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Items: 1 to 50 of 95

1.

A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models.

Falgàs A, Pallarès V, Unzueta U, Céspedes MV, Arroyo-Solera I, Moreno MJ, Gallardo A, Mangues MA, Sierra J, Villaverde A, Vázquez E, Mangues R, Casanova I.

Haematologica. 2019 Jun 27. pii: haematol.2018.211490. doi: 10.3324/haematol.2018.211490. [Epub ahead of print]

2.

Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy.

Aviñó A, Unzueta U, Virtudes Céspedes M, Casanova I, Vázquez E, Villaverde A, Mangues R, Eritja R.

ChemistryOpen. 2019 Mar 28;8(3):382-387. doi: 10.1002/open.201900038. eCollection 2019 Mar.

3.

Protein-driven nanomedicines in oncotherapy.

Casanova I, Unzueta U, Arroyo-Solera I, Céspedes MV, Villaverde A, Mangues R, Vazquez E.

Curr Opin Pharmacol. 2019 Jan 24;47:1-7. doi: 10.1016/j.coph.2018.12.004. [Epub ahead of print] Review.

PMID:
30685732
4.

A Pilot Study of the Efficacy of a Cognitive Training Based on Board Games in Children with Attention-Deficit/Hyperactivity Disorder: A Randomized Controlled Trial.

Estrada-Plana V, Esquerda M, Mangues R, March-Llanes J, Moya-Higueras J.

Games Health J. 2019 Aug;8(4):265-274. doi: 10.1089/g4h.2018.0051. Epub 2019 Jan 17.

PMID:
30653355
5.

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes.

Pavón MA, Arroyo-Solera I, León X, Téllez-Gabriel M, Virós D, Gallardo A, Céspedes MV, Casanova I, Lopez-Pousa A, Barnadas A, Quer M, Mangues R.

Head Neck. 2019 Jun;41(6):1830-1845. doi: 10.1002/hed.25623. Epub 2019 Jan 16.

PMID:
30652380
6.

Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles.

Serna N, Sánchez JM, Unzueta U, Sánchez-García L, Sánchez-Chardi A, Mangues R, Vázquez E, Villaverde A.

Nanotechnology. 2019 Mar 15;30(11):115101. doi: 10.1088/1361-6528/aaf959. Epub 2018 Dec 18.

PMID:
30561375
7.

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma.

Arroyo-Solera I, Pavón MÁ, León X, López M, Gallardo A, Céspedes MV, Casanova I, Pallarès V, López-Pousa A, Mangues MA, Barnadas A, Quer M, Mangues R.

Head Neck. 2019 Feb;41(2):429-439. doi: 10.1002/hed.25437. Epub 2018 Dec 12.

PMID:
30548470
8.

Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia.

Pallarès V, Hoyos M, Chillón MC, Barragán E, Prieto Conde MI, Llop M, Falgàs A, Céspedes MV, Montesinos P, Nomdedeu JF, Brunet S, Sanz MÁ, González-Díaz M, Sierra J, Mangues R, Casanova I.

Cancers (Basel). 2018 Nov 13;10(11). pii: E436. doi: 10.3390/cancers10110436.

9.

Assembly of histidine-rich protein materials controlled through divalent cations.

López-Laguna H, Unzueta U, Conchillo-Solé O, Sánchez-Chardi A, Pesarrodona M, Cano-Garrido O, Voltà E, Sánchez-García L, Serna N, Saccardo P, Mangues R, Villaverde A, Vázquez E.

Acta Biomater. 2019 Jan 1;83:257-264. doi: 10.1016/j.actbio.2018.10.030. Epub 2018 Oct 24.

PMID:
30366134
10.

Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Céspedes MV, Unzueta U, Aviñó A, Gallardo A, Álamo P, Sala R, Sánchez-Chardi A, Casanova I, Mangues MA, Lopez-Pousa A, Eritja R, Villaverde A, Vázquez E, Mangues R.

EMBO Mol Med. 2018 Oct;10(10). pii: e8772. doi: 10.15252/emmm.201708772.

11.

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles.

Sánchez JM, Sánchez-García L, Pesarrodona M, Serna N, Sánchez-Chardi A, Unzueta U, Mangues R, Vázquez E, Villaverde A.

Biomacromolecules. 2018 Sep 10;19(9):3788-3797. doi: 10.1021/acs.biomac.8b00924. Epub 2018 Aug 13.

PMID:
30052033
12.

Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma.

Recasens-Zorzo C, Cardesa-Salzmann T, Petazzi P, Ros-Blanco L, Esteve-Arenys A, Clot G, Guerrero-Hernández M, Rodríguez V, Soldini D, Valera A, Moros A, Climent F, González-Barca E, Mercadal S, Arenillas L, Calvo X, Mate JL, Gutiérrez-García G, Casanova I, Mangues R, Sanjuan-Pla A, Bueno C, Menéndez P, Martínez A, Colomer D, Tejedor RE, Teixidó J, Campo E, López-Guillermo A, Borrell JI, Colomo L, Pérez-Galán P, Roué G.

Haematologica. 2019 Apr;104(4):778-788. doi: 10.3324/haematol.2017.180505. Epub 2018 Jun 28.

13.

CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis.

Moreno MJ, Gallardo A, Novelli S, Mozos A, Aragó M, Pavón MÁ, Céspedes MV, Pallarès V, Falgàs A, Alcoceba M, Blanco O, Gonzalez-Díaz M, Sierra J, Mangues R, Casanova I.

PLoS One. 2018 Jun 19;13(6):e0198789. doi: 10.1371/journal.pone.0198789. eCollection 2018.

14.

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin.

Díaz R, Pallarès V, Cano-Garrido O, Serna N, Sánchez-García L, Falgàs A, Pesarrodona M, Unzueta U, Sánchez-Chardi A, Sánchez JM, Casanova I, Vázquez E, Mangues R, Villaverde A.

Small. 2018 Jun;14(26):e1800665. doi: 10.1002/smll.201800665. Epub 2018 May 29.

PMID:
29845742
15.

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

Favaro MTP, Serna N, Sánchez-García L, Cubarsi R, Roldán M, Sánchez-Chardi A, Unzueta U, Mangues R, Ferrer-Miralles N, Azzoni AR, Vázquez E, Villaverde A.

Nanomedicine. 2018 Aug;14(6):1777-1786. doi: 10.1016/j.nano.2018.05.002. Epub 2018 May 16.

PMID:
29777875
16.

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

Unzueta U, Cespedes MV, Sala R, Alamo P, Sánchez-Chardi A, Pesarrodona M, Sánchez-García L, Cano-Garrido O, Villaverde A, Vázquez E, Mangues R, Seras-Franzoso J.

J Control Release. 2018 Jun 10;279:29-39. doi: 10.1016/j.jconrel.2018.04.004. Epub 2018 Apr 8.

PMID:
29641987
17.

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sánchez-García L, Serna N, Álamo P, Sala R, Céspedes MV, Roldan M, Sánchez-Chardi A, Unzueta U, Casanova I, Mangues R, Vázquez E, Villaverde A.

J Control Release. 2018 Mar 28;274:81-92. doi: 10.1016/j.jconrel.2018.01.031. Epub 2018 Jan 31.

PMID:
29408658
18.

Protein-Based Therapeutic Killing for Cancer Therapies.

Serna N, Sánchez-García L, Unzueta U, Díaz R, Vázquez E, Mangues R, Villaverde A.

Trends Biotechnol. 2018 Mar;36(3):318-335. doi: 10.1016/j.tibtech.2017.11.007. Epub 2017 Dec 12. Review.

PMID:
29246477
19.

NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients.

Pallarès V, Hoyos M, Chillón MC, Barragán E, Conde MIP, Llop M, Céspedes MV, Nomdedeu JF, Brunet S, Sanz MÁ, González-Díaz M, Sierra J, Casanova I, Mangues R.

Oncotarget. 2017 Jun 16;8(44):76003-76014. doi: 10.18632/oncotarget.18537. eCollection 2017 Sep 29.

20.

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks.

Unzueta U, Serna N, Sánchez-García L, Roldán M, Sánchez-Chardi A, Mangues R, Villaverde A, Vázquez E.

Nanotechnology. 2017 Dec 15;28(50):505102. doi: 10.1088/1361-6528/aa963e.

PMID:
29072576
21.

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.

Body S, Esteve-Arenys A, Miloudi H, Recasens-Zorzo C, Tchakarska G, Moros A, Bustany S, Vidal-Crespo A, Rodriguez V, Lavigne R, Com E, Casanova I, Mangues R, Weigert O, Sanjuan-Pla A, Menéndez P, Marcq B, Picquenot JM, Pérez-Galán P, Jardin F, Roué G, Sola B.

Sci Rep. 2017 Oct 24;7(1):13946. doi: 10.1038/s41598-017-14222-1.

22.

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

Serna N, Sánchez-García L, Sánchez-Chardi A, Unzueta U, Roldán M, Mangues R, Vázquez E, Villaverde A.

Acta Biomater. 2017 Sep 15;60:256-263. doi: 10.1016/j.actbio.2017.07.027. Epub 2017 Jul 19.

PMID:
28735028
23.

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles.

Pesarrodona M, Crosas E, Cubarsi R, Sánchez-Chardi A, Saccardo P, Unzueta U, Rueda F, Sanchez-García L, Serna N, Mangues R, Ferrer-Miralles N, Vázquez E, Villaverde A.

Nanoscale. 2017 May 18;9(19):6427-6435. doi: 10.1039/c6nr09182b.

PMID:
28463351
24.

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.

Mira A, Morello V, Céspedes MV, Perera T, Comoglio PM, Mangues R, Michieli P.

Oncotarget. 2017 Jun 13;8(24):38193-38213. doi: 10.18632/oncotarget.16942.

25.

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

Sánchez-García L, Serna N, Mattanovich M, Cazzanelli P, Sánchez-Chardi A, Conchillo-Solé O, Cortés F, Daura X, Unzueta U, Mangues R, Villaverde A, Vázquez E.

Chem Commun (Camb). 2017 Apr 20;53(33):4565-4568. doi: 10.1039/c6cc09900a.

PMID:
28322369
26.

Engineering tumor cell targeting in nanoscale amyloidal materials.

Unzueta U, Seras-Franzoso J, Céspedes MV, Saccardo P, Cortés F, Rueda F, Garcia-Fruitós E, Ferrer-Miralles N, Mangues R, Vázquez E, Villaverde A.

Nanotechnology. 2017 Jan 6;28(1):015102. Epub 2016 Nov 28.

PMID:
27893441
27.

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.

Céspedes MV, Guillén MJ, López-Casas PP, Sarno F, Gallardo A, Álamo P, Cuevas C, Hidalgo M, Galmarini CM, Allavena P, Avilés P, Mangues R.

Dis Model Mech. 2016 Dec 1;9(12):1461-1471. Epub 2016 Oct 20.

28.

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Céspedes MV, Fernández Y, Unzueta U, Mendoza R, Seras-Franzoso J, Sánchez-Chardi A, Álamo P, Toledo-Rubio V, Ferrer-Miralles N, Vázquez E, Schwartz S, Abasolo I, Corchero JL, Mangues R, Villaverde A.

Sci Rep. 2016 Oct 24;6:35765. doi: 10.1038/srep35765.

29.

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

Cano-Garrido O, Céspedes MV, Unzueta U, Saccardo P, Roldán M, Sánchez-Chardi A, Cubarsi R, Vázquez E, Mangues R, García-Fruitós E, Villaverde A.

Nanomedicine (Lond). 2016 Sep;11(18):2387-98. doi: 10.2217/nnm-2016-0200. Epub 2016 Aug 16.

30.

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy.

Pavón MA, Arroyo-Solera I, Céspedes MV, Casanova I, León X, Mangues R.

Oncotarget. 2016 Aug 30;7(35):57351-57366. doi: 10.18632/oncotarget.10344. Review.

31.

Functional recruitment for drug delivery through protein-based nanotechnologies.

Vazquez E, Mangues R, Villaverde A.

Nanomedicine (Lond). 2016 Jun;11(11):1333-6. doi: 10.2217/nnm-2016-0090. Epub 2016 May 12. No abstract available.

PMID:
27221076
32.

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models.

Céspedes MV, Unzueta U, Álamo P, Gallardo A, Sala R, Casanova I, Pavón MA, Mangues MA, Trías M, López-Pousa A, Villaverde A, Vázquez E, Mangues R.

Nanomedicine. 2016 Oct;12(7):1987-1996. doi: 10.1016/j.nano.2016.04.003. Epub 2016 Apr 13.

PMID:
27085904
33.

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Rueda F, Céspedes MV, Sánchez-Chardi A, Seras-Franzoso J, Pesarrodona M, Ferrer-Miralles N, Vázquez E, Rinas U, Unzueta U, Mamat U, Mangues R, García-Fruitós E, Villaverde A.

Microb Cell Fact. 2016 Apr 8;15:59. doi: 10.1186/s12934-016-0457-z.

34.

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Serna N, Céspedes MV, Saccardo P, Xu Z, Unzueta U, Álamo P, Pesarrodona M, Sánchez-Chardi A, Roldán M, Mangues R, Vázquez E, Villaverde A, Ferrer-Miralles N.

Nanomedicine. 2016 Jul;12(5):1241-51. doi: 10.1016/j.nano.2016.01.004. Epub 2016 Mar 4.

PMID:
26949165
35.

Targeting in Cancer Therapies.

Mangues R, Vázquez E, Villaverde A.

Med Sci (Basel). 2016 Mar 8;4(1). pii: E6. doi: 10.3390/medsci4010006.

36.

Recombinant pharmaceuticals from microbial cells: a 2015 update.

Sanchez-Garcia L, Martín L, Mangues R, Ferrer-Miralles N, Vázquez E, Villaverde A.

Microb Cell Fact. 2016 Feb 9;15:33. doi: 10.1186/s12934-016-0437-3. Review.

37.

CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma.

Pavón MA, Parreño M, Téllez-Gabriel M, León X, Arroyo-Solera I, López M, Céspedes MV, Casanova I, Gallardo A, López-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R.

Head Neck. 2016 Apr;38 Suppl 1:E1392-403. doi: 10.1002/hed.24232. Epub 2015 Oct 30.

PMID:
26516695
38.

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials.

Rueda F, Céspedes MV, Conchillo-Solé O, Sánchez-Chardi A, Seras-Franzoso J, Cubarsi R, Gallardo A, Pesarrodona M, Ferrer-Miralles N, Daura X, Vázquez E, García-Fruitós E, Mangues R, Unzueta U, Villaverde A.

Adv Mater. 2015 Dec 16;27(47):7816-22. doi: 10.1002/adma.201503676. Epub 2015 Oct 28.

PMID:
26509451
39.

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients.

Pavón MA, Arroyo-Solera I, Téllez-Gabriel M, León X, Virós D, López M, Gallardo A, Céspedes MV, Casanova I, López-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R.

Oncotarget. 2015 Oct 6;6(30):29016-33. doi: 10.18632/oncotarget.5032.

40.

Towards protein-based viral mimetics for cancer therapies.

Unzueta U, Céspedes MV, Vázquez E, Ferrer-Miralles N, Mangues R, Villaverde A.

Trends Biotechnol. 2015 May;33(5):253-8. doi: 10.1016/j.tibtech.2015.02.007. Epub 2015 Mar 22.

PMID:
25805413
41.

Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model.

Alamo P, Gallardo A, Di Nicolantonio F, Pavón MA, Casanova I, Trias M, Mangues MA, Lopez-Pousa A, Villaverde A, Vázquez E, Bardelli A, Céspedes MV, Mangues R.

FASEB J. 2015 Feb;29(2):464-76. doi: 10.1096/fj.14-262303. Epub 2014 Oct 30.

42.

CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival.

Moreno MJ, Bosch R, Dieguez-Gonzalez R, Novelli S, Mozos A, Gallardo A, Pavón MÁ, Céspedes MV, Grañena A, Alcoceba M, Blanco O, Gonzalez-Díaz M, Sierra J, Mangues R, Casanova I.

J Pathol. 2015 Feb;235(3):445-55. doi: 10.1002/path.4446. Epub 2014 Dec 11.

PMID:
25231113
43.

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR, Gomis RR.

Nat Cell Biol. 2014 Jul;16(7):685-94. doi: 10.1038/ncb2977. Epub 2014 Jun 1.

PMID:
24880666
44.

Immunostaining Protocol: P-Stat3 (Xenograft and Mice).

Calon A, Espinet E, Palomo-Ponce S, Tauriello DVF, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massague J, Sancho E, Batlle E.

Bio Protoc. 2014 May 5;4(9). pii: e1120. doi: 10.21769/BioProtoc.1120.

45.

In vivo architectonic stability of fully de novo designed protein-only nanoparticles.

Céspedes MV, Unzueta U, Tatkiewicz W, Sánchez-Chardi A, Conchillo-Solé O, Álamo P, Xu Z, Casanova I, Corchero JL, Pesarrodona M, Cedano J, Daura X, Ratera I, Veciana J, Ferrer-Miralles N, Vazquez E, Villaverde A, Mangues R.

ACS Nano. 2014 May 27;8(5):4166-76. doi: 10.1021/nn4055732. Epub 2014 Apr 14.

PMID:
24708510
46.

Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models.

Alamo P, Gallardo A, Pavón MA, Casanova I, Trias M, Mangues MA, Vázquez E, Villaverde A, Mangues R, Céspedes MV.

Dis Model Mech. 2014 Mar;7(3):387-96. doi: 10.1242/dmm.013995. Epub 2014 Jan 30.

47.

Focal adhesion protein expression in human diffuse large B-cell lymphoma.

Bosch R, Dieguez-Gonzalez R, Moreno MJ, Gallardo A, Novelli S, Espinosa I, Céspedes MV, Pavón MÁ, Briones J, Grañena A, Sierra J, Mangues R, Casanova I.

Histopathology. 2014 Jul;65(1):119-31. doi: 10.1111/his.12381. Epub 2014 Apr 3.

PMID:
24467224
48.

High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.

Téllez-Gabriel M, Arroyo-Solera I, León X, Gallardo A, López M, Céspedes MV, Casanova I, López-Pousa A, Quer M, Mangues MA, Barnadas A, Mangues R, Pavón MA.

Cancer Med. 2013 Dec;2(6):950-63. doi: 10.1002/cam4.153. Epub 2013 Oct 31.

49.

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

Unzueta U, Saccardo P, Domingo-Espín J, Cedano J, Conchillo-Solé O, García-Fruitós E, Céspedes MV, Corchero JL, Daura X, Mangues R, Ferrer-Miralles N, Villaverde A, Vázquez E.

Nanomedicine. 2014 Apr;10(3):535-41. doi: 10.1016/j.nano.2013.11.006. Epub 2013 Nov 21.

PMID:
24269989
50.

Improved performance of protein-based recombinant gene therapy vehicles by tuning downstream procedures.

Unzueta U, Saccardo P, Ferrer-Miralles N, García-Fruitós E, Vazquez E, Villaverde A, Cortés F, Mangues R.

Biotechnol Prog. 2013 Nov-Dec;29(6):1458-63. doi: 10.1002/btpr.1798. Epub 2013 Sep 16.

PMID:
23956238

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