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Items: 41

1.

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.

Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A.

Nature. 2019 Jul;571(7764):284-288. doi: 10.1038/s41586-019-1355-4. Epub 2019 Jul 1.

PMID:
31263273
2.

Transgenic zebrafish model of DUX4 misexpression reveals a developmental role in FSHD pathogenesis.

Pakula A, Lek A, Widrick J, Mitsuhashi H, Bugda Gwilt KM, Gupta VA, Rahimov F, Criscione J, Zhang Y, Gibbs D, Murphy Q, Manglik A, Mead L, Kunkel L.

Hum Mol Genet. 2019 Jan 15;28(2):320-331. doi: 10.1093/hmg/ddy348.

PMID:
30307508
3.

Development of an antibody fragment that stabilizes GPCR/G-protein complexes.

Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK.

Nat Commun. 2018 Sep 13;9(1):3712. doi: 10.1038/s41467-018-06002-w.

4.

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.

Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR.

Elife. 2018 Jun 22;7. pii: e32499. doi: 10.7554/eLife.32499.

5.

Structure of the µ-opioid receptor-Gi protein complex.

Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK.

Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13.

6.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

7.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839. doi: 10.1073/pnas.1722336115. Epub 2018 Mar 26.

8.

Yeast surface display platform for rapid discovery of conformationally selective nanobodies.

McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC.

Nat Struct Mol Biol. 2018 Mar;25(3):289-296. doi: 10.1038/s41594-018-0028-6. Epub 2018 Feb 12.

9.

Structural Basis for G Protein-Coupled Receptor Activation.

Manglik A, Kruse AC.

Biochemistry. 2017 Oct 24;56(42):5628-5634. doi: 10.1021/acs.biochem.7b00747. Epub 2017 Oct 10. Review.

10.

Nanobodies to Study G Protein-Coupled Receptor Structure and Function.

Manglik A, Kobilka BK, Steyaert J.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:19-37. doi: 10.1146/annurev-pharmtox-010716-104710. Epub 2016 Dec 7. Review.

11.

Structure-based discovery of opioid analgesics with reduced side effects.

Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK.

Nature. 2016 Sep 8;537(7619):185-190. doi: 10.1038/nature19112. Epub 2016 Aug 17.

12.

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.

13.

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.

DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK.

Nature. 2016 Jul 7;535(7610):182-6. Epub 2016 Jun 29.

14.

Crystal structure of the human σ1 receptor.

Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC.

Nature. 2016 Apr 28;532(7600):527-30. doi: 10.1038/nature17391. Epub 2016 Apr 4.

15.

High-density grids for efficient data collection from multiple crystals.

Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):2-11. doi: 10.1107/S2059798315020847. Epub 2016 Jan 1.

16.

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.

Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6506-14. doi: 10.1073/pnas.1519623112. Epub 2015 Nov 10.

17.

Structural insights into µ-opioid receptor activation.

Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK.

Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5.

18.

Propagation of conformational changes during μ-opioid receptor activation.

Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S.

Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680. Epub 2015 Aug 5.

19.

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE.

Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264.

20.

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK.

Cell. 2015 May 21;161(5):1101-1111. doi: 10.1016/j.cell.2015.04.043. Epub 2015 May 14. Erratum in: Cell. 2015 Sep 10;162(6):1431.

21.

A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins.

Ye L, Larda ST, Frank Li YF, Manglik A, Prosser RS.

J Biomol NMR. 2015 May;62(1):97-103. doi: 10.1007/s10858-015-9922-y. Epub 2015 Mar 27.

PMID:
25813845
22.

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV.

J Biol Chem. 2015 Apr 24;290(17):10775-90. doi: 10.1074/jbc.M115.644773. Epub 2015 Mar 13.

23.

Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31.

24.

Covalent agonists for studying G protein-coupled receptor activation.

Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10744-8. doi: 10.1073/pnas.1410415111. Epub 2014 Jul 8.

25.

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin.

Manglik A, Kobilka B.

Curr Opin Cell Biol. 2014 Apr;27:136-43. doi: 10.1016/j.ceb.2014.01.008. Epub 2014 Feb 17. Review.

26.
27.

Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK.

Nature. 2013 Dec 5;504(7478):101-6. doi: 10.1038/nature12735. Epub 2013 Nov 20.

28.

Applications of molecular replacement to G protein-coupled receptors.

Kruse AC, Manglik A, Kobilka BK, Weis WI.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2287-92. doi: 10.1107/S090744491301322X. Epub 2013 Oct 18.

29.

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.

Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK.

Nature. 2013 Oct 24;502(7472):575-579. doi: 10.1038/nature12572. Epub 2013 Sep 22.

30.

The role of ligands on the equilibria between functional states of a G protein-coupled receptor.

Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS.

J Am Chem Soc. 2013 Jun 26;135(25):9465-74. doi: 10.1021/ja404305k. Epub 2013 Jun 14.

31.

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.

Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ.

Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.

32.

The dynamic process of β(2)-adrenergic receptor activation.

Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK.

Cell. 2013 Jan 31;152(3):532-42. doi: 10.1016/j.cell.2013.01.008.

33.

Role of detergents in conformational exchange of a G protein-coupled receptor.

Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS.

J Biol Chem. 2012 Oct 19;287(43):36305-11. doi: 10.1074/jbc.M112.406371. Epub 2012 Aug 14.

34.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.

Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH.

Chemistry. 2012 Jul 27;18(31):9485-90. doi: 10.1002/chem.201200069. Epub 2012 Jun 22. No abstract available. Erratum in: Chemistry. 2013 Apr 15;19(16):4964.

35.

Structure of the δ-opioid receptor bound to naltrindole.

Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK.

Nature. 2012 May 16;485(7398):400-4. doi: 10.1038/nature11111.

36.

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.

Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954.

37.

Stably integrated luxCDABE for assessment of Salmonella invasion kinetics.

Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS.

Mol Imaging. 2008 Sep-Oct;7(5):222-33.

38.

A case of Mayer-Rokitansky-Kuster-Hayser syndrome with absence of the right thumb.

Pal R, Manglik A, Sinha N.

Saudi J Kidney Dis Transpl. 2008 Mar;19(2):236-40.

39.

Efficacy and safety of montelukast as monotherapy in children with mild persistent asthma.

Ghosh G, Manglik AK, Roy S.

Indian Pediatr. 2006 Sep;43(9):780-5.

40.

Aicardi syndrome: a report of five Indian cases.

Banerjee TK, Chattopadhyay A, Manglik AK, Ghosh B.

Neurol India. 2006 Mar;54(1):91-3.

41.

Umbilical cord blood TSH levels in term neonates: a screening tool for congenital hypothyroidism.

Manglik AK, Chatterjee N, Ghosh G.

Indian Pediatr. 2005 Oct;42(10):1029-32.

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