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Items: 34

1.

Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence.

Mangas-Sanjuán V, Pleguezuelos-Villa M, Merino-Sanjuán M, Hernández MJ, Nácher A, García-Arieta A, Peris D, Hidalgo I, Soler L, Sallan M, Merino V.

Pharmaceutics. 2019 Oct 1;11(10). pii: E503. doi: 10.3390/pharmaceutics11100503.

2.

Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration.

García-Quintanilla L, Luaces-Rodríguez A, Gil-Martínez M, Mondelo-García C, Maroñas O, Mangas-Sanjuan V, González-Barcia M, Zarra-Ferro I, Aguiar P, Otero-Espinar FJ, Fernández-Ferreiro A.

Pharmaceutics. 2019 Jul 31;11(8). pii: E365. doi: 10.3390/pharmaceutics11080365. Review.

3.

Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule.

Marques MR, Garcia-Robles A, Usach I, Vento M, Poveda JL, Peris JE, Mangas-Sanjuan V.

Acta Paediatr. 2019 Jul 23. doi: 10.1111/apa.14944. [Epub ahead of print]

PMID:
31336401
4.

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

Reynaldo-Fernández G, Solozábal J, Amaro D, Fernández-Sánchez EM, Rodríguez-Vera L, Bermejo M, Mangas-Sanjuan V, Troconiz IF.

Eur J Pharm Sci. 2018 Jul 30;120:123-132. doi: 10.1016/j.ejps.2018.04.047. Epub 2018 May 2.

PMID:
29729414
5.

Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts.

Parra-Guillen ZP, Mangas-Sanjuan V, Garcia-Cremades M, Troconiz IF, Mo G, Pitou C, Iversen PW, Wallin JE.

J Pharmacol Exp Ther. 2018 Jul;366(1):96-104. doi: 10.1124/jpet.118.248286. Epub 2018 Apr 24.

PMID:
29691287
6.

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

González-García I, García-Arieta A, Merino-Sanjuan M, Mangas-Sanjuan V, Bermejo M.

Eur J Pharm Sci. 2018 Jul 1;119:200-207. doi: 10.1016/j.ejps.2018.04.025. Epub 2018 Apr 20.

PMID:
29680456
7.

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter.

Mangas-Sanjuan V, Navarro-Fontestad C, García-Arieta A, Trocóniz IF, Bermejo M.

Eur J Pharm Sci. 2018 May 30;117:193-203. doi: 10.1016/j.ejps.2018.02.014. Epub 2018 Feb 13.

PMID:
29452210
8.

IVIVC approach based on carbamazepine bioequivalence studies combination.

González-García I, Mangas-Sanjuan V, Merino-Sanjuán M, Álvarez-Álvarez C, Díaz-Garzón Marco J, Rodríguez-Bonnín MA, Langguth T, Torrado-Durán JJ, Langguth P, García-Arieta A, Bermejo M.

Pharmazie. 2017 Aug 1;72(8):449-455. doi: 10.1691/ph.2017.7011.

PMID:
29441903
9.

Commentary on the MID3 Good Practices Paper.

Manolis E, Brogren J, Cole S, Hay JL, Nordmark A, Karlsson KE, Lentz F, Benda N, Wangorsch G, Pons G, Zhao W, Gigante V, Serone F, Standing JF, Dokoumetzidis A, Vakkilainen J, van den Heuvel M, Mangas Sanjuan V, Taminiau J, Kerwash E, Khan D, Musuamba FT, Skottheim Rusten I; EMA Modelling and Simulation Working Group.

CPT Pharmacometrics Syst Pharmacol. 2017 Jul;6(7):416-417. doi: 10.1002/psp4.12223. Epub 2017 Jul 22.

10.

Population pharmacokinetic model of lithium and drug compliance assessment.

Pérez-Castelló I, Mangas-Sanjuan V, González-García I, Gonzalez-Alvarez I, Bermejo M, Marco-Garbayo JL, Trocóniz IF.

Eur Neuropsychopharmacol. 2016 Dec;26(12):1868-1876. doi: 10.1016/j.euroneuro.2016.11.005. Epub 2016 Nov 16.

PMID:
27865605
11.

Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.

Shimizu S, den Hoedt SM, Mangas-Sanjuan V, Cristea S, Geuer JK, van den Berg DJ, Hartman R, Bellanti F, de Lange EC.

Drug Metab Dispos. 2017 Feb;45(2):152-159. doi: 10.1124/dmd.116.072306. Epub 2016 Nov 11.

PMID:
27836941
12.

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

Mangas-Sanjuan V, Colon-Useche S, Gonzalez-Alvarez I, Bermejo M, Garcia-Arieta A.

AAPS J. 2016 Nov;18(6):1550-1561. Epub 2016 Aug 29.

PMID:
27571779
13.

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

Bermejo M, Mangas-Sanjuan V, Gonzalez-Alvarez I, Gonzalez-Alvarez M.

Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):1-10. doi: 10.1007/s13318-016-0369-7. Review.

PMID:
27538882
14.

Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.

Mangas-Sanjuan V, Pastor JM, Rengelshausen J, Bursi R, Troconiz IF.

Br J Clin Pharmacol. 2016 Jul;82(1):92-107. doi: 10.1111/bcp.12921. Epub 2016 Apr 14.

15.

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures.

Mangas-Sanjuan V, Gutiérrez-Nieto J, Echezarreta-López M, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M, Landin M.

Eur J Drug Metab Pharmacokinet. 2016 Dec;41(6):795-806.

PMID:
26602766
16.

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

Colón-Useche S, González-Álvarez I, Mangas-Sanjuan V, González-Álvarez M, Pastoriza P, Molina-Martínez I, Bermejo M, García-Arieta A.

Mol Pharm. 2015 Sep 8;12(9):3167-74. doi: 10.1021/acs.molpharmaceut.5b00076. Epub 2015 Aug 26.

PMID:
26287948
17.

Agitation Rate and Time for Complete Dissolution in BCS Biowaivers Based on Investigation of a BCS Biowaiver for Dexketoprofen Tablets.

Garcia-Arieta A, Gordon J, Gwaza L, Mangas-Sanjuan V, Álvarez C, Torrado JJ.

Mol Pharm. 2015 Sep 8;12(9):3194-201. doi: 10.1021/acs.molpharmaceut.5b00131. Epub 2015 Aug 10.

PMID:
26237401
18.

Drug gastrointestinal absorption in rat: Strain and gender differences.

Oltra-Noguera D, Mangas-Sanjuan V, González-Álvarez I, Colon-Useche S, González-Álvarez M, Bermejo M.

Eur J Pharm Sci. 2015 Oct 12;78:198-203. doi: 10.1016/j.ejps.2015.07.021. Epub 2015 Jul 28.

PMID:
26225436
19.

Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties.

Frik M, Fernández-Gallardo J, Gonzalo O, Mangas-Sanjuan V, González-Alvarez M, Serrano del Valle A, Hu C, González-Alvarez I, Bermejo M, Marzo I, Contel M.

J Med Chem. 2015 Aug 13;58(15):5825-41. doi: 10.1021/acs.jmedchem.5b00427. Epub 2015 Jul 22.

20.

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications.

González-García I, Mangas-Sanjuán V, Merino-Sanjuán M, Bermejo M.

Drug Dev Ind Pharm. 2015;41(12):1935-47. doi: 10.3109/03639045.2015.1054833. Epub 2015 Jul 2. Review.

PMID:
26133085
21.

Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules.

Mangas-Sanjuan V, Buil-Bruna N, Garrido MJ, Soto E, Trocóniz IF.

J Pharmacol Exp Ther. 2015 Jul;354(1):55-64. doi: 10.1124/jpet.115.223776. Epub 2015 May 6.

PMID:
25948593
22.

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

Cuesta-Gragera A, Navarro-Fontestad C, Mangas-Sanjuan V, González-Álvarez I, García-Arieta A, Trocóniz IF, Casabó VG, Bermejo M.

Eur J Pharm Sci. 2015 Jul 10;74:86-94. doi: 10.1016/j.ejps.2015.04.002. Epub 2015 Apr 11.

PMID:
25869458
23.

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

Cuesta-Gragera A, Navarro-Fontestad C, Mangas-Sanjuan V, González-Álvarez I, García-Arieta A, Trocóniz IF, Casabó VG, Bermejo M.

Eur J Pharm Sci. 2015 Jun 20;73:57-63. doi: 10.1016/j.ejps.2015.03.018. Epub 2015 Apr 2.

PMID:
25843043
24.

Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.

Oltra-Noguera D, Mangas-Sanjuan V, Centelles-Sangüesa A, Gonzalez-Garcia I, Sanchez-Castaño G, Gonzalez-Alvarez M, Casabo VG, Merino V, Gonzalez-Alvarez I, Bermejo M.

J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:21-32. doi: 10.1016/j.vascn.2014.11.004. Epub 2014 Nov 26.

PMID:
25433164
25.

Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.

Mangas-Sanjuan V, Oláh J, Gonzalez-Alvarez I, Lehotzky A, Tőkési N, Bermejo M, Ovádi J.

Br J Pharmacol. 2015 Feb;172(3):829-40. doi: 10.1111/bph.12946. Epub 2014 Dec 15.

26.

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.

Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, Gonzalez-Alvarez I, García-Giménez JL, Díaz Cabañas MJ, Bermejo M, Corma A.

Eur J Med Chem. 2014 Aug 18;83:366-73. doi: 10.1016/j.ejmech.2014.06.050. Epub 2014 Jun 25.

PMID:
24980118
27.

Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.

Rodriguez-Berna G, Cabañas MJ, Mangas-Sanjuán V, Gonzalez-Alvarez M, Gonzalez-Alvarez I, Abasolo I, Schwartz S Jr, Bermejo M, Corma A.

ACS Med Chem Lett. 2013 May 28;4(7):651-5. doi: 10.1021/ml400125z. eCollection 2013 Jul 11.

28.

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

Mangas-Sanjuan V, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M.

Mol Pharm. 2014 May 5;11(5):1403-14. doi: 10.1021/mp400555e. Epub 2014 Apr 7.

PMID:
24665996
29.

Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier.

Mangas-Sanjuan V, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M.

Mol Pharm. 2013 Oct 7;10(10):3822-31. doi: 10.1021/mp400294x. Epub 2013 Sep 9.

PMID:
23977999
30.

Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments.

Samiei N, Mangas-Sanjuan V, González-Álvarez I, Foroutan M, Shafaati A, Zarghi A, Bermejo M.

Eur J Pharm Sci. 2013 Jul 16;49(4):499-504. doi: 10.1016/j.ejps.2013.04.025. Epub 2013 May 2.

PMID:
23643735
31.

Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract.

Fernandez-Teruel C, Mangas-Sanjuan V, Gonzalez-Alvarez I, Ruiz-Garcia A, Casabó VG, Bermejo M.

Xenobiotica. 2013 Sep;43(9):745-54. doi: 10.3109/00498254.2012.759667. Epub 2013 Jan 8.

PMID:
23294363
32.

In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate.

Gundogdu E, Mangas-Sanjuan V, Gonzalez-Alvarez I, Bermejo M, Karasulu E.

Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):65-75. doi: 10.1007/s13318-011-0059-4. Epub 2011 Aug 11.

PMID:
21833762
33.

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach.

Pham The H, González-Álvarez I, Bermejo M, Mangas Sanjuan V, Centelles I, Garrigues TM, Cabrera-Pérez MÁ.

Mol Inform. 2011 Apr 18;30(4):376-85. doi: 10.1002/minf.201000118. Epub 2011 Mar 31.

PMID:
27466954
34.

Drug penetration across the blood-brain barrier: an overview.

Mangas-Sanjuan V, González-Alvarez M, Gonzalez-Alvarez I, Bermejo M.

Ther Deliv. 2010 Oct;1(4):535-62. Review.

PMID:
22833966

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