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Items: 14

1.

A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes.

Somers GI, Lindsay N, Lowdon BM, Jones AE, Freathy C, Ho S, Woodrooffe AJ, Bayliss MK, Manchee GR.

Drug Metab Dispos. 2007 Oct;35(10):1797-805. Epub 2007 Jul 12.

PMID:
17627976
2.

Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.

Watson NS, Brown D, Campbell M, Chan C, Chaudry L, Convery MA, Fenwick R, Hamblin JN, Haslam C, Kelly HA, King NP, Kurtis CL, Leach AR, Manchee GR, Mason AM, Mitchell C, Patel C, Patel VK, Senger S, Shah GP, Weston HE, Whitworth C, Young RJ.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3784-8. Epub 2006 May 11.

PMID:
16697194
3.

X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity.

Dajani R, Cleasby A, Neu M, Wonacott AJ, Jhoti H, Hood AM, Modi S, Hersey A, Taskinen J, Cooke RM, Manchee GR, Coughtrie MW.

J Biol Chem. 1999 Dec 31;274(53):37862-8.

4.
5.

Purification and characterization of a canine liver phenol sulfotransferase.

Oddy EA, Manchee GR, Freeman NM, Ward MA, Coughtrie MW.

Drug Metab Dispos. 1997 Oct;25(10):1205-10.

PMID:
9321525
7.

Absorption and disposition of ranitidine hydrochloride in rat and dog.

Eddershaw PJ, Chadwick AP, Higton DM, Fenwick SH, Linacre P, Jenner WN, Bell JA, Manchee GR.

Xenobiotica. 1996 Sep;26(9):947-56.

PMID:
8893041
8.

The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.

Manchee GR, Eddershaw PJ, Ranshaw LE, Herriott D, Park GR, Bayliss MK, Tarbit MH.

Drug Metab Dispos. 1996 May;24(5):555-9.

PMID:
8723736
9.

Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite.

Cannell RJ, Knaggs AR, Dawson MJ, Manchee GR, Eddershaw PJ, Waterhouse I, Sutherland DR, Bowers GD, Sidebottom PJ.

Drug Metab Dispos. 1995 Jul;23(7):724-9.

PMID:
7587961
11.

Characterization of glucuronic acid conjugates of a novel angiotensin receptor antagonist.

Bowers GD, Eddershaw PJ, Hughes SY, Manchee GR, Oxford J.

Rapid Commun Mass Spectrom. 1994 Feb;8(2):217-21.

PMID:
8155901
12.

Disposition of salmeterol xinafoate in laboratory animals and humans.

Manchee GR, Barrow A, Kulkarni S, Palmer E, Oxford J, Colthup PV, Maconochie JG, Tarbit MH.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1022-8.

PMID:
7905380
13.

GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity.

Rogers H, Birch PJ, Harrison SM, Palmer E, Manchee GR, Judd DB, Naylor A, Scopes DI, Hayes AG.

Br J Pharmacol. 1992 Aug;106(4):783-9.

14.

Thermospray liquid chromatography-mass spectrometry for the characterisation of sulphate ester conjugates.

Bowers GD, Higton DM, Manchee GR, Oxford J, Saynor DA.

J Chromatogr. 1991 Aug 21;554(1-2):175-80.

PMID:
1839028

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