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Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections.

Ciofu O, Mandsberg LF, Wang H, Høiby N.

FEMS Immunol Med Microbiol. 2012 Jul;65(2):215-25. doi: 10.1111/j.1574-695X.2012.00983.x. Epub 2012 Jun 1. Review. Erratum in: FEMS Immunol Med Microbiol. 2012 Oct;66(1):120.


Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM).

Mandsberg LF, Maciá MD, Bergmann KR, Christiansen LE, Alhede M, Kirkby N, Høiby N, Oliver A, Ciofu O.

FEMS Microbiol Lett. 2011 Nov;324(1):28-37. doi: 10.1111/j.1574-6968.2011.02383.x. Epub 2011 Sep 13.


Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants.

Ciofu O, Mandsberg LF, Bjarnsholt T, Wassermann T, Høiby N.

Microbiology. 2010 Apr;156(Pt 4):1108-19. doi: 10.1099/mic.0.033993-0. Epub 2009 Dec 17.


Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.

Mandsberg LF, Ciofu O, Kirkby N, Christiansen LE, Poulsen HE, Høiby N.

Antimicrob Agents Chemother. 2009 Jun;53(6):2483-91. doi: 10.1128/AAC.00428-08. Epub 2009 Mar 30.


Maximum Likelihood based comparison of the specific growth rates for P. aeruginosa and four mutator strains.

Philipsen KR, Christiansen LE, Mandsberg LF, Ciofu O, Madsen H.

J Microbiol Methods. 2008 Dec;75(3):551-7. doi: 10.1016/j.mimet.2008.08.009. Epub 2008 Sep 5.


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