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Items: 1 to 50 of 58

1.

Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.

Li F, Yuan CW, Xu S, Zu T, Woappi Y, Lee CAA, Abarzua P, Wells M, Ramsey MR, Frank NY, Wu X, Mandinova A, Frank MH, Lian CG, Murphy GF.

J Invest Dermatol. 2019 Dec 11. pii: S0022-202X(19)33467-0. doi: 10.1016/j.jid.2019.10.016. [Epub ahead of print]

PMID:
31837302
2.

Withdrawal: DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation.

Kim HG, Hwang SY, Aaronson SA, Mandinova A, Lee SW.

J Biol Chem. 2019 Dec 6;294(49):18950. doi: 10.1074/jbc.W119.011784. No abstract available.

3.

Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.

El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB, Sorensen PH.

EMBO Rep. 2019 Dec 5;20(12):e48375. doi: 10.15252/embr.201948375. Epub 2019 Oct 31.

4.

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2018 Sep;561(7723):420. doi: 10.1038/s41586-018-0284-y.

5.

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.

Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, Negri GL, Sorensen PH, Lee SW, Hentze MW, Mandinova A.

Nat Commun. 2018 Apr 30;9(1):1734. doi: 10.1038/s41467-018-04092-0.

6.

GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death.

Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, Greka A.

Cell Chem Biol. 2018 Feb 15;25(2):175-184.e4. doi: 10.1016/j.chembiol.2017.11.006. Epub 2017 Dec 14.

7.

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R.

Science. 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043.

8.

DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation.

Kim HG, Hwang SY, Aaronson SA, Mandinova A, Lee SW.

J Biol Chem. 2017 Apr 28;292(17):7162. doi: 10.1074/jbc.A111.236612. No abstract available.

9.

Emerging roles of p53 and other tumour-suppressor genes in immune regulation.

Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW.

Nat Rev Immunol. 2016 Dec;16(12):741-750. doi: 10.1038/nri.2016.99. Epub 2016 Sep 26. Review.

10.

Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.

Vafai SB, Mevers E, Higgins KW, Fomina Y, Zhang J, Mandinova A, Newman D, Shaw SY, Clardy J, Mootha VK.

PLoS One. 2016 Sep 13;11(9):e0162686. doi: 10.1371/journal.pone.0162686. eCollection 2016.

11.

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.

Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW.

Cell Rep. 2016 Jun 28;16(1):28-36. doi: 10.1016/j.celrep.2016.05.071. Epub 2016 Jun 16.

12.

Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor.

Neel VA, Todorova K, Wang J, Kwon E, Kang M, Liu Q, Gray N, Lee SW, Mandinova A.

J Invest Dermatol. 2016 Mar;136(3):696-705. doi: 10.1016/j.jid.2015.12.023. Epub 2015 Dec 29.

13.

Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2015 Oct 22;526(7574):596. doi: 10.1038/nature15370. Epub 2015 Sep 16. No abstract available.

PMID:
26375002
14.

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.

Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW.

Chem Biol. 2015 Sep 17;22(9):1206-16. doi: 10.1016/j.chembiol.2015.07.016. Epub 2015 Aug 27.

15.

Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway.

Namba T, Chu K, Kodama R, Byun S, Yoon KW, Hiraki M, Mandinova A, Lee SW.

Oncotarget. 2015 Aug 21;6(24):19990-20001.

16.

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW.

Science. 2015 Jul 31;349(6247):1261669. doi: 10.1126/science.1261669.

17.

Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.

Zhu Z, Todorova K, Lee KK, Wang J, Kwon E, Kehayov I, Kim HG, Kolev V, Dotto GP, Lee SW, Mandinova A.

Cancer Res. 2014 Apr 1;74(7):2082-93. doi: 10.1158/0008-5472.CAN-12-0452. Epub 2014 Feb 13.

18.

High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system.

Lee JH, Chen H, Kolev V, Aull KH, Jung I, Wang J, Miyamoto S, Hosoi J, Mandinova A, Fisher DE.

Exp Dermatol. 2014 Feb;23(2):125-9. doi: 10.1111/exd.12322.

19.

CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress.

Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A, Lee SW.

Cell Rep. 2013 Oct 31;5(2):331-9. doi: 10.1016/j.celrep.2013.09.020. Epub 2013 Oct 17.

20.

Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

Kim HG, Tan L, Weisberg EL, Liu F, Canning P, Choi HG, Ezell SA, Wu H, Zhao Z, Wang J, Mandinova A, Griffin JD, Bullock AN, Liu Q, Lee SW, Gray NS.

ACS Chem Biol. 2013 Oct 18;8(10):2145-50. doi: 10.1021/cb400430t. Epub 2013 Aug 13. Erratum in: ACS Chem Biol. 2014 Mar 21;9(3):840.

21.

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.

Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW.

Nat Commun. 2013;4:2189. doi: 10.1038/ncomms3189.

22.

Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells.

Brown-Endres L, Schoenfeld D, Tian F, Kim HG, Namba T, Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW.

Cancer Res. 2012 May 1;72(9):2373-82. doi: 10.1158/0008-5472.CAN-11-3369.

23.

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.

Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13716-21. doi: 10.1073/pnas.1111378108. Epub 2011 Aug 15.

24.

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Erratum in: Nature. 2012 Jan 26;481(7382):534. Erratum in: Nature. 2015 Oct 22;526(7574):596. Retraction in: Nature. 2018 Sep;561(7723):420.

25.

DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation.

Kim HG, Hwang SY, Aaronson SA, Mandinova A, Lee SW.

J Biol Chem. 2011 May 20;286(20):17672-81. doi: 10.1074/jbc.M111.236612. Epub 2011 Mar 13. Retraction in: J Biol Chem. 2019 Dec 6;294(49):18950.

26.

The p53 pathway as a target in cancer therapeutics: obstacles and promise.

Mandinova A, Lee SW.

Sci Transl Med. 2011 Jan 5;3(64):64rv1. doi: 10.1126/scitranslmed.3001366. Review.

27.

Maximizing early detection of esophageal squamous cell carcinoma via SILAC-proteomics.

Lee KK, Todorova K, Mandinova A.

Cancer Biol Ther. 2010 Oct 15;10(8):811-3. Epub 2010 Oct 15. No abstract available.

28.

A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.

Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Ostano P, Dummer R, Brissette JL, Dotto GP.

J Clin Invest. 2009 Oct;119(10):3127-37. doi: 10.1172/JCI38543. Erratum in: J Clin Invest. 2010 Feb;120(2):6455. Pazin, Mike [corrected to Pazin, Michael J].

29.

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL.

Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18.

30.

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP.

Nat Cell Biol. 2008 Aug;10(8):902-11. doi: 10.1038/ncb1750. Epub 2008 Jul 6. Erratum in: Nat Cell Biol. 2013 Jan;15(1):124.

31.

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.

Mandinova A, Lefort K, Tommasi di Vignano A, Stonely W, Ostano P, Chiorino G, Iwaki H, Nakanishi J, Dotto GP.

EMBO J. 2008 Apr 23;27(8):1243-54. doi: 10.1038/emboj.2008.45. Epub 2008 Apr 3.

32.

Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63.

Antonini D, Dentice M, Mahtani P, De Rosa L, Della Gatta G, Mandinova A, Salvatore D, Stupka E, Missero C.

J Invest Dermatol. 2008 Jul;128(7):1676-85. doi: 10.1038/jid.2008.12. Epub 2008 Feb 7.

33.

Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway.

Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I.

Exp Cell Res. 2007 Sep 10;313(15):3308-18. Epub 2007 Jul 6.

34.

CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

Brown L, Ongusaha PP, Kim HG, Nuti S, Mandinova A, Lee JW, Khosravi-Far R, Aaronson SA, Lee SW.

EMBO J. 2007 Jul 25;26(14):3410-22. Epub 2007 Jun 28.

35.

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.

Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP.

Genes Dev. 2007 Mar 1;21(5):562-77.

36.

Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries.

Mandinov L, Moodie KL, Mandinova A, Zhuang Z, Redican F, Baklanov D, Lindner V, Maciag T, Simons M, de Muinck ED.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2692-7. Epub 2006 May 26.

37.

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.

Nguyen BC, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster MI, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop DR, Missero C, Dotto GP.

Genes Dev. 2006 Apr 15;20(8):1028-42.

38.

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.

Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, Brisken C.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3799-804. Epub 2006 Feb 24.

39.

Dynamics of membrane translocation of phosphatidylserine during apoptosis detected by a monoclonal antibody.

Mourdjeva M, Kyurkchiev D, Mandinova A, Altankova I, Kehayov I, Kyurkchiev S.

Apoptosis. 2005 Jan;10(1):209-17.

PMID:
15711937
40.

The non-transmembrane form of Delta1, but not of Jagged1, induces normal migratory behavior accompanied by fibroblast growth factor receptor 1-dependent transformation.

Trifonova R, Small D, Kacer D, Kovalenko D, Kolev V, Mandinova A, Soldi R, Liaw L, Prudovsky I, Maciag T.

J Biol Chem. 2004 Apr 2;279(14):13285-8. Epub 2004 Feb 9.

41.

The non-classical export routes: FGF1 and IL-1alpha point the way.

Prudovsky I, Mandinova A, Soldi R, Bagala C, Graziani I, Landriscina M, Tarantini F, Duarte M, Bellum S, Doherty H, Maciag T.

J Cell Sci. 2003 Dec 15;116(Pt 24):4871-81. Review.

42.

The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1.

Bagalá C, Kolev V, Mandinova A, Soldi R, Mouta C, Graziani I, Prudovsky I, Maciag T.

Biochem Biophys Res Commun. 2003 Oct 31;310(4):1041-7.

PMID:
14559220
43.

Interleukin 1: the choreographer for the restenotic ballet.

Mandinov L, Mandinova A, Soldi R, Graziani I, Bagala C, Prudovsky I, Maciag T.

Thromb Haemost. 2003 Sep;90(3):369-71. No abstract available.

PMID:
12958603
44.

Copper chelation represses the vascular response to injury.

Mandinov L, Mandinova A, Kyurkchiev S, Kyurkchiev D, Kehayov I, Kolev V, Soldi R, Bagala C, de Muinck ED, Lindner V, Post MJ, Simons M, Bellum S, Prudovsky I, Maciag T.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6700-5. Epub 2003 May 16.

45.

S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.

Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini F, Prudovsky I, Maciag T.

J Cell Sci. 2003 Jul 1;116(Pt 13):2687-96. Epub 2003 May 13.

46.

Notch activation suppresses fibroblast growth factor-dependent cellular transformation.

Small D, Kovalenko D, Soldi R, Mandinova A, Kolev V, Trifonova R, Bagala C, Kacer D, Battelli C, Liaw L, Prudovsky I, Maciag T.

J Biol Chem. 2003 May 2;278(18):16405-13. Epub 2003 Feb 21.

47.

The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export.

Prudovsky I, Bagala C, Tarantini F, Mandinova A, Soldi R, Bellum S, Maciag T.

J Cell Biol. 2002 Jul 22;158(2):201-8. Epub 2002 Jul 22.

48.

Ultrastructural distribution of the S100A1 Ca2+-binding protein in the human heart.

Maco B, Mandinova A, Dürrenberger MB, Schäfer BW, Uhrík B, Heizmann CW.

Physiol Res. 2001;50(6):567-74.

49.

Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.

Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T.

J Biol Chem. 2001 Jul 6;276(27):25549-57. Epub 2001 May 10.

50.

Translocation of S100A1(1) calcium binding protein during heart surgery.

Brett W, Mandinova A, Remppis A, Sauder U, Rüter F, Heizmann CW, Aebi U, Zerkowski HR.

Biochem Biophys Res Commun. 2001 Jun 15;284(3):698-703.

PMID:
11396958

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