Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 132

1.

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.

Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ.

Genes Dev. 2019 Jul 1;33(13-14):747-762. doi: 10.1101/gad.321059.118. Epub 2019 May 23.

2.

Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets.

Wiwie C, Kuznetsova I, Mostafa A, Rauch A, Haakonsson A, Barrio-Hernandez I, Blagoev B, Mandrup S, Schmidt HHHW, Pleschka S, Röttger R, Baumbach J.

Syst Med (New Rochelle). 2019 Mar 28;2(1):1-9. doi: 10.1089/sysm.2018.0013. eCollection 2019.

3.

Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Rauch A, Haakonsson AK, Madsen JGS, Larsen M, Forss I, Madsen MR, Van Hauwaert EL, Wiwie C, Jespersen NZ, Tencerova M, Nielsen R, Larsen BD, Röttger R, Baumbach J, Scheele C, Kassem M, Mandrup S.

Nat Genet. 2019 Apr;51(4):766. doi: 10.1038/s41588-019-0400-4.

PMID:
30911162
4.

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Rauch A, Haakonsson AK, Madsen JGS, Larsen M, Forss I, Madsen MR, Van Hauwaert EL, Wiwie C, Jespersen NZ, Tencerova M, Nielsen R, Larsen BD, Röttger R, Baumbach J, Scheele C, Kassem M, Mandrup S.

Nat Genet. 2019 Apr;51(4):716-727. doi: 10.1038/s41588-019-0359-1. Epub 2019 Mar 4. Erratum in: Nat Genet. 2019 Mar 25;:.

PMID:
30833796
5.

Transcriptional regulation of Hepatic Stellate Cell activation in NASH.

Marcher AB, Bendixen SM, Terkelsen MK, Hohmann SS, Hansen MH, Larsen BD, Mandrup S, Dimke H, Detlefsen S, Ravnskjaer K.

Sci Rep. 2019 Feb 20;9(1):2324. doi: 10.1038/s41598-019-39112-6.

6.

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.

Kalvisa A, Siersbæk MS, Præstholm SM, Christensen LJL, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L.

PLoS Biol. 2018 Dec 10;16(12):e2006249. doi: 10.1371/journal.pbio.2006249. eCollection 2018 Dec.

7.

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.

Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva I, Havelund JF, Nielsen CH, Jedrychowski MP, Moreno-Torres M, Lundh M, Plucinska K, Jespersen NZ, Grevengoed TJ, Kramar B, Peics J, Hansen JB, Shamsi F, Forss I, Neess D, Keipert S, Wang J, Stohlmann K, Brandslund I, Christensen C, Jørgensen ME, Linneberg A, Pedersen O, Kiebish MA, Qvortrup K, Han X, Pedersen BK, Jastroch M, Mandrup S, Kjær A, Gygi SP, Hansen T, Gillum MP, Grarup N, Emanuelli B, Nielsen S, Scheele C, Tseng YH, Færgeman NJ, Gerhart-Hines Z.

Cell Metab. 2018 Jul 3;28(1):159-174.e11. doi: 10.1016/j.cmet.2018.05.003. Epub 2018 May 31.

8.

Chromatin Immunoprecipitation for Identification of Protein-DNA Interactions in Human Cells.

Larsen BD, Madsen MR, Nielsen R, Mandrup S.

Methods Mol Biol. 2018;1794:335-352. doi: 10.1007/978-1-4939-7871-7_24.

PMID:
29855970
9.

SnapShot: Niche Determines Adipocyte Character II.

Bagchi DP, Forss I, Mandrup S, MacDougald OA.

Cell Metab. 2018 Jan 9;27(1):266-266.e1. doi: 10.1016/j.cmet.2017.11.013.

10.

SnapShot: Niche Determines Adipocyte Character I.

Bagchi DP, Forss I, Mandrup S, MacDougald OA.

Cell Metab. 2018 Jan 9;27(1):264-264.e1. doi: 10.1016/j.cmet.2017.11.012.

11.

Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease.

Bahdoudi S, Ghouili I, Hmiden M, do Rego JL, Lefranc B, Leprince J, Chuquet J, do Rego JC, Marcher AB, Mandrup S, Vaudry H, Tonon MC, Amri M, Masmoudi-Kouki O, Vaudry D.

Cell Mol Life Sci. 2018 Jun;75(11):2075-2091. doi: 10.1007/s00018-017-2727-2. Epub 2017 Dec 20.

PMID:
29264673
12.

Integrated analysis of motif activity and gene expression changes of transcription factors.

Madsen JGS, Rauch A, Van Hauwaert EL, Schmidt SF, Winnefeld M, Mandrup S.

Genome Res. 2018 Feb;28(2):243-255. doi: 10.1101/gr.227231.117. Epub 2017 Dec 12.

13.

Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis.

Sarusi Portuguez A, Schwartz M, Siersbaek R, Nielsen R, Sung MH, Mandrup S, Kaplan T, Hakim O.

FEBS J. 2017 Oct;284(19):3230-3244. doi: 10.1111/febs.14183. Epub 2017 Aug 16.

14.

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans.

Harvald EB, Sprenger RR, Dall KB, Ejsing CS, Nielsen R, Mandrup S, Murillo AB, Larance M, Gartner A, Lamond AI, Færgeman NJ.

Cell Syst. 2017 Jul 26;5(1):38-52.e4. doi: 10.1016/j.cels.2017.06.004. Epub 2017 Jul 19.

15.

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation.

Siersbæk R, Madsen JGS, Javierre BM, Nielsen R, Bagge EK, Cairns J, Wingett SW, Traynor S, Spivakov M, Fraser P, Mandrup S.

Mol Cell. 2017 May 4;66(3):420-435.e5. doi: 10.1016/j.molcel.2017.04.010.

16.

Hypoxia-Inducible Lipid Droplet-Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue.

Dijk W, Mattijssen F, de la Rosa Rodriguez M, Loza Valdes A, Loft A, Mandrup S, Kalkhoven E, Qi L, Borst JW, Kersten S.

Endocrinology. 2017 May 1;158(5):1231-1251. doi: 10.1210/en.2016-1809.

17.

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P.

J Clin Invest. 2017 Mar 1;127(3):987-1004. doi: 10.1172/JCI89484. Epub 2017 Feb 13.

18.

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.

Siersbæk M, Varticovski L, Yang S, Baek S, Nielsen R, Mandrup S, Hager GL, Chung JH, Grøntved L.

Sci Rep. 2017 Jan 10;7:40220. doi: 10.1038/srep40220.

19.

Genome-Wide Insights into the Development and Function of Thermogenic Adipocytes.

Loft A, Forss I, Mandrup S.

Trends Endocrinol Metab. 2017 Feb;28(2):104-120. doi: 10.1016/j.tem.2016.11.005. Epub 2016 Dec 12. Review.

PMID:
27979331
20.

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation.

Brier AB, Loft A, Madsen JGS, Rosengren T, Nielsen R, Schmidt SF, Liu Z, Yan Q, Gronemeyer H, Mandrup S.

Nucleic Acids Res. 2017 Feb 28;45(4):1743-1759. doi: 10.1093/nar/gkw1156.

21.

Nuclear phosphoproteome analysis of 3T3-L1 preadipocyte differentiation reveals system-wide phosphorylation of transcriptional regulators.

Rabiee A, Schwämmle V, Sidoli S, Dai J, Rogowska-Wrzesinska A, Mandrup S, Jensen ON.

Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600248. Epub 2016 Dec 14.

PMID:
27717184
22.

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.

Schmidt SF, Madsen JG, Frafjord KØ, Poulsen Ll, Salö S, Boergesen M, Loft A, Larsen BD, Madsen MS, Holst JJ, Maechler P, Dalgaard LT, Mandrup S.

Cell Rep. 2016 Aug 30;16(9):2359-72. doi: 10.1016/j.celrep.2016.07.063. Epub 2016 Aug 18.

23.

DBI/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice.

Budry L, Bouyakdan K, Tobin S, Rodaros D, Marcher AB, Mandrup S, Fulton S, Alquier T.

Behav Brain Res. 2016 Oct 15;313:201-207. doi: 10.1016/j.bbr.2016.06.052. Epub 2016 Jun 27.

PMID:
27363924
24.

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.

Hallenborg P, Siersbæk M, Barrio-Hernandez I, Nielsen R, Kristiansen K, Mandrup S, Grøntved L, Blagoev B.

Cell Death Dis. 2016 Jun 30;7(6):e2289. doi: 10.1038/cddis.2016.188.

25.

Cofactor squelching: Artifact or fact?

Schmidt SF, Larsen BD, Loft A, Mandrup S.

Bioessays. 2016 Jul;38(7):618-26. doi: 10.1002/bies.201600034. Epub 2016 Jun 7. Review.

PMID:
27273739
26.

Effects of selected bioactive food compounds on human white adipocyte function.

Björk C, Wilhelm U, Mandrup S, Larsen BD, Bordoni A, Hedén P, Rydén M, Arner P, Laurencikiene J.

Nutr Metab (Lond). 2016 Jan 19;13:4. doi: 10.1186/s12986-016-0064-3. eCollection 2016.

27.

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold.

Marcher AB, Loft A, Nielsen R, Vihervaara T, Madsen JG, Sysi-Aho M, Ekroos K, Mandrup S.

Cell Rep. 2015 Dec 1;13(9):2000-13. doi: 10.1016/j.celrep.2015.10.069. Epub 2015 Nov 25.

28.

Lessons Learned from Systems Approaches to Metabolism.

Mandrup S.

Trends Endocrinol Metab. 2015 Dec;26(12):669-670. doi: 10.1016/j.tem.2015.11.001. Epub 2015 Nov 17. No abstract available.

PMID:
26596675
29.

Modulating the Genomic Programming of Adipocytes.

Loft A, Schmidt SF, Mandrup S.

Cold Spring Harb Symp Quant Biol. 2015;80:239-48. doi: 10.1101/sqb.2015.80.027516. Epub 2015 Oct 2. Review.

PMID:
26432526
30.

Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice.

Bek S, Neess D, Dixen K, Bloksgaard M, Marcher AB, Chemnitz J, Færgeman NJ, Mandrup S.

J Lipid Res. 2015 Sep;56(9):1738-46. doi: 10.1194/jlr.M060780. Epub 2015 Jul 4.

31.

Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers.

Schmidt SF, Larsen BD, Loft A, Nielsen R, Madsen JG, Mandrup S.

Genome Res. 2015 Sep;25(9):1281-94. doi: 10.1101/gr.188300.114. Epub 2015 Jun 25.

32.

A Genome-Wide Perspective on Metabolism.

Rauch A, Mandrup S.

Handb Exp Pharmacol. 2016;233:1-28. doi: 10.1007/164_2015_2. Review.

PMID:
25903411
33.

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity.

Bindesbøll C, Fan Q, Nørgaard RC, MacPherson L, Ruan HB, Wu J, Pedersen TÅ, Steffensen KR, Yang X, Matthews J, Mandrup S, Nebb HI, Grønning-Wang LM.

J Lipid Res. 2015 Apr;56(4):771-85. doi: 10.1194/jlr.M049130. Epub 2015 Feb 27.

34.

Selection of LNA-containing DNA aptamers against recombinant human CD73.

Elle IC, Karlsen KK, Terp MG, Larsen N, Nielsen R, Derbyshire N, Mandrup S, Ditzel HJ, Wengel J.

Mol Biosyst. 2015 May;11(5):1260-70. doi: 10.1039/c5mb00045a.

PMID:
25720604
35.

A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes.

Bouyakdan K, Taïb B, Budry L, Zhao S, Rodaros D, Neess D, Mandrup S, Faergeman NJ, Alquier T.

J Neurochem. 2015 Apr;133(2):253-65. doi: 10.1111/jnc.13035. Epub 2015 Feb 6.

36.

iRNA-seq: computational method for genome-wide assessment of acute transcriptional regulation from total RNA-seq data.

Madsen JG, Schmidt SF, Larsen BD, Loft A, Nielsen R, Mandrup S.

Nucleic Acids Res. 2015 Mar 31;43(6):e40. doi: 10.1093/nar/gku1365. Epub 2015 Jan 6.

37.

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.

Loft A, Forss I, Siersbæk MS, Schmidt SF, Larsen AS, Madsen JG, Pisani DF, Nielsen R, Aagaard MM, Mathison A, Neville MJ, Urrutia R, Karpe F, Amri EZ, Mandrup S.

Genes Dev. 2015 Jan 1;29(1):7-22. doi: 10.1101/gad.250829.114. Epub 2014 Dec 12.

38.

In memoriam: M. Daniel Lane, 1930-2014.

Mandrup S, MacDougald OA, Moss J, Ntambi J, Pekala P, Tang QQ, Wolfgang M, Bernlohr DA.

Trends Endocrinol Metab. 2014 Sep;25(9):437-9. doi: 10.1016/j.tem.2014.06.013. Epub 2014 Jul 29. No abstract available. Erratum in: Trends Endocrinol Metab. 2014 Nov;25(11):609.

39.

CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein.

Rakhshandehroo M, Gijzel SM, Siersbæk R, Broekema MF, de Haar C, Schipper HS, Boes M, Mandrup S, Kalkhoven E.

J Biol Chem. 2014 Aug 8;289(32):22128-39. doi: 10.1074/jbc.M114.551242. Epub 2014 Jun 25.

40.

Molecular architecture of transcription factor hotspots in early adipogenesis.

Siersbæk R, Baek S, Rabiee A, Nielsen R, Traynor S, Clark N, Sandelin A, Jensen ON, Sung MH, Hager GL, Mandrup S.

Cell Rep. 2014 Jun 12;7(5):1434-1442. doi: 10.1016/j.celrep.2014.04.043. Epub 2014 May 22.

41.

Transcription factor cooperativity in early adipogenic hotspots and super-enhancers.

Siersbæk R, Rabiee A, Nielsen R, Sidoli S, Traynor S, Loft A, Poulsen LC, Rogowska-Wrzesinska A, Jensen ON, Mandrup S.

Cell Rep. 2014 Jun 12;7(5):1443-1455. doi: 10.1016/j.celrep.2014.04.042. Epub 2014 May 22.

42.

PPARγ and the global map of adipogenesis and beyond.

Lefterova MI, Haakonsson AK, Lazar MA, Mandrup S.

Trends Endocrinol Metab. 2014 Jun;25(6):293-302. doi: 10.1016/j.tem.2014.04.001. Epub 2014 Apr 29. Review.

43.

Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47.

Kamstra JH, Hruba E, Blumberg B, Janesick A, Mandrup S, Hamers T, Legler J.

Environ Sci Technol. 2014 Apr 1;48(7):4110-9. doi: 10.1021/es405524b. Epub 2014 Mar 11.

44.

Genome-wide profiling of transcription factor binding and epigenetic marks in adipocytes by ChIP-seq.

Nielsen R, Mandrup S.

Methods Enzymol. 2014;537:261-79. doi: 10.1016/B978-0-12-411619-1.00014-8.

PMID:
24480351
45.

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.

Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9. doi: 10.1073/pnas.1320850111. Epub 2014 Jan 6.

46.

Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading.

Madsen MS, Siersbæk R, Boergesen M, Nielsen R, Mandrup S.

Mol Cell Biol. 2014 Mar;34(6):939-54. doi: 10.1128/MCB.01344-13. Epub 2013 Dec 30.

47.

Delayed hepatic adaptation to weaning in ACBP-/- mice is caused by disruption of the epidermal barrier.

Neess D, Bek S, Bloksgaard M, Marcher AB, Færgeman NJ, Mandrup S.

Cell Rep. 2013 Dec 12;5(5):1403-12. doi: 10.1016/j.celrep.2013.11.010. Epub 2013 Dec 5.

48.

Acyl-CoA binding protein and epidermal barrier function.

Bloksgaard M, Neess D, Færgeman NJ, Mandrup S.

Biochim Biophys Acta. 2014 Mar;1841(3):369-76. doi: 10.1016/j.bbalip.2013.09.013. Epub 2013 Sep 29.

PMID:
24080521
49.

Acute genome-wide effects of rosiglitazone on PPARγ transcriptional networks in adipocytes.

Haakonsson AK, Stahl Madsen M, Nielsen R, Sandelin A, Mandrup S.

Mol Endocrinol. 2013 Sep;27(9):1536-49. doi: 10.1210/me.2013-1080. Epub 2013 Jul 24.

50.

Archived neonatal dried blood spot samples can be used for accurate whole genome and exome-targeted next-generation sequencing.

Hollegaard MV, Grauholm J, Nielsen R, Grove J, Mandrup S, Hougaard DM.

Mol Genet Metab. 2013 Sep-Oct;110(1-2):65-72. doi: 10.1016/j.ymgme.2013.06.004. Epub 2013 Jun 13.

PMID:
23830478

Supplemental Content

Loading ...
Support Center