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Items: 48

1.

A Simple and Robust Approach for Evaluation of Antivirals Using a Recombinant Influenza Virus Expressing Gaussia Luciferase.

Li P, Cui Q, Wang L, Zhao X, Zhang Y, Manicassamy B, Yang Y, Rong L, Du R.

Viruses. 2018 Jun 13;10(6). pii: E325. doi: 10.3390/v10060325.

2.

Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication.

Han J, Perez JT, Chen C, Li Y, Benitez A, Kandasamy M, Lee Y, Andrade J, tenOever B, Manicassamy B.

Cell Rep. 2018 Apr 10;23(2):596-607. doi: 10.1016/j.celrep.2018.03.045.

3.

Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis.

Yildiz S, Mazel-Sanchez B, Kandasamy M, Manicassamy B, Schmolke M.

Microbiome. 2018 Jan 10;6(1):9. doi: 10.1186/s40168-017-0386-z.

4.

Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein.

White KM, Abreu P Jr, Wang H, De Jesus PD, Manicassamy B, García-Sastre A, Chanda SK, DeVita RJ, Shaw ML.

ACS Infect Dis. 2018 Feb 9;4(2):146-157. doi: 10.1021/acsinfecdis.7b00120. Epub 2018 Jan 4.

5.

Igβ ubiquitination activates PI3K signals required for endosomal sorting.

Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill SK, Wilson P, Sciammas R, Clark MR.

J Exp Med. 2017 Dec 4;214(12):3775-3790. doi: 10.1084/jem.20161868. Epub 2017 Nov 15.

6.

Development of Potential Small Molecule Therapeutics for Treatment of Ebola Virus Disease.

Schafer A, Cheng H, Lee C, Du R, Han J, Perez J, Peet N, Manicassamy B, Rong L.

Curr Med Chem. 2018;25(38):5177-5190. doi: 10.2174/0929867324666171010141416. Review.

PMID:
29032747
7.

Influenza Virus: Small Molecule Therapeutics and Mechanisms of Antiviral Resistance.

Han J, Perez J, Schafer A, Cheng H, Peet N, Rong L, Manicassamy B.

Curr Med Chem. 2018;25(38):5115-5127. doi: 10.2174/0929867324666170920165926. Review.

PMID:
28933281
8.

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species.

Tundup S, Kandasamy M, Perez JT, Mena N, Steel J, Nagy T, Albrecht RA, Manicassamy B.

PLoS Pathog. 2017 Mar 10;13(3):e1006270. doi: 10.1371/journal.ppat.1006270. eCollection 2017 Mar.

9.

Stabilization and Improvement of a Promising Influenza Antiviral: Making a PAIN PAINless.

Antanasijevic A, Hafeman NJ, Tundup S, Kingsley C, Mishra RK, Rong L, Manicassamy B, Wardrop D, Caffrey M.

ACS Infect Dis. 2016 Sep 9;2(9):608-615. Epub 2016 Aug 1.

PMID:
27759373
10.

RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.

Kandasamy M, Suryawanshi A, Tundup S, Perez JT, Schmolke M, Manicassamy S, Manicassamy B.

PLoS Pathog. 2016 Jul 20;12(7):e1005754. doi: 10.1371/journal.ppat.1005754. eCollection 2016 Jul.

11.

Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine.

Manoharan I, Suryawanshi A, Hong Y, Ranganathan P, Shanmugam A, Ahmad S, Swafford D, Manicassamy B, Ramesh G, Koni PA, Thangaraju M, Manicassamy S.

J Immunol. 2016 Jun 1;196(11):4739-49. doi: 10.4049/jimmunol.1501489. Epub 2016 Apr 25.

12.

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity.

Hong Y, Manoharan I, Suryawanshi A, Shanmugam A, Swafford D, Ahmad S, Chinnadurai R, Manicassamy B, He Y, Mellor AL, Thangaraju M, Munn DH, Manicassamy S.

Oncoimmunology. 2015 Dec 14;5(4):e1115941. eCollection 2016 Apr.

13.

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.

Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SK.

Cell Host Microbe. 2015 Dec 9;18(6):723-35. doi: 10.1016/j.chom.2015.11.002.

14.

La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation.

Pisanelli G, Laurent-Rolle M, Manicassamy B, Belicha-Villanueva A, Morrison J, Lozano-Dubernard B, Castro-Peralta F, Iovane G, García-Sastre A.

Virus Res. 2016 Feb 2;213:11-22. doi: 10.1016/j.virusres.2015.10.027. Epub 2015 Nov 3.

15.

Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.

Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.

Nature. 2015 Sep 3;525(7567):144. doi: 10.1038/nature14555. Epub 2015 Jul 8. No abstract available.

PMID:
26153856
16.

Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2015 Apr 1;194(7):3295-304. doi: 10.4049/jimmunol.1402691. Epub 2015 Feb 20.

17.

β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.

Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus-Hill ML, Koni PA, Manicassamy B, Mellor AL, Munn DH, Manicassamy S.

Cancer Res. 2015 Feb 15;75(4):656-665. doi: 10.1158/0008-5472.CAN-14-2377. Epub 2015 Jan 7.

18.

Influenza A virus uses intercellular connections to spread to neighboring cells.

Roberts KL, Manicassamy B, Lamb RA.

J Virol. 2015 Feb;89(3):1537-49. doi: 10.1128/JVI.03306-14. Epub 2014 Nov 26.

19.

Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells.

Danzy S, Studdard LR, Manicassamy B, Solorzano A, Marshall N, García-Sastre A, Steel J, Lowen AC.

J Virol. 2014 Nov;88(22):13436-46. doi: 10.1128/JVI.01093-14. Epub 2014 Sep 10.

20.

RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.

Schmolke M, Patel JR, de Castro E, Sánchez-Aparicio MT, Uccellini MB, Miller JC, Manicassamy B, Satoh T, Kawai T, Akira S, Merad M, García-Sastre A.

MBio. 2014 Apr 1;5(2):e01006-14. doi: 10.1128/mBio.01006-14.

21.

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.

Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.

Nature. 2014 Jan 30;505(7485):691-5. doi: 10.1038/nature12862. Epub 2013 Nov 27. Erratum in: Nature. 2015 Sep 3;525(7567):144.

22.

Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses.

Medina RA, Stertz S, Manicassamy B, Zimmermann P, Sun X, Albrecht RA, Uusi-Kerttula H, Zagordi O, Belshe RB, Frey SE, Tumpey TM, García-Sastre A.

Sci Transl Med. 2013 May 29;5(187):187ra70. doi: 10.1126/scitranslmed.3005996.

23.

Insertion of a GFP reporter gene in influenza virus.

Perez JT, García-Sastre A, Manicassamy B.

Curr Protoc Microbiol. 2013;Chapter 15:Unit 15G.4. doi: 10.1002/9780471729259.mc15g04s29.

24.

Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells.

Hufford MM, Richardson G, Zhou H, Manicassamy B, García-Sastre A, Enelow RI, Braciale TJ.

PLoS One. 2012;7(10):e46581. doi: 10.1371/journal.pone.0046581. Epub 2012 Oct 8.

25.

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M.

J Clin Invest. 2012 Nov;122(11):4037-47. doi: 10.1172/JCI60659. Epub 2012 Oct 8.

26.

Host modulators of H1N1 cytopathogenicity.

Ward SE, Kim HS, Komurov K, Mendiratta S, Tsai PL, Schmolke M, Satterly N, Manicassamy B, Forst CV, Roth MG, García-Sastre A, Blazewska KM, McKenna CE, Fontoura BM, White MA.

PLoS One. 2012;7(8):e39284. doi: 10.1371/journal.pone.0039284. Epub 2012 Aug 2.

27.

Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potential.

Varga ZT, Grant A, Manicassamy B, Palese P.

J Virol. 2012 Aug;86(16):8359-66. doi: 10.1128/JVI.01122-12. Epub 2012 Jun 6.

28.

Suppression of the antiviral response by an influenza histone mimic.

Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A.

Nature. 2012 Mar 14;483(7390):428-33. doi: 10.1038/nature10892.

29.

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.

Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM.

J Cell Biol. 2012 Feb 6;196(3):315-26. doi: 10.1083/jcb.201107058.

30.

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species.

Schmolke M, Manicassamy B, Pena L, Sutton T, Hai R, Varga ZT, Hale BG, Steel J, Pérez DR, García-Sastre A.

PLoS Pathog. 2011 Aug;7(8):e1002186. doi: 10.1371/journal.ppat.1002186. Epub 2011 Aug 11.

31.

Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.

Bortz E, Westera L, Maamary J, Steel J, Albrecht RA, Manicassamy B, Chase G, Martínez-Sobrido L, Schwemmle M, García-Sastre A.

MBio. 2011 Aug 16;2(4). pii: e00151-11. doi: 10.1128/mBio.00151-11. Print 2011.

32.

Characterization of the receptor-binding domain of Ebola glycoprotein in viral entry.

Wang J, Manicassamy B, Caffrey M, Rong L.

Virol Sin. 2011 Jun;26(3):156-70. doi: 10.1007/s12250-011-3194-9. Epub 2011 Jun 12.

PMID:
21667336
33.

Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?

Ye J, Sorrell EM, Cai Y, Shao H, Xu K, Pena L, Hickman D, Song H, Angel M, Medina RA, Manicassamy B, Garcia-Sastre A, Perez DR.

PLoS Pathog. 2010 Oct 14;6(10):e1001145. doi: 10.1371/journal.ppat.1001145.

34.

Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus.

Medina RA, Manicassamy B, Stertz S, Seibert CW, Hai R, Belshe RB, Frey SE, Basler CF, Palese P, García-Sastre A.

Nat Commun. 2010 Jun 15;1:28. doi: 10.1038/ncomms1026.

35.

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus.

Manicassamy B, Manicassamy S, Belicha-Villanueva A, Pisanelli G, Pulendran B, García-Sastre A.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11531-6. doi: 10.1073/pnas.0914994107. Epub 2010 Jun 7.

36.

Engineered RNA viral synthesis of microRNAs.

Varble A, Chua MA, Perez JT, Manicassamy B, García-Sastre A, tenOever BR.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11519-24. doi: 10.1073/pnas.1003115107. Epub 2010 Jun 7.

37.

Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.

Hale BG, Steel J, Medina RA, Manicassamy B, Ye J, Hickman D, Hai R, Schmolke M, Lowen AC, Perez DR, García-Sastre A.

J Virol. 2010 Jul;84(14):6909-22. doi: 10.1128/JVI.00081-10. Epub 2010 May 5.

38.

Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus.

Hale BG, Steel J, Manicassamy B, Medina RA, Ye J, Hickman D, Lowen AC, Perez DR, García-Sastre A.

J Gen Virol. 2010 Jul;91(Pt 7):1737-42. doi: 10.1099/vir.0.020925-0. Epub 2010 Mar 17.

39.

PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models.

Hai R, Schmolke M, Varga ZT, Manicassamy B, Wang TT, Belser JA, Pearce MB, García-Sastre A, Tumpey TM, Palese P.

J Virol. 2010 May;84(9):4442-50. doi: 10.1128/JVI.02717-09. Epub 2010 Feb 24.

40.

Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines.

Manicassamy B, Medina RA, Hai R, Tsibane T, Stertz S, Nistal-Villán E, Palese P, Basler CF, García-Sastre A.

PLoS Pathog. 2010 Jan 29;6(1):e1000745. doi: 10.1371/journal.ppat.1000745.

41.

An enzymatic virus-like particle assay for sensitive detection of virus entry.

Tscherne DM, Manicassamy B, García-Sastre A.

J Virol Methods. 2010 Feb;163(2):336-43. doi: 10.1016/j.jviromet.2009.10.020. Epub 2009 Oct 29.

42.

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.

Martinez O, Johnson J, Manicassamy B, Rong L, Olinger GG, Hensley LE, Basler CF.

Cell Microbiol. 2010 Feb;12(2):148-57. doi: 10.1111/j.1462-5822.2009.01385.x. Epub 2009 Sep 22.

43.

Expression of Ebolavirus glycoprotein on the target cells enhances viral entry.

Manicassamy B, Rong L.

Virol J. 2009 Jun 8;6:75. doi: 10.1186/1743-422X-6-75.

44.

The Role of the Charged Residues of the GP2 Helical Regions in Ebola Entry().

Jiang H, Wang J, Manicassamy B, Manicassamy S, Caffrey M, Rong L.

Virol Sin. 2009 Apr;24(2):121-135.

45.

Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: putative CD81 binding region 1 is not involved in CD81 binding.

Rothwangl KB, Manicassamy B, Uprichard SL, Rong L.

Virol J. 2008 Mar 20;5:46. doi: 10.1186/1743-422X-5-46.

46.

Characterization of Marburg virus glycoprotein in viral entry.

Manicassamy B, Wang J, Rumschlag E, Tymen S, Volchkova V, Volchkov V, Rong L.

Virology. 2007 Feb 5;358(1):79-88. Epub 2006 Sep 20.

47.

Comprehensive analysis of ebola virus GP1 in viral entry.

Manicassamy B, Wang J, Jiang H, Rong L.

J Virol. 2005 Apr;79(8):4793-805.

48.

Characterization of the LDL-A module mutants of Tva, the subgroup A Rous sarcoma virus receptor, and the implications in protein folding.

Wang QY, Manicassamy B, Yu X, Dolmer K, Gettins PG, Rong L.

Protein Sci. 2002 Nov;11(11):2596-605.

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