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Items: 50

1.

[Genesis of cardiac sinus automaticity and therapeutic perspectives].

Mesirca P, Torrente AG, Bidaud I, Baudot M, Nargeot J, Mangoni ME.

Arch Mal Coeur Vaiss Pratique. 2018 Apr;2018(267):35-39. doi: 10.1016/j.amcp.2018.02.007. Epub 2018 Mar 12. French. No abstract available.

2.

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

Saponaro A, Cantini F, Porro A, Bucchi A, DiFrancesco D, Maione V, Donadoni C, Introini B, Mesirca P, Mangoni ME, Thiel G, Banci L, Santoro B, Moroni A.

Elife. 2018 Jun 20;7. pii: e35753. doi: 10.7554/eLife.35753.

3.

Clock-dependent and system-driven oscillators interact in the suprachiasmatic nuclei to pace mammalian circadian rhythms.

Abitbol K, Debiesse S, Molino F, Mesirca P, Bidaud I, Minami Y, Mangoni ME, Yagita K, Mollard P, Bonnefont X.

PLoS One. 2017 Oct 23;12(10):e0187001. doi: 10.1371/journal.pone.0187001. eCollection 2017.

4.

CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current.

Toyoda F, Mesirca P, Dubel S, Ding WG, Striessnig J, Mangoni ME, Matsuura H.

Sci Rep. 2017 Aug 11;7(1):7869. doi: 10.1038/s41598-017-08191-8.

5.

RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.

Wang YY, Mesirca P, Marqués-Sulé E, Zahradnikova A Jr, Villejoubert O, D'Ocon P, Ruiz C, Domingo D, Zorio E, Mangoni ME, Benitah JP, Gómez AM.

JCI Insight. 2017 Apr 20;2(8). pii: 91872. doi: 10.1172/jci.insight.91872. eCollection 2017 Apr 20.

6.

Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond.

Mesirca P, Bidaud I, Mangoni ME.

J Physiol. 2016 Oct 15;594(20):5869-5879. doi: 10.1113/JP270678. Epub 2016 Aug 2. Review.

7.

Desmosomes and sino-atrial dysfunction.

Mangoni ME.

Cardiovasc Res. 2016 Aug 1;111(3):167-8. doi: 10.1093/cvr/cvw171. Epub 2016 Jun 19. No abstract available.

PMID:
27325669
8.

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni AL, Baudot M, Marger L, Chung You Chong A, Nargeot J, Striessnig J, Wickman K, Charpentier F, Mangoni ME.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1.

9.

L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity.

Torrente AG, Mesirca P, Neco P, Rizzetto R, Dubel S, Barrere C, Sinegger-Brauns M, Striessnig J, Richard S, Nargeot J, Gomez AM, Mangoni ME.

Cardiovasc Res. 2016 Mar 1;109(3):451-61. doi: 10.1093/cvr/cvw006. Epub 2016 Jan 19.

PMID:
26786159
10.

Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'.

Faucherre A, Kissa K, Nargeot J, Mangoni ME, Jopling C.

Haematologica. 2016 Jan;101(1):e38. doi: 10.3324/haematol.2015.137398. No abstract available.

11.

Functional role of voltage gated Ca(2+) channels in heart automaticity.

Mesirca P, Torrente AG, Mangoni ME.

Front Physiol. 2015 Feb 2;6:19. doi: 10.3389/fphys.2015.00019. eCollection 2015. Review.

12.

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.

Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.

Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664.

13.

T-type channels in the sino-atrial and atrioventricular pacemaker mechanism.

Mesirca P, Torrente AG, Mangoni ME.

Pflugers Arch. 2014 Apr;466(4):791-9. doi: 10.1007/s00424-014-1482-6. Epub 2014 Feb 27. Review.

PMID:
24573175
14.

piezo2b regulates vertebrate light touch response.

Faucherre A, Nargeot J, Mangoni ME, Jopling C.

J Neurosci. 2013 Oct 23;33(43):17089-94. doi: 10.1523/JNEUROSCI.0522-13.2013.

15.

Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.

Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3037-46. doi: 10.1073/pnas.1311865110. Epub 2013 Jul 22. Erratum in: Proc Natl Acad Sci U S A. 2014 April 29;111(17):6528.

16.

Piezo1 plays a role in erythrocyte volume homeostasis.

Faucherre A, Kissa K, Nargeot J, Mangoni ME, Jopling C.

Haematologica. 2014 Jan;99(1):70-5. doi: 10.3324/haematol.2013.086090. Epub 2013 Jul 19.

17.

The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation.

Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME.

J Gen Physiol. 2013 Aug;142(2):113-26. doi: 10.1085/jgp.201310996. Epub 2013 Jul 15.

18.

Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.

Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE.

Circulation. 2013 Jul 9;128(2):101-14. doi: 10.1161/CIRCULATIONAHA.112.000768. Epub 2013 Jun 3.

19.

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.

Christel CJ, Cardona N, Mesirca P, Herrmann S, Hofmann F, Striessnig J, Ludwig A, Mangoni ME, Lee A.

J Physiol. 2012 Dec 15;590(24):6327-42. doi: 10.1113/jphysiol.2012.239954. Epub 2012 Oct 8.

20.

Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

Neco P, Torrente AG, Mesirca P, Zorio E, Liu N, Priori SG, Napolitano C, Richard S, Benitah JP, Mangoni ME, Gómez AM.

Circulation. 2012 Jul 24;126(4):392-401. doi: 10.1161/CIRCULATIONAHA.111.075382. Epub 2012 Jun 18.

21.

Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels.

Bock G, Gebhart M, Scharinger A, Jangsangthong W, Busquet P, Poggiani C, Sartori S, Mangoni ME, Sinnegger-Brauns MJ, Herzig S, Striessnig J, Koschak A.

J Biol Chem. 2011 Dec 9;286(49):42736-48. doi: 10.1074/jbc.M111.269951. Epub 2011 Oct 13.

22.

Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):251-61. Epub 2011 May 1.

23.

Pacemaker activity and ionic currents in mouse atrioventricular node cells.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):241-50. Epub 2011 May 1.

24.

Killing the primary heart pacemaker.

Mangoni ME.

Cardiovasc Res. 2011 Apr 1;90(1):3-4. doi: 10.1093/cvr/cvr048. Epub 2011 Feb 18. No abstract available.

PMID:
21335411
25.

Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.

Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nürnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nürnberg P, Striessnig J, Bolz HJ.

Nat Neurosci. 2011 Jan;14(1):77-84. doi: 10.1038/nn.2694. Epub 2010 Dec 5.

PMID:
21131953
26.

Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate.

Gros D, Théveniau-Ruissy M, Bernard M, Calmels T, Kober F, Söhl G, Willecke K, Nargeot J, Jongsma HJ, Mangoni ME.

Cardiovasc Res. 2010 Jan 1;85(1):45-55. doi: 10.1093/cvr/cvp280.

PMID:
19679680
27.

Control of heart rate by cAMP sensitivity of HCN channels.

Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12189-94. doi: 10.1073/pnas.0810332106. Epub 2009 Jul 1.

28.

Identification of potential pharmacological targets by analysis of the comprehensive G protein-coupled receptor repertoire in the four cardiac chambers.

Moore-Morris T, Varrault A, Mangoni ME, Le Digarcher A, Negre V, Dantec C, Journot L, Nargeot J, Couette B.

Mol Pharmacol. 2009 May;75(5):1108-16. doi: 10.1124/mol.108.054155. Epub 2009 Feb 19.

PMID:
19229040
29.

Genesis and regulation of the heart automaticity.

Mangoni ME, Nargeot J.

Physiol Rev. 2008 Jul;88(3):919-82. doi: 10.1152/physrev.00018.2007. Review.

30.

Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system.

Meysen S, Marger L, Hewett KW, Jarry-Guichard T, Agarkova I, Chauvin JP, Perriard JC, Izumo S, Gourdie RG, Mangoni ME, Nargeot J, Gros D, Miquerol L.

Dev Biol. 2007 Mar 15;303(2):740-53. Epub 2006 Dec 23.

31.

Ionic channels underlying cardiac automaticity: new insights from genetically-modified mouse strains.

Nargeot J, Mangoni ME.

Arch Mal Coeur Vaiss. 2006 Sep;99(9):856-61. Review.

PMID:
17067108
32.

Physiological and pharmacological insights into the role of ionic channels in cardiac pacemaker activity.

Couette B, Marger L, Nargeot J, Mangoni ME.

Cardiovasc Hematol Disord Drug Targets. 2006 Sep;6(3):169-90. Review.

PMID:
17017901
33.

If current inhibition: cellular basis and physiology.

Mangoni ME, Marger L, Nargeot J.

Adv Cardiol. 2006;43:17-30. doi: 10.1159/000095403. Review.

PMID:
16936469
34.

Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels.

Mangoni ME, Traboulsie A, Leoni AL, Couette B, Marger L, Le Quang K, Kupfer E, Cohen-Solal A, Vilar J, Shin HS, Escande D, Charpentier F, Nargeot J, Lory P.

Circ Res. 2006 Jun 9;98(11):1422-30. Epub 2006 May 11.

PMID:
16690884
35.

Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.

Leoni AL, Marionneau C, Demolombe S, Le Bouter S, Mangoni ME, Escande D, Charpentier F.

Physiol Genomics. 2005 Dec 14;24(1):4-12. Epub 2005 Oct 11.

PMID:
16219869
36.

Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes.

Mangoni ME, Couette B, Marger L, Bourinet E, Striessnig J, Nargeot J.

Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):38-63. Epub 2005 Jun 6. Review.

PMID:
15979127
37.

Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.

Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S.

J Physiol. 2005 Jan 1;562(Pt 1):223-34. Epub 2004 Oct 21.

38.

Adenosine receptors, heart rate, and cardioprotection.

Mangoni ME, Barrère-Lemaire S.

Cardiovasc Res. 2004 Jun 1;62(3):447-9. No abstract available.

PMID:
15158136
39.

Dissecting the functional role of different isoforms of the L-type Ca2+ channel.

Bourinet E, Mangoni ME, Nargeot J.

J Clin Invest. 2004 May;113(10):1382-4. Review.

40.

A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.

Clark RB, Mangoni ME, Lueger A, Couette B, Nargeot J, Giles WR.

Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1757-66. Epub 2003 Dec 23.

41.

Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.

Mangoni ME, Couette B, Bourinet E, Platzer J, Reimer D, Striessnig J, Nargeot J.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5543-8. Epub 2003 Apr 16.

42.
43.

Inhibition of T-type and L-type calcium channels by mibefradil: physiologic and pharmacologic bases of cardiovascular effects.

Leuranguer V, Mangoni ME, Nargeot J, Richard S.

J Cardiovasc Pharmacol. 2001 Jun;37(6):649-61.

PMID:
11392461
44.

Cyclosporin A increases basal intracellular calcium and calcium responses to endothelin and vasopressin in human coronary myocytes.

Frapier JM, Choby C, Mangoni ME, Nargeot J, Albat B, Richard S.

FEBS Lett. 2001 Mar 23;493(1):57-62.

45.

Facilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity.

Mangoni ME, Fontanaud P, Noble PJ, Noble D, Benkemoun H, Nargeot J, Richard S.

Cardiovasc Res. 2000 Dec;48(3):375-92.

PMID:
11090833
46.

Evidence for tetrodotoxin-sensitive sodium currents in primary cultured myocytes from human, pig and rabbit arteries.

Choby C, Mangoni ME, Boccara G, Nargeot J, Richard S.

Pflugers Arch. 2000 May;440(1):149-52.

PMID:
10864008
47.

Characterisation of alpha 1A Ba2+, Sr2+ and Ca2+ currents recorded with the ancillary beta 1-4 subunits.

Mangoni ME, Cens T, Dalle C, Nargeot J, Charnet P.

Receptors Channels. 1997;5(1):1-14.

PMID:
9272572
48.

Modulation of the alpha 1A Ca2+ channel by beta subunits at physiological Ca2+ concentration.

Cens T, Mangoni ME, Nargeot J, Charnet P.

FEBS Lett. 1996 Aug 12;391(3):232-7.

49.

Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation.

Mangoni ME, Aumelas A, Charnet P, Roumestand C, Chiche L, Despaux E, Grassy G, Calas B, Chavanieu A.

FEBS Lett. 1996 Mar 25;383(1-2):93-8.

50.

Coexpression of the beta2 subunit does not induce voltage-dependent facilitation of the class C L-type Ca channel.

Cens T, Mangoni ME, Richard S, Nargeot J, Charnet P.

Pflugers Arch. 1996 Mar;431(5):771-4.

PMID:
8596729

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