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Items: 35

1.

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.

Einolf HJ, Lin W, Won CS, Wang L, Gu H, Chun DY, He H, Mangold JB.

Drug Metab Dispos. 2017 Dec;45(12):1304-1316. doi: 10.1124/dmd.117.076851. Epub 2017 Sep 14.

PMID:
28912253
2.

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.

Flarakos J, Du Y, Gu H, Wang L, Einolf HJ, Chun DY, Zhu B, Alexander N, Natrillo A, Hanna I, Ting L, Zhou W, Dole K, Sun H, Kovacs SJ, Stein DS, Tanaka SK, Villano S, Mangold JB.

Xenobiotica. 2017 Aug;47(8):682-696. doi: 10.1080/00498254.2016.1213465. Epub 2016 Aug 8.

PMID:
27499331
3.

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.

Huskey SE, Forseth RR, Li H, Jian Z, Catoire A, Zhang J, Ray T, He H, Flarakos J, Mangold JB.

Drug Metab Dispos. 2016 Oct;44(10):1697-708. doi: 10.1124/dmd.116.072108. Epub 2016 Aug 2.

PMID:
27486238
4.

Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4β-Hydroxycholesterol and Changes in Midazolam Exposure.

Mangold JB, Wu F, Rebello S.

Clin Pharmacol Drug Dev. 2016 Jul;5(4):245-9. doi: 10.1002/cpdd.265. No abstract available.

PMID:
27138133
5.

Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.

Flarakos J, Du Y, Bedman T, Al-Share Q, Jordaan P, Chandra P, Albrecht D, Wang L, Gu H, Einolf HJ, Huskey SE, Mangold JB.

Xenobiotica. 2016 Nov;46(11):986-1000. doi: 10.3109/00498254.2015.1014944. Epub 2016 Mar 2.

PMID:
26931777
6.

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.

Huskey SE, Zhu CQ, Fredenhagen A, Kühnöl J, Luneau A, Jian Z, Yang Z, Miao Z, Yang F, Jain JP, Sunkara G, Mangold JB, Stein DS.

Drug Metab Dispos. 2016 May;44(5):672-82. doi: 10.1124/dmd.115.069187. Epub 2016 Feb 26.

PMID:
26921387
7.

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB.

Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26.

PMID:
26921386
8.

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G.

Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4.

PMID:
25008118
9.

An industry perspective on tiered approach to the investigation of metabolites in drug development.

Huskey SE, Li W, Mangold JB, Flarakos J.

Bioanalysis. 2014 Mar;6(5):617-28. doi: 10.4155/bio.14.25.

PMID:
24620804
10.

Assessment of the absorption, metabolism and excretion of [¹⁴C]pasireotide in healthy volunteers using accelerator mass spectrometry.

Lin TH, Hu K, Flarakos J, Sharr-McMahon M, Mangold JB, He H, Wang Y.

Cancer Chemother Pharmacol. 2013 Jul;72(1):181-8. doi: 10.1007/s00280-013-2183-0. Epub 2013 May 17.

PMID:
23680921
11.

Disposition and metabolism of [¹⁴C]PTZ601 in healthy volunteers.

Flarakos J, Ting LS, Du Y, Stein DS, Reynolds CV, Patel M, Roy S, Mangold JB.

Xenobiotica. 2013 Mar;43(3):283-92. doi: 10.3109/00498254.2012.715696. Epub 2012 Aug 29.

PMID:
22931187
12.

Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species.

Argikar UA, Mangold JB, Harriman SP.

Curr Top Med Chem. 2011;11(4):419-49. Review.

PMID:
21320068
13.

Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.

He H, Tran P, Yin H, Smith H, Batard Y, Wang L, Einolf H, Gu H, Mangold JB, Fischer V, Howard D.

Drug Metab Dispos. 2009 Mar;37(3):536-44. doi: 10.1124/dmd.108.023010. Epub 2008 Dec 15.

PMID:
19074975
14.

Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor.

Rordorf CM, Choi L, Marshall P, Mangold JB.

Clin Pharmacokinet. 2005;44(12):1247-66. Review.

PMID:
16372823
15.

Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.

Mangold JB, Gu H, Rodriguez LC, Bonner J, Dickson J, Rordorf C.

Drug Metab Dispos. 2004 May;32(5):566-71.

PMID:
15100180
16.

N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.

Hackbarth CJ, Chen DZ, Lewis JG, Clark K, Mangold JB, Cramer JA, Margolis PS, Wang W, Koehn J, Wu C, Lopez S, Withers G 3rd, Gu H, Dunn E, Kulathila R, Pan SH, Porter WL, Jacobs J, Trias J, Patel DV, Weidmann B, White RJ, Yuan Z.

Antimicrob Agents Chemother. 2002 Sep;46(9):2752-64.

17.

Pharmacokinetics and metabolism of nateglinide in humans.

Weaver ML, Orwig BA, Rodriguez LC, Graham ED, Chin JA, Shapiro MJ, McLeod JF, Mangold JB.

Drug Metab Dispos. 2001 Apr;29(4 Pt 1):415-21.

PMID:
11259325
18.

Metabolism of cyclosporin G in the mouse, rat, and dog.

Mangold JB, Rodriguez LC, Wang YK.

Drug Metab Dispos. 1995 Jun;23(6):615-21.

PMID:
7587942
19.

Pharmacokinetics and metabolism of cyclosporin G in humans.

Mangold JB, Schran HF, Tse FL.

Drug Metab Dispos. 1994 Nov-Dec;22(6):873-9.

PMID:
7895604
20.

Biotransformation of cyclosporin G in comparison to cyclosporine.

Mangold JB, Schran HF, Yatscoff RW, Weitzel WF, Leichtman AB.

Transplant Proc. 1994 Oct;26(5):3013-6. No abstract available. Erratum in: Transplant Proc 1994 Dec;26(6):3741.

PMID:
7940950
21.

Effects of deuterium labeling on azido amino acid mutagenicity in Salmonella typhimurium.

Mangold JB, Du Y, Mischke MR, LaVelle JM.

Mutat Res. 1994 Jul 1;308(1):33-42.

PMID:
7516484
22.

Sulfation of di- and tricyclic phenols by rat liver aryl sulfotransferase isozymes.

Parker MH, McCann DJ, Mangold JB.

Arch Biochem Biophys. 1994 May 1;310(2):325-31.

PMID:
8179315
23.

Aryl sulfotransferase-IV-catalyzed sulfation of aryl oximes: steric and substituent effects.

Mangold JB, McCann DJ, Spina A.

Biochim Biophys Acta. 1993 May 13;1163(2):217-22.

PMID:
8490054
24.

Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by N-hydroxy-2-acetylaminofluorene.

Mangold BL, Erickson J, Lohr C, McCann DJ, Mangold JB.

Carcinogenesis. 1990 Sep;11(9):1563-7.

PMID:
2401045
25.

Selective protein arylation by acetaminophen and 2,6-dimethylacetaminophen in cultured hepatocytes from phenobarbital-induced and uninduced mice. Relationship to cytotoxicity.

Birge RB, Bartolone JB, McCann DJ, Mangold JB, Cohen SD, Khairallah EA.

Biochem Pharmacol. 1989 Dec 15;38(24):4429-38.

PMID:
2604745
26.

Sulfation of mono- and diaryl oximes by aryl sulfotransferase isozymes.

Mangold JB, Spina A, McCann DJ.

Biochim Biophys Acta. 1989 Jun 27;991(3):453-8.

PMID:
2730921
27.

Azidoalanine mutagenicity in Salmonella: effect of homologation and alpha-methyl substitution.

Mangold JB, Mischke MR, LaVelle JM.

Mutat Res. 1989 Feb;216(1):27-33.

PMID:
2645513
28.

Dissociation of covalent binding from the oxidative effects of acetaminophen. Studies using dimethylated acetaminophen derivatives.

Birge RB, Bartolone JB, Nishanian EV, Bruno MK, Mangold JB, Cohen SD, Khairallah EA.

Biochem Pharmacol. 1988 Sep 15;37(18):3383-93.

PMID:
3421990
29.

Structure-activity relationships of the azide metabolite, azidoalanine, in S. typhimurium.

LaVelle JM, Mangold JB.

Mutat Res. 1987 Mar;177(1):27-33.

PMID:
3547101
30.

Rat liver aryl sulfotransferase-catalyzed sulfation and rearrangement of 9-fluorenone oxime.

Mangold JB, Mangold BL, Spina A.

Biochim Biophys Acta. 1986 Nov 7;874(1):37-43.

PMID:
3464317
31.

Synthesis and enantioselective mutagenicity of azidoalanine in Salmonella typhimurium.

Mangold JB, Lavelle JM.

Chem Biol Interact. 1986 Nov;60(2):183-90.

PMID:
3539375
32.

Mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.

Mangold JB, Klinman JP.

J Biol Chem. 1984 Jun 25;259(12):7772-9.

33.
34.

Stereoselectivity of the glutathione S-transferase catalyzed conjugation of aralkyl halides.

Mangold JB, Abdel-Monem MM.

Biochem Biophys Res Commun. 1980 Sep 16;96(1):333-40. No abstract available.

PMID:
7437037

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