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Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.

Vargas-Ayala RC, Jay A, Manara F, Maroui MA, Hernandez-Vargas H, Diederichs A, Robitaille A, Sirand C, Ceraolo MG, Romero-Medina MC, Cros MP, Cuenin C, Durand G, Le Calvez-Kelm F, Mundo L, Leoncini L, Manet E, Herceg Z, Gruffat H, Accardi R.

J Virol. 2019 Jun 14;93(13). pii: e00273-19. doi: 10.1128/JVI.00273-19. Print 2019 Jul 1.


[SRSF3: from mRNA decay to mRNA nuclear export. Epstein-Barr virus helps to make a choice].

Gruffat H, Mure F, Manet E.

Med Sci (Paris). 2019 Feb;35(2):103-105. doi: 10.1051/medsci/2019015. Epub 2019 Feb 18. French. No abstract available.


The splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay.

Mure F, Corbin A, Benbahouche NEH, Bertrand E, Manet E, Gruffat H.

Sci Rep. 2018 Aug 27;8(1):12901. doi: 10.1038/s41598-018-31078-1.


EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.

Wilson JB, Manet E, Gruffat H, Busson P, Blondel M, Fahraeus R.

Cancers (Basel). 2018 Apr 6;10(4). pii: E109. doi: 10.3390/cancers10040109. Review.


[EBV/KSHV co-infection: an effective partnership].

Gruffat H, Manet E.

Med Sci (Paris). 2018 Jan;34(1):79-82. doi: 10.1051/medsci/20183401017. Epub 2018 Jan 31. Review. French.


Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G.

Mure F, Panthu B, Zanella-Cléon I, Delolme F, Manet E, Ohlmann T, Gruffat H.

J Virol. 2018 Jan 17;92(3). pii: e01917-17. doi: 10.1128/JVI.01917-17. Print 2018 Feb 1.


Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.

Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH.

Cell Rep. 2017 Oct 10;21(2):366-380. doi: 10.1016/j.celrep.2017.09.039.


Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines.

Hernandez-Vargas H, Gruffat H, Cros MP, Diederichs A, Sirand C, Vargas-Ayala RC, Jay A, Durand G, Le Calvez-Kelm F, Herceg Z, Manet E, Wild CP, Tommasino M, Accardi R.

Sci Rep. 2017 Jul 19;7(1):5852. doi: 10.1038/s41598-017-05713-2.


Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.

Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E.

J Gen Virol. 2017 Feb;98(2):251-265. doi: 10.1099/jgv.0.000681.


Herpesvirus Late Gene Expression: A Viral-Specific Pre-initiation Complex Is Key.

Gruffat H, Marchione R, Manet E.

Front Microbiol. 2016 Jun 6;7:869. doi: 10.3389/fmicb.2016.00869. eCollection 2016. Review.


Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis.

Kweder H, Ainouze M, Brunel J, Gerlier D, Manet E, Buckland R.

Adv Virol. 2015;2015:769837. doi: 10.1155/2015/769837. Epub 2015 Oct 26.


The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.

Accardi R, Gruffat H, Sirand C, Fusil F, Gheit T, Hernandez-Vargas H, Le Calvez-Kelm F, Traverse-Glehen A, Cosset FL, Manet E, Wild CP, Tommasino M.

Carcinogenesis. 2015 Nov;36(11):1440-51. doi: 10.1093/carcin/bgv142. Epub 2015 Sep 30.


TLR9 transcriptional regulation in response to double-stranded DNA viruses.

Zannetti C, Parroche P, Panaye M, Roblot G, Gruffat H, Manet E, Debaud AL, Plumas J, Vey N, Caux C, Bendriss-Vermare N, Hasan UA.

J Immunol. 2014 Oct 1;193(7):3398-408. doi: 10.4049/jimmunol.1400249. Epub 2014 Sep 5.


Epstein-Barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex.

Aubry V, Mure F, Mariamé B, Deschamps T, Wyrwicz LS, Manet E, Gruffat H.

J Virol. 2014 Nov;88(21):12825-38. doi: 10.1128/JVI.02139-14. Epub 2014 Aug 27.


Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.

Bazot Q, Deschamps T, Tafforeau L, Siouda M, Leblanc P, Harth-Hertle ML, Rabourdin-Combe C, Lotteau V, Kempkes B, Tommasino M, Gruffat H, Manet E.

Nucleic Acids Res. 2014 Sep;42(15):9700-16. doi: 10.1093/nar/gku697. Epub 2014 Aug 4.


Epstein-Barr virus down-regulates tumor suppressor DOK1 expression.

Siouda M, Frecha C, Accardi R, Yue J, Cuenin C, Gruffat H, Manet E, Herceg Z, Sylla BS, Tommasino M.

PLoS Pathog. 2014 May 8;10(5):e1004125. doi: 10.1371/journal.ppat.1004125. eCollection 2014 May.


Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera.

Kweder H, Ainouze M, Cosby SL, Muller CP, Lévy C, Verhoeyen E, Cosset FL, Manet E, Buckland R.

Adv Virol. 2014;2014:205617. doi: 10.1155/2014/205617. Epub 2014 Feb 4.


Post-transcriptional regulation of Herpesvirus productive cycle genes expression: importance of EB2 factor from Epstein-Barr virus (EBV) and its similar proteins.

Juillard F, Mure F, Bazot Q, Manet É, Gruffat H.

Virologie (Montrouge). 2013 Apr 1;17(2):96-110. doi: 10.1684/vir.2013.0483.


Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.

Accardi R, Fathallah I, Gruffat H, Mariggiò G, Le Calvez-Kelm F, Voegele C, Bartosch B, Hernandez-Vargas H, McKay J, Sylla BS, Manet E, Tommasino M.

PLoS Pathog. 2013 Mar;9(3):e1003186. doi: 10.1371/journal.ppat.1003186. Epub 2013 Mar 14.


Interaction of Ubinuclein-1, a nuclear and adhesion junction protein, with the 14-3-3 epsilon protein in epithelial cells: implication of the PKA pathway.

Conti A, Sueur C, Lupo J, Brazzolotto X, Burmeister WP, Manet E, Gruffat H, Morand P, Boyer V.

Eur J Cell Biol. 2013 Mar;92(3):105-11. doi: 10.1016/j.ejcb.2012.12.001. Epub 2013 Feb 8.


Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.

Juillard F, Bazot Q, Mure F, Tafforeau L, Macri C, Rabourdin-Combe C, Lotteau V, Manet E, Gruffat H.

Nucleic Acids Res. 2012 Aug;40(14):6834-49. doi: 10.1093/nar/gks319. Epub 2012 Apr 13.


The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an essential role in late gene expression.

Gruffat H, Kadjouf F, Mariamé B, Manet E.

J Virol. 2012 Jun;86(11):6023-32. doi: 10.1128/JVI.00159-12. Epub 2012 Mar 28.


Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).

Lupo J, Conti A, Sueur C, Coly PA, Couté Y, Hunziker W, Burmeister WP, Germi R, Manet E, Gruffat H, Morand P, Boyer V.

Exp Cell Res. 2012 Mar 10;318(5):509-20. doi: 10.1016/j.yexcr.2011.12.020. Epub 2012 Jan 4.


Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.

Alais S, Soto-Rifo R, Balter V, Gruffat H, Manet E, Schaeffer L, Darlix JL, Cimarelli A, Raposo G, Ohlmann T, Leblanc P.

Cell Mol Life Sci. 2012 Apr;69(8):1331-52. doi: 10.1007/s00018-011-0879-z. Epub 2011 Nov 11.


The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells.

Gruffat H, Lupo J, Morand P, Boyer V, Manet E.

J Virol. 2011 Jan;85(2):784-94. doi: 10.1128/JVI.01397-10. Epub 2010 Nov 17.


EBV latent membrane protein 1 is a negative regulator of TLR9.

Fathallah I, Parroche P, Gruffat H, Zannetti C, Johansson H, Yue J, Manet E, Tommasino M, Sylla BS, Hasan UA.

J Immunol. 2010 Dec 1;185(11):6439-47. doi: 10.4049/jimmunol.0903459. Epub 2010 Oct 27.


Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.

Ote I, Lebrun M, Vandevenne P, Bontems S, Medina-Palazon C, Manet E, Piette J, Sadzot-Delvaux C.

PLoS One. 2009 Nov 18;4(11):e7882. doi: 10.1371/journal.pone.0007882.


Epstein-Barr virus protein EB2 contains an N-terminal transferable nuclear export signal that promotes nucleocytoplasmic export by directly binding TAP/NXF1.

Juillard F, Hiriart E, Sergeant N, Vingtdeux-Didier V, Drobecq H, Sergeant A, Manet E, Gruffat H.

J Virol. 2009 Dec;83(24):12759-68. doi: 10.1128/JVI.01276-09. Epub 2009 Sep 30.


Translation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2.

Ricci EP, Mure F, Gruffat H, Decimo D, Medina-Palazon C, Ohlmann T, Manet E.

Nucleic Acids Res. 2009 Aug;37(15):4932-43. doi: 10.1093/nar/gkp497. Epub 2009 Jun 15.


Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).

Aho S, Lupo J, Coly PA, Sabine A, Castellazzi M, Morand P, Sergeant A, Manet E, Boyer V, Gruffat H.

Biol Cell. 2009 Jun;101(6):319-34. doi: 10.1042/BC20080072.


The Epstein-Barr virus (EBV) protein EB is an mRNA export factor essential for virus production.

Sergeant A, Gruffat H, Manet E.

Front Biosci. 2008 May 1;13:3798-813.


Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

Medina-Palazon C, Gruffat H, Mure F, Filhol O, Vingtdeux-Didier V, Drobecq H, Cochet C, Sergeant N, Sergeant A, Manet E.

J Virol. 2007 Nov;81(21):11850-60. Epub 2007 Aug 15.


Autoactivation of the Epstein-Barr virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-kappaB and JNK signaling pathways.

Goormachtigh G, Ouk TS, Mougel A, Tranchand-Bunel D, Masy E, Le Clorennec C, Feuillard J, Bornkamm GW, Auriault C, Manet E, Fafeur V, Adriaenssens E, Coll J.

J Virol. 2006 Aug;80(15):7382-93.


Epstein-Barr virus mRNA export factor EB2 is essential for intranuclear capsid assembly and production of gp350.

Batisse J, Manet E, Middeldorp J, Sergeant A, Gruffat H.

J Virol. 2005 Nov;79(22):14102-11.


Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.

Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P, Mercher T, Bernard OA, Sergeant A, Manet E.

J Biol Chem. 2005 Nov 4;280(44):36935-45. Epub 2005 Aug 29.


[Latency vs lytic cycle of Epstein-Barr virus: regulation of a viral gene expression is the clue].

Gruffat H, Manet E, Sergeant A.

Pathol Biol (Paris). 2004 Mar;52(2):63-5. French. No abstract available.


A region of the Epstein-Barr virus (EBV) mRNA export factor EB2 containing an arginine-rich motif mediates direct binding to RNA.

Hiriart E, Bardouillet L, Manet E, Gruffat H, Penin F, Montserret R, Farjot G, Sergeant A.

J Biol Chem. 2003 Sep 26;278(39):37790-8. Epub 2003 Jul 12.


A novel nuclear export signal and a REF interaction domain both promote mRNA export by the Epstein-Barr virus EB2 protein.

Hiriart E, Farjot G, Gruffat H, Nguyen MV, Sergeant A, Manet E.

J Biol Chem. 2003 Jan 3;278(1):335-42. Epub 2002 Oct 25.


Epstein-Barr virus mRNA export factor EB2 is essential for production of infectious virus.

Gruffat H, Batisse J, Pich D, Neuhierl B, Manet E, Hammerschmidt W, Sergeant A.

J Virol. 2002 Oct;76(19):9635-44.


Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma.

Gruffat H, Sergeant A, Manet E.

Microbes Infect. 2000 May;2(6):671-80. Review.


Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.

Gruffat H, Portes-Sentis S, Sergeant A, Manet E.

J Gen Virol. 1999 Mar;80 ( Pt 3):557-61.


EBV genes and B cell proliferation.

Manet E, Bourillot PY, Waltzer L, Sergeant A.

Crit Rev Oncol Hematol. 1998 Aug;28(2):129-37. Review. No abstract available.


Transcriptional repression by the Epstein-Barr virus EBNA3A protein tethered to DNA does not require RBP-Jkappa.

Bourillot PY, Waltzer L, Sergeant A, Manet E.

J Gen Virol. 1998 Feb;79 ( Pt 2):363-70.


The bZIP motif of the Epstein-Barr virus (EBV) transcription factor EB1 mediates a direct interaction with TBP.

Mikaelian I, Manet E, Sergeant A.

C R Acad Sci III. 1993 Dec;316(12):1424-32.


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