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Items: 50

1.

Highly efficient therapeutic gene editing of human hematopoietic stem cells.

Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE.

Nat Med. 2019 May;25(5):776-783. doi: 10.1038/s41591-019-0401-y. Epub 2019 Mar 25.

2.

Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients.

Esrick EB, Manis JP, Daley H, Baricordi C, Trébéden-Negre H, Pierciey FJ, Armant M, Nikiforow S, Heeney MM, London WB, Biasco L, Asmal M, Williams DA, Biffi A.

Blood Adv. 2018 Oct 9;2(19):2505-2512. doi: 10.1182/bloodadvances.2018016725.

3.

Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development.

Ott de Bruin LM, Bosticardo M, Barbieri A, Lin SG, Rowe JH, Poliani PL, Ching K, Eriksson D, Landegren N, Kämpe O, Manis JP, Notarangelo LD.

Blood. 2018 Jul 19;132(3):281-292. doi: 10.1182/blood-2017-12-820985. Epub 2018 May 9.

4.

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Dobbs K, Tabellini G, Calzoni E, Patrizi O, Martinez P, Giliani SC, Moratto D, Al-Herz W, Cancrini C, Cowan M, Bleesing J, Booth C, Buchbinder D, Burns SO, Chatila TA, Chou J, Daza-Cajigal V, Ott de Bruin LM, de la Morena MT, Di Matteo G, Finocchi A, Geha R, Goyal RK, Hayward A, Holland S, Huang CH, Kanariou MG, King A, Kaplan B, Kleva A, Kuijpers TW, Lee BW, Lougaris V, Massaad M, Meyts I, Morsheimer M, Neven B, Pai SY, Parvaneh N, Plebani A, Prockop S, Reisli I, Soh JY, Somech R, Torgerson TR, Kim YJ, Walter JE, Gennery AR, Keles S, Manis JP, Marcenaro E, Moretta A, Parolini S, Notarangelo LD.

Front Immunol. 2017 Oct 10;8:1244. doi: 10.3389/fimmu.2017.01244. eCollection 2017.

5.

DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.

Massaad MJ, Cangemi B, Al-Herz W, LeFranc G, Freeman A, Baxi S, Keles S, Metin A, Dasouki M, Sobh A, Kanariou M, Al-Sukaiti N, Ozen A, Ochs H, Chatila TA, Manis JP, Geha R.

Clin Immunol. 2017 Oct;183:263-265. doi: 10.1016/j.clim.2017.08.020. Epub 2017 Sep 4. No abstract available.

PMID:
28882618
6.

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Dobbs K, Tabellini G, Calzoni E, Patrizi O, Martinez P, Giliani SC, Moratto D, Al-Herz W, Cancrini C, Cowan M, Bleesing J, Booth C, Buchbinder D, Burns SO, Chatila TA, Chou J, Daza-Cajigal V, Ott de Bruin LM, de la Morena M, Di Matteo G, Finocchi A, Geha R, Goyal RK, Hayward A, Holland S, Huang CH, Kanariou MG, King A, Kaplan B, Kleva A, Kuijpers TW, Lee BW, Lougaris V, Massaad M, Meyts I, Morsheimer M, Neven B, Pai SY, Parvaneh N, Plebani A, Prockop S, Reisli I, Soh JY, Somech R, Torgerson TR, Kim YJ, Walter JE, Gennery AR, Keles S, Manis JP, Marcenaro E, Moretta A, Parolini S, Notarangelo LD.

Front Immunol. 2017 Jul 17;8:798. doi: 10.3389/fimmu.2017.00798. eCollection 2017. Erratum in: Front Immunol. 2017 Oct 10;8:1244.

7.

Correction: Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells.

Hartlerode AJ, Willis NA, Rajendran A, Manis JP, Scully R.

PLoS Genet. 2016 Dec 13;12(12):e1006509. doi: 10.1371/journal.pgen.1006509. eCollection 2016 Dec.

8.

Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells.

Hartlerode AJ, Willis NA, Rajendran A, Manis JP, Scully R.

PLoS Genet. 2016 Nov 10;12(11):e1006410. doi: 10.1371/journal.pgen.1006410. eCollection 2016 Nov. Erratum in: PLoS Genet. 2016 Dec 13;12 (12 ):e1006509.

9.

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Massaad MJ, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, Glauzy S, Olson BG, Morbach H, Ohsumi TK, Schmitz K, Kyriacos M, Kane J, Torisu K, Nakabeppu Y, Notarangelo LD, Chouery E, Megarbane A, Kang PB, Al-Idrissi E, Aldhekri H, Meffre E, Mizui M, Tsokos GC, Manis JP, Al-Herz W, Wallace SS, Geha RS.

J Clin Invest. 2016 Nov 1;126(11):4219-4236. doi: 10.1172/JCI85647. Epub 2016 Oct 17.

10.

Platelet refractoriness: it's not the B-all and end-all.

Manis JP, Silberstein LE.

Blood. 2016 Apr 7;127(14):1740-1. doi: 10.1182/blood-2016-02-695437.

PMID:
27056995
11.

A novel mutation in the POLE2 gene causing combined immunodeficiency.

Frugoni F, Dobbs K, Felgentreff K, Aldhekri H, Al Saud BK, Arnaout R, Ali AA, Abhyankar A, Alroqi F, Giliani S, Ojeda MM, Tsitsikov E, Pai SY, Casanova JL, Notarangelo LD, Manis JP.

J Allergy Clin Immunol. 2016 Feb;137(2):635-638.e1. doi: 10.1016/j.jaci.2015.06.049. Epub 2015 Sep 11. No abstract available.

12.

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW.

Nature. 2015 Sep 3;525(7567):134-139. doi: 10.1038/nature14970. Epub 2015 Aug 26.

13.

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

Kumar L, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander G, Manis JP, Poliani PL, Geha RS.

J Exp Med. 2014 May 5;211(5):929-42. doi: 10.1084/jem.20131379. Epub 2014 Apr 21.

14.

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.

Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW.

J Exp Med. 2011 Dec 19;208(13):2733-46. doi: 10.1084/jem.20111155. Epub 2011 Dec 5.

15.

Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.

Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2873-8. doi: 10.1073/pnas.1019537108. Epub 2011 Jan 31.

16.

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW.

PLoS One. 2010 Nov 15;5(11):e13992. doi: 10.1371/journal.pone.0013992.

17.

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

Sherman MH, Kuraishy AI, Deshpande C, Hong JS, Cacalano NA, Gatti RA, Manis JP, Damore MA, Pellegrini M, Teitell MA.

Mol Cell. 2010 Sep 24;39(6):873-85. doi: 10.1016/j.molcel.2010.08.019.

18.

Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.

Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. doi: 10.1073/pnas.0915072107. Epub 2010 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5731.

19.

BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.

Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA.

Mol Cell. 2009 Oct 9;36(1):110-20. doi: 10.1016/j.molcel.2009.08.019.

20.

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.

Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT.

J Exp Med. 2008 Dec 22;205(13):3079-90. doi: 10.1084/jem.20082271. Epub 2008 Dec 8.

21.

Fixing DNA breaks during class switch recombination.

Jolly CJ, Cook AJ, Manis JP.

J Exp Med. 2008 Mar 17;205(3):509-13. doi: 10.1084/jem.20080356. Epub 2008 Mar 10. Review.

22.

Knock out, knock in, knock down--genetically manipulated mice and the Nobel Prize.

Manis JP.

N Engl J Med. 2007 Dec 13;357(24):2426-9. No abstract available.

PMID:
18077807
23.

SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.

Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE.

Immunity. 2007 Nov;27(5):811-23.

24.

IgH class switching and translocations use a robust non-classical end-joining pathway.

Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.

Nature. 2007 Sep 27;449(7161):478-82. Epub 2007 Aug 22.

PMID:
17713479
25.

Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.

Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.

Oncogene. 2008 Jan 10;27(3):318-22. Epub 2007 Jul 16.

PMID:
17637749
26.

Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.

Franco S, Alt FW, Manis JP.

DNA Repair (Amst). 2006 Sep 8;5(9-10):1030-41. Epub 2006 Aug 24. Review.

PMID:
16934538
27.

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3310-5. Epub 2006 Feb 21.

28.

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.

Mol Cell. 2006 Jan 20;21(2):201-14.

29.

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J.

Mol Cell. 2006 Jan 20;21(2):187-200.

30.

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW.

Nature. 2005 Nov 24;438(7067):508-11. Epub 2005 Oct 26.

PMID:
16251902
31.

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.

Rooney S, Alt FW, Sekiguchi J, Manis JP.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2471-5. Epub 2005 Feb 7.

32.

p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.

Senoo M, Manis JP, Alt FW, McKeon F.

Cancer Cell. 2004 Jul;6(1):85-9.

33.

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB.

Nat Immunol. 2004 May;5(5):481-7. Epub 2004 Apr 11.

PMID:
15077110
34.

Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW.

Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2410-5.

35.

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.

Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9. Epub 2003 Sep 5.

36.

Novel antibody switching defects in human patients.

Manis JP, Alt FW.

J Clin Invest. 2003 Jul;112(1):19-22. No abstract available.

37.

Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.

Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G.

J Exp Med. 2003 May 5;197(9):1213-9.

38.

Elucidation of a downstream boundary of the 3' IgH regulatory region.

Manis JP, Michaelson JS, Birshtein BK, Alt FW.

Mol Immunol. 2003 Jan;39(12):753-60.

PMID:
12531286
39.

Internal IgH class switch region deletions are position-independent and enhanced by AID expression.

Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9. Epub 2002 Jul 11.

40.

The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.

Chua KF, Alt FW, Manis JP.

J Exp Med. 2002 May 6;195(9):F37-41. No abstract available.

41.

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.

Manis JP, Dudley D, Kaylor L, Alt FW.

Immunity. 2002 Apr;16(4):607-17.

42.

Mechanism and control of class-switch recombination.

Manis JP, Tian M, Alt FW.

Trends Immunol. 2002 Jan;23(1):31-9. Review.

PMID:
11801452
43.

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.

Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW.

Mol Cell. 2000 Jun;5(6):993-1002.

44.

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.

Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW.

Nature. 2000 Apr 20;404(6780):897-900.

PMID:
10786799
45.

Precursors of Hodgkin's disease and B-cell lymphomas.

Manis JP.

N Engl J Med. 1999 Apr 22;340(16):1280-2. No abstract available.

PMID:
10210714
46.

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3000-5.

47.

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

Manis JP, van der Stoep N, Tian M, Ferrini R, Davidson L, Bottaro A, Alt FW.

J Exp Med. 1998 Oct 19;188(8):1421-31.

48.

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.

Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW.

J Exp Med. 1998 Jun 15;187(12):2081-9.

49.

Ig heavy chain class switching in Rag-deficient mice.

Lansford R, Manis JP, Sonoda E, Rajewsky K, Alt FW.

Int Immunol. 1998 Mar;10(3):325-32.

PMID:
9576620
50.

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW.

Immunity. 1997 Nov;7(5):653-65.

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