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Items: 38


Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.

Swafford D, Shanmugam A, Ranganathan P, Hussein MS, Koni PA, Prasad PD, Thangaraju M, Manicassamy S.

J Immunol. 2018 May 1;200(9):3259-3268. doi: 10.4049/jimmunol.1701086. Epub 2018 Mar 30.


GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis.

Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein MS, Koni PA, Prasad PD, Kurago ZB, Thangaraju M, Ganapathy V, Manicassamy S.

J Immunol. 2018 Mar 1;200(5):1781-1789. doi: 10.4049/jimmunol.1700604. Epub 2018 Jan 31.


Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer.

Suryawanshi A, Tadagavadi RK, Swafford D, Manicassamy S.

Front Immunol. 2016 Oct 27;7:460. eCollection 2016. Review.


RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.

Kandasamy M, Suryawanshi A, Tundup S, Perez JT, Schmolke M, Manicassamy S, Manicassamy B.

PLoS Pathog. 2016 Jul 20;12(7):e1005754. doi: 10.1371/journal.ppat.1005754. eCollection 2016 Jul.


Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.

Pathania R, Ramachandran S, Mariappan G, Thakur P, Shi H, Choi JH, Manicassamy S, Kolhe R, Prasad PD, Sharma S, Lokeshwar BL, Ganapathy V, Thangaraju M.

Cancer Res. 2016 Jun 1;76(11):3224-35. doi: 10.1158/0008-5472.CAN-15-2249. Epub 2016 Apr 5.


Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine.

Manoharan I, Suryawanshi A, Hong Y, Ranganathan P, Shanmugam A, Ahmad S, Swafford D, Manicassamy B, Ramesh G, Koni PA, Thangaraju M, Manicassamy S.

J Immunol. 2016 Jun 1;196(11):4739-49. doi: 10.4049/jimmunol.1501489. Epub 2016 Apr 25.


Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity.

Hong Y, Manoharan I, Suryawanshi A, Shanmugam A, Swafford D, Ahmad S, Chinnadurai R, Manicassamy B, He Y, Mellor AL, Thangaraju M, Munn DH, Manicassamy S.

Oncoimmunology. 2015 Dec 14;5(4):e1115941. eCollection 2016 Apr.


Wnt signaling in dendritic cells: its role in regulation of immunity and tolerance.

Swafford D, Manicassamy S.

Discov Med. 2015 Apr;19(105):303-10. Review.


DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.

Pathania R, Ramachandran S, Elangovan S, Padia R, Yang P, Cinghu S, Veeranan-Karmegam R, Arjunan P, Gnana-Prakasam JP, Sadanand F, Pei L, Chang CS, Choi JH, Shi H, Manicassamy S, Prasad PD, Sharma S, Ganapathy V, Jothi R, Thangaraju M.

Nat Commun. 2015 Apr 24;6:6910. doi: 10.1038/ncomms7910.


Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2015 Apr 1;194(7):3295-304. doi: 10.4049/jimmunol.1402691. Epub 2015 Feb 20.


β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.

Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus-Hill ML, Koni PA, Manicassamy B, Mellor AL, Munn DH, Manicassamy S.

Cancer Res. 2015 Feb 15;75(4):656-665. doi: 10.1158/0008-5472.CAN-14-2377. Epub 2015 Jan 7.


TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation.

Manoharan I, Hong Y, Suryawanshi A, Angus-Hill ML, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2014 Oct 15;193(8):4203-13. doi: 10.4049/jimmunol.1400614. Epub 2014 Sep 10.


Mouse models of acute and chronic colitis.

Manicassamy S, Manoharan I.

Methods Mol Biol. 2014;1194:437-48. doi: 10.1007/978-1-4939-1215-5_25.


Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V.

Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.


CXCR2 knockout mice are protected against DSS-colitis-induced acute kidney injury and inflammation.

Ranganathan P, Jayakumar C, Manicassamy S, Ramesh G.

Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1422-7. doi: 10.1152/ajprenal.00319.2013. Epub 2013 Aug 28.


Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL, Pulendran B.

J Immunol. 2011 Jul 15;187(2):733-47. doi: 10.4049/jimmunol.1002701. Epub 2011 Jun 10.


Dendritic cell control of tolerogenic responses.

Manicassamy S, Pulendran B.

Immunol Rev. 2011 May;241(1):206-27. doi: 10.1111/j.1600-065X.2011.01015.x. Review.


Adenovirus type 5 induces vitamin A-metabolizing enzymes in dendritic cells and enhances priming of gut-homing CD8 T cells.

Ganguly S, Manicassamy S, Blackwell J, Pulendran B, Amara RR.

Mucosal Immunol. 2011 Sep;4(5):528-38. doi: 10.1038/mi.2011.1. Epub 2011 Feb 2.


Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.

Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, Wang YC, Pulendran B.

Science. 2010 Aug 13;329(5993):849-53. doi: 10.1126/science.1188510. Erratum in: Science. 2011 Nov 4;334(6056):594.


Programming dendritic cells to induce T(H)2 and tolerogenic responses.

Pulendran B, Tang H, Manicassamy S.

Nat Immunol. 2010 Aug;11(8):647-55. doi: 10.1038/ni.1894. Epub 2010 Jul 20. Review.


Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus.

Manicassamy B, Manicassamy S, Belicha-Villanueva A, Pisanelli G, Pulendran B, García-Sastre A.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11531-6. doi: 10.1073/pnas.0914994107. Epub 2010 Jun 7.


Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.

Manicassamy S.

Curr Opin Investig Drugs. 2009 Nov;10(11):1225-35. Review.


Modulation of adaptive immunity with Toll-like receptors.

Manicassamy S, Pulendran B.

Semin Immunol. 2009 Aug;21(4):185-93. doi: 10.1016/j.smim.2009.05.005. Epub 2009 Jun 6. Review.


The Role of the Charged Residues of the GP2 Helical Regions in Ebola Entry().

Jiang H, Wang J, Manicassamy B, Manicassamy S, Caffrey M, Rong L.

Virol Sin. 2009 Apr;24(2):121-135.


Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.

Manicassamy S, Ravindran R, Deng J, Oluoch H, Denning TL, Kasturi SP, Rosenthal KM, Evavold BD, Pulendran B.

Nat Med. 2009 Apr;15(4):401-9. doi: 10.1038/nm.1925. Epub 2009 Mar 1.


Differential requirement of PKC-theta in the development and function of natural regulatory T cells.

Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z.

Mol Immunol. 2008 Dec;46(2):213-24. doi: 10.1016/j.molimm.2008.08.275. Epub 2008 Oct 8.


Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages.

Manicassamy S, Pulendran B.

Semin Immunol. 2009 Feb;21(1):22-7. doi: 10.1016/j.smim.2008.07.007. Epub 2008 Sep 7. Review.


Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.

Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B.

Nat Immunol. 2008 Oct;9(10):1157-64. doi: 10.1038/ni.1645. Epub 2008 Aug 31.


A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection.

Manicassamy S, Yin D, Zhang Z, Molinero LL, Alegre ML, Sun Z.

J Immunol. 2008 Jul 1;181(1):513-20.


Stabilized beta-catenin potentiates Fas-mediated T cell apoptosis.

Huang Z, Wang R, Xie H, Shang W, Manicassamy S, Sun Z.

J Immunol. 2008 May 15;180(10):6586-92.


CD4+ T cells are sufficient to elicit allograft rejection and major histocompatibility complex class I molecule is required to induce recurrent autoimmune diabetes after pancreas transplantation in mice.

Xiang Z, Ma LL, Manicassamy S, Ganesh BB, Williams P, Chari R, Chong A, Yin DP.

Transplantation. 2008 Apr 27;85(8):1205-11. doi: 10.1097/TP.0b013e31816b70bf.


Requirement of calcineurin a beta for the survival of naive T cells.

Manicassamy S, Gupta S, Huang Z, Molkentin JD, Shang W, Sun Z.

J Immunol. 2008 Jan 1;180(1):106-12.


Selective function of PKC-theta in T cells.

Manicassamy S, Gupta S, Sun Z.

Cell Mol Immunol. 2006 Aug;3(4):263-70. Review.


Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL.

Manicassamy S, Gupta S, Huang Z, Sun Z.

J Immunol. 2006 Jun 1;176(11):6709-16.


Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD).

Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan JS, Prasad KV.

Oncogene. 2006 Jun 8;25(24):3458-62. Epub 2006 Feb 20.


Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells.

Manicassamy S, Sadim M, Ye RD, Sun Z.

J Mol Biol. 2006 Jan 20;355(3):347-59. Epub 2005 Nov 8.


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