub 2011 Dec 1.

34.

Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.

Kannan K, Mankin AS.

Ann N Y Acad Sci. 2011 Dec;1241:33-47. doi: 10.1111/j.1749-6632.2011.06315.x. Review.

PMID:
22191525
35.

Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05.

Locke JB, Rahawi S, Lamarre J, Mankin AS, Shaw KJ.

Antimicrob Agents Chemother. 2012 Jan;56(1):332-40. doi: 10.1128/AAC.05420-11. Epub 2011 Oct 24.

36.

Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.

Vázquez-Laslop N, Klepacki D, Mulhearn DC, Ramu H, Krasnykh O, Franzblau S, Mankin AS.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10496-501. doi: 10.1073/pnas.1103474108. Epub 2011 Jun 13.

37.

Low fitness cost of the multidrug resistance gene cfr.

LaMarre JM, Locke JB, Shaw KJ, Mankin AS.

Antimicrob Agents Chemother. 2011 Aug;55(8):3714-9. doi: 10.1128/AAC.00153-11. Epub 2011 Jun 6.

38.

Picky nascent peptides do not talk to foreign ribosomes.

Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5931-2. doi: 10.1073/pnas.1103011108. Epub 2011 Apr 4. No abstract available.

39.

Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance.

LaMarre JM, Howden BP, Mankin AS.

Antimicrob Agents Chemother. 2011 Jun;55(6):2989-91. doi: 10.1128/AAC.00183-11. Epub 2011 Mar 28.

40.

Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center.

Ramu H, Vázquez-Laslop N, Klepacki D, Dai Q, Piccirilli J, Micura R, Mankin AS.

Mol Cell. 2011 Feb 4;41(3):321-30. doi: 10.1016/j.molcel.2010.12.031.

41.

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

Dunkle JA, Xiong L, Mankin AS, Cate JH.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17152-7. doi: 10.1073/pnas.1007988107. Epub 2010 Sep 27.

42.

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.

Llano-Sotelo B, Dunkle J, Klepacki D, Zhang W, Fernandes P, Cate JH, Mankin AS.

Antimicrob Agents Chemother. 2010 Dec;54(12):4961-70. doi: 10.1128/AAC.00860-10. Epub 2010 Sep 20.

43.

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.

Vázquez-Laslop N, Ramu H, Klepacki D, Kannan K, Mankin AS.

EMBO J. 2010 Sep 15;29(18):3108-17. doi: 10.1038/emboj.2010.180. Epub 2010 Jul 30.

44.

Structural signatures of antibiotic binding sites on the ribosome.

David-Eden H, Mankin AS, Mandel-Gutfreund Y.

Nucleic Acids Res. 2010 Oct;38(18):5982-94. doi: 10.1093/nar/gkq411. Epub 2010 May 21.

45.

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.

Yan F, LaMarre JM, Röhrich R, Wiesner J, Jomaa H, Mankin AS, Fujimori DG.

J Am Chem Soc. 2010 Mar 24;132(11):3953-64. doi: 10.1021/ja910850y.

46.

The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.

Auerbach T, Mermershtain I, Davidovich C, Bashan A, Belousoff M, Wekselman I, Zimmerman E, Xiong L, Klepacki D, Arakawa K, Kinashi H, Mankin AS, Yonath A.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1983-8. doi: 10.1073/pnas.0914100107. Epub 2010 Jan 11.

47.

Selection of small peptides, inhibitors of translation.

Llano-Sotelo B, Klepacki D, Mankin AS.

J Mol Biol. 2009 Sep 4;391(5):813-9. doi: 10.1016/j.jmb.2009.06.069. Epub 2009 Jul 2.

48.

Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding.

Llano-Sotelo B, Hickerson RP, Lancaster L, Noller HF, Mankin AS.

RNA. 2009 Aug;15(8):1597-604. doi: 10.1261/rna.1681609. Epub 2009 Jun 24.

49.

Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma.

Frankel AE, Zuckero SL, Mankin AA, Grable M, Mitchell K, Lee YJ, Neville DM, Woo JH.

Curr Drug Targets. 2009 Feb;10(2):104-9. Review.

PMID:
19199905
50.

Programmed drug-dependent ribosome stalling.

Ramu H, Mankin A, Vazquez-Laslop N.

Mol Microbiol. 2009 Feb;71(4):811-24. doi: 10.1111/j.1365-2958.2008.06576.x. Epub 2008 Nov 30. Review.

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