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Items: 1 to 50 of 67

1.

Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model.

Goswami R, Nelson AN, Tu JJ, Dennis M, Feng L, Kumar A, Mangold J, Mangan RJ, Mattingly C, Curtis AD 2nd, Obregon-Perko V, Mavigner M, Pollara J, Shaw GM, Bar KJ, Chahroudi A, De Paris K, Chan C, Van Rompay KKA, Permar SR.

MBio. 2019 Sep 5;10(5). pii: e01971-19. doi: 10.1128/mBio.01971-19.

2.

Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.

Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, Harrell EA, Mangold JF, Goswami R, Seage GR 3rd, Alter G, Ackerman ME, Peng X, Fouda GG, Permar SR.

Cell. 2019 Jun 27;178(1):190-201.e11. doi: 10.1016/j.cell.2019.05.046. Epub 2019 Jun 13.

3.

Effect of a Single Aspirin Dose Prior to Fecal Immunochemical Testing on Test Sensitivity for Detecting Advanced Colorectal Neoplasms: A Randomized Clinical Trial.

Brenner H, Calderazzo S, Seufferlein T, Ludwig L, Dikopoulos N, Mangold J, Böck W, Stolz T, Eisenbach T, Block T, Kopp-Schneider A, Czock D, Tikk K.

JAMA. 2019 May 7;321(17):1686-1692. doi: 10.1001/jama.2019.4755.

PMID:
31063574
4.

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.

Einolf HJ, Lin W, Won CS, Wang L, Gu H, Chun DY, He H, Mangold JB.

Drug Metab Dispos. 2017 Dec;45(12):1304-1316. doi: 10.1124/dmd.117.076851. Epub 2017 Sep 14.

PMID:
28912253
5.

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats.

Lin W, Flarakos J, Du Y, Hu W, He H, Mangold J, Tanaka SK, Villano S.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01784-16. doi: 10.1128/AAC.01784-16. Print 2017 Jan.

6.

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.

Flarakos J, Du Y, Gu H, Wang L, Einolf HJ, Chun DY, Zhu B, Alexander N, Natrillo A, Hanna I, Ting L, Zhou W, Dole K, Sun H, Kovacs SJ, Stein DS, Tanaka SK, Villano S, Mangold JB.

Xenobiotica. 2017 Aug;47(8):682-696. doi: 10.1080/00498254.2016.1213465. Epub 2016 Aug 8.

PMID:
27499331
7.

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.

Huskey SE, Forseth RR, Li H, Jian Z, Catoire A, Zhang J, Ray T, He H, Flarakos J, Mangold JB.

Drug Metab Dispos. 2016 Oct;44(10):1697-708. doi: 10.1124/dmd.116.072108. Epub 2016 Aug 2.

PMID:
27486238
8.

Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4β-Hydroxycholesterol and Changes in Midazolam Exposure.

Mangold JB, Wu F, Rebello S.

Clin Pharmacol Drug Dev. 2016 Jul;5(4):245-9. doi: 10.1002/cpdd.265. No abstract available.

PMID:
27138133
9.

Fragility of epidermis in newborns, children and adolescents.

Blume-Peytavi U, Tan J, Tennstedt D, Boralevi F, Fabbrocini G, Torrelo A, Soares-Oliveira R, Haftek M, Rossi AB, Thouvenin MD, Mangold J, Galliano MF, Hernandez-Pigeon H, Aries MF, Rouvrais C, Bessou-Touya S, Duplan H, Castex-Rizzi N, Mengeaud V, Ferret PJ, Clouet E, Saint Aroman M, Carrasco C, Coutanceau C, Guiraud B, Boyal S, Herman A, Delga H, Biniek K, Dauskardt R.

J Eur Acad Dermatol Venereol. 2016 May;30 Suppl 4:3-56. doi: 10.1111/jdv.13636. Review. Erratum in: J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1634.

PMID:
27062556
10.

Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.

Flarakos J, Du Y, Bedman T, Al-Share Q, Jordaan P, Chandra P, Albrecht D, Wang L, Gu H, Einolf HJ, Huskey SE, Mangold JB.

Xenobiotica. 2016 Nov;46(11):986-1000. doi: 10.3109/00498254.2015.1014944. Epub 2016 Mar 2.

PMID:
26931777
11.

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.

Huskey SE, Zhu CQ, Fredenhagen A, Kühnöl J, Luneau A, Jian Z, Yang Z, Miao Z, Yang F, Jain JP, Sunkara G, Mangold JB, Stein DS.

Drug Metab Dispos. 2016 May;44(5):672-82. doi: 10.1124/dmd.115.069187. Epub 2016 Feb 26.

PMID:
26921387
12.

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB.

Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26.

PMID:
26921386
13.

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G.

Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4.

PMID:
25008118
14.

An industry perspective on tiered approach to the investigation of metabolites in drug development.

Huskey SE, Li W, Mangold JB, Flarakos J.

Bioanalysis. 2014 Mar;6(5):617-28. doi: 10.4155/bio.14.25.

PMID:
24620804
15.

Surface complexation modeling of Hg(II) adsorption at the goethite/water interface using the charge distribution multi-site complexation (CD-MUSIC) model.

Mangold JE, Park CM, Liljestrand HM, Katz LE.

J Colloid Interface Sci. 2014 Mar 15;418:147-61. doi: 10.1016/j.jcis.2013.10.066. Epub 2013 Nov 9.

PMID:
24461830
16.

Assessment of the absorption, metabolism and excretion of [¹⁴C]pasireotide in healthy volunteers using accelerator mass spectrometry.

Lin TH, Hu K, Flarakos J, Sharr-McMahon M, Mangold JB, He H, Wang Y.

Cancer Chemother Pharmacol. 2013 Jul;72(1):181-8. doi: 10.1007/s00280-013-2183-0. Epub 2013 May 17.

PMID:
23680921
17.

Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects.

Dhuria S, Einolf H, Mangold J, Sen S, Gu H, Wang L, Cameron S.

J Clin Pharmacol. 2013 Jun;53(6):642-53. doi: 10.1002/jcph.79. Epub 2013 Apr 15.

PMID:
23585187
18.

Perchlorate production by photodecomposition of aqueous chlorine solutions.

Rao B, Estrada N, McGee S, Mangold J, Gu B, Jackson WA.

Environ Sci Technol. 2012 Nov 6;46(21):11635-43. doi: 10.1021/es3015277. Epub 2012 Oct 17.

PMID:
22962844
19.

Disposition and metabolism of [¹⁴C]PTZ601 in healthy volunteers.

Flarakos J, Ting LS, Du Y, Stein DS, Reynolds CV, Patel M, Roy S, Mangold JB.

Xenobiotica. 2013 Mar;43(3):283-92. doi: 10.3109/00498254.2012.715696. Epub 2012 Aug 29.

PMID:
22931187
20.

Long-term population dynamics of seeded plants in invaded grasslands.

Rinella MJ, Mangold JM, Espeland EK, Sheley RL, Jacobs JS.

Ecol Appl. 2012 Jun;22(4):1320-9.

PMID:
22827138
21.

Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.

Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Mariggio MA, Onofrj M, Thomas A, Li H, Mangold JE, Signore AP, Demarco U, Demady DR, Nabili P, Lazrove E, Smith PJ, Gribkoff VK, Jonas EA.

Brain Res. 2012 Mar 29;1446:1-11. doi: 10.1016/j.brainres.2012.01.046. Epub 2012 Jan 28.

22.

Mass balance, excretion and metabolism of [¹⁴C] ASA404 in cancer patients in a phase I trial.

McKeage MJ, Fong PC, Hong X, Flarakos J, Mangold J, Du Y, Tanaka C, Schran H.

Cancer Chemother Pharmacol. 2012 May;69(5):1145-54. doi: 10.1007/s00280-011-1809-3. Epub 2012 Jan 3.

PMID:
22212299
23.
24.

Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species.

Argikar UA, Mangold JB, Harriman SP.

Curr Top Med Chem. 2011;11(4):419-49. Review.

PMID:
21320068
25.

Gestational nicotine treatment modulates cell death/survival-related pathways in the brains of adolescent female rats.

Wei J, Wang J, Dwyer JB, Mangold J, Cao J, Leslie FM, Li MD.

Int J Neuropsychopharmacol. 2011 Feb;14(1):91-106. doi: 10.1017/S1461145710000416. Epub 2010 Apr 29. Erratum in: Int J Neuropsychopharmacol. 2011 Mar;14(2):285-7.

PMID:
20426880
26.

Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats.

Cao J, Dwyer JB, Mangold JE, Wang J, Wei J, Leslie FM, Li MD.

Int J Neuropsychopharmacol. 2011 Mar;14(2):157-74. doi: 10.1017/S1461145710000179. Epub 2010 Mar 3.

27.

Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations.

Li MD, Mangold JE, Seneviratne C, Chen GB, Ma JZ, Lou XY, Payne TJ.

PLoS One. 2009 Sep 18;4(9):e7055. doi: 10.1371/journal.pone.0007055.

28.

Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.

He H, Tran P, Yin H, Smith H, Batard Y, Wang L, Einolf H, Gu H, Mangold JB, Fischer V, Howard D.

Drug Metab Dispos. 2009 Mar;37(3):536-44. doi: 10.1124/dmd.108.023010. Epub 2008 Dec 15.

PMID:
19074975
29.

A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

Lou XY, Chen GB, Yan L, Ma JZ, Mangold JE, Zhu J, Elston RC, Li MD.

Am J Hum Genet. 2008 Oct;83(4):457-67. doi: 10.1016/j.ajhg.2008.09.001. Epub 2008 Oct 2.

30.
31.

Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans.

Mangold JE, Payne TJ, Ma JZ, Chen G, Li MD.

J Med Genet. 2008 Sep;45(9):578-82. doi: 10.1136/jmg.2008.057844. Epub 2008 Jun 4.

PMID:
18524836
33.

Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor.

Rordorf CM, Choi L, Marshall P, Mangold JB.

Clin Pharmacokinet. 2005;44(12):1247-66. Review.

PMID:
16372823
34.

Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.

Mangold JB, Gu H, Rodriguez LC, Bonner J, Dickson J, Rordorf C.

Drug Metab Dispos. 2004 May;32(5):566-71.

PMID:
15100180
35.

N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.

Hackbarth CJ, Chen DZ, Lewis JG, Clark K, Mangold JB, Cramer JA, Margolis PS, Wang W, Koehn J, Wu C, Lopez S, Withers G 3rd, Gu H, Dunn E, Kulathila R, Pan SH, Porter WL, Jacobs J, Trias J, Patel DV, Weidmann B, White RJ, Yuan Z.

Antimicrob Agents Chemother. 2002 Sep;46(9):2752-64.

36.

Pharmacokinetics and metabolism of nateglinide in humans.

Weaver ML, Orwig BA, Rodriguez LC, Graham ED, Chin JA, Shapiro MJ, McLeod JF, Mangold JB.

Drug Metab Dispos. 2001 Apr;29(4 Pt 1):415-21.

PMID:
11259325
37.

Mechanisms of infarction in the superficial posterior cerebral artery territory.

Steinke W, Mangold J, Schwartz A, Hennerici M.

J Neurol. 1997 Sep;244(9):571-8.

PMID:
9352455
38.

[Splenic peliosis. Apropos of 2 cases].

Allimant P, Mangold J, Froelich N, Zachar D.

J Chir (Paris). 1995 Nov;132(11):451-3. French.

PMID:
8550711
39.

Metabolism of cyclosporin G in the mouse, rat, and dog.

Mangold JB, Rodriguez LC, Wang YK.

Drug Metab Dispos. 1995 Jun;23(6):615-21.

PMID:
7587942
40.

Pharmacokinetics and metabolism of cyclosporin G in humans.

Mangold JB, Schran HF, Tse FL.

Drug Metab Dispos. 1994 Nov-Dec;22(6):873-9.

PMID:
7895604
41.

Biotransformation of cyclosporin G in comparison to cyclosporine.

Mangold JB, Schran HF, Yatscoff RW, Weitzel WF, Leichtman AB.

Transplant Proc. 1994 Oct;26(5):3013-6. No abstract available. Erratum in: Transplant Proc 1994 Dec;26(6):3741.

PMID:
7940950
42.

Effects of deuterium labeling on azido amino acid mutagenicity in Salmonella typhimurium.

Mangold JB, Du Y, Mischke MR, LaVelle JM.

Mutat Res. 1994 Jul 1;308(1):33-42.

PMID:
7516484
43.

[Perforation of the small intestine caused by endometriosis].

Allimant P, Bietiger M, Alhawary I, Mangold J, Zeyer B.

J Chir (Paris). 1994 Jun-Jul;131(6-7):313-5. French.

PMID:
7844185
44.

Sulfation of di- and tricyclic phenols by rat liver aryl sulfotransferase isozymes.

Parker MH, McCann DJ, Mangold JB.

Arch Biochem Biophys. 1994 May 1;310(2):325-31.

PMID:
8179315
45.

Aryl sulfotransferase-IV-catalyzed sulfation of aryl oximes: steric and substituent effects.

Mangold JB, McCann DJ, Spina A.

Biochim Biophys Acta. 1993 May 13;1163(2):217-22.

PMID:
8490054
46.

Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by N-hydroxy-2-acetylaminofluorene.

Mangold BL, Erickson J, Lohr C, McCann DJ, Mangold JB.

Carcinogenesis. 1990 Sep;11(9):1563-7.

PMID:
2401045
47.

Selective protein arylation by acetaminophen and 2,6-dimethylacetaminophen in cultured hepatocytes from phenobarbital-induced and uninduced mice. Relationship to cytotoxicity.

Birge RB, Bartolone JB, McCann DJ, Mangold JB, Cohen SD, Khairallah EA.

Biochem Pharmacol. 1989 Dec 15;38(24):4429-38.

PMID:
2604745
48.
49.

Energy production, intracellular amino acid pools, and protein synthesis in chronic renal disease.

Metcoff J, Furst P, Scharer K, Distler G, Weber R, Mangold J, Graser TA, Pfaff G, Schonberg D.

J Am Coll Nutr. 1989 Aug;8(4):271-84. Review.

PMID:
2674253
50.

Sulfation of mono- and diaryl oximes by aryl sulfotransferase isozymes.

Mangold JB, Spina A, McCann DJ.

Biochim Biophys Acta. 1989 Jun 27;991(3):453-8.

PMID:
2730921

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