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Items: 29

1.

Serine Metabolism Supports Macrophage IL-1β Production.

Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS.

Cell Metab. 2019 Apr 2;29(4):1003-1011.e4. doi: 10.1016/j.cmet.2019.01.014. Epub 2019 Feb 14.

PMID:
30773464
2.

Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond.

Muller AJ, Manfredi MG, Zakharia Y, Prendergast GC.

Semin Immunopathol. 2019 Jan;41(1):41-48. doi: 10.1007/s00281-018-0702-0. Epub 2018 Sep 10. Review.

PMID:
30203227
3.

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.

Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9.

4.

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.

Sells TB, Chau R, Ecsedy JA, Gershman RE, Hoar K, Huck J, Janowick DA, Kadambi VJ, LeRoy PJ, Stirling M, Stroud SG, Vos TJ, Weatherhead GS, Wysong DR, Zhang M, Balani SK, Bolen JB, Manfredi MG, Claiborne CF.

ACS Med Chem Lett. 2015 Apr 22;6(6):630-4. doi: 10.1021/ml500409n. eCollection 2015 Jun 11.

5.

Translational exposure-efficacy modeling to optimize the dose and schedule of taxanes combined with the investigational Aurora A kinase inhibitor MLN8237 (alisertib).

Huck JJ, Zhang M, Mettetal J, Chakravarty A, Venkatakrishnan K, Zhou X, Kleinfield R, Hyer ML, Kannan K, Shinde V, Dorner A, Manfredi MG, Shyu WC, Ecsedy JA.

Mol Cancer Ther. 2014 Sep;13(9):2170-83. doi: 10.1158/1535-7163.MCT-14-0027. Epub 2014 Jun 30.

6.

Preclinical drug metabolism and pharmacokinetics, and prediction of human pharmacokinetics and efficacious dose of the investigational Aurora A kinase inhibitor alisertib (MLN8237).

Yang JJ, Li Y, Chakravarty A, Lu C, Xia CQ, Chen S, Pusalkar S, Zhang M, Ecsedy J, Manfredi MG, Wu JT, Shyu WC, Balani SK.

Drug Metab Lett. 2014 Jul;7(2):96-104.

PMID:
24484538
7.

MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma.

Shi JQ, Lasky K, Shinde V, Stringer B, Qian MG, Liao D, Liu R, Driscoll D, Nestor MT, Amidon BS, Rao Y, Duffey MO, Manfredi MG, Vos TJ, D' Amore N, Hyer ML.

Mol Cancer Ther. 2012 Sep;11(9):2045-53. doi: 10.1158/1535-7163.MCT-11-1036. Epub 2012 May 18.

8.

Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

Milhollen MA, Thomas MP, Narayanan U, Traore T, Riceberg J, Amidon BS, Bence NF, Bolen JB, Brownell J, Dick LR, Loke HK, McDonald AA, Ma J, Manfredi MG, Sells TB, Sintchak MD, Yang X, Xu Q, Koenig EM, Gavin JM, Smith PG.

Cancer Cell. 2012 Mar 20;21(3):388-401. doi: 10.1016/j.ccr.2012.02.009.

9.

Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.

Manfredi MG, Ecsedy JA, Chakravarty A, Silverman L, Zhang M, Hoar KM, Stroud SG, Chen W, Shinde V, Huck JJ, Wysong DR, Janowick DA, Hyer ML, Leroy PJ, Gershman RE, Silva MD, Germanos MS, Bolen JB, Claiborne CF, Sells TB.

Clin Cancer Res. 2011 Dec 15;17(24):7614-24. doi: 10.1158/1078-0432.CCR-11-1536. Epub 2011 Oct 20.

10.

Multimodal imaging with (18)F-FDG PET and Cerenkov luminescence imaging after MLN4924 treatment in a human lymphoma xenograft model.

Robertson R, Germanos MS, Manfredi MG, Smith PG, Silva MD.

J Nucl Med. 2011 Nov;52(11):1764-9. doi: 10.2967/jnumed.111.091710. Epub 2011 Oct 12.

11.

MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.

Huck JJ, Zhang M, McDonald A, Bowman D, Hoar KM, Stringer B, Ecsedy J, Manfredi MG, Hyer ML.

Mol Cancer Res. 2010 Mar;8(3):373-84. doi: 10.1158/1541-7786.MCR-09-0300. Epub 2010 Mar 2.

12.

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.

Manfredi MG, Ecsedy JA, Meetze KA, Balani SK, Burenkova O, Chen W, Galvin KM, Hoar KM, Huck JJ, LeRoy PJ, Ray ET, Sells TB, Stringer B, Stroud SG, Vos TJ, Weatherhead GS, Wysong DR, Zhang M, Bolen JB, Claiborne CF.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. Epub 2007 Feb 23.

13.

N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours.

Ranes MK, El-Abbadi M, Manfredi MG, Mukherjee P, Platt FM, Seyfried TN.

Br J Cancer. 2001 Apr 20;84(8):1107-14.

14.

Gangliosides influence angiogenesis in an experimental mouse brain tumor.

Manfredi MG, Lim S, Claffey KP, Seyfried TN.

Cancer Res. 1999 Oct 15;59(20):5392-7.

15.

Ganglioside biosynthetic gene expression in experimental mouse brain tumors.

Ecsedy JA, Manfredi MG, Yohe HC, Seyfried TN.

Cancer Res. 1997 Apr 15;57(8):1580-3.

16.

Cytokine antagonists in aged subjects and their relation with cellular immunity.

Catania A, Airaghi L, Motta P, Manfredi MG, Annoni G, Pettenati C, Brambilla F, Lipton JM.

J Gerontol A Biol Sci Med Sci. 1997 Mar;52(2):B93-7.

PMID:
9060965
17.

Endogenous cytokine antagonists during myocardial ischemia and thrombolytic therapy.

Airaghi L, Lettino M, Manfredi MG, Lipton JM, Catania A.

Am Heart J. 1995 Aug;130(2):204-11.

PMID:
7631597
18.

Cytokine antagonists in infectious and inflammatory disorders.

Catania A, Manfredi MG, Airaghi L, Ceriani G, Gandino A, Lipton JM.

Ann N Y Acad Sci. 1994 Nov 25;741:149-61. Review. No abstract available.

PMID:
7825802
19.

The anticytokine neuropeptide alpha-melanocyte-stimulating hormone in synovial fluid of patients with rheumatic diseases: comparisons with other anticytokine molecules.

Catania A, Gerloni V, Procaccia S, Airaghi L, Manfredi MG, Lomater C, Grossi L, Lipton JM.

Neuroimmunomodulation. 1994 Sep-Oct;1(5):321-8.

PMID:
8528899
20.

Plasma concentration of cytokine antagonists in patients with HIV infection.

Catania A, Manfredi MG, Airaghi L, Vivirito MC, Capetti A, Milazzo F, Lipton JM, Zanussi C.

Neuroimmunomodulation. 1994 Jan;1(1):42-9.

PMID:
8528884
21.

Proopiomelanocortin-derived peptides and cytokines: relations in patients with acquired immunodeficiency syndrome.

Catania A, Airaghi L, Manfredi MG, Vivirito MC, Milazzo F, Lipton JM, Zanussi C.

Clin Immunol Immunopathol. 1993 Jan;66(1):73-9.

PMID:
8382570
22.

The neuropeptide alpha-MSH in control of fever.

Catania A, Manfredi MG, Airaghi L, Lipton JM.

Pharmacol Res. 1992 Sep;26 Suppl 2:72-3. No abstract available.

PMID:
1329067
23.

Scintigraphic study of extra-adrenal ganglioneuroma in a patient with overlap between multiple endocrine neoplasia types 1 and 2.

Reschini E, Catania A, Airaghi L, Manfredi MG, Crosignani PG.

Clin Nucl Med. 1992 Jul;17(7):573-6.

PMID:
1353424
24.

Delayed cortisol response to antigenic challenge in patients with acquired immunodeficiency syndrome.

Catania A, Manfredi MG, Airaghi L, Vivirito MC, Milazzo F, Lipton JM, Zanussi C.

Ann N Y Acad Sci. 1992 Apr 15;650:202-4. No abstract available.

PMID:
1318657
25.

Inhibitory effect of somatostatin on abnormal GH response to TRH in primary hypothyroidism.

Baldini M, Catania A, Orsatti A, Manfredi MG, Motta P, Cantalamessa L.

Exp Clin Endocrinol. 1992;99(2):80-3.

PMID:
1353454
26.

ACTH and cortisol secretion in patients with Alzheimer's disease.

Franceschi M, Airaghi L, Gramigna C, Truci G, Manfredi MG, Canal N, Catania A.

J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):836-7.

27.

Resistance of beta-endorphin to dexamethasone inhibition in Parkinson's and Alzheimer's diseases.

Airaghi L, Catania A, Gramigna C, Manfredi MG, Franceschi M, Zanussi C.

Int J Neurosci. 1991 Jan-Feb;56(1-4):73-9.

PMID:
1657808
28.

Evidence for an impairment of the immune-adrenal circuit in patients with acquired immunodeficiency syndrome.

Catania A, Manfredi MG, Airaghi L, Vivirito MC, Milazzo F, Zanussi C.

Horm Metab Res. 1990 Nov;22(11):597-8. No abstract available.

PMID:
2177033
29.

[Histochemical observations on Micrococcus lysodeikticus].

MANFREDI MG, ALBANI AM.

Mikroskopie. 1955 Sep;10(3-4):124-7. Italian. No abstract available.

PMID:
13279569

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