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Lack of multidrug-resistance associated protein 4 prolongs partial hepatectomy-induced hepatic steatosis.

Donepudi AC, Smith GJ, Aladelokun O, Lee Y, Toro SJ, Pfohl M, Slitt AL, Wang L, Lee JY, Schuetz JD, Manautou JE.

Toxicol Sci. 2020 Mar 6. pii: kfaa032. doi: 10.1093/toxsci/kfaa032. [Epub ahead of print]


Acetaminophen-induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-dependent Manner in Mouse Liver.

Bao Y, Wang P, Shao X, Zhu J, Xiao J, Shi J, Zhang L, Zhu HJ, Ma X, Manautou JE, Zhong XB.

Drug Metab Dispos. 2020 Feb 24. pii: dmd.119.089557. doi: 10.1124/dmd.119.089557. [Epub ahead of print]


Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver.

Chen L, Wang P, Bahal R, Manautou JE, Zhong XB.

PLoS One. 2019 Dec 31;14(12):e0227102. doi: 10.1371/journal.pone.0227102. eCollection 2019.


Acute acetaminophen intoxication induces direct neurotoxicity in rats manifested as astrogliosis and decreased dopaminergic markers in brain areas associated with locomotor regulation.

Vigo MB, Pérez MJ, De Fino F, Gómez G, Martínez SA, Bisagno V, Di Carlo MB, Scazziota A, Manautou JE, Ghanem CI.

Biochem Pharmacol. 2019 Dec;170:113662. doi: 10.1016/j.bcp.2019.113662. Epub 2019 Oct 10.


Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.

Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE.

Drug Metab Dispos. 2019 Oct;47(10):1080-1092. doi: 10.1124/dmd.119.086603. Epub 2019 Aug 9.


Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2.

Chen L, Manautou JE, Rasmussen TP, Zhong XB.

Acta Pharm Sin B. 2019 Jul;9(4):659-674. doi: 10.1016/j.apsb.2019.01.007. Epub 2019 Jan 15. Review.


Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics.

Ghanem CI, Manautou JE.

Curr Med Chem. 2019;26(7):1185-1223. doi: 10.2174/0929867325666180221142315. Review.


Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus.

Flores K, Manautou JE, Renfro JL.

Toxicology. 2017 Jul 1;386:84-92. doi: 10.1016/j.tox.2017.05.019. Epub 2017 Jun 3.


From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective.

Rudraiah S, Manautou JE.

Version 2. F1000Res. 2016 Jul 14 [revised 2016 Jan 1];5. pii: F1000 Faculty Rev-1698. doi: 10.12688/f1000research.8609.2. eCollection 2016. Review.


Acetaminophen Attenuates House Dust Mite-Induced Allergic Airway Disease in Mice.

Smith GJ, Thrall RS, Cloutier MM, Manautou JE, Morris JB.

J Pharmacol Exp Ther. 2016 Sep;358(3):569-79. doi: 10.1124/jpet.116.233684. Epub 2016 Jul 11.


The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).

Rigalli JP, Perdomo VG, Ciriaci N, Francés DE, Ronco MT, Bataille AM, Ghanem CI, Ruiz ML, Manautou JE, Catania VA.

Toxicol Appl Pharmacol. 2016 Aug 1;304:90-8. doi: 10.1016/j.taap.2016.05.007. Epub 2016 May 12.


Reduced in vivo toxicity of doxorubicin by encapsulation in cholesterol-containing self-assembled nanoparticles.

Gonzalez-Fajardo L, Mahajan LH, Ndaya D, Hargrove D, Manautou JE, Liang BT, Chen MH, Kasi RM, Lu X.

Pharmacol Res. 2016 May;107:93-101. doi: 10.1016/j.phrs.2016.03.006. Epub 2016 Mar 11.


Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.

Ghanem CI, Pérez MJ, Manautou JE, Mottino AD.

Pharmacol Res. 2016 Jul;109:119-31. doi: 10.1016/j.phrs.2016.02.020. Epub 2016 Feb 26. Review.


Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity.

Scialis RJ, Manautou JE.

J Pharmacol Exp Ther. 2016 Apr;357(1):167-76. doi: 10.1124/jpet.115.230755. Epub 2016 Feb 11.


Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.

Ferreira DW, Goedken MJ, Rommelaere S, Chasson L, Galland F, Naquet P, Manautou JE.

Biochim Biophys Acta. 2016 Apr;1862(4):662-669. doi: 10.1016/j.bbadis.2016.02.001. Epub 2016 Feb 2.


Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet.

Li J, Sapper TN, Mah E, Rudraiah S, Schill KE, Chitchumroonchokchai C, Moller MV, McDonald JD, Rohrer PR, Manautou JE, Bruno RS.

Mol Nutr Food Res. 2016 Apr;60(4):858-70. doi: 10.1002/mnfr.201500814. Epub 2016 Feb 18.


Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells.

Rudraiah S, Gu X, Hines RN, Manautou JE.

Toxicol In Vitro. 2016 Mar;31:54-9. doi: 10.1016/j.tiv.2015.11.016. Epub 2015 Nov 23.


Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions.

Ferreira DW, Naquet P, Manautou JE.

Curr Med Chem. 2015;22(20):2407-16. Review.


Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.

Smith GJ, Cichocki JA, Doughty BJ, Manautou JE, Jordt SE, Morris JB.

Environ Health Perspect. 2016 May;124(5):642-50. doi: 10.1289/ehp.1509851. Epub 2015 Oct 9.


Antioxidant fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. induce nuclear translocation of Nrf2 in HC-04 cells.

Njayou FN, Amougou AM, Fouemene Tsayem R, Njikam Manjia J, Rudraiah S, Bradley B, Manautou JE, Fewou Moundipa P.

Cell Stress Chaperones. 2015 Nov;20(6):991-1000. doi: 10.1007/s12192-015-0628-6. Epub 2015 Aug 14.


Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.

Scialis RJ, Csanaky IL, Goedken MJ, Manautou JE.

Drug Metab Dispos. 2015 Jul;43(7):944-50. doi: 10.1124/dmd.114.061705. Epub 2015 Apr 20.


Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.

Canet MJ, Merrell MD, Hardwick RN, Bataille AM, Campion SN, Ferreira DW, Xanthakos SA, Manautou JE, A-Kader HH, Erickson RP, Cherrington NJ.

Drug Metab Dispos. 2015 Jun;43(6):829-35. doi: 10.1124/dmd.114.062703. Epub 2015 Mar 18.


Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice.

Ghanem CI, Rudraiah S, Bataille AM, Vigo MB, Goedken MJ, Manautou JE.

Biochem Pharmacol. 2015 Apr 1;94(3):203-11. doi: 10.1016/j.bcp.2015.01.013. Epub 2015 Feb 7.


Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice.

Rudraiah S, Moscovitz JE, Donepudi AC, Campion SN, Slitt AL, Aleksunes LM, Manautou JE.

Toxicology. 2014 Nov 5;325:85-95. doi: 10.1016/j.tox.2014.08.013. Epub 2014 Sep 2.


Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?

Rohrer PR, Rudraiah S, Goedken MJ, Manautou JE.

Drug Metab Dispos. 2014 Oct;42(10):1663-74. doi: 10.1124/dmd.114.059006. Epub 2014 Aug 4.


Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.

Rudraiah S, Rohrer PR, Gurevich I, Goedken MJ, Rasmussen T, Hines RN, Manautou JE.

Toxicol Sci. 2014 Sep;141(1):263-77. doi: 10.1093/toxsci/kfu124. Epub 2014 Jun 27.


Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.

Wen X, Buckley B, McCandlish E, Goedken MJ, Syed S, Pelis R, Manautou JE, Aleksunes LM.

Am J Pathol. 2014 May;184(5):1299-308. doi: 10.1016/j.ajpath.2014.01.025. Epub 2014 Mar 15.


Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection).

O'Connor MA, Koza-Taylor P, Campion SN, Aleksunes LM, Gu X, Enayetallah AE, Lawton MP, Manautou JE.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):156-67. doi: 10.1016/j.taap.2013.09.025. Epub 2013 Oct 11.


Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate.

Masterjohn C, Mah E, Park Y, Pei R, Lee J, Manautou JE, Bruno RS.

Exp Biol Med (Maywood). 2013 Apr;238(4):360-9. doi: 10.1177/1535370213477987.


Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.

Hardwick RN, Ferreira DW, More VR, Lake AD, Lu Z, Manautou JE, Slitt AL, Cherrington NJ.

Drug Metab Dispos. 2013 Mar;41(3):554-61. doi: 10.1124/dmd.112.048439. Epub 2012 Dec 7.


Nrf2: a potential target for new therapeutics in liver disease.

Bataille AM, Manautou JE.

Clin Pharmacol Ther. 2012 Sep;92(3):340-8. doi: 10.1038/clpt.2012.110. Epub 2012 Aug 8. Review.


Molecular mechanisms underlying chemical liver injury.

Gu X, Manautou JE.

Expert Rev Mol Med. 2012 Feb 3;14:e4. doi: 10.1017/S1462399411002110. Review.


Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes.

Chung MY, Park HJ, Manautou JE, Koo SI, Bruno RS.

J Nutr Biochem. 2012 Apr;23(4):361-7. doi: 10.1016/j.jnutbio.2011.01.001. Epub 2011 May 2.


Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.

Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL.

J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):320-9. doi: 10.1002/jbt.20392. Epub 2011 May 2.


Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice.

Park HJ, DiNatale DA, Chung MY, Park YK, Lee JY, Koo SI, O'Connor M, Manautou JE, Bruno RS.

J Nutr Biochem. 2011 Apr;22(4):393-400. doi: 10.1016/j.jnutbio.2010.03.009. Epub 2010 Jul 23.


Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD.

J Pharmacol Exp Ther. 2010 Oct;335(1):2-12. doi: 10.1124/jpet.110.170084. Epub 2010 Jul 6.


Regulation of hepatic ABCC transporters by xenobiotics and in disease states.

Gu X, Manautou JE.

Drug Metab Rev. 2010 Aug;42(3):482-538. doi: 10.3109/03602531003654915. Review.


Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function.

Campion SN, Tatis-Rios C, Augustine LM, Goedken MJ, van Rooijen N, Cherrington NJ, Manautou JE.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):49-58. doi: 10.1016/j.taap.2009.01.007. Epub 2009 Jan 24.


Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

Maher JM, Aleksunes LM, Dieter MZ, Tanaka Y, Peters JM, Manautou JE, Klaassen CD.

Toxicol Sci. 2008 Dec;106(2):319-28. doi: 10.1093/toxsci/kfn177. Epub 2008 Aug 29.


Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment.

Aleksunes LM, Augustine LM, Scheffer GL, Cherrington NJ, Manautou JE.

Toxicology. 2008 Sep 4;250(2-3):82-8. doi: 10.1016/j.tox.2008.06.009. Epub 2008 Jul 2.


Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.

Tanaka Y, Aleksunes LM, Goedken MJ, Chen C, Reisman SA, Manautou JE, Klaassen CD.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):364-73. doi: 10.1016/j.taap.2008.05.022. Epub 2008 Jul 9.


Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.

Campion SN, Johnson R, Aleksunes LM, Goedken MJ, van Rooijen N, Scheffer GL, Cherrington NJ, Manautou JE.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G294-304. doi: 10.1152/ajpgi.00541.2007. Epub 2008 Jun 12.


Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes.

Aleksunes LM, Campion SN, Goedken MJ, Manautou JE.

Toxicol Sci. 2008 Aug;104(2):261-73. doi: 10.1093/toxsci/kfn093. Epub 2008 May 8.


Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.

Cheng Q, Aleksunes LM, Manautou JE, Cherrington NJ, Scheffer GL, Yamasaki H, Slitt AL.

Mol Pharm. 2008 Jan-Feb;5(1):77-91. doi: 10.1021/mp700114j. Epub 2008 Jan 12.


Renal and hepatic transporter expression in type 2 diabetic rats.

Nowicki MT, Aleksunes LM, Sawant SP, Dnyanmote AV, Mehendale HM, Manautou JE.

Drug Metab Lett. 2008 Jan;2(1):11-7.


Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.

Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE.

Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83. Epub 2007 Aug 31.


Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity.

Aleksunes LM, Augustine LM, Cherrington NJ, Manautou JE.

J Toxicol Environ Health A. 2007 Nov;70(21):1870-2.


Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.

Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD.

Hepatology. 2007 Nov;46(5):1597-610.


Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease.

Lickteig AJ, Fisher CD, Augustine LM, Aleksunes LM, Besselsen DG, Slitt AL, Manautou JE, Cherrington NJ.

Drug Metab Dispos. 2007 Oct;35(10):1970-8. Epub 2007 Jul 19.


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