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Most gene fusions in cancer are stochastic events.

Johansson B, Mertens F, Schyman T, Björk J, Mandahl N, Mitelman F.

Genes Chromosomes Cancer. 2019 Sep;58(9):607-611. doi: 10.1002/gcc.22745. Epub 2019 Mar 18.


Cancer chromosome breakpoints cluster in gene-rich genomic regions.

Mitelman F, Johansson B, Mertens F, Schyman T, Mandahl N.

Genes Chromosomes Cancer. 2019 Mar;58(3):149-154. doi: 10.1002/gcc.22713. Epub 2018 Dec 26.


Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years.

Hofvander J, Viklund B, Isaksson A, Brosjö O, Vult von Steyern F, Rissler P, Mandahl N, Mertens F.

Nat Commun. 2018 Sep 10;9(1):3662. doi: 10.1038/s41467-018-06098-0.


Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53.

Høland M, Kolberg M, Danielsen SA, Bjerkehagen B, Eilertsen IA, Hektoen M, Mandahl N, van den Berg E, Smeland S, Mertens F, Sundby Hall K, Picci P, Sveen A, Lothe RA.

Mod Pathol. 2018 Nov;31(11):1694-1707. doi: 10.1038/s41379-018-0074-y. Epub 2018 Jun 26.


Scattered genomic amplification in dedifferentiated liposarcoma.

Mandahl N, Magnusson L, Nilsson J, Viklund B, Arbajian E, von Steyern FV, Isaksson A, Mertens F.

Mol Cytogenet. 2017 Jun 24;10:25. doi: 10.1186/s13039-017-0325-5. eCollection 2017.


Genetic heterogeneity in rhabdomyosarcoma revealed by SNP array analysis.

Walther C, Mayrhofer M, Nilsson J, Hofvander J, Jonson T, Mandahl N, Øra I, Gisselsson D, Mertens F.

Genes Chromosomes Cancer. 2016 Jan;55(1):3-15. doi: 10.1002/gcc.22285. Epub 2015 Oct 20.


RNA sequencing of sarcomas with simple karyotypes: identification and enrichment of fusion transcripts.

Hofvander J, Tayebwa J, Nilsson J, Magnusson L, Brosjö O, Larsson O, von Steyern FV, Domanski HA, Mandahl N, Mertens F.

Lab Invest. 2015 Jun;95(6):603-9. doi: 10.1038/labinvest.2015.50. Epub 2015 Apr 13.


Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.

Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA.

Mol Oncol. 2015 Jun;9(6):1129-39. doi: 10.1016/j.molonc.2015.02.005. Epub 2015 Feb 18.


Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma.

Hofvander J, Tayebwa J, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Mandahl N, Fletcher CD, Mertens F.

Clin Cancer Res. 2015 Feb 15;21(4):864-9. doi: 10.1158/1078-0432.CCR-14-2399. Epub 2014 Dec 16.


Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.

Płaszczyca A, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Domanski HA, Lilljebjörn H, Fioretos T, Tayebwa J, Mandahl N, Nord KH, Mertens F.

Int J Biochem Cell Biol. 2014 Aug;53:475-81. doi: 10.1016/j.biocel.2014.03.027. Epub 2014 Apr 8.


Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.

Macchia G, Nord KH, D'Alessandro G, Nilsson J, Magnusson L, Mandahl N, Storlazzi CT, Mertens F.

Oncol Rep. 2014 Feb;31(2):807-11. doi: 10.3892/or.2013.2889. Epub 2013 Dec 2.


Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.

Joseph CG, Hwang H, Jiao Y, Wood LD, Kinde I, Wu J, Mandahl N, Luo J, Hruban RH, Diaz LA Jr, He TC, Vogelstein B, Kinzler KW, Mertens F, Papadopoulos N.

Genes Chromosomes Cancer. 2014 Jan;53(1):15-24. doi: 10.1002/gcc.22114. Epub 2013 Nov 5.


Integrative genome and transcriptome analyses reveal two distinct types of ring chromosome in soft tissue sarcomas.

Nord KH, Macchia G, Tayebwa J, Nilsson J, Vult von Steyern F, Brosjö O, Mandahl N, Mertens F.

Hum Mol Genet. 2014 Feb 15;23(4):878-88. doi: 10.1093/hmg/ddt479. Epub 2013 Sep 26.


Cytogenetic and single nucleotide polymorphism array findings in soft tissue tumors in infants.

Walther C, Nilsson J, von Steyern FV, Wiebe T, Bauer HC, Nord KH, Gisselsson D, Domanski HA, Mandahl N, Mertens F.

Cancer Genet. 2013 Jul-Aug;206(7-8):299-303. doi: 10.1016/j.cancergen.2013.06.004. Epub 2013 Aug 12.


Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor.

Mohajeri A, Tayebwa J, Collin A, Nilsson J, Magnusson L, von Steyern FV, Brosjö O, Domanski HA, Larsson O, Sciot R, Debiec-Rychter M, Hornick JL, Mandahl N, Nord KH, Mertens F.

Genes Chromosomes Cancer. 2013 Oct;52(10):873-86. doi: 10.1002/gcc.22083. Epub 2013 Jun 12.


TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, Rasheed BA, Riggins GJ, Rosenquist TA, Schiffman M, Shih IeM, Theodorescu D, Torbenson MS, Velculescu VE, Wang TL, Wentzensen N, Wood LD, Zhang M, McLendon RE, Bigner DD, Kinzler KW, Vogelstein B, Papadopoulos N, Yan H.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6. doi: 10.1073/pnas.1303607110. Epub 2013 Mar 25.


Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma.

Nord KH, Paulsson K, Veerla S, Wejde J, Brosjö O, Mandahl N, Mertens F.

Neoplasia. 2012 Sep;14(9):807-12.


The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors.

Mertens F, Brosjö O, von Steyern FV, Nord KH, Mandahl N.

Cancer Genet. 2012 Sep;205(9):470-3. doi: 10.1016/j.cancergen.2012.06.001.


Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone.

Trombetta D, Macchia G, Mandahl N, Nord KH, Mertens F.

Cancer Genet. 2012 Jul-Aug;205(7-8):410-3. doi: 10.1016/j.cancergen.2012.05.002.


Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumors.

Gebre-Medhin S, Nord KH, Möller E, Mandahl N, Magnusson L, Nilsson J, Jo VY, Vult von Steyern F, Brosjö O, Larsson O, Domanski HA, Sciot R, Debiec-Rychter M, Fletcher CD, Mertens F.

Am J Pathol. 2012 Sep;181(3):1069-77. doi: 10.1016/j.ajpath.2012.05.030. Epub 2012 Jul 13.


Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.

Jin Y, Möller E, Nord KH, Mandahl N, Von Steyern FV, Domanski HA, Mariño-Enríquez A, Magnusson L, Nilsson J, Sciot R, Fletcher CD, Debiec-Rychter M, Mertens F.

Genes Chromosomes Cancer. 2012 May;51(5):510-20. doi: 10.1002/gcc.21939. Epub 2012 Feb 15.


Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.

Mandahl N, Johansson B, Mertens F, Mitelman F.

Genes Chromosomes Cancer. 2012 Jun;51(6):536-44. doi: 10.1002/gcc.21947. Epub 2012 Feb 15. Review.


HMGA2 and MDM2 expression in lipomatous tumors with partial, low-level amplification of sequences from the long arm of chromosome 12.

Mandahl N, Bartuma H, Magnusson L, Isaksson M, Macchia G, Mertens F.

Cancer Genet. 2011 Oct;204(10):550-6. doi: 10.1016/j.cancergen.2011.09.005.


Gene expression and single nucleotide polymorphism array analyses of spindle cell lipomas and conventional lipomas with 13q14 deletion.

Bartuma H, Nord KH, Macchia G, Isaksson M, Nilsson J, Domanski HA, Mandahl N, Mertens F.

Genes Chromosomes Cancer. 2011 Aug;50(8):619-32. doi: 10.1002/gcc.20884. Epub 2011 May 11.


Chromosome banding analysis of cells from fine-needle aspiration biopsy samples from soft tissue and bone tumors: is it clinically meaningful?

Walther C, Domanski HA, von Steyern FV, Mandahl N, Mertens F.

Cancer Genet. 2011 Apr;204(4):203-6. doi: 10.1016/j.cancergen.2011.01.001.


Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features.

Mertens F, Romeo S, Bovée JV, Tirabosco R, Athanasou N, Alberghini M, Hogendoorn PC, Dei Tos AP, Sciot R, Domanski HA, Aström K, Mandahl N, Debiec-Rychter M.

Clin Sarcoma Res. 2011 Oct 13;1(1):10. doi: 10.1186/2045-3329-1-10.


Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.

Nord KH, Magnusson L, Isaksson M, Nilsson J, Lilljebjörn H, Domanski HA, Kindblom LG, Mandahl N, Mertens F.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21122-7. doi: 10.1073/pnas.1013512107. Epub 2010 Nov 15.


Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.

Gisselsson D, Jin Y, Lindgren D, Persson J, Gisselsson L, Hanks S, Sehic D, Mengelbier LH, Øra I, Rahman N, Mertens F, Mitelman F, Mandahl N.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20489-93. doi: 10.1073/pnas.1006829107. Epub 2010 Nov 8.


Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma.

Bartuma H, Möller E, Collin A, Domanski HA, Von Steyern FV, Mandahl N, Mertens F.

Cancer Genet Cytogenet. 2010 Jun;199(2):143-6. doi: 10.1016/j.cancergencyto.2010.02.011.


The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.

Mertens F, Möller E, Mandahl N, Picci P, Perez-Atayde AR, Samson I, Sciot R, Debiec-Rychter M.

Int J Cancer. 2011 Jan 15;128(2):487-91. doi: 10.1002/ijc.25353.


Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group.

Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA.

J Clin Oncol. 2010 Mar 20;28(9):1573-82. doi: 10.1200/JCO.2009.24.8989. Epub 2010 Feb 16.


Characterization of a hotspot region on chromosome 12 for amplification in ring chromosomes in atypical lipomatous tumors.

Trombetta D, Mertens F, Lonoce A, D'Addabbo P, Rennstam K, Mandahl N, Storlazzi CT.

Genes Chromosomes Cancer. 2009 Nov;48(11):993-1001. doi: 10.1002/gcc.20700.


Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups.

Bartuma H, Panagopoulos I, Collin A, Trombetta D, Domanski HA, Mandahl N, Mertens F.

Mol Cancer. 2009 Jun 9;8:36. doi: 10.1186/1476-4598-8-36.


Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone.

Gebre-Medhin S, Broberg K, Jonson T, Gorunova L, von Steyern FV, Brosjö O, Jin Y, Gisselsson D, Panagopoulos I, Mandahl N, Mertens F.

Cytogenet Genome Res. 2009;124(2):121-7. doi: 10.1159/000207516. Epub 2009 May 5.


Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrations.

Gorunova L, Vult von Steyern F, Storlazzi CT, Bjerkehagen B, Follerås G, Heim S, Mandahl N, Mertens F.

Genes Chromosomes Cancer. 2009 Jul;48(7):583-602. doi: 10.1002/gcc.20667.


Genomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors.

Hallor KH, Staaf J, Bovée JV, Hogendoorn PC, Cleton-Jansen AM, Knuutila S, Savola S, Niini T, Brosjö O, Bauer HC, Vult von Steyern F, Jonsson K, Skorpil M, Mandahl N, Mertens F.

Clin Cancer Res. 2009 Apr 15;15(8):2685-94. doi: 10.1158/1078-0432.CCR-08-2330. Epub 2009 Mar 31.


Bidirectionality and transcriptional activity of the EWSR1 promoter region.

Möller E, Mandahl N, Iliszko M, Mertens F, Panagopoulos I.

Oncol Rep. 2009 Mar;21(3):641-8.


Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions.

Hallor KH, Sciot R, Staaf J, Heidenblad M, Rydholm A, Bauer HC, Aström K, Domanski HA, Meis JM, Kindblom LG, Panagopoulos I, Mandahl N, Mertens F.

J Pathol. 2009 Apr;217(5):716-27. doi: 10.1002/path.2513.


Genomic characteristics of soft tissue sarcomas.

Mertens F, Panagopoulos I, Mandahl N.

Virchows Arch. 2010 Feb;456(2):129-39. doi: 10.1007/s00428-009-0736-8. Epub 2009 Feb 3. Review.


Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors.

Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA.

Neuro Oncol. 2009 Oct;11(5):514-28. doi: 10.1215/15228517-2008-127. Epub 2009 Jan 30.


Heterogeneous genetic profiles in soft tissue myoepitheliomas.

Hallor KH, Teixeira MR, Fletcher CD, Bizarro S, Staaf J, Domanski HA, von Steyern FV, Panagopoulos I, Mandahl N, Mertens F.

Mod Pathol. 2008 Nov;21(11):1311-9. doi: 10.1038/modpathol.2008.124. Epub 2008 Jul 4.


Cytogenetic and molecular cytogenetic findings in lipoblastoma.

Bartuma H, Domanski HA, Von Steyern FV, Kullendorff CM, Mandahl N, Mertens F.

Cancer Genet Cytogenet. 2008 May;183(1):60-3. doi: 10.1016/j.cancergencyto.2008.01.017.


POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.

Möller E, Stenman G, Mandahl N, Hamberg H, Mölne L, van den Oord JJ, Brosjö O, Mertens F, Panagopoulos I.

J Pathol. 2008 May;215(1):78-86. doi: 10.1002/path.2327.


Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation.

Hallor KH, Staaf J, Jönsson G, Heidenblad M, Vult von Steyern F, Bauer HC, Ijszenga M, Hogendoorn PC, Mandahl N, Szuhai K, Mertens F.

Br J Cancer. 2008 Jan 29;98(2):434-42. Epub 2007 Dec 11.


Fusion of the COL1A1 and USP6 genes in a benign bone tumor.

Panagopoulos I, Mertens F, Löfvenberg R, Mandahl N.

Cancer Genet Cytogenet. 2008 Jan 1;180(1):70-3.


Comparison of the proximal promoter regions of the PAX3 and PAX7 genes.

Möller E, Isaksson M, Mandahl N, Mertens F, Panagopoulos I.

Cancer Genet Cytogenet. 2007 Oct 15;178(2):114-9.


Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors.

Möller E, Mandahl N, Mertens F, Panagopoulos I.

Genes Chromosomes Cancer. 2008 Jan;47(1):21-5.


Unstable translocation (8;22) in a case of giant cell reparative granuloma.

Johnsson A, Collin A, Rydholm A, Domanski HA, Mertens F, Mandahl N.

Cancer Genet Cytogenet. 2007 Aug;177(1):59-63.


Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets.

Persson O, Krogh M, Saal LH, Englund E, Liu J, Parsons R, Mandahl N, Borg A, Widegren B, Salford LG.

J Neurooncol. 2007 Oct;85(1):11-24. Epub 2007 Jul 17.


Genetic intratumour heterogeneity in high-grade brain tumours is associated with telomere-dependent mitotic instability.

Glanz C, Rebetz J, Stewénius Y, Persson A, Englund E, Mandahl N, Mertens F, Salford LG, Widegren B, Fan X, Gisselsson D.

Neuropathol Appl Neurobiol. 2007 Aug;33(4):440-54.


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