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Items: 1 to 50 of 68

1.

Reply to "Are the TR46/Y121F/T289A Mutations in Azole-Resistant Aspergillosis Patient Acquired or Environmental?".

Vazquez JA, Manavathu EK.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3261. doi: 10.1128/AAC.00380-16. Print 2016 May. No abstract available.

2.

Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States.

Vazquez JA, Manavathu EK.

Antimicrob Agents Chemother. 2015 Nov 16;60(2):1129-33. doi: 10.1128/AAC.01130-15. Print 2016 Feb.

3.
4.

Efficacy of anidulafungin, caspofungin and fluconazole in the early phase of infection in a neutropenic murine invasive candidiasis model.

Krishnan-Natesan S, Manavathu EK, Cutright JL, Chandrasekar PH.

Int J Antimicrob Agents. 2010 Jul;36(1):33-6. doi: 10.1016/j.ijantimicag.2010.02.020. Epub 2010 Apr 18.

PMID:
20400270
5.

A comparison of the fungicidal activity of amphotericin B and posaconazole against Zygomycetes in vitro.

Krishnan-Natesan S, Manavathu EK, Alangaden GJ, Chandrasekar PH.

Diagn Microbiol Infect Dis. 2009 Apr;63(4):361-4. doi: 10.1016/j.diagmicrobio.2008.12.013.

PMID:
19302924
6.

Aspergillus flavus: an emerging non-fumigatus Aspergillus species of significance.

Krishnan S, Manavathu EK, Chandrasekar PH.

Mycoses. 2009 May;52(3):206-22. doi: 10.1111/j.1439-0507.2008.01642.x. Epub 2009 Jan 14. Review.

PMID:
19207851
7.

Successful treatment of primary cutaneous Aspergillus ustus infection with surgical debridement and a combination of voriconazole and terbinafine.

Krishnan-Natesan S, Chandrasekar PH, Manavathu EK, Revankar SG.

Diagn Microbiol Infect Dis. 2008 Dec;62(4):443-6. doi: 10.1016/j.diagmicrobio.2008.08.003. Epub 2008 Oct 7.

PMID:
18842377
8.

Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus.

Krishnan-Natesan S, Chandrasekar PH, Alangaden GJ, Manavathu EK.

Int J Antimicrob Agents. 2008 Dec;32(6):519-24. doi: 10.1016/j.ijantimicag.2008.06.018. Epub 2008 Sep 4.

PMID:
18775650
9.
10.

Do Aspergillus species produce biofilm?

Chandrasekar PH, Manavathu EK.

Future Microbiol. 2008 Feb;3(1):19-21. doi: 10.2217/17460913.3.1.19.

PMID:
18230030
11.

Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro.

Natesan SK, Chandrasekar PH, Alangaden GJ, Manavathu EK.

Diagn Microbiol Infect Dis. 2008 Apr;60(4):369-73. Epub 2007 Dec 3.

PMID:
18061388
12.

E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.

Jha A, Mukherjee C, Prasad AK, Parmar VS, Clercq ED, Balzarini J, Stables JP, Manavathu EK, Shrivastav A, Sharma RK, Nienaber KH, Zello GA, Dimmock JR.

Bioorg Med Chem. 2007 Sep 1;15(17):5854-65. Epub 2007 Jun 2.

PMID:
17562365
13.

Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds.

Das U, Gul HI, Alcorn J, Shrivastav A, George T, Sharma RK, Nienaber KH, De Clercq E, Balzarini J, Kawase M, Kan N, Tanaka T, Tani S, Werbovetz KA, Yakovich AJ, Manavathu EK, Stables JP, Dimmock JR.

Eur J Med Chem. 2006 May;41(5):577-85. Epub 2006 Apr 3.

PMID:
16581158
14.

A comparative study of fungicidal activities of voriconazole and amphotericin B against hyphae of Aspergillus fumigatus.

Krishnan S, Manavathu EK, Chandrasekar PH.

J Antimicrob Chemother. 2005 Jun;55(6):914-20. Epub 2005 Apr 11.

PMID:
15824093
15.

Effect of test medium on in vitro susceptibility testing results for Aspergillus fumigatus.

Chandrasekar PH, Abraham OC, Manavathu EK, Nune U, Kanuri K.

Rev Iberoam Micol. 2000 Sep;17(3):107-10.

16.

In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B.

Manavathu EK, Cutright JL, Chandrasekar PH.

Antimicrob Agents Chemother. 2005 Jan;49(1):428-30.

17.

In-vitro activity of nikkomycin Z alone and in combination with polyenes, triazoles or echinocandins against Aspergillus fumigatus.

Ganesan LT, Manavathu EK, Cutright JL, Alangaden GJ, Chandrasekar PH.

Clin Microbiol Infect. 2004 Nov;10(11):961-6.

18.

Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis.

Chandrasekar PH, Cutright JL, Manavathu EK.

Clin Microbiol Infect. 2004 Oct;10(10):925-8.

19.

Novel effect of voriconazole on conidiation of Aspergillus species.

Varanasi NL, Baskaran I, Alangaden GJ, Chandrasekar PH, Manavathu EK.

Int J Antimicrob Agents. 2004 Jan;23(1):72-9.

PMID:
14732317
20.

A comparative study of the post-antifungal effect (PAFE) of amphotericin B, triazoles and echinocandins on Aspergillus fumigatus and Candida albicans.

Manavathu EK, Ramesh MS, Baskaran I, Ganesan LT, Chandrasekar PH.

J Antimicrob Chemother. 2004 Feb;53(2):386-9. Epub 2004 Jan 16.

PMID:
14729762
21.

3,5-bis(phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: a novel group of cytotoxic agents.

Dimmock JR, Jha A, Zello GA, Sharma RK, Shrivastav A, Selvakumar P, Allen TM, Santos CL, Balzarini J, De Clercq E, Manavathu EK, Stables JP.

J Enzyme Inhib Med Chem. 2003 Aug;18(4):325-32.

PMID:
14567547
22.

CAN-296-P is effective against cutaneous candidiasis in guinea pigs.

Ben-Josef AM, Cutright JL, Manavathu EK, Sobel JD.

Int J Antimicrob Agents. 2003 Aug;22(2):168-71.

PMID:
12927959
23.

Cytotoxic 4'-aminochalcones and related compounds.

Dimmock JR, Jha A, Zello GA, Allen TM, Santos CL, Balzarini J, De Clercq E, Manavathu EK, Stables JP.

Pharmazie. 2003 Apr;58(4):227-32.

PMID:
12749401
24.

Differential activity of triazoles in two-drug combinations with the echinocandin caspofungin against Aspergillus fumigatus.

Manavathu EK, Alangaden GJ, Chandrasekar PH.

J Antimicrob Chemother. 2003 Jun;51(6):1423-5. Epub 2003 Apr 25.

PMID:
12716776
25.

Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds.

Dimmock JR, Jha A, Zello GA, Quail JW, Oloo EO, Nienaber KH, Kowalczyk ES, Allen TM, Santos CL, De Clercq E, Balzarini J, Manavathu EK, Stables JP.

Eur J Med Chem. 2002 Dec;37(12):961-72.

PMID:
12660021
26.

Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones.

Dimmock JR, Padmanilayam MP, Zello GA, Nienaber KH, Allen TM, Santos CL, De Clercq E, Balzarini J, Manavathu EK, Stables JP.

Eur J Med Chem. 2003 Feb;38(2):169-77.

PMID:
12620661
27.

Caspofungin.

Chandrasekar PH, Manavathu EK.

Drugs Today (Barc). 2002 Dec;38(12):829-46. Review.

PMID:
12582472
28.

Cytotoxic 1,3-diarylidene-2-tetralones and related compounds.

Dimmock JR, Padmanilyam MP, Zello GA, Quail JW, Oloo EO, Prisciak JS, Kraatz HB, Cherkasov A, Lee JS, Allen TM, Santos CL, Manavathu EK, De Clercq E, Balzarini J, Stables JP.

Eur J Med Chem. 2002 Oct;37(10):813-24.

PMID:
12446039
29.

Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds.

Dimmock JR, Jha A, Kumar P, Zello GA, Quail JW, Oloo EO, Oucharek JJ, Pasha MK, Seitz D, Sharma RK, Allen TM, Santos CL, Manavathu EK, De Clercq E, Balzarini J, Stables JP.

Eur J Med Chem. 2002 Jan;37(1):35-44.

PMID:
11841873
30.

Aspergillus: rising frequency of clinical isolation and continued susceptibility to antifungal agents, 1994-1999.

Chandrasekar PH, Cutright JL, Manavathu EK.

Diagn Microbiol Infect Dis. 2001 Dec;41(4):211-4.

PMID:
11777662
31.
32.

Inhibition of H(+)-ATPase-mediated proton pumping in Cryptococcus neoformans by a novel conjugated styryl ketone.

Manavathu EK, Dimmock JR, Vashishtha SC, Chandrasekar PH.

J Antimicrob Chemother. 2001 Apr;47(4):491-4.

PMID:
11266429
33.

A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.

Dimmock JR, Padmanilayam MP, Puthucode RN, Nazarali AJ, Motaganahalli NL, Zello GA, Quail JW, Oloo EO, Kraatz HB, Prisciak JS, Allen TM, Santos CL, Balzarini J, De Clercq E, Manavathu EK.

J Med Chem. 2001 Feb 15;44(4):586-93.

PMID:
11170648
35.

Proton translocating ATPase mediated fungicidal activity of a novel complex carbohydrate: CAN-296.

Ben-Josef AM, Manavathu EK, Platt D, Sobel JD.

Int J Antimicrob Agents. 2000 Feb;13(4):287-95.

PMID:
10755243
36.

Proton-pumping-ATPase-targeted antifungal activity of a novel conjugated styryl ketone.

Manavathu EK, Dimmock JR, Vashishtha SC, Chandrasekar PH.

Antimicrob Agents Chemother. 1999 Dec;43(12):2950-9.

37.

Involvement of calcium inhibitable binding to the cell wall in the fungicidal activity of CAN-296.

Ben-Josef AM, Manavathu EK, Platt D, Sobel JD.

J Antimicrob Chemother. 1999 Aug;44(2):217-22.

PMID:
10473228
38.
39.

In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B.

Abraham OC, Manavathu EK, Cutright JL, Chandrasekar PH.

Diagn Microbiol Infect Dis. 1999 Jan;33(1):7-11.

PMID:
9990469
40.
41.

In-vitro and in-vivo susceptibility of Aspergillus fumigatus to a novel conjugated styryl ketone.

Manavathu EK, Dimmock JR, Vashishtha SC, Cutright J, Chandrasekar PH.

J Antimicrob Chemother. 1998 Nov;42(5):585-90.

PMID:
9848441
42.

Organism-dependent fungicidal activities of azoles.

Manavathu EK, Cutright JL, Chandrasekar PH.

Antimicrob Agents Chemother. 1998 Nov;42(11):3018-21.

43.

Antifungal activity of some quaternary ammonium salts of 4-(2-arylvinyl)-3-(3-aryl-2-propenoyl)-1-ethyl-4-piperidinols and related compounds.

Vashishtha SC, Dimmock JR, Manavathu EK.

Pharmazie. 1998 Jul;53(7):499-500. No abstract available.

PMID:
9699227
44.

In-vitro isolation and antifungal susceptibility of amphotericin B-resistant mutants of Aspergillus fumigatus.

Manavathu EK, Alangaden GJ, Chandrasekar PH.

J Antimicrob Chemother. 1998 Jun;41(6):615-9.

PMID:
9687099
45.

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.

Alangaden GJ, Kreiswirth BN, Aouad A, Khetarpal M, Igno FR, Moghazeh SL, Manavathu EK, Lerner SA.

Antimicrob Agents Chemother. 1998 May;42(5):1295-7.

46.

In vitro antifungal activity of CAN-296: a naturally occurring complex carbohydrate.

Ben-Josef AM, Manavathu EK, Platt D, Sobel JD.

J Antibiot (Tokyo). 1997 Nov;50(11):937-43.

47.

Cytotoxic activities of Mannich bases of chalcones and related compounds.

Dimmock JR, Kandepu NM, Hetherington M, Quail JW, Pugazhenthi U, Sudom AM, Chamankhah M, Rose P, Pass E, Allen TM, Halleran S, Szydlowski J, Mutus B, Tannous M, Manavathu EK, Myers TG, De Clercq E, Balzarini J.

J Med Chem. 1998 Mar 26;41(7):1014-26.

PMID:
9544201
48.

In vitro antifungal activity of some Mannich bases of conjugated styryl ketones.

Manavathu EK, Vashishtha SC, Alangaden GJ, Dimmock JR.

Can J Microbiol. 1998 Jan;44(1):74-9.

PMID:
9522452
49.

Antifungal activity of conjugated styryl ketones.

Manavathu EK, McDonald LA, Gunasekaran S, Gunasekaran M.

Indian J Exp Biol. 1997 Apr;35(4):361-5.

PMID:
9315235
50.

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