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Items: 1 to 50 of 158

1.

A pathophysiological role of PDE3 in allergic airway inflammation.

Beute J, Lukkes M, Koekoek EP, Nastiti H, Ganesh K, de Bruijn MJ, Hockman S, van Nimwegen M, Braunstahl GJ, Boon L, Lambrecht BN, Manganiello VC, Hendriks RW, KleinJan A.

JCI Insight. 2018 Jan 25;3(2). pii: 94888. doi: 10.1172/jci.insight.94888. eCollection 2018 Jan 25.

2.

SFPQ, a multifunctional nuclear protein, regulates the transcription of PDE3A.

Rhee DK, Hockman SC, Choi SK, Kim YE, Park C, Manganiello VC, Kim KK.

Biosci Rep. 2017 Aug 31;37(4). pii: BSR20170975. doi: 10.1042/BSR20170975. Epub 2017 Jul 25.

3.

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).

Vandenberghe P, Hagué P, Hockman SC, Manganiello VC, Demetter P, Erneux C, Vanderwinden JM.

Oncotarget. 2017 Jun 20;8(25):41026-41043. doi: 10.18632/oncotarget.17010.

4.

White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.

Chung YW, Ahmad F, Tang Y, Hockman SC, Kee HJ, Berger K, Guirguis E, Choi YH, Schimel DM, Aponte AM, Park S, Degerman E, Manganiello VC.

Sci Rep. 2017 Jan 13;7:40445. doi: 10.1038/srep40445.

5.

Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast.

Rhee DK, Lim JC, Hockman SC, Ahmad F, Woo DH, Chung YW, Liu S, Hockman AL, Manganiello VC.

Biochem J. 2016 Nov 15;473(22):4205-4225. Epub 2016 Sep 19.

PMID:
27647936
6.

Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.

Ahmad F, Chung YW, Tang Y, Hockman SC, Liu S, Khan Y, Huo K, Billings E, Amar MJ, Remaley AT, Manganiello VC.

Sci Rep. 2016 Jun 20;6:28056. doi: 10.1038/srep28056.

7.

Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies.

Ye H, Wang X, Sussman CR, Hopp K, Irazabal MV, Bakeberg JL, LaRiviere WB, Manganiello VC, Vorhees CV, Zhao H, Harris PC, van Deursen J, Ward CJ, Torres VE.

J Am Soc Nephrol. 2016 May;27(5):1312-20. doi: 10.1681/ASN.2015010057. Epub 2015 Sep 15.

8.

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.

Andrade BB, Pavan Kumar N, Amaral EP, Riteau N, Mayer-Barber KD, Tosh KW, Maier N, Conceição EL, Kubler A, Sridhar R, Banurekha VV, Jawahar MS, Barbosa T, Manganiello VC, Moss J, Fontana JR, Marciano BE, Sampaio EP, Olivier KN, Holland SM, Jackson SH, Moayeri M, Leppla S, Sereti I, Barber DL, Nutman TB, Babu S, Sher A.

J Immunol. 2015 Sep 15;195(6):2763-73. doi: 10.4049/jimmunol.1500942. Epub 2015 Aug 12.

9.

Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.

Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2253-62. doi: 10.1073/pnas.1416230112. Epub 2015 Apr 15.

10.

Tuberous sclerosis complex 2 loss of heterozygosity in patients with lung disease and cancer.

Zhang L, Pacheco-Rodriguez G, Steagall WK, Kato J, Haughey M, Fontana JR, Manganiello VC, Moss J.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):352-5. doi: 10.1164/rccm.201408-1480LE. No abstract available.

11.

Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.

Hiramoto K, Murata T, Shimizu K, Morita H, Inui M, Manganiello VC, Tagawa T, Arai N.

Cell Signal. 2014 Sep;26(9):1807-17. doi: 10.1016/j.cellsig.2014.03.031. Epub 2014 Apr 3.

12.

Advances in targeting cyclic nucleotide phosphodiesterases.

Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC.

Nat Rev Drug Discov. 2014 Apr;13(4):290-314. doi: 10.1038/nrd4228. Review.

13.

Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms.

Vandeput F, Szabo-Fresnais N, Ahmad F, Kho C, Lee A, Krall J, Dunlop A, Hazel MW, Wohlschlegel JA, Hajjar RJ, Houslay MD, Manganiello VC, Movsesian MA.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19778-83. doi: 10.1073/pnas.1305427110. Epub 2013 Nov 18.

14.

Cyclic nucleotide phosphodiesterase 3 signaling complexes.

Ahmad F, Degerman E, Manganiello VC.

Horm Metab Res. 2012 Sep;44(10):776-85. doi: 10.1055/s-0032-1312646. Epub 2012 Jun 12. Review. Erratum in: Horm Metab Res. 2012 Nov;44(12):930.

PMID:
22692928
16.

Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.

Heimann E, Jones HA, Resjö S, Manganiello VC, Stenson L, Degerman E.

PLoS One. 2010 Dec 1;5(12):e14191. doi: 10.1371/journal.pone.0014191.

17.

Steroid-sparing effects of pentoxifylline in pulmonary sarcoidosis.

Park MK, Fontana Jr, Babaali H, Gilbert-McClain LI, Stylianou M, Joo J, Moss J, Manganiello VC.

Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):121-31.

18.

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.

Biochem J. 2009 Dec 10;424(3):399-410. doi: 10.1042/BJ20090842.

19.

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.

Puxeddu E, Uhart M, Li CC, Ahmad F, Pacheco-Rodriguez G, Manganiello VC, Moss J, Vaughan M.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6158-63. doi: 10.1073/pnas.0901558106. Epub 2009 Mar 30.

20.

Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.

Berger K, Lindh R, Wierup N, Zmuda-Trzebiatowska E, Lindqvist A, Manganiello VC, Degerman E.

PLoS One. 2009;4(3):e4671. doi: 10.1371/journal.pone.0004671. Epub 2009 Mar 5.

21.

Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.

Sun B, Li H, Shakur Y, Hensley J, Hockman S, Kambayashi J, Manganiello VC, Liu Y.

Cell Signal. 2007 Aug;19(8):1765-71. Epub 2007 Apr 6.

PMID:
17482796
22.

Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.

Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS.

Cell Signal. 2007 Jul;19(7):1505-13. Epub 2007 Feb 12.

PMID:
17368848
23.
24.

Foxp3-dependent programme of regulatory T-cell differentiation.

Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY.

Nature. 2007 Feb 15;445(7129):771-5. Epub 2007 Jan 14.

PMID:
17220874
25.

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.

Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.

J Clin Invest. 2006 Dec;116(12):3240-51.

26.

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

J Endocrinol. 2006 Jun;189(3):629-41.

PMID:
16731793
27.

Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes.

Liu H, Tang JR, Choi YH, Napolitano M, Hockman S, Taira M, Degerman E, Manganiello VC.

J Biol Chem. 2006 Jul 28;281(30):21096-113. Epub 2006 May 15.

28.

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.

Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, Leroith D.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1227-36.

29.

Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium.

Hambleton R, Krall J, Tikishvili E, Honeggar M, Ahmad F, Manganiello VC, Movsesian MA.

J Biol Chem. 2005 Nov 25;280(47):39168-74. Epub 2005 Sep 19.

30.

Expression of cyclic nucleotide phosphodiesterase 3A in isolated rat submandibular acini.

Shimizu K, Murata T, Hiramoto K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.

Arch Oral Biol. 2006 Feb;51(2):83-8. Epub 2005 Aug 15.

PMID:
16102722
31.

Identification of promoter elements in 5'-flanking region of murine cyclic nucleotide phosphodiesterase 3B gene.

Liu H, Tang JR, Degerman E, Manganiello VC.

Methods Mol Biol. 2005;307:109-24.

PMID:
15988059
32.

Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.

Ahmad F, Härndahl L, Tang Y, Holst LS, Manganiello VC.

Methods Mol Biol. 2005;307:93-107.

PMID:
15988058
33.

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.

Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS.

J Biol Chem. 2004 Apr 9;279(15):15214-22. Epub 2004 Jan 20.

34.

Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes.

Akesson L, Ahrén B, Manganiello VC, Holst LS, Edgren G, Degerman E.

Endocrinology. 2003 Dec;144(12):5293-9. Epub 2003 Aug 28.

PMID:
12960103
35.

Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition.

Narita M, Murata T, Shimizu K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.

Anticancer Drugs. 2003 Jun;14(5):377-81.

PMID:
12782945
36.

Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.

Osawa H, Niiya T, Onuma H, Murakami A, Ochi M, Nishimiya T, Ogura T, Kato K, Shimizu I, Fujii Y, Ohashi J, Yamada K, Liang SJ, Manganiello VC, Fujita-Yamaguchi Y, Makino H.

Mol Genet Metab. 2003 May;79(1):43-51.

PMID:
12765845
37.
38.

Characterization of phosphodiesterase 3 in human malignant melanoma cell line.

Murata T, Shimizu K, Narita M, Manganiello VC, Tagawa T.

Anticancer Res. 2002 Nov-Dec;22(6A):3171-4.

PMID:
12530061
39.

Expression and role of phosphodiesterase 3 in human squamous cell carcinoma KB cells.

Shimizu K, Murata T, Okumura K, Manganiello VC, Tagawa T.

Anticancer Drugs. 2002 Sep;13(8):875-80.

PMID:
12394274
41.

Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.

Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS.

J Biol Chem. 2002 Oct 4;277(40):37446-55. Epub 2002 Aug 6.

42.

Isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes.

Wechsler J, Choi YH, Krall J, Ahmad F, Manganiello VC, Movsesian MA.

J Biol Chem. 2002 Oct 11;277(41):38072-8. Epub 2002 Aug 1.

43.

Expression of phosphodiesterase 3 in rat submandibular gland cell lines.

Murata T, Sugatani T, Manganiello VC, Shimizu K, Tagawa T.

Arch Oral Biol. 2001 May;46(5):453-7.

PMID:
11286810
44.

Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.

Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.

Anticancer Drugs. 2001 Jan;12(1):79-83.

PMID:
11272291
45.

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes.

Choi YH, Ekholm D, Krall J, Ahmad F, Degerman E, Manganiello VC, Movsesian MA.

Biochem J. 2001 Jan 1;353(Pt 1):41-50.

46.

Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.

Shakur Y, Takeda K, Kenan Y, Yu ZX, Rena G, Brandt D, Houslay MD, Degerman E, Ferrans VJ, Manganiello VC.

J Biol Chem. 2000 Dec 8;275(49):38749-61.

47.

Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.

Ahmad F, Cong LN, Stenson Holst L, Wang LM, Rahn Landstrom T, Pierce JH, Quon MJ, Degerman E, Manganiello VC.

J Immunol. 2000 May 1;164(9):4678-88.

48.

Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms.

Kenan Y, Murata T, Shakur Y, Degerman E, Manganiello VC.

J Biol Chem. 2000 Apr 21;275(16):12331-8.

49.

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.

Rondinone CM, Carvalho E, Rahn T, Manganiello VC, Degerman E, Smith UP.

J Biol Chem. 2000 Apr 7;275(14):10093-8.

50.

Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene.

Kasuya J, Liang SJ, Goko H, Park SH, Kato K, Xu ZD, Hockman S, Manganiello VC, Fujita-Yamaguchi Y.

Biochem Biophys Res Commun. 2000 Feb 24;268(3):827-34.

PMID:
10679291

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