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Items: 1 to 50 of 96

1.

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections.

Casciaro B, Calcaterra A, Cappiello F, Mori M, Loffredo MR, Ghirga F, Mangoni ML, Botta B, Quaglio D.

Toxins (Basel). 2019 Sep 1;11(9). pii: E511. doi: 10.3390/toxins11090511.

2.

The Potential of Frog Skin Peptides for Anti-Infective Therapies: the Case of Esculentin-1a(1-21)NH2.

Casciaro B, Cappiello F, Loffredo MR, Ghirga F, Mangoni ML.

Curr Med Chem. 2019 Jul 21. doi: 10.2174/0929867326666190722095408. [Epub ahead of print]

PMID:
31333082
3.

Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin-1a(1-21)NH2.

Casciaro B, Lin Q, Afonin S, Loffredo MR, de Turris V, Middel V, Ulrich AS, Di YP, Mangoni ML.

FEBS J. 2019 Oct;286(19):3874-3891. doi: 10.1111/febs.14940. Epub 2019 Jun 13.

PMID:
31144441
4.

The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.

Buommino E, Carotenuto A, Antignano I, Bellavita R, Casciaro B, Loffredo MR, Merlino F, Novellino E, Mangoni ML, Nocera FP, Brancaccio D, Punzi P, Roversi D, Ingenito R, Bianchi E, Grieco P.

ChemMedChem. 2019 Jul 3;14(13):1283-1290. doi: 10.1002/cmdc.201900221. Epub 2019 Jun 3.

PMID:
31087626
5.

Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies.

Casciaro B, d'Angelo I, Zhang X, Loffredo MR, Conte G, Cappiello F, Quaglia F, Di YP, Ungaro F, Mangoni ML.

Biomacromolecules. 2019 May 13;20(5):1876-1888. doi: 10.1021/acs.biomac.8b01829. Epub 2019 Apr 23.

PMID:
31013061
6.

Esculentin-1a Derived Antipseudomonal Peptides: Limited Induction of Resistance and Synergy with Aztreonam.

Casciaro B, Loffredo MR, Luca V, Verrusio W, Cacciafesta M, Mangoni ML.

Protein Pept Lett. 2018;25(12):1155-1162. doi: 10.2174/0929866525666181101104649.

PMID:
30381056
7.

Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae).

Mechkarska M, Coquet L, Leprince J, Auguste RJ, Jouenne T, Mangoni ML, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2018 Dec;28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.

PMID:
29980138
8.

A Novel In Vitro Wound Healing Assay to Evaluate Cell Migration.

Cappiello F, Casciaro B, Mangoni ML.

J Vis Exp. 2018 Mar 17;(133). doi: 10.3791/56825.

PMID:
29608162
9.

Insulinotropic, glucose-lowering, and beta-cell anti-apoptotic actions of peptides related to esculentin-1a(1-21).NH2.

Musale V, Abdel-Wahab YHA, Flatt PR, Conlon JM, Mangoni ML.

Amino Acids. 2018 Jun;50(6):723-734. doi: 10.1007/s00726-018-2551-5. Epub 2018 Mar 17.

PMID:
29549522
10.

The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection.

Marcocci ME, Amatore D, Villa S, Casciaro B, Aimola P, Franci G, Grieco P, Galdiero M, Palamara AT, Mangoni ML, Nencioni L.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02367-17. doi: 10.1128/AAC.02367-17. Print 2018 May.

11.

Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti-diabetic agents.

Musale V, Casciaro B, Mangoni ML, Abdel-Wahab YHA, Flatt PR, Conlon JM.

J Pept Sci. 2018 Feb;24(2). doi: 10.1002/psc.3065. Epub 2018 Jan 19.

PMID:
29349894
12.

Esculentin-1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface.

Casciaro B, Dutta D, Loffredo MR, Marcheggiani S, McDermott AM, Willcox MD, Mangoni ML.

Biopolymers. 2017 Oct 31. doi: 10.1002/bip.23074. [Epub ahead of print]

PMID:
29086910
13.

Peptidomic analysis of skin secretions of the Mexican burrowing toad Rhinophrynus dorsalis (Rhinophrynidae): Insight into the origin of host-defense peptides within the Pipidae and characterization of a proline-arginine-rich peptide.

Conlon JM, Guilhaudis L, Leprince J, Coquet L, Mangoni ML, Attoub S, Jouenne T, King JD.

Peptides. 2017 Nov;97:22-28. doi: 10.1016/j.peptides.2017.09.012. Epub 2017 Sep 23.

PMID:
28951157
14.

Membrane perturbing activities and structural properties of the frog-skin derived peptide Esculentin-1a(1-21)NH2 and its Diastereomer Esc(1-21)-1c: Correlation with their antipseudomonal and cytotoxic activity.

Loffredo MR, Ghosh A, Harmouche N, Casciaro B, Luca V, Bortolotti A, Cappiello F, Stella L, Bhunia A, Bechinger B, Mangoni ML.

Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2327-2339. doi: 10.1016/j.bbamem.2017.09.009. Epub 2017 Sep 12.

15.

Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities.

Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P.

Eur J Med Chem. 2017 Oct 20;139:750-761. doi: 10.1016/j.ejmech.2017.08.040. Epub 2017 Aug 21.

PMID:
28863356
16.

In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection.

Chen C, Mangoni ML, Di YP.

Sci Rep. 2017 Aug 17;7(1):8548. doi: 10.1038/s41598-017-08361-8.

17.

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae).

Conlon JM, Musale V, Attoub S, Mangoni ML, Leprince J, Coquet L, Jouenne T, Abdel-Wahab YHA, Flatt PR, Rinaldi AC.

J Pept Sci. 2017 Oct;23(10):769-776. doi: 10.1002/psc.3025. Epub 2017 Jul 11.

PMID:
28699258
18.

Promising Approaches to Optimize the Biological Properties of the Antimicrobial Peptide Esculentin-1a(1-21)NH2: Amino Acids Substitution and Conjugation to Nanoparticles.

Casciaro B, Cappiello F, Cacciafesta M, Mangoni ML.

Front Chem. 2017 Apr 25;5:26. doi: 10.3389/fchem.2017.00026. eCollection 2017. Review.

19.

Methods for In Vivo/Ex Vivo Analysis of Antimicrobial Peptides in Bacterial Keratitis: siRNA Knockdown, Colony Counts, Myeloperoxidase, Immunostaining, and RT-PCR Assays.

Kolar SS, Baidouri H, Mangoni ML, McDermott AM.

Methods Mol Biol. 2017;1548:411-425. doi: 10.1007/978-1-4939-6737-7_30.

PMID:
28013522
20.

Methods for In Vitro Analysis of Antimicrobial Activity and Toxicity of Anti-keratitis Peptides: Bacterial Viability in Tears, MTT, and TNF-α Release Assays.

Cappiello F, Casciaro B, Kolar SS, Baidouri H, McDermott AM, Mangoni ML.

Methods Mol Biol. 2017;1548:395-409. doi: 10.1007/978-1-4939-6737-7_29.

PMID:
28013521
21.

Cell-Density Dependence of Host-Defense Peptide Activity and Selectivity in the Presence of Host Cells.

Savini F, Luca V, Bocedi A, Massoud R, Park Y, Mangoni ML, Stella L.

ACS Chem Biol. 2017 Jan 20;12(1):52-56. doi: 10.1021/acschembio.6b00910. Epub 2016 Dec 9.

22.

Effects of Aib residues insertion on the structural-functional properties of the frog skin-derived peptide esculentin-1a(1-21)NH2.

Biondi B, Casciaro B, Di Grazia A, Cappiello F, Luca V, Crisma M, Mangoni ML.

Amino Acids. 2017 Jan;49(1):139-150. doi: 10.1007/s00726-016-2341-x. Epub 2016 Oct 11.

PMID:
27726008
23.

Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a(1-21)NH2 as a reliable strategy for antipseudomonal drugs.

Casciaro B, Moros M, Rivera-Fernández S, Bellelli A, de la Fuente JM, Mangoni ML.

Acta Biomater. 2017 Jan 1;47:170-181. doi: 10.1016/j.actbio.2016.09.041. Epub 2016 Sep 29.

PMID:
27693686
24.

Esculentin-1a-Derived Peptides Promote Clearance of Pseudomonas aeruginosa Internalized in Bronchial Cells of Cystic Fibrosis Patients and Lung Cell Migration: Biochemical Properties and a Plausible Mode of Action.

Cappiello F, Di Grazia A, Segev-Zarko LA, Scali S, Ferrera L, Galietta L, Pini A, Shai Y, Di YP, Mangoni ML.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7252-7262. Print 2016 Dec.

25.

Purification, Conformational Analysis, and Properties of a Family of Tigerinin Peptides from Skin Secretions of the Crowned Bullfrog Hoplobatrachus occipitalis.

McLaughlin CM, Lampis S, Mechkarska M, Coquet L, Jouenne T, King JD, Mangoni ML, Lukic ML, Scorciapino MA, Conlon JM.

J Nat Prod. 2016 Sep 23;79(9):2350-6. doi: 10.1021/acs.jnatprod.6b00494. Epub 2016 Aug 25.

PMID:
27560386
26.

Antimicrobial peptides and wound healing: biological and therapeutic considerations.

Mangoni ML, McDermott AM, Zasloff M.

Exp Dermatol. 2016 Mar;25(3):167-73. doi: 10.1111/exd.12929. Epub 2016 Feb 10. Review.

27.

NMR structure and binding of esculentin-1a (1-21)NH2 and its diastereomer to lipopolysaccharide: Correlation with biological functions.

Ghosh A, Bera S, Shai Y, Mangoni ML, Bhunia A.

Biochim Biophys Acta. 2016 Apr;1858(4):800-12. doi: 10.1016/j.bbamem.2015.12.027. Epub 2015 Dec 23.

28.

Bacillomycin D and its combination with amphotericin B: promising antifungal compounds with powerful antibiofilm activity and wound-healing potency.

Tabbene O, Azaiez S, Di Grazia A, Karkouch I, Ben Slimene I, Elkahoui S, Alfeddy MN, Casciaro B, Luca V, Limam F, Mangoni ML.

J Appl Microbiol. 2016 Feb;120(2):289-300. doi: 10.1111/jam.13030.

29.

Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties.

Batoni G, Casu M, Giuliani A, Luca V, Maisetta G, Mangoni ML, Manzo G, Pintus M, Pirri G, Rinaldi AC, Scorciapino MA, Serra I, Ulrich AS, Wadhwani P.

Amino Acids. 2016 Mar;48(3):887-900. doi: 10.1007/s00726-015-2136-5. Epub 2015 Nov 27.

PMID:
26614437
30.

Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities.

Manzo G, Scorciapino MA, Srinivasan D, Attoub S, Mangoni ML, Rinaldi AC, Casu M, Flatt PR, Conlon JM.

J Nat Prod. 2015 Dec 24;78(12):3041-8. doi: 10.1021/acs.jnatprod.5b00843. Epub 2015 Nov 25.

PMID:
26606380
31.

Editorial: Antimicrobial Peptides in Medicinal Chemistry: Advances and Applications.

Mangoni ML, Bhunia A.

Curr Top Med Chem. 2016;16(1):2-3. No abstract available.

PMID:
26391965
32.

Overcoming barriers in Pseudomonas aeruginosa lung infections: Engineered nanoparticles for local delivery of a cationic antimicrobial peptide.

d'Angelo I, Casciaro B, Miro A, Quaglia F, Mangoni ML, Ungaro F.

Colloids Surf B Biointerfaces. 2015 Nov 1;135:717-25. doi: 10.1016/j.colsurfb.2015.08.027. Epub 2015 Aug 22.

PMID:
26340361
33.

D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions.

Di Grazia A, Cappiello F, Cohen H, Casciaro B, Luca V, Pini A, Di YP, Shai Y, Mangoni ML.

Amino Acids. 2015 Dec;47(12):2505-19. doi: 10.1007/s00726-015-2041-y. Epub 2015 Jul 11.

PMID:
26162435
34.

Naturally Occurring Peptides from Rana temporaria: Antimicrobial Properties and More.

Mangoni ML, Grazia AD, Cappiello F, Casciaro B, Luca V.

Curr Top Med Chem. 2016;16(1):54-64. Review.

PMID:
26139114
35.

The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH2 Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent Manner: A Novel Promoter of Human Skin Wound Healing?

Di Grazia A, Cappiello F, Imanishi A, Mastrofrancesco A, Picardo M, Paus R, Mangoni ML.

PLoS One. 2015 Jun 12;10(6):e0128663. doi: 10.1371/journal.pone.0128663. eCollection 2015.

36.

Fighting microbial infections: A lesson from amphibian skin-derived esculentin-1 peptides.

Mangoni ML, Luca V, McDermott AM.

Peptides. 2015 Sep;71:286-95. doi: 10.1016/j.peptides.2015.04.018. Epub 2015 May 8. Review.

PMID:
25959536
37.

Synergistic fungicidal activity of the lipopeptide bacillomycin D with amphotericin B against pathogenic Candida species.

Tabbene O, Di Grazia A, Azaiez S, Ben Slimene I, Elkahoui S, Alfeddy MN, Casciaro B, Luca V, Limam F, Mangoni ML.

FEMS Yeast Res. 2015 Jun;15(4):fov022. doi: 10.1093/femsyr/fov022. Epub 2015 May 7.

PMID:
25956541
38.

Mechanisms of biofilm inhibition and degradation by antimicrobial peptides.

Segev-Zarko L, Saar-Dover R, Brumfeld V, Mangoni ML, Shai Y.

Biochem J. 2015 Jun 1;468(2):259-70. doi: 10.1042/BJ20141251.

PMID:
25761937
39.

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis.

Kolar SSN, Luca V, Baidouri H, Mannino G, McDermott AM, Mangoni ML.

Cell Mol Life Sci. 2015 Feb;72(3):617-627. doi: 10.1007/s00018-014-1694-0. Epub 2014 Aug 3.

40.

How many antimicrobial peptide molecules kill a bacterium? The case of PMAP-23.

Roversi D, Luca V, Aureli S, Park Y, Mangoni ML, Stella L.

ACS Chem Biol. 2014 Sep 19;9(9):2003-7. doi: 10.1021/cb500426r. Epub 2014 Jul 30.

PMID:
25058470
41.

Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus.

Di Grazia A, Luca V, Segev-Zarko LA, Shai Y, Mangoni ML.

Antimicrob Agents Chemother. 2014 May;58(5):2520-7. doi: 10.1128/AAC.02801-13. Epub 2014 Feb 10.

42.

A lesson from Bombinins H, mildly cationic diastereomeric antimicrobial peptides from Bombina skin.

Mangoni ML.

Curr Protein Pept Sci. 2013 Dec;14(8):734-43. Review.

PMID:
24384035
43.

P-113 peptide: New experimental evidences on its biological activity and conformational insights from molecular dynamics simulations.

Di Giampaolo A, Luzi C, Casciaro B, Bozzi A, Mangoni ML, Aschi M.

Biopolymers. 2014 Mar;102(2):159-67. doi: 10.1002/bip.22452.

PMID:
24347202
44.

From frog integument to human skin: dermatological perspectives from frog skin biology.

Haslam IS, Roubos EW, Mangoni ML, Yoshizato K, Vaudry H, Kloepper JE, Pattwell DM, Maderson PF, Paus R.

Biol Rev Camb Philos Soc. 2014 Aug;89(3):618-55. doi: 10.1111/brv.12072. Epub 2013 Dec 3.

PMID:
24299058
45.

Anti-Candida activity of 1-18 fragment of the frog skin peptide esculentin-1b: in vitro and in vivo studies in a Caenorhabditis elegans infection model.

Luca V, Olivi M, Di Grazia A, Palleschi C, Uccelletti D, Mangoni ML.

Cell Mol Life Sci. 2014 Jul;71(13):2535-46. doi: 10.1007/s00018-013-1500-4. Epub 2013 Nov 10.

PMID:
24221134
46.

NMR structure of temporin-1 ta in lipopolysaccharide micelles: mechanistic insight into inactivation by outer membrane.

Saravanan R, Joshi M, Mohanram H, Bhunia A, Mangoni ML, Bhattacharjya S.

PLoS One. 2013 Sep 9;8(9):e72718. doi: 10.1371/journal.pone.0072718. eCollection 2013.

47.

Novel α-MSH peptide analogues with broad spectrum antimicrobial activity.

Grieco P, Carotenuto A, Auriemma L, Limatola A, Di Maro S, Merlino F, Mangoni ML, Luca V, Di Grazia A, Gatti S, Campiglia P, Gomez-Monterrey I, Novellino E, Catania A.

PLoS One. 2013 Apr 23;8(4):e61614. doi: 10.1371/journal.pone.0061614. Print 2013.

48.

Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa.

Luca V, Stringaro A, Colone M, Pini A, Mangoni ML.

Cell Mol Life Sci. 2013 Aug;70(15):2773-86. doi: 10.1007/s00018-013-1291-7. Epub 2013 Mar 16.

PMID:
23503622
49.

Antioxidative and DNA protective effects of bacillomycin D-like lipopeptides produced by b38 strain.

Tabbene O, Gharbi D, Slimene IB, Elkahoui S, Alfeddy MN, Cosette P, Mangoni ML, Jouenne T, Limam F.

Appl Biochem Biotechnol. 2012 Dec;168(8):2245-56. doi: 10.1007/s12010-012-9933-z. Epub 2012 Oct 12.

PMID:
23065405
50.

Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens.

Falciani C, Lozzi L, Pollini S, Luca V, Carnicelli V, Brunetti J, Lelli B, Bindi S, Scali S, Di Giulio A, Rossolini GM, Mangoni ML, Bracci L, Pini A.

PLoS One. 2012;7(10):e46259. doi: 10.1371/journal.pone.0046259. Epub 2012 Oct 2.

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