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Items: 1 to 50 of 87

1.

Packing density of the PEG-shell in PEG-albumins: PEGylation induced viscosity and COP are inverse correlate of packing density.

Ananda K, Manjula BN, Meng F, Acharya VN, Intaglietta M, Acharya SA.

Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb;40(1-2):14-27. doi: 10.3109/10731199.2011.579568. Epub 2011 May 31.

PMID:
21623695
2.

Induced plasma expander-like properties as a function of PEG-chains on extension arm facilitated PEGylation of albumin: "mushroom to brush-like" conformational transition of the PEG-albumin conjugate.

Sahu RK, Nacharaju P, Manjula BN, Acharya SA.

Artif Cells Blood Substit Immobil Biotechnol. 2009;37(6):245-56. doi: 10.3109/10731190903356438.

PMID:
19922165
4.

Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts.

Meng F, Manjula BN, Tsai AG, Cabrales P, Intaglietta M, Smith PK, Prabhakaran M, Acharya SA.

Protein J. 2009 Jun;28(5):199-212. doi: 10.1007/s10930-009-9185-0.

PMID:
19653083
5.

PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin.

Hu T, Li D, Manjula BN, Brenowitz M, Prabhakaran M, Acharya SA.

Biochemistry. 2009 Jan 27;48(3):608-16. doi: 10.1021/bi801880y.

PMID:
19119852
6.

Autoxidation of the site-specifically PEGylated hemoglobins: role of the PEG chains and the sites of PEGylation in the autoxidation.

Hu T, Li D, Manjula BN, Acharya SA.

Biochemistry. 2008 Oct 14;47(41):10981-90. doi: 10.1021/bi800906z. Epub 2008 Sep 23.

PMID:
18808150
7.

PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein.

Meng F, Manjula BN, Smith PK, Acharya SA.

Bioconjug Chem. 2008 Jul;19(7):1352-60. doi: 10.1021/bc7003878. Epub 2008 Jun 24.

PMID:
18572961
8.

Non-conservative surface decoration of hemoglobin: influence of neutralization of positive charges at PEGylation sites on molecular and functional properties of PEGylated hemoglobin.

Li D, Hu T, Manjula BN, Acharya SA.

Biochim Biophys Acta. 2008 Oct;1784(10):1395-401. doi: 10.1016/j.bbapap.2008.03.014. Epub 2008 Apr 11.

PMID:
18452721
9.

Analysis of functionalization of methoxy-PEG as maleimide-PEG.

Ananda K, Nacharaju P, Smith PK, Acharya SA, Manjula BN.

Anal Biochem. 2008 Mar 15;374(2):231-42. Epub 2007 Dec 4.

PMID:
18158909
10.

Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation.

Acharya SA, Acharya VN, Kanika ND, Tsai AG, Intaglietta M, Manjula BN.

Biochem J. 2007 Aug 1;405(3):503-11.

11.

Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin.

Nacharaju P, Friedman JM, Prabhakaran M, Acharya SA, Manjula BN.

Biochemistry. 2007 Apr 17;46(15):4554-64. Epub 2007 Mar 24.

12.

Thiolation mediated pegylation platform to generate functional universal red blood cells.

Nacharaju P, Manjula BN, Acharya SA.

Artif Cells Blood Substit Immobil Biotechnol. 2007;35(1):107-18.

PMID:
17364475
13.

Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb].

Li D, Manjula BN, Ho NT, Simplaceanu V, Ho C, Acharya AS.

Artif Cells Blood Substit Immobil Biotechnol. 2007;35(1):19-29.

PMID:
17364468
14.

Pair-wise interactions of polymerization inhibitory contact site mutations of hemoglobin-S.

Srinivasulu S, Perumalsamy K, Upadhya R, Manjula BN, Feiring S, Alami R, Bouhassira E, Fabry ME, Nagel RL, Acharya AS.

Protein J. 2006 Dec;25(7-8):503-16.

PMID:
17131194
15.
16.

Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.

Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M.

Blood. 2006 Nov 15;108(10):3603-10. Epub 2006 Jul 20.

17.

Molecular modeling studies of surface decoration of hemoglobin by maleimide PEG.

Prabhakaran M, Manjula BN, Acharya SA.

Artif Cells Blood Substit Immobil Biotechnol. 2006;34(4):381-93.

PMID:
16818412
18.
19.

Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia.

Hangai-Hoger N, Nacharaju P, Manjula BN, Cabrales P, Tsai AG, Acharya SA, Intaglietta M.

Crit Care Med. 2006 Jan;34(1):108-17.

PMID:
16374164
20.

Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive.

Acharya SA, Friedman JM, Manjula BN, Intaglietta M, Tsai AG, Winslow RM, Malavalli A, Vandegriff K, Smith PK.

Artif Cells Blood Substit Immobil Biotechnol. 2005;33(3):239-55.

PMID:
16152690
21.
22.

Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function.

Manjula BN, Tsai AG, Intaglietta M, Tsai CH, Ho C, Smith PK, Perumalsamy K, Kanika ND, Friedman JM, Acharya SA.

Protein J. 2005 Apr;24(3):133-46.

PMID:
16096719
23.
25.

WITHDRAWN: PEGylated hemoglobin: Role of surface configuration of PEG for the modulation of hemoglobin vasoactivity.

Manjula BN, Tsai AG, Intaglietta M, Tsai CH, Ho C, Malavalli A, Vandegriff KD, Winslow RM, Smith PK, Perumalsamy K, Devi Kanika N, Friedman JM, Acharya SA.

J Biol Chem. 2004 Aug 27. [Epub ahead of print]

26.

Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber.

Cabrales P, Kanika ND, Manjula BN, Tsai AG, Acharya SA, Intaglietta M.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1609-17. Epub 2004 Jun 10.

27.

Hemoglobin Einstein: semisynthetic deletion in the B-helix of the alpha-chain.

Srinivasulu S, Manjula BN, Nagel RL, Tsai CH, Ho C, Prabhakaran M, Acharya SA.

Protein Sci. 2004 May;13(5):1266-75.

28.

Probing the conformation of hemoglobin presbyterian in the R-state.

Acharya SA, Malavalli A, Peterson E, Sun PD, Ho C, Prabhakaran M, Arnone A, Manjula BN, Friedman JM.

J Protein Chem. 2003 Apr;22(3):221-30.

PMID:
12962322
29.

Purification and molecular analysis of hemoglobin by high-performance liquid chromatography.

Manjula BN, Acharya SA.

Methods Mol Med. 2003;82:31-47. No abstract available.

PMID:
12669636
30.

Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain.

Manjula BN, Tsai A, Upadhya R, Perumalsamy K, Smith PK, Malavalli A, Vandegriff K, Winslow RM, Intaglietta M, Prabhakaran M, Friedman JM, Acharya AS.

Bioconjug Chem. 2003 Mar-Apr;14(2):464-72.

PMID:
12643758
31.

Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungs.

Deem S, Kim JU, Manjula BN, Acharya AS, Kerr ME, Patel RP, Gladwin MT, Swenson ER.

Circ Res. 2002 Oct 4;91(7):626-32.

32.
33.
34.

Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains.

Rao MJ, Malavalli A, Manjula BN, Kumar R, Prabhakaran M, Sun DP, Ho NT, Ho C, Nagel RL, Acharya AS.

J Mol Biol. 2000 Jul 28;300(5):1389-406.

PMID:
10903876
35.

Cys-93-betabeta-succinimidophenyl polyethylene glycol 2000 hemoglobin A. Intramolecular cross-bridging of hemoglobin outside the central cavity.

Manjula BN, Malavalli A, Smith PK, Chan NL, Arnone A, Friedman JM, Acharya AS.

J Biol Chem. 2000 Feb 25;275(8):5527-34.

36.

Probing the diphosphoglycerate binding pocket of HbA and HbPresbyterian (beta 108Asn --> Lys).

Gottfried DS, Manjula BN, Malavalli A, Acharya AS, Friedman JM.

Biochemistry. 1999 Aug 31;38(35):11307-15.

PMID:
10471280
37.
39.
40.

Intramolecular cross-linking of oxy hemoglobin by bis sulfosuccinimidyl suberate and sebacate: generation of cross-linked hemoglobin with reduced oxygen affinity.

Manjula BN, Smith PK, Malavalli A, Acharya AS.

Artif Cells Blood Substit Immobil Biotechnol. 1995;23(3):311-8.

PMID:
7493052
41.
42.

High-efficiency synthesis of human alpha-endorphin and magainin in the erythrocytes of transgenic mice: a production system for therapeutic peptides.

Sharma A, Khoury-Christianson AM, White SP, Dhanjal NK, Huang W, Paulhiac C, Friedman EJ, Manjula BN, Kumar R.

Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9337-41.

43.

Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA.

Manjula BN, Roy RP, Smith PK, Acharya AS.

Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):747-52.

PMID:
7994397
44.

Recombinant hemoglobin A produced in transgenic swine: structural equivalence with human hemoglobin A.

Rao MJ, Schneider K, Chait BT, Chao TL, Keller H, Anderson S, Manjula BN, Kumar R, Acharya AS.

Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):695-700.

PMID:
7994390
45.

Purification and characterization of polyphosphate kinase from Neisseria meningitidis.

Tinsley CR, Manjula BN, Gotschlich EC.

Infect Immun. 1993 Sep;61(9):3703-10.

46.
47.
49.

The amino-terminal region of group A streptococcal M protein determines its molecular state of assembly and function.

Khandke KM, Fairwell T, Braswell EH, Manjula BN.

J Protein Chem. 1991 Feb;10(1):49-59.

PMID:
2054063
50.

Domain structure and molecular flexibility of streptococcal M protein in situ probed by limited proteolysis.

Khandke KM, Fairwell T, Acharya AS, Manjula BN.

J Protein Chem. 1990 Oct;9(5):511-22.

PMID:
2085376

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