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Items: 1 to 50 of 315

1.

Visualization of clustered protocadherin neuronal self-recognition complexes.

Brasch J, Goodman KM, Noble AJ, Rapp M, Mannepalli S, Bahna F, Dandey VP, Bepler T, Berger B, Maniatis T, Potter CS, Carragher B, Honig B, Shapiro L.

Nature. 2019 May;569(7755):280-283. doi: 10.1038/s41586-019-1089-3. Epub 2019 Apr 10.

PMID:
30971825
2.

Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice.

Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T.

Cell. 2019 Apr 18;177(3):639-653.e15. doi: 10.1016/j.cell.2019.03.008. Epub 2019 Apr 4.

PMID:
30955885
3.

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS.

Gelfman S, Dugger S, de Araujo Martins Moreno C, Ren Z, Wolock CJ, Shneider NA, Phatnani H, Cirulli ET, Lasseigne BN, Harris T, Maniatis T, Rouleau GA, Brown RH Jr, Gitler AD, Myers RM, Petrovski S, Allen A, Goldstein DB, Harms MB.

Genome Res. 2019 May;29(5):809-818. doi: 10.1101/gr.243592.118. Epub 2019 Apr 2.

PMID:
30940688
4.

Are Health-Care Providers Well Prepared in Providing Optimal End-of-Life Care to Critically Ill Patients? A Cross-Sectional Study at a Tertiary Care Hospital in the United States.

Rajdev K, Loghmanieh N, Farberov MA, Demissie S, Maniatis T.

J Intensive Care Med. 2018 Dec 3:885066618811794. doi: 10.1177/0885066618811794. [Epub ahead of print]

PMID:
30501452
5.

Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly.

Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T.

Annu Rev Cell Dev Biol. 2018 Oct 6;34:471-493. doi: 10.1146/annurev-cellbio-100616-060701. Review.

PMID:
30296392
6.

Mycophenolate Mofetil-Induced Status Epilepticus.

Pellerin D, Singh K, Maniatis T, Chalk CH, Green L.

Can J Neurol Sci. 2018 Sep;45(5):585-587. doi: 10.1017/cjn.2018.326. No abstract available.

PMID:
30234475
7.

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons.

Yuan Y, Xie S, Darnell JC, Darnell AJ, Saito Y, Phatnani H, Murphy EA, Zhang C, Maniatis T, Darnell RB.

Genome Biol. 2018 Aug 15;19(1):117. doi: 10.1186/s13059-018-1493-2.

8.

Solid phase chemistry to covalently and reversibly capture thiolated RNA.

Duffy EE, Canzio D, Maniatis T, Simon MD.

Nucleic Acids Res. 2018 Aug 21;46(14):6996-7005. doi: 10.1093/nar/gky556.

9.

Protocadherin cis-dimer architecture and recognition unit diversity.

Goodman KM, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsén G, Aye Thu C, Sampogna RV, Maniatis T, Honig B, Shapiro L.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9829-E9837. doi: 10.1073/pnas.1713449114. Epub 2017 Oct 30.

10.

Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.

Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8294-E8303. doi: 10.1073/pnas.1704294114. Epub 2017 Sep 13.

11.

Structural origins of clustered protocadherin-mediated neuronal barcoding.

Rubinstein R, Goodman KM, Maniatis T, Shapiro L, Honig B.

Semin Cell Dev Biol. 2017 Sep;69:140-150. doi: 10.1016/j.semcdb.2017.07.023. Epub 2017 Jul 22. Review.

12.

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development.

Rizvi AH, Camara PG, Kandror EK, Roberts TJ, Schieren I, Maniatis T, Rabadan R.

Nat Biotechnol. 2017 Jun;35(6):551-560. doi: 10.1038/nbt.3854. Epub 2017 May 1.

13.

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.

Mountoufaris G, Chen WV, Hirabayashi Y, O'Keeffe S, Chevee M, Nwakeze CL, Polleux F, Maniatis T.

Science. 2017 Apr 28;356(6336):411-414. doi: 10.1126/science.aai8801.

14.

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T.

Science. 2017 Apr 28;356(6336):406-411. doi: 10.1126/science.aal3231.

15.

γ-Protocadherin structural diversity and functional implications.

Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L.

Elife. 2016 Oct 26;5. pii: e20930. doi: 10.7554/eLife.20930.

16.

Histone and DNA Modifications as Regulators of Neuronal Development and Function.

Lomvardas S, Maniatis T.

Cold Spring Harb Perspect Biol. 2016 Jul 1;8(7). pii: a024208. doi: 10.1101/cshperspect.a024208. Review.

17.

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6029-34. doi: 10.1073/pnas.1605707113. Epub 2016 May 9.

18.

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.

Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L.

Neuron. 2016 May 18;90(4):709-23. doi: 10.1016/j.neuron.2016.04.004. Epub 2016 May 5.

19.

Differential Risk Factors for Chronic Obstructive Pulmonary Disease 30-Day Readmissions According to Indication for Readmission.

Glaser JB, Pau D, Maniatis T.

Ann Am Thorac Soc. 2016 Mar;13(3):447. doi: 10.1513/AnnalsATS.201512-813LE. No abstract available.

PMID:
26963359
20.

Molecular logic of neuronal self-recognition through protocadherin domain interactions.

Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B.

Cell. 2015 Oct 22;163(3):629-42. doi: 10.1016/j.cell.2015.09.026. Epub 2015 Oct 17.

21.

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.

Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, Ren B, Krainer AR, Maniatis T, Wu Q.

Cell. 2015 Aug 13;162(4):900-10. doi: 10.1016/j.cell.2015.07.038.

22.

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.

Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9. doi: 10.1073/pnas.1508461112. Epub 2015 May 26.

23.

Astrocytes in neurodegenerative disease.

Phatnani H, Maniatis T.

Cold Spring Harb Perspect Biol. 2015 Apr 15;7(6). pii: a020628. doi: 10.1101/cshperspect.a020628. Review.

24.

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.

Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JM, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A; FALS Sequencing Consortium, Al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, Van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB.

Science. 2015 Mar 27;347(6229):1436-41. doi: 10.1126/science.aaa3650. Epub 2015 Feb 19.

25.

Resident duty-hour reform: moving beyond "change for change's sake".

Maniatis T.

CMAJ. 2015 Mar 17;187(5):309-10. doi: 10.1503/cmaj.150010. Epub 2015 Feb 9. No abstract available.

26.

Scheduling in the context of resident duty hour reform.

Sun NZ, Maniatis T.

BMC Med Educ. 2014;14 Suppl 1:S18. doi: 10.1186/1472-6920-14-S1-S18. Epub 2014 Dec 11. Review.

27.

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ.

J Neurosci. 2014 Sep 3;34(36):11929-47. doi: 10.1523/JNEUROSCI.1860-14.2014. Erratum in: J Neurosci. 2015 Jan 14;35(2):846-6.

28.

Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins.

Thu CA, Chen WV, Rubinstein R, Chevee M, Wolcott HN, Felsovalyi KO, Tapia JC, Shapiro L, Honig B, Maniatis T.

Cell. 2014 Aug 28;158(5):1045-1059. doi: 10.1016/j.cell.2014.07.012.

29.

Isolated dysphagia unmasking bulbar neurosarcoidosis and pulmonary sarcoidosis.

Abdallah T, Abdallah M, Elsayegh D, Chalhoub M, Khoueiry G, Glatman A, Maniatis T.

Arab J Gastroenterol. 2014 Jun;15(2):85-7. doi: 10.1016/j.ajg.2014.03.001. Epub 2014 Apr 26.

PMID:
25097053
30.

A renal angiomyolipoma with extension to the renal vein and asymptomatic fat pulmonary embolus.

Harris K, Hatem E, Maroun R, Seminara D, Maniatis T.

Ther Adv Respir Dis. 2014 Aug;8(4):133-135. Epub 2014 Jul 17.

PMID:
25034022
31.

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.

Nishimura AL, Shum C, Scotter EL, Abdelgany A, Sardone V, Wright J, Lee YB, Chen HJ, Bilican B, Carrasco M, Maniatis T, Chandran S, Rogelj B, Gallo JM, Shaw CE.

PLoS One. 2014 Mar 20;9(3):e91269. doi: 10.1371/journal.pone.0091269. eCollection 2014.

32.

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP.

Neuron. 2014 Feb 5;81(3):536-543. doi: 10.1016/j.neuron.2013.12.018.

33.

Clustered protocadherins.

Chen WV, Maniatis T.

Development. 2013 Aug;140(16):3297-302. doi: 10.1242/dev.090621. Review.

34.

Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time.

Bilican B, Serio A, Shaw CE, Maniatis T, Chandran S.

Cell Cycle. 2013 Aug 1;12(15):2339-40. doi: 10.4161/cc.25705. Epub 2013 Jul 11. No abstract available.

35.

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T.

Cell Rep. 2013 Jul 25;4(2):385-401. doi: 10.1016/j.celrep.2013.06.018. Epub 2013 Jul 11.

36.

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S.

Sci Transl Med. 2013 Jun 5;5(188):188le2. doi: 10.1126/scitranslmed.3005065.

37.

Ovarian vein thrombosis in the nonpregnant woman: an overlooked diagnosis.

Harris K, Mehta S, Iskhakov E, Chalhoub M, Maniatis T, Forte F, Alkaied H.

Ther Adv Hematol. 2012 Oct;3(5):325-8. doi: 10.1177/2040620712450887. No abstract available.

38.

Gastroduodenal artery aneurysm, diagnosis, clinical presentation and management: a concise review.

Habib N, Hassan S, Abdou R, Torbey E, Alkaied H, Maniatis T, Azab B, Chalhoub M, Harris K.

Ann Surg Innov Res. 2013 Apr 16;7(1):4. doi: 10.1186/1750-1164-7-4.

39.

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells.

Gebhardt JC, Suter DM, Roy R, Zhao ZW, Chapman AR, Basu S, Maniatis T, Xie XS.

Nat Methods. 2013 May;10(5):421-6. doi: 10.1038/nmeth.2411. Epub 2013 Mar 24.

40.

Crystal structure and mechanism of activation of TANK-binding kinase 1.

Larabi A, Devos JM, Ng SL, Nanao MH, Round A, Maniatis T, Panne D.

Cell Rep. 2013 Mar 28;3(3):734-46. doi: 10.1016/j.celrep.2013.01.034. Epub 2013 Feb 28.

41.

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, Shaw CE, Finkbeiner S, Chandran S.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4697-702. doi: 10.1073/pnas.1300398110. Epub 2013 Feb 11.

42.

Intricate interplay between astrocytes and motor neurons in ALS.

Phatnani HP, Guarnieri P, Friedman BA, Carrasco MA, Muratet M, O'Keeffe S, Nwakeze C, Pauli-Behn F, Newberry KM, Meadows SK, Tapia JC, Myers RM, Maniatis T.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E756-65. doi: 10.1073/pnas.1222361110. Epub 2013 Feb 6.

43.

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.

Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H.

J Neurosci. 2013 Jan 9;33(2):574-86. doi: 10.1523/JNEUROSCI.0906-12.2013.

44.

CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice.

Guo Y, Monahan K, Wu H, Gertz J, Varley KE, Li W, Myers RM, Maniatis T, Wu Q.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21081-6. doi: 10.1073/pnas.1219280110. Epub 2012 Nov 30.

45.

Phrenic nerve injury and diaphragmatic paralysis following pacemaker pulse generator replacement.

Harris K, Maniatis G, Siddiqui F, Maniatis T.

Heart Lung. 2013 Jan-Feb;42(1):65-6. doi: 10.1016/j.hrtlng.2012.09.002. Epub 2012 Oct 22.

PMID:
23083538
46.

On the road from classical to modern molecular biology.

Maniatis T.

Nat Med. 2012 Oct;18(10):1499-502. doi: 10.1038/nm.2931. No abstract available.

PMID:
23042362
47.

Structure-based prediction of protein-protein interactions on a genome-wide scale.

Zhang QC, Petrey D, Deng L, Qiang L, Shi Y, Thu CA, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, Honig B.

Nature. 2012 Oct 25;490(7421):556-60. doi: 10.1038/nature11503. Epub 2012 Sep 30. Erratum in: Nature. 2013 Mar 7;495(7439):127.

48.

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.

Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, Gygi SP, Shneider NA, Maniatis T, Reed R.

Cell Rep. 2012 Oct 25;2(4):799-806. doi: 10.1016/j.celrep.2012.08.025. Epub 2012 Sep 27.

49.

Molecular and functional interaction between protocadherin-γC5 and GABAA receptors.

Li Y, Xiao H, Chiou TT, Jin H, Bonhomme B, Miralles CP, Pinal N, Ali R, Chen WV, Maniatis T, De Blas AL.

J Neurosci. 2012 Aug 22;32(34):11780-97. doi: 10.1523/JNEUROSCI.0969-12.2012.

50.

Functional significance of isoform diversification in the protocadherin gamma gene cluster.

Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E, Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR, Maniatis T.

Neuron. 2012 Aug 9;75(3):402-9. doi: 10.1016/j.neuron.2012.06.039. Erratum in: Neuron. 2012 Sep 6;75(5):928-9.

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