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Return to Sport after Injury: A Web-Based Survey of Owners and Handlers of Agility Dogs.

Tomlinson JE, Manfredi JM.

Vet Comp Orthop Traumatol. 2018 Nov;31(6):473-478. doi: 10.1055/s-0038-1670676. Epub 2018 Oct 22.


Prevalence, awareness, treatment and control of diabetes and impaired fasting glucose in the Southern Cone of Latin America.

Irazola V, Rubinstein A, Bazzano L, Calandrelli M, Chung-Shiuan C, Elorriaga N, Gutierrez L, Lanas F, Manfredi JA, Mores N, Olivera H, Poggio R, Ponzo J, Seron P, He J.

PLoS One. 2017 Sep 6;12(9):e0183953. doi: 10.1371/journal.pone.0183953. eCollection 2017.


Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase.

Giono LE, Resnick-Silverman L, Carvajal LA, St Clair S, Manfredi JJ.

Oncogene. 2017 Dec 7;36(49):6762-6773. doi: 10.1038/onc.2017.254. Epub 2017 Aug 14.


Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53.

Senturk JC, Bohlman S, Manfredi JJ.

Oncogene. 2017 Nov 2;36(44):6085-6096. doi: 10.1038/onc.2017.229. Epub 2017 Jul 10.


p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes.

Pappas K, Xu J, Zairis S, Resnick-Silverman L, Abate F, Steinbach N, Ozturk S, Saal LH, Su T, Cheung P, Schmidt H, Aaronson S, Hibshoosh H, Manfredi J, Rabadan R, Parsons R.

Mol Cancer Res. 2017 Aug;15(8):1051-1062. doi: 10.1158/1541-7786.MCR-17-0089. Epub 2017 May 8.


Tumor suppression by p53 involves inhibiting an enabler, FGF13.

Manfredi JJ.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):632-633. doi: 10.1073/pnas.1619815114. Epub 2017 Jan 12. No abstract available.


Prevalence, Distributions and Determinants of Obesity and Central Obesity in the Southern Cone of America.

Lanas F, Bazzano L, Rubinstein A, Calandrelli M, Chen CS, Elorriaga N, Gutierrez L, Manfredi JA, Seron P, Mores N, Poggio R, Ponzo J, Olivera H, He J, Irazola VE.

PLoS One. 2016 Oct 14;11(10):e0163727. doi: 10.1371/journal.pone.0163727. eCollection 2016.


Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53.

Bohlman S, Manfredi JJ.

Cancer Cell. 2016 Oct 10;30(4):513-514. doi: 10.1016/j.ccell.2016.09.017.


The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

Laptenko O, Tong DR, Manfredi J, Prives C.

Trends Biochem Sci. 2016 Dec;41(12):1022-1034. doi: 10.1016/j.tibs.2016.08.011. Epub 2016 Sep 23. Review.


Prevalence, Awareness, Treatment, and Control of Hypertension in the Southern Cone of Latin America.

Rubinstein AL, Irazola VE, Calandrelli M, Chen CS, Gutierrez L, Lanas F, Manfredi JA, Mores N, Poggio R, Ponzo J, Seron P, Bazzano LA, He J.

Am J Hypertens. 2016 Dec 1;29(12):1343-1352. doi: 10.1093/ajh/hpw092.


A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction.

Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-Silverman L, Manfredi JJ, Berger SL, McMahon SB.

Mol Oncol. 2016 Oct;10(8):1207-20. doi: 10.1016/j.molonc.2016.05.007. Epub 2016 Jun 7.


Cerebellum Development and Tumorigenesis: A p53-Centric Perspective.

Barthelery NJ, Manfredi JJ.

Trends Mol Med. 2016 May;22(5):404-413. doi: 10.1016/j.molmed.2016.03.006. Epub 2016 Apr 13. Review.


USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation.

Mungamuri SK, Qiao RF, Yao S, Manfredi JJ, Gu W, Aaronson SA.

Cell Rep. 2016 Mar 22;14(11):2528-37. doi: 10.1016/j.celrep.2016.02.049. Epub 2016 Mar 10.


Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging.

Li T, Liu X, Jiang L, Manfredi J, Zha S, Gu W.

Oncotarget. 2016 Mar 15;7(11):11838-49. doi: 10.18632/oncotarget.7864.


Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation.

McPherson AD, Barrios JP, Luks-Morgan SJ, Manfredi JP, Bonkowsky JL, Douglass AD, Dorsky RI.

Curr Biol. 2016 Jan 25;26(2):263-269. doi: 10.1016/j.cub.2015.11.064. Epub 2016 Jan 7.


Dimensions of 65 Extracted Equine First Premolar Teeth.

Hole SL, Manfredi JM, Clayton HM.

J Vet Dent. 2016 Sep;33(3):157-159. doi: 10.1177/0898756416675763.


The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo.

Gaynes JA, Otsuna H, Campbell DS, Manfredi JP, Levine EM, Chien CB.

PLoS One. 2015 Sep 1;10(9):e0134751. doi: 10.1371/journal.pone.0134751. eCollection 2015.


Two Faces of SIVA.

Resnick-Silverman L, Manfredi JJ.

Cancer Discov. 2015 Jun;5(6):581-3. doi: 10.1158/2159-8290.CD-15-0484.


The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Laptenko O, Shiff I, Freed-Pastor W, Zupnick A, Mattia M, Freulich E, Shamir I, Kadouri N, Kahan T, Manfredi J, Simon I, Prives C.

Mol Cell. 2015 Mar 19;57(6):1034-1046. doi: 10.1016/j.molcel.2015.02.015.


Multiple cardiometabolic risk factors in the Southern Cone of Latin America: a population-based study in Argentina, Chile, and Uruguay.

Rubinstein AL, Irazola VE, Calandrelli M, Elorriaga N, Gutierrez L, Lanas F, Manfredi JA, Mores N, Olivera H, Poggio R, Ponzo J, Seron P, Chen CS, Bazzano LA, He J.

Int J Cardiol. 2015 Mar 15;183:82-8. doi: 10.1016/j.ijcard.2015.01.062. Epub 2015 Jan 27.


Observation of long-range three-body coulomb effects in the decay of (16)Ne.

Brown KW, Charity RJ, Sobotka LG, Chajecki Z, Grigorenko LV, Egorova IA, Parfenova YL, Zhukov MV, Bedoor S, Buhro WW, Elson JM, Lynch WG, Manfredi J, McNeel DG, Reviol W, Shane R, Showalter RH, Tsang MB, Winkelbauer JR, Wuosmaa AH.

Phys Rev Lett. 2014 Dec 5;113(23):232501. Epub 2014 Dec 2.


p53-independent effects of Mdm2.

Bohlman S, Manfredi JJ.

Subcell Biochem. 2014;85:235-46. doi: 10.1007/978-94-017-9211-0_13. Review.


p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints.

Lukin DJ, Carvajal LA, Liu WJ, Resnick-Silverman L, Manfredi JJ.

Mol Cancer Res. 2015 Jan;13(1):16-28. doi: 10.1158/1541-7786.MCR-14-0177. Epub 2014 Aug 26.


Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters.

Mungamuri SK, Wang S, Manfredi JJ, Gu W, Aaronson SA.

Oncogene. 2015 May 7;34(19):2461-70. doi: 10.1038/onc.2014.198. Epub 2014 Jul 14.


Bleeding risk factors affecting warfarin therapy in the elderly with atrial fibrillation.

Darnell SW, Davis SC, Whitcomb JJ, Manfredi JA, McLaurin BT.

Dimens Crit Care Nurs. 2014 Mar-Apr;33(2):57-63. doi: 10.1097/DCC.0000000000000022. Review.


Evaluation of application of a carpal brace as a treatment for carpal ligament instability in dogs: 14 cases (2008-2011).

Tomlinson JE, Manfredi JM.

J Am Vet Med Assoc. 2014 Feb 15;244(4):438-43. doi: 10.2460/javma.244.4.438.


Insulation failure with externalized conductor of a Linox SD lead: a case report.

Manfredi JA, Smithgall SM, Kircher CM, Lollis MA.

J Cardiovasc Electrophysiol. 2014 Apr;25(4):440-441. doi: 10.1111/jce.12351. Epub 2014 Jan 30.


p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes.

Benson EK, Mungamuri SK, Attie O, Kracikova M, Sachidanandam R, Manfredi JJ, Aaronson SA.

Oncogene. 2014 Jul 24;33(30):3959-69. doi: 10.1038/onc.2013.378. Epub 2013 Oct 7.


Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.

Gassman A, Hao le T, Bhoite L, Bradford CL, Chien CB, Beattie CE, Manfredi JP.

PLoS One. 2013 Sep 4;8(9):e74325. doi: 10.1371/journal.pone.0074325. eCollection 2013.


The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo.

Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ.

Genes Dev. 2013 Sep 1;27(17):1868-85. doi: 10.1101/gad.224386.113.


Another fork in the road--life or death decisions by the tumour suppressor p53.

Carvajal LA, Manfredi JJ.

EMBO Rep. 2013 May;14(5):414-21. doi: 10.1038/embor.2013.25. Epub 2013 Apr 16. Review.


Association between left ventricular ejection fraction post-cardiac resynchronization treatment and subsequent implantable cardioverter defibrillator therapy for sustained ventricular tachyarrhythmias.

Manfredi JA, Al-Khatib SM, Shaw LK, Thomas L, Fogel RI, Padanilam B, Rardon D, Vatthyam R, Gemma LW, Golden K, Prystowsky EN.

Circ Arrhythm Electrophysiol. 2013 Apr;6(2):257-64. doi: 10.1161/CIRCEP.112.000214. Epub 2013 Feb 26.


Democratic decay of 6Be exposed by correlations.

Egorova IA, Charity RJ, Grigorenko LV, Chajecki Z, Coupland D, Elson JM, Ghosh TK, Howard ME, Iwasaki H, Kilburn M, Lee J, Lynch WG, Manfredi J, Marley ST, Sanetullaev A, Shane R, Shetty DV, Sobotka LG, Tsang MB, Winkelbauer J, Wuosmaa AH, Youngs M, Zhukov MV.

Phys Rev Lett. 2012 Nov 16;109(20):202502. Epub 2012 Nov 13.


Mdm2 and tumorigenesis: evolving theories and unsolved mysteries.

Senturk E, Manfredi JJ.

Genes Cancer. 2012 Mar;3(3-4):192-8. doi: 10.1177/1947601912457368.


Monographs editor.

Manfredi JJ.

Genes Cancer. 2012 Mar;3(3-4):191. doi: 10.1177/1947601912458919. No abstract available.


Determine the effect of p53 on chemosensitivity.

Senturk E, Manfredi JJ.

Methods Mol Biol. 2013;962:113-25. doi: 10.1007/978-1-62703-236-0_9.


p53 and cell cycle effects after DNA damage.

Senturk E, Manfredi JJ.

Methods Mol Biol. 2013;962:49-61. doi: 10.1007/978-1-62703-236-0_4.


Steroid diffusion into the navicular bursa occurs in horses affected by palmar foot pain.

Manfredi JM, Boyce M, Malone ED, Anderson C, Anderson LB, Trumble TN.

Vet Rec. 2012 Dec 22-29;171(25):642. doi: 10.1136/vr.101075. Epub 2012 Nov 7.


E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.

Carvajal LA, Hamard PJ, Tonnessen C, Manfredi JJ.

Genes Dev. 2012 Jul 15;26(14):1533-45. doi: 10.1101/gad.184911.111.


p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes.

Hamard PJ, Lukin DJ, Manfredi JJ.

J Biol Chem. 2012 Jun 22;287(26):22397-407. doi: 10.1074/jbc.M111.331298. Epub 2012 Apr 18.


p53/HMGB1 complexes regulate autophagy and apoptosis.

Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC, Zhang L, Manfredi JJ, Zeh HJ 3rd, Li L, Lotze MT, Tang D.

Cancer Res. 2012 Apr 15;72(8):1996-2005. doi: 10.1158/0008-5472.CAN-11-2291. Epub 2012 Feb 16.


Mdm2's dilemma: to degrade or to translate p53?

Hamard PJ, Manfredi JJ.

Cancer Cell. 2012 Jan 17;21(1):3-5. doi: 10.1016/j.ccr.2011.12.018.


Detection and follow-up of cardiovascular disease and risk factors in the Southern Cone of Latin America: the CESCAS I study.

Rubinstein AL, Irazola VE, Poggio R, Bazzano L, Calandrelli M, Lanas Zanetti FT, Manfredi JA, Olivera H, Seron P, Ponzo J, He J.

BMJ Open. 2011 May 26;1(1):e000126. doi: 10.1136/bmjopen-2011-000126.


Analyzing p53 regulated DNA damage checkpoints by flow cytometry.

Resnick-Silverman L, Manfredi JJ.

Methods Mol Biol. 2011;782:193-203. doi: 10.1007/978-1-61779-273-1_14.


Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.

Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D.

PLoS One. 2011;6(8):e22456. doi: 10.1371/journal.pone.0022456. Epub 2011 Aug 4.


Detection and follow-up of chronic obstructive pulmonary disease (COPD) and risk factors in the Southern Cone of Latin America: the pulmonary risk in South America (PRISA) study.

Rubinstein AL, Irazola VE, Bazzano LA, Sobrino E, Calandrelli M, Lanas F, Lee AG, Manfredi JA, Olivera H, Ponzo J, Seron P, He J.

BMC Pulm Med. 2011 Jun 1;11:34. doi: 10.1186/1471-2466-11-34.


An identity crisis for a cancer gene: subcellular location determines ASPP1 function.

Manfredi JJ.

Cancer Cell. 2010 Nov 16;18(5):409-10. doi: 10.1016/j.ccr.2010.11.003. No abstract available.


The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.

Manfredi JJ.

Genes Dev. 2010 Aug 1;24(15):1580-9. doi: 10.1101/gad.1941710. Review. Erratum in: Genes Dev. 2010 Sep 15;24(18):2105.


Papillary fibroelastoma of an anomalous mitral valve chorda.

Pederzolli N, Tappainer E, Manfredi J, Fiorani V, Nocchi A, Agostini F, Zogno M.

J Cardiovasc Med (Hagerstown). 2010 Apr;11(4):291-3.


Skp2B attenuates p53 function by inhibiting prohibitin.

Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D.

EMBO Rep. 2010 Mar;11(3):220-5. doi: 10.1038/embor.2010.2. Epub 2010 Feb 5.

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