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Items: 1 to 50 of 271

1.

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.

Khilji MS, Verstappen D, Dahlby T, Burstein Prause MC, Pihl C, Bresson SE, Bryde TH, Keller Andersen PA, Klindt K, Zivkovic D, Bousquet-Dubouch MP, Tyrberg B, Mandrup-Poulsen T, Marzec MT.

PLoS One. 2020 Feb 13;15(2):e0222432. doi: 10.1371/journal.pone.0222432. eCollection 2020.

2.

Targeting innate immune mediators in type 1 and type 2 diabetes.

Donath MY, Dinarello CA, Mandrup-Poulsen T.

Nat Rev Immunol. 2019 Dec;19(12):734-746. doi: 10.1038/s41577-019-0213-9. Epub 2019 Sep 9. Review.

PMID:
31501536
3.

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.

Backe MB, Jin C, Andreone L, Sankar A, Agger K, Helin K, Madsen AN, Poulsen SS, Bysani M, Bacos K, Ling C, Perone MJ, Holst B, Mandrup-Poulsen T.

J Diabetes Res. 2019 Jul 28;2019:5451038. doi: 10.1155/2019/5451038. eCollection 2019.

4.

Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes.

Kofoed Kjær L, Cejvanovic V, Henriksen T, Hansen T, Pedersen O, Kjeldahl Christensen C, Torp-Pedersen C, Alexander Gerds T, Brandslund I, Mandrup-Poulsen T, Enghusen Poulsen H.

Free Radic Res. 2019 Jun;53(6):694-703. doi: 10.1080/10715762.2019.1622011. Epub 2019 Jun 4.

PMID:
31161826
5.

Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients.

Kataria Y, Ellervik C, Mandrup-Poulsen T.

Semin Immunopathol. 2019 Jul;41(4):413-425. doi: 10.1007/s00281-019-00743-6. Epub 2019 Apr 25. Review.

PMID:
31025084
6.

No direct effect of SGLT2 activity on glucagon secretion.

Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ.

Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22.

PMID:
30903205
7.

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.

Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT.

Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22.

8.

Neuromedin U Does Not Act as a Decretin in Rats.

Kuhre RE, Christiansen CB, Ghiasi SM, Gabe MBN, Skat-Rørdam PA, Modvig IM, Mandrup-Poulsen T, Albrechtsen R, Rosenkilde MM, Hartmann B, Wewer Albrechtsen NJ, Holst JJ.

Cell Metab. 2019 Mar 5;29(3):719-726.e5. doi: 10.1016/j.cmet.2018.10.008. Epub 2018 Nov 15.

PMID:
30449683
9.

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage.

Lindeløv Vestergaard A, Heiner Bang-Berthelsen C, Fløyel T, Lucien Stahl J, Christen L, Taheri Sotudeh F, de Hemmer Horskjær P, Stensgaard Frederiksen K, Greek Kofod F, Bruun C, Adrian Berchtold L, Størling J, Regazzi R, Kaur S, Pociot F, Mandrup-Poulsen T.

PLoS One. 2018 Sep 27;13(9):e0203713. doi: 10.1371/journal.pone.0203713. eCollection 2018.

10.

Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis.

Ghiasi SM, Dahllöf MS, Osmai Y, Osmai M, Jakobsen KK, Aivazidis A, Tyrberg B, Perruzza L, Prause MCB, Christensen DP, Fog-Tonnesen M, Lundh M, Grassi F, Chatenoud L, Mandrup-Poulsen T.

Mol Cell Endocrinol. 2018 Dec 15;478:106-114. doi: 10.1016/j.mce.2018.08.001. Epub 2018 Aug 16.

PMID:
30121202
11.
12.

Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis.

Hansen JB, Dos Santos LRB, Liu Y, Prentice KJ, Teudt F, Tonnesen M, Jonas JC, Wheeler MB, Mandrup-Poulsen T.

J Mol Endocrinol. 2018 Aug;61(2):69-77. doi: 10.1530/JME-17-0262.

PMID:
30030388
13.

Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue.

Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Klück V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA.

J Biol Chem. 2018 Sep 14;293(37):14224-14236. doi: 10.1074/jbc.RA118.003698. Epub 2018 Jul 13.

14.

Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice.

Christiansen CB, Lind SJ, Svendsen B, Balk-Møller E, Dahlby T, Kuhre RE, Hartmann B, Mandrup-Poulsen T, Deacon CF, Wewer Albrechtsen NJ, Holst JJ.

Physiol Rep. 2018 Jul;6(13):e13788. doi: 10.14814/phy2.13788.

15.

Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients.

Østergaard HB, Mandrup-Poulsen T, Berkelmans GFN, van der Graaf Y, Visseren FLJ, Westerink J; SMART Study Group.

Diabetes Metab. 2019 Jun;45(3):254-260. doi: 10.1016/j.diabet.2018.04.006. Epub 2018 May 8.

PMID:
29784563
16.

Iron Status and Gestational Diabetes-A Meta-Analysis.

Kataria Y, Wu Y, Horskjær PH, Mandrup-Poulsen T, Ellervik C.

Nutrients. 2018 May 15;10(5). pii: E621. doi: 10.3390/nu10050621. Review.

17.

Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing.

Mandrup-Poulsen T.

Nat Rev Endocrinol. 2018 Feb;14(2):72-74. doi: 10.1038/nrendo.2017.175. Epub 2017 Dec 29. Review. No abstract available.

PMID:
29286048
18.

Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No.

Mandrup-Poulsen T.

Diabetes. 2017 Dec;66(12):2937-2939. doi: 10.2337/dbi17-0037. No abstract available.

19.

Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study.

Kjær LK, Cejvanovic V, Henriksen T, Petersen KM, Hansen T, Pedersen O, Christensen CK, Torp-Pedersen C, Gerds TA, Brandslund I, Mandrup-Poulsen T, Poulsen HE.

Diabetes Care. 2017 Dec;40(12):1771-1778. doi: 10.2337/dc17-1150. Epub 2017 Oct 23.

PMID:
29061564
20.

Increased Plasma Ferritin Concentration and Low-Grade Inflammation-A Mendelian Randomization Study.

Moen IW, Bergholdt HKM, Mandrup-Poulsen T, Nordestgaard BG, Ellervik C.

Clin Chem. 2018 Feb;64(2):374-385. doi: 10.1373/clinchem.2017.276055. Epub 2017 Oct 16.

PMID:
29038157
21.

Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice.

Besançon A, Goncalves T, Valette F, Dahllöf MS, Mandrup-Poulsen T, Chatenoud L, You S.

Diabetologia. 2018 Feb;61(2):389-398. doi: 10.1007/s00125-017-4459-0. Epub 2017 Oct 13.

PMID:
29030662
22.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

23.

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function.

Backe MB, Andersson JL, Bacos K, Christensen DP, Hansen JB, Dorosz JJ, Gajhede M, Dahlby T, Bysani M, Kristensen LH, Ling C, Olsen L, Mandrup-Poulsen T.

Mol Cell Endocrinol. 2018 Jan 15;460:47-56. doi: 10.1016/j.mce.2017.07.001. Epub 2017 Jul 4.

PMID:
28684291
24.

The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.

Lundh M, Bugliani M, Dahlby T, Chou DH, Wagner B, Ghiasi SM, De Tata V, Chen Z, Lund MN, Davies MJ, Marchetti P, Mandrup-Poulsen T.

J Endocrinol. 2017 Jun;233(3):369-379. doi: 10.1530/JOE-17-0110. Epub 2017 Apr 24.

25.

Cytokines and Pancreatic β-Cell Apoptosis.

Berchtold LA, Prause M, Størling J, Mandrup-Poulsen T.

Adv Clin Chem. 2016;75:99-158. doi: 10.1016/bs.acc.2016.02.001. Epub 2016 Apr 20. Review.

PMID:
27346618
26.

A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells.

Vestergaard AL, Blankestijn M, Stahl JL, Pallesen EM, Bang-Berthelsen CH, Pociot F, Novotny GW, Lundh M, Mandrup-Poulsen T.

Int J Mol Sci. 2016 Jun 7;17(6). pii: E896. doi: 10.3390/ijms17060896.

27.

Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress.

Backe MB, Moen IW, Ellervik C, Hansen JB, Mandrup-Poulsen T.

Annu Rev Nutr. 2016 Jul 17;36:241-73. doi: 10.1146/annurev-nutr-071715-050939. Epub 2016 May 4. Review.

PMID:
27146016
28.

A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats.

Hoelmkjaer KM, Wewer Albrechtsen NJ, Holst JJ, Cronin AM, Nielsen DH, Mandrup-Poulsen T, Bjornvad CR.

PLoS One. 2016 May 2;11(5):e0154727. doi: 10.1371/journal.pone.0154727. eCollection 2016.

29.

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression.

Prause M, Mayer CM, Brorsson C, Frederiksen KS, Billestrup N, Størling J, Mandrup-Poulsen T.

J Diabetes Res. 2016;2016:1312705. doi: 10.1155/2016/1312705. Epub 2016 Jan 10.

30.

Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset.

Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ; Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T; AIDA Study Group, Hessner MJ.

Eur J Immunol. 2016 Apr;46(4):1030-46. doi: 10.1002/eji.201546005. Epub 2016 Jan 21.

31.

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.

Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB.

ACS Chem Biol. 2016 Feb 19;11(2):363-74. doi: 10.1021/acschembio.5b00640. Epub 2015 Dec 7.

PMID:
26640968
32.

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells.

Prause M, Berchtold LA, Urizar AI, Hyldgaard Trauelsen M, Billestrup N, Mandrup-Poulsen T, Størling J.

Mol Cell Endocrinol. 2016 Jan 15;420:24-36. doi: 10.1016/j.mce.2015.11.021. Epub 2015 Nov 22.

PMID:
26610752
33.

MicroRNAs as regulators of beta-cell function and dysfunction.

Osmai M, Osmai Y, Bang-Berthelsen CH, Pallesen EM, Vestergaard AL, Novotny GW, Pociot F, Mandrup-Poulsen T.

Diabetes Metab Res Rev. 2016 May;32(4):334-49. doi: 10.1002/dmrr.2719. Epub 2015 Nov 11. Review.

PMID:
26418758
34.

Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis.

Christensen CS, Christensen DP, Lundh M, Dahllöf MS, Haase TN, Velasquez JM, Laye MJ, Mandrup-Poulsen T, Solomon TP.

J Clin Endocrinol Metab. 2015 Oct;100(10):E1289-98. doi: 10.1210/jc.2014-4506. Epub 2015 Jul 28. Erratum in: J Clin Endocrinol Metab. 2016 May;101(5):2265.

PMID:
26218753
35.

Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice.

Fjære E, Andersen C, Myrmel LS, Petersen RK, Hansen JB, Tastesen HS, Mandrup-Poulsen T, Brünner N, Kristiansen K, Madsen L, Rømer MU.

PLoS One. 2015 Jul 13;10(7):e0132910. doi: 10.1371/journal.pone.0132910. eCollection 2015.

36.

Helsinki alert of biodiversity and health.

von Hertzen L, Beutler B, Bienenstock J, Blaser M, Cani PD, Eriksson J, Färkkilä M, Haahtela T, Hanski I, Jenmalm MC, Kere J, Knip M, Kontula K, Koskenvuo M, Ling C, Mandrup-Poulsen T, von Mutius E, Mäkelä MJ, Paunio T, Pershagen G, Renz H, Rook G, Saarela M, Vaarala O, Veldhoen M, de Vos WM.

Ann Med. 2015 May;47(3):218-25. doi: 10.3109/07853890.2015.1010226. Epub 2015 Apr 23. Review.

37.

Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats.

Lundh M, Galbo T, Poulsen SS, Mandrup-Poulsen T.

Diabetes Obes Metab. 2015 Jul;17(7):703-7. doi: 10.1111/dom.12470. Epub 2015 May 26.

PMID:
25846481
38.

Altering β-cell number through stable alteration of miR-21 and miR-34a expression.

Backe MB, Novotny GW, Christensen DP, Grunnet LG, Mandrup-Poulsen T.

Islets. 2014;6(1):e27754. doi: 10.4161/isl.27754.

39.

Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice.

Brandt C, Hansen RH, Hansen JB, Olsen CH, Galle P, Mandrup-Poulsen T, Gehl J, Pedersen BK, Hojman P.

Metabolism. 2015 Feb;64(2):283-95. doi: 10.1016/j.metabol.2014.10.007. Epub 2014 Oct 14.

PMID:
25456456
40.

BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children.

Lauria A, Barker A, Schloot N, Hosszufalusi N, Ludvigsson J, Mathieu C, Mauricio D, Nordwall M, Van der Schueren B, Mandrup-Poulsen T, Scherbaum WA, Weets I, Gorus FK, Wareham N, Leslie RD, Pozzilli P.

Eur J Endocrinol. 2015 Feb;172(2):107-13. doi: 10.1530/EJE-14-0522. Epub 2014 Nov 6.

PMID:
25378371
41.

Inhibition of beta cell growth and function by bone morphogenetic proteins.

Bruun C, Christensen GL, Jacobsen ML, Kanstrup MB, Jensen PR, Fjordvang H, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2014 Dec;57(12):2546-54. doi: 10.1007/s00125-014-3384-8. Epub 2014 Sep 27.

PMID:
25260823
42.

HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent.

Dahllöf MS, Christensen DP, Harving M, Wagner BK, Mandrup-Poulsen T, Lundh M.

J Interferon Cytokine Res. 2015 Jan;35(1):63-70. doi: 10.1089/jir.2014.0022. Epub 2014 Jul 25.

43.

Need for reclassification of diabetes secondary to iron overload in the ADA and WHO classifications.

Ellervik C, Birgens H, Mandrup-Poulsen T.

Diabetes Care. 2014 Jun;37(6):e137-8. doi: 10.2337/dc14-0119. No abstract available.

PMID:
24855170
44.

Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?

Mandrup-Poulsen T.

Diabetes. 2014 Jun;63(6):1833-5. doi: 10.2337/db14-0371. No abstract available.

45.

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.

Fjære E, Aune UL, Røen K, Keenan AH, Ma T, Borkowski K, Kristensen DM, Novotny GW, Mandrup-Poulsen T, Hudson BD, Milligan G, Xi Y, Newman JW, Haj FG, Liaset B, Kristiansen K, Madsen L.

J Biol Chem. 2014 Jun 6;289(23):16032-45. doi: 10.1074/jbc.M113.525220. Epub 2014 Apr 17.

46.

Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation.

Bartels ED, Ploug T, Størling J, Mandrup-Poulsen T, Nielsen LB.

Scand J Clin Lab Invest. 2014 Jun;74(4):351-7. doi: 10.3109/00365513.2014.893446. Epub 2014 Mar 27.

PMID:
24673444
47.

Iron: the hard player in diabetes pathophysiology.

Hansen JB, Moen IW, Mandrup-Poulsen T.

Acta Physiol (Oxf). 2014 Apr;210(4):717-32. doi: 10.1111/apha.12256. Review.

PMID:
24521359
48.

Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist.

Klementiev B, Li S, Korshunova I, Dmytriyeva O, Pankratova S, Walmod PS, Kjær LK, Dahllöf MS, Lundh M, Christensen DP, Mandrup-Poulsen T, Bock E, Berezin V.

J Neuroinflammation. 2014 Feb 3;11:27. doi: 10.1186/1742-2094-11-27.

49.

JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis.

Prause M, Christensen DP, Billestrup N, Mandrup-Poulsen T.

PLoS One. 2014 Jan 24;9(1):e87067. doi: 10.1371/journal.pone.0087067. eCollection 2014.

50.

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.

Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9. doi: 10.1073/pnas.1320850111. Epub 2014 Jan 6.

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