Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26

1.

Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes.

Tshabalala S, Choudhury A, Beeton-Kempen N, Martinson N, Ramsay M, Mancama D.

Pharmacogenet Genomics. 2019 Sep;29(7):167-178. doi: 10.1097/FPC.0000000000000380.

PMID:
31162291
2.

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01941-18. doi: 10.1128/AAC.01941-18. Print 2018 Nov. No abstract available.

3.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.

4.

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.

van der Watt ME, Reader J, Churchyard A, Nondaba SH, Lauterbach SB, Niemand J, Abayomi S, van Biljon RA, Connacher JI, van Wyk RDJ, Le Manach C, Paquet T, González Cabrera D, Brunschwig C, Theron A, Lozano-Arias S, Rodrigues JFI, Herreros E, Leroy D, Duffy J, Street LJ, Chibale K, Mancama D, Coetzer TL, Birkholtz LM.

J Antimicrob Chemother. 2018 May 1;73(5):1279-1290. doi: 10.1093/jac/dky008.

PMID:
29420756
5.

In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine.

Forkuo AD, Ansah C, Mensah KB, Annan K, Gyan B, Theron A, Mancama D, Wright CW.

Malar J. 2017 Dec 28;16(1):496. doi: 10.1186/s12936-017-2142-z.

6.

Acute Kidney Injury, Risk Factors, and Prognosis in Hospitalized HIV-Infected Adults in South Africa, Compared by Tenofovir Exposure.

Seedat F, Martinson N, Motlhaoleng K, Abraham P, Mancama D, Naicker S, Variava E.

AIDS Res Hum Retroviruses. 2017 Jan;33(1):33-40. doi: 10.1089/AID.2016.0098. Epub 2016 Sep 7.

7.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

8.

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities.

Birkholtz LM, Coetzer TL, Mancama D, Leroy D, Alano P.

Trends Parasitol. 2016 Sep;32(9):669-681. doi: 10.1016/j.pt.2016.04.017. Epub 2016 May 18. Review.

PMID:
27209388
9.

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Reader J, Botha M, Theron A, Lauterbach SB, Rossouw C, Engelbrecht D, Wepener M, Smit A, Leroy D, Mancama D, Coetzer TL, Birkholtz LM.

Malar J. 2015 May 22;14:213. doi: 10.1186/s12936-015-0718-z.

10.

Review of existing experimental approaches for the clinical evaluation of the benefits of plant food supplements on cardiovascular function.

Meoni P, Restani P, Mancama DT.

Food Funct. 2013 Jun;4(6):856-70. doi: 10.1039/c3fo30323c. Epub 2013 May 15. Review.

11.

Thermo-responsive non-woven scaffolds for "smart" 3D cell culture.

Rossouw CL, Chetty A, Moolman FS, Birkholtz LM, Hoppe H, Mancama DT.

Biotechnol Bioeng. 2012 Aug;109(8):2147-58. doi: 10.1002/bit.24469. Epub 2012 Feb 24.

PMID:
22367720
12.

In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling.

Becker JV, van der Merwe MM, van Brummelen AC, Pillay P, Crampton BG, Mmutlane EM, Parkinson C, van Heerden FR, Crouch NR, Smith PJ, Mancama DT, Maharaj VJ.

Malar J. 2011 Oct 11;10:295. doi: 10.1186/1475-2875-10-295.

13.

Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels.

Becker JV, Mtwisha L, Crampton BG, Stoychev S, van Brummelen AC, Reeksting S, Louw AI, Birkholtz LM, Mancama DT.

BMC Genomics. 2010 Apr 12;11:235. doi: 10.1186/1471-2164-11-235.

14.

Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response.

Mancama D, Mata I, Kerwin RW, Arranz MJ.

Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):849-53.

PMID:
17503482
15.

Expression of the alpha1A-adrenergic receptor in schizophrenia.

Clark DA, Mancama D, Kerwin RW, Arranz MJ.

Neurosci Lett. 2006 Jul 3;401(3):248-51. Epub 2006 Apr 4.

PMID:
16600500
16.

Pharmacogenomics--can genetics help in the care of psychiatric patients?

Bolonna AA, Arranz MJ, Mancama D, Kerwin RW.

Int Rev Psychiatry. 2004 Nov;16(4):311-9. Review.

PMID:
16194764
17.

Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population.

Staddon S, Arranz MJ, Mancama D, Perez-Nievas F, Arrizabalaga I, Anney R, Buckland P, Elkin A, Osborne S, Munro J, Mata I, Kerwin RW.

Schizophr Res. 2005 Feb 1;73(1):49-54.

PMID:
15567076
18.

Pharmacogenomics of psychiatric drug treatment.

Mancama D, Arranz MJ, Kerwin RW.

Curr Opin Mol Ther. 2003 Dec;5(6):642-9. Review.

PMID:
14755891
19.

Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia.

Mancama D, Arranz MJ, Landau S, Kerwin R.

Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):2-6.

PMID:
12707929
20.

Role of pharmacogenomics in individualising treatment with SSRIs.

Mancama D, Kerwin RW.

CNS Drugs. 2003;17(3):143-51. Review.

PMID:
12617694
21.

Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response.

Mancama D, Arranz MJ, Munro J, Osborne S, Makoff A, Collier D, Kerwin R.

Neurosci Lett. 2002 Nov 29;333(3):207-11.

PMID:
12429384
22.

Clinical applications of pharmacogenetics in psychiatry.

Staddon S, Arranz MJ, Mancama D, Mata I, Kerwin RW.

Psychopharmacology (Berl). 2002 Jun;162(1):18-23. Epub 2002 Apr 25. Review.

PMID:
12107612
23.

Genetic predictors of therapeutic response to clozapine: current status of research.

Mancama D, Arranz MJ, Kerwin RW.

CNS Drugs. 2002;16(5):317-24. Review.

PMID:
11994021
24.

Genetic strategies for the personalization of antipsychotic treatment.

Kerwin RW, Mancama DT, Arranz MJ.

Expert Rev Mol Diagn. 2001 Sep;1(3):275-80. Review.

PMID:
11901832
25.

Neurotransmitter receptor variants and their influence on antipsychotic treatment (Review)).

Arranz MJ, Mancama D, Kerwin RW.

Int J Mol Med. 2001 Jan;7(1):27-30. Review.

PMID:
11115604
26.

Pharmacogenetic prediction of clozapine response.

Arranz MJ, Munro J, Birkett J, Bolonna A, Mancama D, Sodhi M, Lesch KP, Meyer JF, Sham P, Collier DA, Murray RM, Kerwin RW.

Lancet. 2000 May 6;355(9215):1615-6.

PMID:
10821369

Supplemental Content

Loading ...
Support Center