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Items: 1 to 50 of 97

1.

Speeding up biomolecular interactions by molecular sledding.

Turkin A, Zhang L, Marcozzi A, Mangel WF, Herrmann A, van Oijen AM.

Chem Sci. 2016 Feb 1;7(2):916-920. Epub 2015 Oct 7.

2.

Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA.

Mangel WF, McGrath WJ, Xiong K, Graziano V, Blainey PC.

Nat Commun. 2016 Feb 2;7:10202. doi: 10.1038/ncomms10202.

3.

Single-molecule imaging at high fluorophore concentrations by local activation of dye.

Geertsema HJ, Schulte AC, Spenkelink LM, McGrath WJ, Morrone SR, Sohn J, Mangel WF, Robinson A, van Oijen AM.

Biophys J. 2015 Feb 17;108(4):949-956. doi: 10.1016/j.bpj.2014.12.019.

4.

Structure, function and dynamics in adenovirus maturation.

Mangel WF, San Martín C.

Viruses. 2014 Nov 21;6(11):4536-70. doi: 10.3390/v6114536. Review.

5.

Processing of the l1 52/55k protein by the adenovirus protease: a new substrate and new insights into virion maturation.

Pérez-Berná AJ, Mangel WF, McGrath WJ, Graziano V, Flint J, San Martín C.

J Virol. 2014 Feb;88(3):1513-24. doi: 10.1128/JVI.02884-13. Epub 2013 Nov 13.

6.

First generation inhibitors of the adenovirus proteinase.

McGrath WJ, Graziano V, Zabrocka K, Mangel WF.

FEBS Lett. 2013 Aug 2;587(15):2332-9. doi: 10.1016/j.febslet.2013.05.033. Epub 2013 May 24.

7.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: III. atomic resolution structure of the nascent form of the adenovirus proteinase.

Baniecki ML, McGrath WJ, Mangel WF.

J Biol Chem. 2013 Jan 18;288(3):2081-91. doi: 10.1074/jbc.M112.407429. Epub 2012 Oct 7.

8.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates.

Blainey PC, Graziano V, Pérez-Berná AJ, McGrath WJ, Flint SJ, San Martín C, Xie XS, Mangel WF.

J Biol Chem. 2013 Jan 18;288(3):2092-102. doi: 10.1074/jbc.M112.407460. Epub 2012 Oct 7.

9.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction.

Graziano V, Luo G, Blainey PC, Pérez-Berná AJ, McGrath WJ, Flint SJ, San Martín C, Xie XS, Mangel WF.

J Biol Chem. 2013 Jan 18;288(3):2068-80. doi: 10.1074/jbc.M112.407312. Epub 2012 Oct 7.

10.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus.

Graziano V, McGrath WJ, Suomalainen M, Greber UF, Freimuth P, Blainey PC, Luo G, Xie XS, Mangel WF.

J Biol Chem. 2013 Jan 18;288(3):2059-67. doi: 10.1074/jbc.M112.377150. Epub 2012 Oct 7.

11.

Nonspecifically bound proteins spin while diffusing along DNA.

Blainey PC, Luo G, Kou SC, Mangel WF, Verdine GL, Bagchi B, Xie XS.

Nat Struct Mol Biol. 2009 Dec;16(12):1224-9. doi: 10.1038/nsmb.1716. Epub 2009 Nov 8.

12.

Structure and uncoating of immature adenovirus.

Pérez-Berná AJ, Marabini R, Scheres SH, Menéndez-Conejero R, Dmitriev IP, Curiel DT, Mangel WF, Flint SJ, San Martín C.

J Mol Biol. 2009 Sep 18;392(2):547-57. doi: 10.1016/j.jmb.2009.06.057. Epub 2009 Jun 27.

13.
14.
15.

SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant.

Graziano V, McGrath WJ, Yang L, Mangel WF.

Biochemistry. 2006 Dec 12;45(49):14632-41.

PMID:
17144656
16.

Enzymatic activity of the SARS coronavirus main proteinase dimer.

Graziano V, McGrath WJ, DeGruccio AM, Dunn JJ, Mangel WF.

FEBS Lett. 2006 May 15;580(11):2577-83. Epub 2006 Apr 21.

17.

Interaction of the adenovirus proteinase with protein cofactors with high negative charge densities.

Bajpayee NS, McGrath WJ, Mangel WF.

Biochemistry. 2005 Jun 21;44(24):8721-9.

PMID:
15952779
18.

DNA binding provides a molecular strap activating the adenovirus proteinase.

Gupta S, Mangel WF, McGrath WJ, Perek JL, Lee DW, Takamoto K, Chance MR.

Mol Cell Proteomics. 2004 Oct;3(10):950-9. Epub 2004 Jun 24.

19.
20.

Specific interactions of the adenovirus proteinase with the viral DNA, an 11-amino-acid viral peptide, and the cellular protein actin.

Mangel WF, Baniecki ML, McGrath WJ.

Cell Mol Life Sci. 2003 Nov;60(11):2347-55. Review.

PMID:
14625681
21.

Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo.

Cao W, Baniecki ML, McGrath WJ, Bao C, Deming CB, Rade JJ, Lowenstein CJ, Mangel WF.

FASEB J. 2003 Dec;17(15):2345-6. Epub 2003 Oct 2.

PMID:
14525937
22.
23.

Adenovirus proteinase: crystallization and preliminary X-ray diffraction studies to atomic resolution.

Baniecki ML, McGrath WJ, Dauter Z, Mangel WF.

Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1462-4. Epub 2002 Aug 23.

PMID:
12198302
24.

Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton.

Brown MT, McBride KM, Baniecki ML, Reich NC, Marriott G, Mangel WF.

J Biol Chem. 2002 Nov 29;277(48):46298-303. Epub 2002 Aug 20.

25.
26.

Roles of two conserved cysteine residues in the activation of human adenovirus proteinase.

McGrath WJ, Baniecki ML, Peters E, Green DT, Mangel WF.

Biochemistry. 2001 Dec 4;40(48):14468-74.

PMID:
11724559
27.

Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA.

McGrath WJ, Baniecki ML, Li C, McWhirter SM, Brown MT, Toledo DL, Mangel WF.

Biochemistry. 2001 Nov 6;40(44):13237-45.

PMID:
11683632
28.

Interaction of the human adenovirus proteinase with its 11-amino acid cofactor pVIc.

Baniecki ML, McGrath WJ, McWhirter SM, Li C, Toledo DL, Pellicena P, Barnard DL, Thorn KS, Mangel WF.

Biochemistry. 2001 Oct 16;40(41):12349-56. Erratum in: Biochemistry 2002 Jan 8;41(1):430.

29.

Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.

Pang YP, Xu K, Kollmeyer TM, Perola E, McGrath WJ, Green DT, Mangel WF.

FEBS Lett. 2001 Aug 3;502(3):93-7.

30.

Prevention of viral drug resistance by novel combination therapy.

Mangel WF, Brown MT, Baniecki ML, Barnard D, McGrath WJ.

Curr Opin Investig Drugs. 2001 May;2(5):613-6. Review.

PMID:
11569932
31.

A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it.

Mangel WF, McGrath WJ, Brown MT, Baniecki ML, Barnard DL, Pang YP.

Curr Med Chem. 2001 Jul;8(8):933-9.

PMID:
11375760
32.

Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.

Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB, Mangel WF, Staskawicz B, Dixon JE.

Science. 2000 Nov 24;290(5496):1594-7.

33.

Sensitive method to identify and characterize proteinases in situ after SDS-PAGE.

Williams J, McGrath WJ, Mangel WF.

Biotechniques. 2000 Nov;29(5):1108-13.

34.

Parasitophorous vacuoles of Leishmania mexicana acquire macromolecules from the host cell cytosol via two independent routes.

Schaible UE, Schlesinger PH, Steinberg TH, Mangel WF, Kobayashi T, Russell DG.

J Cell Sci. 1999 Mar;112 ( Pt 5):681-93.

35.

Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA.

Mangel WF, Toledo DL, Ding J, Sweet RM, McGrath WJ.

Trends Biochem Sci. 1997 Oct;22(10):393-8. Review.

PMID:
9357315
36.
37.
38.

Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.

Ding J, McGrath WJ, Sweet RM, Mangel WF.

EMBO J. 1996 Apr 15;15(8):1778-83.

39.

Characterization of human adenovirus proteinase activity in disrupted virus particles.

McGrath WJ, Abola AP, Toledo DL, Brown MT, Mangel WF.

Virology. 1996 Mar 1;217(1):131-8.

40.

Characterization of three components of human adenovirus proteinase activity in vitro.

Mangel WF, Toledo DL, Brown MT, Martin JH, McGrath WJ.

J Biol Chem. 1996 Jan 5;271(1):536-43.

41.

Omptin: an Escherichia coli outer membrane proteinase that activates plasminogen.

Mangel WF, Toledo DL, Brown MT, Worzalla K, Lee M, Dunn JJ.

Methods Enzymol. 1994;244:384-99. No abstract available.

PMID:
7845221
42.

Nonisotopic DNA detection system employing elastase and fluorogenic rhodamine substrate.

Johnson AF, Struthers MD, Pierson KB, Mangel WF, Smith LM.

Anal Chem. 1993 Sep 1;65(17):2352-9.

PMID:
8238930
43.

Response.

Singer PT, Smalds A, Carty RP, Mangel WF, Sweet RM.

Science. 1993 Jul 30;261(5121):621-2. No abstract available.

PMID:
17758171
44.

The hydrolytic water molecule in trypsin, revealed by time-resolved Laue crystallography.

Singer PT, Smalås A, Carty RP, Mangel WF, Sweet RM.

Science. 1993 Jan 29;259(5095):669-73.

PMID:
8430314
45.

Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity.

Mangel WF, McGrath WJ, Toledo DL, Anderson CW.

Nature. 1993 Jan 21;361(6409):274-5.

PMID:
8423855
46.

Membrane permeable fluorogenic rhodamine substrates for selective determination of cathepsin L.

Assfalg-Machleidt I, Rothe G, Klingel S, Banati R, Mangel WF, Valet G, Machleidt W.

Biol Chem Hoppe Seyler. 1992 Jul;373(7):433-40.

PMID:
1515071
47.

Flow cytometric analysis of protease activities in vital cells.

Rothe G, Klingel S, Assfalg-Machleidt I, Machleidt W, Zirkelbach C, Banati RB, Mangel WF, Valet G.

Biol Chem Hoppe Seyler. 1992 Jul;373(7):547-54.

PMID:
1381188
48.

Malarial proteases: assignment of function to activity.

Barale JC, Langsley G, Mangel WF, Braun-Breton C.

Res Immunol. 1991 Oct;142(8):672-81. Review. No abstract available.

PMID:
1817297
50.

Conformation of Lys-plasminogen and the kringle 1-3 fragment of plasminogen analyzed by small-angle neutron scattering.

Ramakrishnan V, Patthy L, Mangel WF.

Biochemistry. 1991 Apr 23;30(16):3963-9.

PMID:
2018765

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