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Items: 1 to 50 of 134

1.

Construction and characterization of the double unmarked Mycobacterium tuberculosis mutant sigE/fadD26 as a vaccine candidate.

Hernandez Pando R, Shin SJ, Clark S, Casonato S, Zambrano MB, Kim H, Boldrin F, Mata Espinoza D, Provvedi R, Arbues A, Marquina Castillo B, Cioetto Mazzabò L, Barrios Payan J, Martin C, Cho SN, Williams A, Manganelli R.

Infect Immun. 2019 Oct 7. pii: IAI.00496-19. doi: 10.1128/IAI.00496-19. [Epub ahead of print]

PMID:
31591165
2.

Improving the stability of the TetR/Pip-OFF mycobacterial repressible promoter system.

Boldrin F, Anoosheh S, Serafini A, Cioetto Mazzabò L, Palù G, Provvedi R, Manganelli R.

Sci Rep. 2019 Apr 8;9(1):5783. doi: 10.1038/s41598-019-42319-2.

3.

Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE.

Boldrin F, Mazzabò LC, Anoosheh S, Palù G, Gaudreau L, Manganelli R, Provvedi R.

Sci Rep. 2019 Mar 14;9(1):4513. doi: 10.1038/s41598-019-41183-4.

4.

PE_PGRS3 of Mycobacterium tuberculosis is specifically expressed at low phosphate concentration, and its arginine-rich C-terminal domain mediates adhesion and persistence in host tissues when expressed in Mycobacterium smegmatis.

De Maio F, Battah B, Palmieri V, Petrone L, Corrente F, Salustri A, Palucci I, Bellesi S, Papi M, Rubino S, Sali M, Goletti D, Sanguinetti M, Manganelli R, De Spirito M, Delogu G.

Cell Microbiol. 2018 Dec;20(12):e12952. doi: 10.1111/cmi.12952. Epub 2018 Sep 26.

PMID:
30192424
5.

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells.

Etna MP, Sinigaglia A, Grassi A, Giacomini E, Romagnoli A, Pardini M, Severa M, Cruciani M, Rizzo F, Anastasiadou E, Di Camillo B, Barzon L, Fimia GM, Manganelli R, Coccia EM.

PLoS Pathog. 2018 Jan 4;14(1):e1006790. doi: 10.1371/journal.ppat.1006790. eCollection 2018 Jan.

6.

[Bilirubin removal with Coupled Plasma Filtration and Adsorption in patients affected by hilar cholangiocarcinoma].

De Simone W, Crafa F, Noviello A, Esposito F, Zito B, Manganelli R, De Simone A, Covotta L, Palladino G, De Simone E.

G Ital Nefrol. 2017 Dec 5;34(Nov-Dec). pii: 2017-vol6. Italian.

PMID:
29207229
7.

PE and PPE Genes: A Tale of Conservation and Diversity.

Delogu G, Brennan MJ, Manganelli R.

Adv Exp Med Biol. 2017;1019:191-207. doi: 10.1007/978-3-319-64371-7_10. Review.

PMID:
29116636
8.

Promoter mutagenesis for fine-tuning expression of essential genes in Mycobacterium tuberculosis.

Boldrin F, Degiacomi G, Serafini A, Kolly GS, Ventura M, Sala C, Provvedi R, Palù G, Cole ST, Manganelli R.

Microb Biotechnol. 2018 Jan;11(1):238-247. doi: 10.1111/1751-7915.12875. Epub 2017 Oct 27.

9.

The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs.

Pisu D, Provvedi R, Espinosa DM, Payan JB, Boldrin F, Palù G, Hernandez-Pando R, Manganelli R.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01596-17. doi: 10.1128/AAC.01596-17. Print 2017 Dec.

10.

Evaluation of PE_PGRS33 as a potential surface target for humoral responses against Mycobacterium tuberculosis.

Minerva M, De Maio F, Camassa S, Battah B, Ivana P, Manganelli R, Sanguinetti M, Sali M, Delogu G.

Pathog Dis. 2017 Nov 30;75(8). doi: 10.1093/femspd/ftx100.

PMID:
28911035
11.

Mycobacterium tuberculosis sigE mutant ST28 used as a vaccine induces protective immunity in the guinea pig model.

Troudt J, Creissen E, Izzo L, Bielefeldt-Ohmann H, Casonato S, Manganelli R, Izzo AA.

Tuberculosis (Edinb). 2017 Sep;106:99-105. doi: 10.1016/j.tube.2017.07.009. Epub 2017 Jul 24.

12.

lysX gene is differentially expressed among Mycobacterium tuberculosis strains with different levels of virulence.

Montoya-Rosales A, Provvedi R, Torres-Juarez F, Enciso-Moreno JA, Hernandez-Pando R, Manganelli R, Rivas-Santiago B.

Tuberculosis (Edinb). 2017 Sep;106:106-117. doi: 10.1016/j.tube.2017.07.005. Epub 2017 Jul 17.

PMID:
28802397
13.

[Gross Hematuria after kidney biopsy. A case report].

Manganelli R, Iannaccone S, Lombardi G, De Siero M, Lago L, Desiderio G, De Simone E, Viscione M, Tirri C.

G Ital Nefrol. 2017 Aug 1;34(4):61-71. Italian.

PMID:
28762683
14.

Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions.

Perrone R, Lavezzo E, Riello E, Manganelli R, Palù G, Toppo S, Provvedi R, Richter SN.

Sci Rep. 2017 Jul 18;7(1):5743. doi: 10.1038/s41598-017-05867-z.

15.

The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis.

Rosado LA, Wahni K, Degiacomi G, Pedre B, Young D, de la Rubia AG, Boldrin F, Martens E, Marcos-Pascual L, Sancho-Vaello E, Albesa-Jové D, Provvedi R, Martin C, Makarov V, Versées W, Verniest G, Guerin ME, Mateos LM, Manganelli R, Messens J.

J Biol Chem. 2017 Aug 11;292(32):13097-13110. doi: 10.1074/jbc.M117.797837. Epub 2017 Jun 15.

16.

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM.

PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May.

17.

Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.

Camassa S, Palucci I, Iantomasi R, Cubeddu T, Minerva M, De Maio F, Jouny S, Petruccioli E, Goletti D, Ria F, Sali M, Sanguinetti M, Manganelli R, Rocca S, Brodin P, Delogu G.

Front Cell Infect Microbiol. 2017 Apr 21;7:137. doi: 10.3389/fcimb.2017.00137. eCollection 2017.

18.

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.

Esposito M, Szadocka S, Degiacomi G, Orena BS, Mori G, Piano V, Boldrin F, Zemanová J, Huszár S, Barros D, Ekins S, Lelièvre J, Manganelli R, Mattevi A, Pasca MR, Riccardi G, Ballell L, Mikušová K, Chiarelli LR.

ACS Infect Dis. 2017 Jun 9;3(6):428-437. doi: 10.1021/acsinfecdis.7b00006. Epub 2017 May 11.

PMID:
28475832
19.

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.

Degiacomi G, Benjak A, Madacki J, Boldrin F, Provvedi R, Palù G, Kordulakova J, Cole ST, Manganelli R.

Sci Rep. 2017 Feb 27;7:43495. doi: 10.1038/srep43495.

20.

[The Ormond's disease: an intriguing obstructive nephrouropathy].

Manganelli R, Manganelli S, Iannaccone S, De Simone W.

G Ital Nefrol. 2016 Nov-Dec;33(6). pii: gin/33.6.11. Italian.

PMID:
28134406
21.

Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme: (Trends in Microbiology 25, 205-216; 2017).

Manganelli R, Gennaro ML.

Trends Microbiol. 2017 Mar;25(3):242. doi: 10.1016/j.tim.2016.11.010. Epub 2016 Dec 4. No abstract available.

PMID:
27923541
22.

Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme.

Manganelli R, Gennaro ML.

Trends Microbiol. 2017 Mar;25(3):205-216. doi: 10.1016/j.tim.2016.10.001. Epub 2016 Nov 16. Review. Erratum in: Trends Microbiol. 2017 Mar;25(3):242.

23.

Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues.

Serafini A, Riello E, Trojan D, Cogliati E, Palù G, Manganelli R, Paolin A.

Cell Tissue Bank. 2016 Dec;17(4):619-628. Epub 2016 Sep 7.

24.

Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.

Degiacomi G, Personne Y, Mondésert G, Ge X, Mandava CS, Hartkoorn RC, Boldrin F, Goel P, Peisker K, Benjak A, Barrio MB, Ventura M, Brown AC, Leblanc V, Bauer A, Sanyal S, Cole ST, Lagrange S, Parish T, Manganelli R.

Tuberculosis (Edinb). 2016 Sep;100:95-101. doi: 10.1016/j.tube.2016.07.011. Epub 2016 Jul 27.

PMID:
27553416
25.

Virological testing of cerebrospinal fluid in children aged less than 14 years with a suspected central nervous system infection: A retrospective study on 304 consecutive children from January 2012 to May 2015.

Parisi SG, Basso M, Del Vecchio C, Andreis S, Franchin E, Bello FD, Pagni S, Biasolo MA, Manganelli R, Barzon L, Palù G.

Eur J Paediatr Neurol. 2016 Jul;20(4):588-96. doi: 10.1016/j.ejpn.2016.04.002. Epub 2016 Apr 16.

PMID:
27129875
26.

Inorganic Phosphate Limitation Modulates Capsular Polysaccharide Composition in Mycobacteria.

van de Weerd R, Boot M, Maaskant J, Sparrius M, Verboom T, van Leeuwen LM, Burggraaf MJ, Paauw NJ, Dainese E, Manganelli R, Bitter W, Appelmelk BJ, Geurtsen J.

J Biol Chem. 2016 May 27;291(22):11787-99. doi: 10.1074/jbc.M116.722454. Epub 2016 Apr 4.

27.

PE_PGRS33 Contributes to Mycobacterium tuberculosis Entry in Macrophages through Interaction with TLR2.

Palucci I, Camassa S, Cascioferro A, Sali M, Anoosheh S, Zumbo A, Minerva M, Iantomasi R, De Maio F, Di Sante G, Ria F, Sanguinetti M, Palù G, Brennan MJ, Manganelli R, Delogu G.

PLoS One. 2016 Mar 15;11(3):e0150800. doi: 10.1371/journal.pone.0150800. eCollection 2016.

28.

[Management of antirheumatic drugs in kidney failure].

Manganelli R, Manganelli S, Iannaccone S, De Simone W.

G Ital Nefrol. 2015 Nov-Dec;32(6). pii: gin/32.6.4. Review. Italian.

PMID:
26845207
29.

Viral infections of the central nervous system in elderly patients: a retrospective study.

Parisi SG, Basso M, Del Vecchio C, Andreis S, Franchin E, Dal Bello F, Pagni S, Biasolo MA, Manganelli R, Barzon L, Palù G.

Int J Infect Dis. 2016 Mar;44:8-10. doi: 10.1016/j.ijid.2016.01.012. Epub 2016 Jan 25.

30.

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.

Albesa-Jové D, Comino N, Tersa M, Mohorko E, Urresti S, Dainese E, Chiarelli LR, Pasca MR, Manganelli R, Makarov V, Riccardi G, Svergun DI, Glockshuber R, Guerin ME.

J Biol Chem. 2015 Dec 25;290(52):31077-89. doi: 10.1074/jbc.M115.677039. Epub 2015 Nov 6.

31.

Mycobacterium tuberculosis virulence: insights and impact on vaccine development.

Delogu G, Provvedi R, Sali M, Manganelli R.

Future Microbiol. 2015;10(7):1177-94. doi: 10.2217/fmb.15.26. Epub 2015 Jun 29. Review.

PMID:
26119086
32.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR.

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

33.

Whole cell screen based identification of spiropiperidines with potent antitubercular properties.

Tantry SJ, Degiacomi G, Sharma S, Jena LK, Narayan A, Guptha S, Shanbhag G, Menasinakai S, Mallya M, Awasthy D, Balakrishnan G, Kaur P, Bhattacharjee D, Narayan C, Reddy J, Naveen Kumar CN, Shandil R, Boldrin F, Ventura M, Manganelli R, Hartkoorn RC, Cole ST, Panda M, Markad SD, Ramachandran V, Ghorpade SR, Dinesh N.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3234-45. doi: 10.1016/j.bmcl.2015.05.087. Epub 2015 Jun 3.

PMID:
26087937
34.

The essential role of SepF in mycobacterial division.

Gola S, Munder T, Casonato S, Manganelli R, Vicente M.

Mol Microbiol. 2015 Aug;97(3):560-76. doi: 10.1111/mmi.13050. Epub 2015 Jun 6.

35.

Impact of protein domains on PE_PGRS30 polar localization in Mycobacteria.

De Maio F, Maulucci G, Minerva M, Anoosheh S, Palucci I, Iantomasi R, Palmieri V, Camassa S, Sali M, Sanguinetti M, Bitter W, Manganelli R, De Spirito M, Delogu G.

PLoS One. 2014 Nov 12;9(11):e112482. doi: 10.1371/journal.pone.0112482. eCollection 2014.

36.

Mycobacterium tuberculosis requires the ECF sigma factor SigE to arrest phagosome maturation.

Casonato S, Provvedi R, Dainese E, Palù G, Manganelli R.

PLoS One. 2014 Sep 30;9(9):e108893. doi: 10.1371/journal.pone.0108893. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e115990.

37.

The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.

Boldrin F, Ventura M, Degiacomi G, Ravishankar S, Sala C, Svetlikova Z, Ambady A, Dhar N, Kordulakova J, Zhang M, Serafini A, Vishwas KG, Kolly GS, Kumar N, Palù G, Guerin ME, Mikusova K, Cole ST, Manganelli R.

J Bacteriol. 2014 Oct;196(19):3441-51. doi: 10.1128/JB.01346-13. Epub 2014 Jul 21. Erratum in: J Bacteriol. 2014 Dec;196(23):4197. Vishwas, V G [Corrected to Vishwas, K G].

38.

Homologous prime boosting based on intranasal delivery of non-pathogenic invasive Escherichia coli expressing MPT64, decreases Mycobacterium tuberculosis dissemination.

Sali M, Dainese E, Morandi M, Zumbo A, Rocca S, Goussard S, Palù G, Grillot-Courvalin C, Delogu G, Manganelli R.

Vaccine. 2014 Jul 7;32(32):4051-8. doi: 10.1016/j.vaccine.2014.05.060. Epub 2014 Jun 2.

PMID:
24886957
39.

Four year longitudinal study of Mycobacterium tuberculosis complex isolates in a region of North-Eastern Italy.

Fallico L, Couvin D, Peracchi M, Pascarella M, Franchin E, Lavezzo E, Rassu M, Manganelli R, Rastogi N, Palù G.

Infect Genet Evol. 2014 Aug;26:58-64. doi: 10.1016/j.meegid.2014.05.004. Epub 2014 May 10.

PMID:
24820340
40.

Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.

Kolly GS, Boldrin F, Sala C, Dhar N, Hartkoorn RC, Ventura M, Serafini A, McKinney JD, Manganelli R, Cole ST.

Mol Microbiol. 2014 Apr;92(1):194-211. doi: 10.1111/mmi.12546. Epub 2014 Mar 7.

41.

Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence.

Manganelli R.

Microbiol Spectr. 2014 Feb;2(1):MGM2-0007-2013. doi: 10.1128/microbiolspec.MGM2-0007-2013. Review.

PMID:
26082107
42.

Critical research concepts in tuberculosis vaccine development.

Delogu G, Manganelli R, Brennan MJ.

Clin Microbiol Infect. 2014 May;20 Suppl 5:59-65. doi: 10.1111/1469-0691.12460. Epub 2014 Jan 20. Review.

43.

Genomic comparative analysis and gene function prediction in infectious diseases: application to the investigation of a meningitis outbreak.

Lavezzo E, Toppo S, Franchin E, Di Camillo B, Finotello F, Falda M, Manganelli R, Palù G, Barzon L.

BMC Infect Dis. 2013 Nov 19;13:554. doi: 10.1186/1471-2334-13-554.

44.

Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs.

Bottai D, Serafini A, Cascioferro A, Brosch R, Manganelli R.

Curr Pharm Des. 2014;20(27):4346-56. Review.

PMID:
24245757
45.

The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.

Serafini A, Pisu D, Palù G, Rodriguez GM, Manganelli R.

PLoS One. 2013 Oct 14;8(10):e78351. doi: 10.1371/journal.pone.0078351. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/56401af3-74aa-4c4f-882c-06481b29aa94.

46.

Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis.

Zumbo A, Palucci I, Cascioferro A, Sali M, Ventura M, D'Alfonso P, Iantomasi R, Di Sante G, Ria F, Sanguinetti M, Fadda G, Manganelli R, Delogu G.

Pathog Dis. 2013 Dec;69(3):232-9. doi: 10.1111/2049-632X.12096. Epub 2013 Oct 7.

PMID:
24106104
47.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM.

Mol Microbiol. 2013 Oct;90(2):356-66. doi: 10.1111/mmi.12368. Epub 2013 Sep 8.

48.

Exploiting the mycobacterial cell wall to design improved vaccines against tuberculosis.

Morandi M, Sali M, Manganelli R, Delogu G.

J Infect Dev Ctries. 2013 Mar 14;7(3):169-81. doi: 10.3855/jidc.3114. Review.

49.

The PPE domain of PPE17 is responsible for its surface localization and can be used to express heterologous proteins on the mycobacterial surface.

Donà V, Ventura M, Sali M, Cascioferro A, Provvedi R, Palù G, Delogu G, Manganelli R.

PLoS One. 2013;8(3):e57517. doi: 10.1371/journal.pone.0057517. Epub 2013 Mar 1.

50.

WhiB5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation.

Casonato S, Cervantes Sánchez A, Haruki H, Rengifo González M, Provvedi R, Dainese E, Jaouen T, Gola S, Bini E, Vicente M, Johnsson K, Ghisotti D, Palù G, Hernández-Pando R, Manganelli R.

Infect Immun. 2012 Sep;80(9):3132-44. doi: 10.1128/IAI.06328-11. Epub 2012 Jun 25.

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