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Mobile and pervasive computing technologies and the future of Alzheimer's clinical trials.

Doraiswamy PM, Narayan VA, Manji HK.

NPJ Digit Med. 2018 Jan 25;1:1. doi: 10.1038/s41746-017-0008-y. eCollection 2018. Review.


Jeffrey Scott Nye.

Manji HK, Flores CM.

Neuropsychopharmacology. 2017 Jul;42(8):1748. doi: 10.1038/npp.2017.62. No abstract available.


The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder.

Dalgard C, Eidelman O, Jozwik C, Olsen CH, Srivastava M, Biswas R, Eudy Y, Rothwell SW, Mueller GP, Yuan P, Drevets WC, Manji HK, Vythlingam M, Charney DS, Neumeister A, Ursano RJ, Jacobowitz DM, Pollard HB, Bonne O.

Transl Psychiatry. 2017 Feb 7;7(2):e1025. doi: 10.1038/tp.2016.285.


Differential effect of lithium on cell number in the hippocampus and prefrontal cortex in adult mice: a stereological study.

Rajkowska G, Clarke G, Mahajan G, Licht CM, van de Werd HJ, Yuan P, Stockmeier CA, Manji HK, Uylings HB.

Bipolar Disord. 2016 Feb;18(1):41-51. doi: 10.1111/bdi.12364. Epub 2016 Feb 4.


Moving from 'diagnose and treat' to 'predict and pre-empt' in neuropsychiatric disorders.

Narayan VA, Manji HK.

Nat Rev Drug Discov. 2016 Feb;15(2):71-2. doi: 10.1038/nrd.2015.20. Epub 2015 Nov 27.


Translating depression biomarkers for improved targeted therapies.

Bredt DS, Furey ML, Chen G, Lovenberg T, Drevets WC, Manji HK.

Neurosci Biobehav Rev. 2015 Dec;59:1-15. doi: 10.1016/j.neubiorev.2015.09.013. Epub 2015 Oct 1. Review.


Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression.

Schloesser RJ, Orvoen S, Jimenez DV, Hardy NF, Maynard KR, Sukumar M, Manji HK, Gardier AM, David DJ, Martinowich K.

Brain Stimul. 2015 Sep-Oct;8(5):862-7. doi: 10.1016/j.brs.2015.05.011. Epub 2015 Jun 9.


Harnessing the informatics revolution for neuroscience drug R&D.

Manji HK, Insel TR, Narayan VA.

Nat Rev Drug Discov. 2014 Aug;13(8):561-2. doi: 10.1038/nrd4395. No abstract available. Erratum in: Nat Rev Drug Discov. 2014 Sep;13(9):708. Insel, Thomas W [corrected to Insel, Thomas R].


Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder.

de Sousa RT, Machado-Vieira R, Zarate CA Jr, Manji HK.

Expert Opin Ther Targets. 2014 Oct;18(10):1131-47. doi: 10.1517/14728222.2014.940893. Epub 2014 Jul 24. Review.


Looking ahead: electroretinographic anomalies, glycogen synthase kinase-3, and biomarkers for neuropsychiatric disorders.

Chen G, Henter ID, Manji HK.

Biol Psychiatry. 2014 Jul 15;76(2):86-8. doi: 10.1016/j.biopsych.2014.05.005. No abstract available.


Arc regulates experience-dependent persistent firing patterns in frontal cortex.

Ren M, Cao V, Ye Y, Manji HK, Wang KH.

J Neurosci. 2014 May 7;34(19):6583-95. doi: 10.1523/JNEUROSCI.0167-14.2014.


Rapid antidepressant effects: moving right along.

Martinowich K, Jimenez DV, Zarate CA Jr, Manji HK.

Mol Psychiatry. 2013 Aug;18(8):856-63. doi: 10.1038/mp.2013.55. Epub 2013 May 21.


Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: a preliminary positron emission tomography study.

Carlson PJ, Diazgranados N, Nugent AC, Ibrahim L, Luckenbaugh DA, Brutsche N, Herscovitch P, Manji HK, Zarate CA Jr, Drevets WC.

Biol Psychiatry. 2013 Jun 15;73(12):1213-21. doi: 10.1016/j.biopsych.2013.02.008. Epub 2013 Mar 27.


Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesis.

Schloesser RJ, Jimenez DV, Hardy NF, Paredes D, Catlow BJ, Manji HK, McKay RD, Martinowich K.

Brain Struct Funct. 2014 May;219(3):1139-48. doi: 10.1007/s00429-013-0532-8. Epub 2013 Mar 13.


Beyond magic bullets: true innovation in health care.

Narayan VA, Mohwinckel M, Pisano G, Yang M, Manji HK.

Nat Rev Drug Discov. 2013 Feb;12(2):85-6. doi: 10.1038/nrd3944.


Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile.

Kaddurah-Daouk R, Yuan P, Boyle SH, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty GG, Yao JK, Chen G, Guitart X, Carlson PJ, Neumeister A, Zarate C, Krishnan RR, Manji HK, Drevets W.

Sci Rep. 2012;2:667. Epub 2012 Sep 19.


Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder.

Duncan WC, Sarasso S, Ferrarelli F, Selter J, Riedner BA, Hejazi NS, Yuan P, Brutsche N, Manji HK, Tononi G, Zarate CA.

Int J Neuropsychopharmacol. 2013 Mar;16(2):301-11. doi: 10.1017/S1461145712000545. Epub 2012 Jun 7.


Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.

Koenigsberg HW, Yuan P, Diaz GA, Guerreri S, Dorantes C, Mayson S, Zamfirescu C, New AS, Goodman M, Manji HK, Siever LJ.

Psychiatry Res. 2012 Sep 30;199(2):92-7. doi: 10.1016/j.psychres.2012.04.026. Epub 2012 May 26.


Acetylcholinesterase inhibition ameliorates deficits in motivational drive.

Martinowich K, Cardinale KM, Schloesser RJ, Hsu M, Greig NH, Manji HK.

Behav Brain Funct. 2012 Mar 20;8:15. doi: 10.1186/1744-9081-8-15.


Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study.

Ibrahim L, Diazgranados N, Franco-Chaves J, Brutsche N, Henter ID, Kronstein P, Moaddel R, Wainer I, Luckenbaugh DA, Manji HK, Zarate CA Jr.

Neuropsychopharmacology. 2012 May;37(6):1526-33. doi: 10.1038/npp.2011.338. Epub 2012 Feb 1.


Estrogen effects on the forced swim test differ in two outbred rat strains.

Koss WA, Einat H, Schloesser RJ, Manji HK, Rubinow DR.

Physiol Behav. 2012 May 15;106(2):81-6. doi: 10.1016/j.physbeh.2012.01.004. Epub 2012 Jan 12.


Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor.

de Bartolomeis A, Tomasetti C, Cicale M, Yuan PX, Manji HK.

Eur Neuropsychopharmacol. 2012 Jul;22(7):527-35. doi: 10.1016/j.euroneuro.2011.11.006. Epub 2012 Jan 14.


Mood-stabilizing drugs: mechanisms of action.

Schloesser RJ, Martinowich K, Manji HK.

Trends Neurosci. 2012 Jan;35(1):36-46. doi: 10.1016/j.tins.2011.11.009. Review.


Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping.

Martinowich K, Schloesser RJ, Lu Y, Jimenez DV, Paredes D, Greene JS, Greig NH, Manji HK, Lu B.

Biol Psychiatry. 2012 Jan 1;71(1):75-83. doi: 10.1016/j.biopsych.2011.08.014. Epub 2011 Oct 5.


Acute D-serine treatment produces antidepressant-like effects in rodents.

Malkesman O, Austin DR, Tragon T, Wang G, Rompala G, Hamidi AB, Cui Z, Young WS, Nakazawa K, Zarate CA, Manji HK, Chen G.

Int J Neuropsychopharmacol. 2012 Sep;15(8):1135-48. doi: 10.1017/S1461145711001386. Epub 2011 Sep 12.


The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome.

Nanavati D, Austin DR, Catapano LA, Luckenbaugh DA, Dosemeci A, Manji HK, Chen G, Markey SP.

J Neurochem. 2011 Nov;119(3):617-29. doi: 10.1111/j.1471-4159.2011.07424.x. Epub 2011 Sep 21.


Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants.

Malkesman O, Austin DR, Tragon T, Henter ID, Reed JC, Pellecchia M, Chen G, Manji HK.

Mol Psychiatry. 2012 Jul;17(8):770-80. doi: 10.1038/mp.2011.77. Epub 2011 Jul 5.


Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience.

Hunsberger JG, Machado-Vieira R, Austin DR, Zarate C, Chuang DM, Chen G, Reed JC, Manji HK.

Brain Res. 2011 Jul 27;1403:19-27. doi: 10.1016/j.brainres.2011.05.067. Epub 2011 Jun 12.


Lithium treatment attenuates muscarinic M(1) receptor dysfunction.

Creson TK, Austin DR, Shaltiel G, McCammon J, Wess J, Manji HK, Chen G.

Bipolar Disord. 2011 May;13(3):238-49. doi: 10.1111/j.1399-5618.2011.00915.x.


Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine.

Bonne O, Gill JM, Luckenbaugh DA, Collins C, Owens MJ, Alesci S, Neumeister A, Yuan P, Kinkead B, Manji HK, Charney DS, Vythilingam M.

J Clin Psychiatry. 2011 Aug;72(8):1124-8. doi: 10.4088/JCP.09m05106blu. Epub 2010 Dec 28.


Bipolar disorder: a neurobiological synthesis.

Manji HK, Henter ID, Zarate CA Jr.

Curr Top Behav Neurosci. 2011;5:331-40. doi: 10.1007/7854_2010_98. No abstract available.


Potential novel therapeutics for bipolar disorders.

Machado-Vieira R, Manji HK, Zarate CA Jr.

Curr Top Behav Neurosci. 2011;5:303-29. doi: 10.1007/7854_2010_51.


Partial rodent genetic models for bipolar disorder.

Chen G, Henter ID, Manji HK.

Curr Top Behav Neurosci. 2011;5:89-106. doi: 10.1007/7854_2010_63.


The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder.

Machado-Vieira R, Pivovarova NB, Stanika RI, Yuan P, Wang Y, Zhou R, Zarate CA Jr, Drevets WC, Brantner CA, Baum A, Laje G, McMahon FJ, Chen G, Du J, Manji HK, Andrews SB.

Biol Psychiatry. 2011 Feb 15;69(4):344-52. doi: 10.1016/j.biopsych.2010.10.019. Epub 2010 Dec 16.


Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study.

Savitz JB, Nugent AC, Bogers W, Roiser JP, Bain EE, Neumeister A, Zarate CA Jr, Manji HK, Cannon DM, Marrett S, Henn F, Charney DS, Drevets WC.

Biol Psychiatry. 2011 Feb 15;69(4):336-43. doi: 10.1016/j.biopsych.2010.09.027. Epub 2010 Nov 20.


Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression.

Mah L, Zarate CA Jr, Nugent AC, Singh JB, Manji HK, Drevets WC.

Int J Neuropsychopharmacol. 2011 May;14(4):545-51. doi: 10.1017/S1461145710001203. Epub 2010 Oct 29.


p11 and gene therapy for severe psychiatric disorders: a practical goal?

Chen G, Twyman R, Manji HK.

Sci Transl Med. 2010 Oct 20;2(54):54ps51. doi: 10.1126/scitranslmed.3001754.


A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

Diazgranados N, Ibrahim L, Brutsche NE, Newberg A, Kronstein P, Khalife S, Kammerer WA, Quezado Z, Luckenbaugh DA, Salvadore G, Machado-Vieira R, Manji HK, Zarate CA Jr.

Arch Gen Psychiatry. 2010 Aug;67(8):793-802. doi: 10.1001/archgenpsychiatry.2010.90.


Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions.

Fan TW, Yuan P, Lane AN, Higashi RM, Wang Y, Hamidi AB, Zhou R, Guitart X, Chen G, Manji HK, Kaddurah-Daouk R.

Metabolomics. 2010 Jun 1;6(2):165-179.


A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.

Du J, Wei Y, Liu L, Wang Y, Khairova R, Blumenthal R, Tragon T, Hunsberger JG, Machado-Vieira R, Drevets W, Wang YT, Manji HK.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11573-8. doi: 10.1073/pnas.0913138107. Epub 2010 Jun 7.


The neurobiology of the switch process in bipolar disorder: a review.

Salvadore G, Quiroz JA, Machado-Vieira R, Henter ID, Manji HK, Zarate CA Jr.

J Clin Psychiatry. 2010 Nov;71(11):1488-501. doi: 10.4088/JCP.09r05259gre. Epub 2010 May 4. Review.


Presynaptic glutamatergic dysfunction in bipolar disorder.

Chen G, Henter ID, Manji HK.

Biol Psychiatry. 2010 Jun 1;67(11):1007-9. doi: 10.1016/j.biopsych.2010.03.027. No abstract available.


Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.

Quiroz JA, Machado-Vieira R, Zarate CA Jr, Manji HK.

Neuropsychobiology. 2010;62(1):50-60. doi: 10.1159/000314310. Epub 2010 May 7. Review.


Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography.

Cornwell BR, Salvadore G, Colon-Rosario V, Latov DR, Holroyd T, Carver FW, Coppola R, Manji HK, Zarate CA Jr, Grillon C.

Am J Psychiatry. 2010 Jul;167(7):836-44. doi: 10.1176/appi.ajp.2009.09050614. Epub 2010 May 3.


Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress.

Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M.

Mol Psychiatry. 2010 Dec;15(12):1152-63. doi: 10.1038/mp.2010.34. Epub 2010 Mar 23.


Translational research in bipolar disorder: emerging insights from genetically based models.

Chen G, Henter ID, Manji HK.

Mol Psychiatry. 2010 Sep;15(9):883-95. doi: 10.1038/mp.2010.3. Epub 2010 Feb 9. Review.


Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission.

Zhou R, Holmes A, Du J, Malkesman O, Yuan P, Wang Y, Damschroder-Williams P, Chen G, Guitart X, Manji HK.

Eur J Neurosci. 2009 Dec;30(12):2318-26. doi: 10.1111/j.1460-9568.2009.07022.x. Epub 2009 Dec 10.


Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.

Laje G, Cannon DM, Allen AS, Klaver JM, Peck SA, Liu X, Manji HK, Drevets WC, McMahon FJ.

Int J Neuropsychopharmacol. 2010 Jul;13(6):715-24. doi: 10.1017/S1461145709991027. Epub 2010 Jan 5.


The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents.

Malkesman O, Scattoni ML, Paredes D, Tragon T, Pearson B, Shaltiel G, Chen G, Crawley JN, Manji HK.

Biol Psychiatry. 2010 May 1;67(9):864-71. doi: 10.1016/j.biopsych.2009.10.018. Epub 2009 Dec 24.

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