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A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.

Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen TD, Campos D, Halim A, Vakhrushev SY, Joshi H, Schreiber H, Mandel U, Narimatsu Y.

Glycobiology. 2019 Feb 6. doi: 10.1093/glycob/cwz004. [Epub ahead of print]


Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines.

Hintze J, Ye Z, Narimatsu Y, Madsen TD, Joshi HJ, Goth CK, Linstedt A, Bachert C, Mandel U, Bennett EP, Vakhrushev SY, Schjoldager KT.

J Biol Chem. 2018 Dec 7;293(49):19064-19077. doi: 10.1074/jbc.RA118.004516. Epub 2018 Oct 16.


Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa.

Nygaard MB, Herlihy AS, Jeanneau C, Nielsen JE, Bennett EP, Jørgensen N, Clausen H, Mandel U, Rajpert-De Meyts E, Almstrup K.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2949. doi: 10.3390/ijms19102949.


Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours.

Coelho R, Marcos-Silva L, Mendes N, Pereira D, Brito C, Jacob F, Steentoft C, Mandel U, Clausen H, David L, Ricardo S.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2045. doi: 10.3390/ijms19072045.


Glycan-directed CAR-T cells.

Steentoft C, Migliorini D, King TR, Mandel U, June CH, Posey AD Jr.

Glycobiology. 2018 Sep 1;28(9):656-669. doi: 10.1093/glycob/cwy008. Review.


De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH.

J Biol Chem. 2018 Jan 26;293(4):1298-1314. doi: 10.1074/jbc.M117.812826. Epub 2017 Nov 29.


Generation and characterization of a monoclonal antibody to the cytoplasmic tail of MUC16.

Gipson IK, Mandel U, Menon B, Michaud S, Tisdale A, Campos D, Clausen H.

Glycobiology. 2017 Oct 1;27(10):920-926. doi: 10.1093/glycob/cwx054.


Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH.

Immunity. 2016 Jun 21;44(6):1444-54. doi: 10.1016/j.immuni.2016.05.014.


Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.

Krishn SR, Kaur S, Smith LM, Johansson SL, Jain M, Patel A, Gautam SK, Hollingsworth MA, Mandel U, Clausen H, Lo WC, Fan WT, Manne U, Batra SK.

Cancer Lett. 2016 May 1;374(2):304-14. doi: 10.1016/j.canlet.2016.02.016. Epub 2016 Feb 16.


A novel monoclonal antibody to a defined peptide epitope in MUC16.

Marcos-Silva L, Ricardo S, Chen K, Blixt O, Arigi E, Pereira D, Høgdall E, Mandel U, Bennett EP, Vakhrushev SY, David L, Clausen H.

Glycobiology. 2015 Nov;25(11):1172-82. doi: 10.1093/glycob/cwv056. Epub 2015 Jul 22.


The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.

Beatson R, Maurstad G, Picco G, Arulappu A, Coleman J, Wandell HH, Clausen H, Mandel U, Taylor-Papadimitriou J, Sletmoen M, Burchell JM.

PLoS One. 2015 May 7;10(5):e0125994. doi: 10.1371/journal.pone.0125994. eCollection 2015.


Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.

Campos D, Freitas D, Gomes J, Magalhães A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA.

Mol Cell Proteomics. 2015 Jun;14(6):1616-29. doi: 10.1074/mcp.M114.046862. Epub 2015 Mar 26.


O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner.

Nordén R, Halim A, Nyström K, Bennett EP, Mandel U, Olofsson S, Nilsson J, Larson G.

J Biol Chem. 2015 Feb 20;290(8):5078-91. doi: 10.1074/jbc.M114.616409. Epub 2014 Dec 29.


Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours.

Ricardo S, Marcos-Silva L, Pereira D, Pinto R, Almeida R, Söderberg O, Mandel U, Clausen H, Felix A, Lunet N, David L.

Mol Oncol. 2015 Feb;9(2):503-12. doi: 10.1016/j.molonc.2014.10.005. Epub 2014 Oct 22.


A glycogene mutation map for discovery of diseases of glycosylation.

Hansen L, Lind-Thomsen A, Joshi HJ, Pedersen NB, Have CT, Kong Y, Wang S, Sparso T, Grarup N, Vester-Christensen MB, Schjoldager K, Freeze HH, Hansen T, Pedersen O, Henrissat B, Mandel U, Clausen H, Wandall HH, Bennett EP.

Glycobiology. 2015 Feb;25(2):211-24. doi: 10.1093/glycob/cwu104. Epub 2014 Sep 28.


Characterization of binding epitopes of CA125 monoclonal antibodies.

Marcos-Silva L, Narimatsu Y, Halim A, Campos D, Yang Z, Tarp MA, Pereira PJ, Mandel U, Bennett EP, Vakhrushev SY, Levery SB, David L, Clausen H.

J Proteome Res. 2014 Jul 3;13(7):3349-59. doi: 10.1021/pr500215g. Epub 2014 Jun 4.


Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localization.

Andrulis M, Ellert E, Mandel U, Clausen H, Lehners N, Raab MS, Goldschmidt H, Schwartz-Albiez R.

Histopathology. 2014 May;64(6):799-806. doi: 10.1111/his.12330. Epub 2014 Jan 21.


Generation of monoclonal antibodies to native active human glycosyltransferases.

Vester-Christensen MB, Bennett EP, Clausen H, Mandel U.

Methods Mol Biol. 2013;1022:403-20. doi: 10.1007/978-1-62703-465-4_30.


Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer.

Burford B, Gentry-Maharaj A, Graham R, Allen D, Pedersen JW, Nudelman AS, Blixt O, Fourkala EO, Bueti D, Dawnay A, Ford J, Desai R, David L, Trinder P, Acres B, Schwientek T, Gammerman A, Reis CA, Silva L, Osório H, Hallett R, Wandall HH, Mandel U, Hollingsworth MA, Jacobs I, Fentiman I, Clausen H, Taylor-Papadimitriou J, Menon U, Burchell JM.

Br J Cancer. 2013 May 28;108(10):2045-55. doi: 10.1038/bjc.2013.214. Epub 2013 May 7.


Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.

Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12.


Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

van der Post S, Subramani DB, Bäckström M, Johansson ME, Vester-Christensen MB, Mandel U, Bennett EP, Clausen H, Dahlén G, Sroka A, Potempa J, Hansson GC.

J Biol Chem. 2013 May 17;288(20):14636-46. doi: 10.1074/jbc.M113.459479. Epub 2013 Apr 1.


Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.

Remmers N, Anderson JM, Linde EM, DiMaio DJ, Lazenby AJ, Wandall HH, Mandel U, Clausen H, Yu F, Hollingsworth MA.

Clin Cancer Res. 2013 Apr 15;19(8):1981-93. doi: 10.1158/1078-0432.CCR-12-2662. Epub 2013 Feb 27.


Microarray Glycoprofiling of CA125 improves differential diagnosis of ovarian cancer.

Chen K, Gentry-Maharaj A, Burnell M, Steentoft C, Marcos-Silva L, Mandel U, Jacobs I, Dawnay A, Menon U, Blixt O.

J Proteome Res. 2013 Mar 1;12(3):1408-18. doi: 10.1021/pr3010474. Epub 2013 Feb 19.


Glycoproteomic analysis of serum from patients with gastric precancerous lesions.

Gomes C, Almeida A, Ferreira JA, Silva L, Santos-Sousa H, Pinto-de-Sousa J, Santos LL, Amado F, Schwientek T, Levery SB, Mandel U, Clausen H, David L, Reis CA, Osório H.

J Proteome Res. 2013 Mar 1;12(3):1454-66. doi: 10.1021/pr301112x. Epub 2013 Jan 31.


Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicity.

Lavrsen K, Madsen CB, Rasch MG, Woetmann A, Ødum N, Mandel U, Clausen H, Pedersen AE, Wandall HH.

Glycoconj J. 2013 Apr;30(3):227-36. doi: 10.1007/s10719-012-9437-7. Epub 2012 Aug 10.


Toward stable genetic engineering of human O-glycosylation in plants.

Yang Z, Bennett EP, Jørgensen B, Drew DP, Arigi E, Mandel U, Ulvskov P, Levery SB, Clausen H, Petersen BL.

Plant Physiol. 2012 Sep;160(1):450-63. doi: 10.1104/pp.112.198200. Epub 2012 Jul 12.


Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7.


Engineering mammalian mucin-type O-glycosylation in plants.

Yang Z, Drew DP, Jørgensen B, Mandel U, Bach SS, Ulvskov P, Levery SB, Bennett EP, Clausen H, Petersen BL.

J Biol Chem. 2012 Apr 6;287(15):11911-23. doi: 10.1074/jbc.M111.312918. Epub 2012 Feb 14.


Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA.

Glycobiology. 2012 Jun;22(6):736-56. doi: 10.1093/glycob/cwr182. Epub 2011 Dec 18. Review.


Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients.

Castro I, Aguilera S, Brockhausen I, Alliende C, Quest AF, Molina C, Urzúa U, Mandel U, Bahamondes V, Barrera MJ, Sánchez M, González S, Hermoso M, Leyton C, González MJ.

Rheumatology (Oxford). 2012 Mar;51(3):482-90. doi: 10.1093/rheumatology/ker351. Epub 2011 Nov 17.


Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process.

Freire-de-Lima L, Gelfenbeyn K, Ding Y, Mandel U, Clausen H, Handa K, Hakomori SI.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17690-5. doi: 10.1073/pnas.1115191108. Epub 2011 Oct 17.


Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.

Steentoft C, Vakhrushev SY, Vester-Christensen MB, Schjoldager KT, Kong Y, Bennett EP, Mandel U, Wandall H, Levery SB, Clausen H.

Nat Methods. 2011 Oct 9;8(11):977-82. doi: 10.1038/nmeth.1731.


Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation.

Pinto R, Carvalho AS, Conze T, Magalhães A, Picco G, Burchell JM, Taylor-Papadimitriou J, Reis CA, Almeida R, Mandel U, Clausen H, Söderberg O, David L.

J Cell Mol Med. 2012 Jul;16(7):1474-84. doi: 10.1111/j.1582-4934.2011.01436.x.


ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.

Marcos NT, Bennett EP, Gomes J, Magalhaes A, Gomes C, David L, Dar I, Jeanneau C, DeFrees S, Krustrup D, Vogel LK, Kure EH, Burchell J, Taylor-Papadimitriou J, Clausen H, Mandel U, Reis CA.

Front Biosci (Elite Ed). 2011 Jun 1;3:1443-55.


Seromic profiling of colorectal cancer patients with novel glycopeptide microarray.

Pedersen JW, Blixt O, Bennett EP, Tarp MA, Dar I, Mandel U, Poulsen SS, Pedersen AE, Rasmussen S, Jess P, Clausen H, Wandall HH.

Int J Cancer. 2011 Apr 15;128(8):1860-71. doi: 10.1002/ijc.25778. Epub 2011 Jan 12.


Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8).

Steentoft C, Schjoldager KT, Cló E, Mandel U, Levery SB, Pedersen JW, Jensen K, Blixt O, Clausen H.

Glycoconj J. 2010 Aug;27(6):571-82. doi: 10.1007/s10719-010-9301-6. Epub 2010 Aug 19.


Over-expression of ST3Gal-I promotes mammary tumorigenesis.

Picco G, Julien S, Brockhausen I, Beatson R, Antonopoulos A, Haslam S, Mandel U, Dell A, Pinder S, Taylor-Papadimitriou J, Burchell J.

Glycobiology. 2010 Oct;20(10):1241-50. doi: 10.1093/glycob/cwq085. Epub 2010 Jun 8.


Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11.

Bennett EP, Chen YW, Schwientek T, Mandel U, Schjoldager Kt, Cohen SM, Clausen H.

Glycoconj J. 2010 May;27(4):435-44. doi: 10.1007/s10719-010-9290-5. Epub 2010 Apr 27.


Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes.

Wandall HH, Blixt O, Tarp MA, Pedersen JW, Bennett EP, Mandel U, Ragupathi G, Livingston PO, Hollingsworth MA, Taylor-Papadimitriou J, Burchell J, Clausen H.

Cancer Res. 2010 Feb 15;70(4):1306-13. doi: 10.1158/0008-5472.CAN-09-2893. Epub 2010 Feb 2.


Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis.

Kato K, Takeuchi H, Kanoh A, Miyahara N, Nemoto-Sasaki Y, Morimoto-Tomita M, Matsubara A, Ohashi Y, Waki M, Usami K, Mandel U, Clausen H, Higashi N, Irimura T.

Glycoconj J. 2010 Feb;27(2):267-76. doi: 10.1007/s10719-009-9275-4.


Asthma induction in mice leads to appearance of alpha2-3- and alpha2-6-linked sialic acid residues in respiratory goblet-like cells.

Kirkeby S, Jensen NE, Mandel U, Poulsen SS.

Virchows Arch. 2008 Sep;453(3):283-90. doi: 10.1007/s00428-008-0645-2. Epub 2008 Aug 6.


Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome.

Alliende C, Kwon YJ, Brito M, Molina C, Aguilera S, Pérez P, Leyton L, Quest AF, Mandel U, Veerman E, Espinosa M, Clausen H, Leyton C, Romo R, González MJ.

Ann Rheum Dis. 2008 Oct;67(10):1480-7. Epub 2007 Nov 12.


Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells.

Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M.

Cancer Res. 2007 Sep 1;67(17):8358-67.


A serial lectin approach to the mucin-type O-glycoproteome of Drosophila melanogaster S2 cells.

Schwientek T, Mandel U, Roth U, Müller S, Hanisch FG.

Proteomics. 2007 Sep;7(18):3264-77.


Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation.

Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U.

Virchows Arch. 2007 Oct;451(4):805-14. Epub 2007 Aug 11.


The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation.

Wandall HH, Irazoqui F, Tarp MA, Bennett EP, Mandel U, Takeuchi H, Kato K, Irimura T, Suryanarayanan G, Hollingsworth MA, Clausen H.

Glycobiology. 2007 Apr;17(4):374-87. Epub 2007 Jan 10.


Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cells.

Nyström K, Grahn A, Lindh M, Brytting M, Mandel U, Larson G, Olofsson S.

Glycobiology. 2007 Apr;17(4):355-66. Epub 2007 Jan 3.


Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat.

Tarp MA, Sørensen AL, Mandel U, Paulsen H, Burchell J, Taylor-Papadimitriou J, Clausen H.

Glycobiology. 2007 Feb;17(2):197-209. Epub 2006 Oct 18.


Cancer specific Mucin-1 glycoforms are expressed on multiple myeloma.

Cloosen S, Gratama J, van Leeuwen EB, Senden-Gijsbers BL, Oving EB, von Mensdorff-Pouilly S, Tarp MA, Mandel U, Clausen H, Germeraad WT, Bos GM.

Br J Haematol. 2006 Nov;135(4):513-6. Epub 2006 Sep 28.


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