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Emerging Activators and Regulators of Inflammasomes and Pyroptosis.

Xue Y, Enosi Tuipulotu D, Tan WH, Kay C, Man SM.

Trends Immunol. 2019 Nov;40(11):1035-1052. doi: 10.1016/ Epub 2019 Oct 29. Review.


DDX3X: stressing the NLRP3 inflammasome.

Fox D, Man SM.

Cell Res. 2019 Dec;29(12):969-970. doi: 10.1038/s41422-019-0250-8. No abstract available.


Use of Pseudocereals Preferment Made with Aromatic Yeast Strains for Enhancing Wheat Bread Quality.

Păucean A, Man SM, Chiş MS, Mureşan V, Pop CR, Socaci SA, Mureşan CC, Muste S.

Foods. 2019 Sep 26;8(10). pii: E443. doi: 10.3390/foods8100443.


Inflammasomes in Colitis and Colorectal Cancer: Mechanism of Action and Therapies.

Pandey A, Shen C, Man SM.

Yale J Biol Med. 2019 Sep 20;92(3):481-498. eCollection 2019 Sep. Review.


IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases.

Wooff Y, Man SM, Aggio-Bruce R, Natoli R, Fernando N.

Front Immunol. 2019 Jul 16;10:1618. doi: 10.3389/fimmu.2019.01618. eCollection 2019. Review.


A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome.

Mathur A, Feng S, Hayward JA, Ngo C, Fox D, Atmosukarto II, Price JD, Schauer K, Märtlbauer E, Robertson AAB, Burgio G, Fox EM, Leppla SH, Kaakoush NO, Man SM.

Nat Microbiol. 2019 Feb;4(2):362-374. doi: 10.1038/s41564-018-0318-0. Epub 2018 Dec 10.


The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.


ALPK1: innate attraction to the sweetness of bacteria.

Xue Y, Man SM.

Cell Res. 2018 Dec;28(12):1125-1126. doi: 10.1038/s41422-018-0100-0. No abstract available.


Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action.

Hayward JA, Mathur A, Ngo C, Man SM.

Microbiol Mol Biol Rev. 2018 Sep 12;82(4). pii: e00015-18. doi: 10.1128/MMBR.00015-18. Print 2018 Dec. Review.


Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis.

Man SM.

Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):721-737. doi: 10.1038/s41575-018-0054-1. Review.


Folic acid, minerals, amino-acids, fatty acids and volatile compounds of green and red lentils. Folic acid content optimization in wheat-lentils composite flours.

Paucean A, Moldovan OP, Mureșan V, Socaci SA, Dulf FV, Alexa E, Man SM, Mureșan AE, Muste S.

Chem Cent J. 2018 Aug 4;12(1):88. doi: 10.1186/s13065-018-0456-8.


Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.

Feng S, Fox D, Man SM.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3068-3080. doi: 10.1016/j.jmb.2018.07.002. Epub 2018 Jul 7. Review.


Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.

Zhu Q, Man SM, Karki R, Malireddi RKS, Kanneganti TD.

Cell Rep. 2018 Mar 20;22(12):3168-3174. doi: 10.1016/j.celrep.2018.02.096.


Stable pH responsive layer-by-layer assemblies of partially hydrolysed poly(2-ethyl-2-oxazoline) and poly(acrylic acid) for effective prevention of protein, cell and bacteria surface attachment.

He T, Jańczewski D, Guo S, Man SM, Jiang S, Tan WS.

Colloids Surf B Biointerfaces. 2018 Jan 1;161:269-278. doi: 10.1016/j.colsurfb.2017.10.031. Epub 2017 Oct 12.


Mechanisms and functions of guanylate-binding proteins and related interferon-inducible GTPases: Roles in intracellular lysis of pathogens.

Ngo CC, Man SM.

Cell Microbiol. 2017 Dec;19(12). doi: 10.1111/cmi.12791. Epub 2017 Oct 19. Review.


Molecular mechanisms of inflammasome signaling.

Mathur A, Hayward JA, Man SM.

J Leukoc Biol. 2018 Feb;103(2):233-257. doi: 10.1189/jlb.3MR0617-250R. Epub 2017 Dec 29. Review.


NLRP9b: a novel RNA-sensing inflammasome complex.

Ngo C, Man SM.

Cell Res. 2017 Nov;27(11):1302-1303. doi: 10.1038/cr.2017.93. Epub 2017 Jul 21.


Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.

Man SM, Karki R, Kanneganti TD.

Immunol Rev. 2017 May;277(1):61-75. doi: 10.1111/imr.12534. Review.


Differential roles of caspase-1 and caspase-11 in infection and inflammation.

Man SM, Karki R, Briard B, Burton A, Gingras S, Pelletier S, Kanneganti TD.

Sci Rep. 2017 Mar 27;7:45126. doi: 10.1038/srep45126.


Inflammasomes and Cancer.

Karki R, Man SM, Kanneganti TD.

Cancer Immunol Res. 2017 Feb;5(2):94-99. doi: 10.1158/2326-6066.CIR-16-0269. Epub 2017 Jan 16. Review.


NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.

Karki R, Man SM, Malireddi RKS, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD.

Nature. 2016 Dec 22;540(7634):583-587. doi: 10.1038/nature20597. Epub 2016 Dec 12.


ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

Kuriakose T, Man SM, Malireddi RK, Karki R, Kesavardhana S, Place DE, Neale G, Vogel P, Kanneganti TD.

Sci Immunol. 2016 Aug 5;1(2). pii: aag2045. Epub 2016 Aug 12.


Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B.

Man SM, Kanneganti TD.

Autophagy. 2016 Dec;12(12):2504-2505. Epub 2016 Oct 27.


IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD.

Cell. 2016 Oct 6;167(2):382-396.e17. doi: 10.1016/j.cell.2016.09.012. Epub 2016 Sep 29.


Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.

Qi X, Man SM, Malireddi RK, Karki R, Lupfer C, Gurung P, Neale G, Guy CS, Lamkanfi M, Kanneganti TD.

J Exp Med. 2016 Sep 19;213(10):2081-97. doi: 10.1084/jem.20151938. Epub 2016 Aug 22.


Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation.

Man SM, Place DE, Kuriakose T, Kanneganti TD.

J Leukoc Biol. 2017 Jan;101(1):143-150. doi: 10.1189/jlb.4MR0516-223R. Epub 2016 Jul 14. Review.


DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.

Liu Z, Man SM, Zhu Q, Vogel P, Frase S, Fukui Y, Kanneganti TD.

Sci Rep. 2016 Jun 13;6:27814. doi: 10.1038/srep27814.


DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.

Man SM, Karki R, Kanneganti TD.

Pathog Dis. 2016 Jun;74(4):ftw028. doi: 10.1093/femspd/ftw028. Epub 2016 Apr 6. Review.


Type I Interferon Keeps IL-1β in Check.

Man SM, Kanneganti TD.

Cell Host Microbe. 2016 Mar 9;19(3):272-4. doi: 10.1016/j.chom.2016.02.015.


ASPECTS discrepancies between CT and MR imaging: analysis and implications for triage protocols in acute ischemic stroke.

Hui FK, Obuchowski NA, John S, Toth G, Katzan I, Wisco D, Cheng-Ching E, Uchino K, Man SM, Hussain S.

J Neurointerv Surg. 2017 Mar;9(3):240-243. doi: 10.1136/neurintsurg-2015-012188. Epub 2016 Feb 17.


Converging roles of caspases in inflammasome activation, cell death and innate immunity.

Man SM, Kanneganti TD.

Nat Rev Immunol. 2016 Jan;16(1):7-21. doi: 10.1038/nri.2015.7. Epub 2015 Dec 14. Review.


AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity.

Man SM, Karki R, Kanneganti TD.

Eur J Immunol. 2016 Feb;46(2):269-80. doi: 10.1002/eji.201545839. Epub 2015 Dec 28. Review.


Gasdermin D: the long-awaited executioner of pyroptosis.

Man SM, Kanneganti TD.

Cell Res. 2015 Nov;25(11):1183-4. doi: 10.1038/cr.2015.124. Epub 2015 Oct 20.


Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

Man SM, Zhu Q, Zhu L, Liu Z, Karki R, Malik A, Sharma D, Li L, Malireddi RK, Gurung P, Neale G, Olsen SR, Carter RA, McGoldrick DJ, Wu G, Finkelstein D, Vogel P, Gilbertson RJ, Kanneganti TD.

Cell. 2015 Jul 2;162(1):45-58. doi: 10.1016/j.cell.2015.06.001. Epub 2015 Jun 18.


Global Epidemiology of Campylobacter Infection.

Kaakoush NO, Castaño-Rodríguez N, Mitchell HM, Man SM.

Clin Microbiol Rev. 2015 Jul;28(3):687-720. doi: 10.1128/CMR.00006-15. Review.


A20 is a regulator of necroptosis.

Gurung P, Man SM, Kanneganti TD.

Nat Immunol. 2015 Jun;16(6):596-7. doi: 10.1038/ni.3174. No abstract available.


Is Campylobacter to esophageal adenocarcinoma as Helicobacter is to gastric adenocarcinoma?

Kaakoush NO, Castaño-Rodríguez N, Man SM, Mitchell HM.

Trends Microbiol. 2015 Aug;23(8):455-62. doi: 10.1016/j.tim.2015.03.009. Epub 2015 Apr 27. Review.


Regulation of inflammasome activation.

Man SM, Kanneganti TD.

Immunol Rev. 2015 May;265(1):6-21. doi: 10.1111/imr.12296. Review.


The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M, Kanneganti TD.

Nat Immunol. 2015 May;16(5):467-75. doi: 10.1038/ni.3118. Epub 2015 Mar 16.


Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection.

Karki R, Man SM, Malireddi RKS, Gurung P, Vogel P, Lamkanfi M, Kanneganti TD.

Cell Host Microbe. 2015 Mar 11;17(3):357-368. doi: 10.1016/j.chom.2015.01.006. Epub 2015 Feb 19.


Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus.

Kaakoush NO, Deshpande NP, Man SM, Burgos-Portugal JA, Khattak FA, Raftery MJ, Wilkins MR, Mitchell HM.

Infect Immun. 2015 Feb;83(2):832-45. doi: 10.1128/IAI.03012-14. Epub 2014 Dec 8.


Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.

Man SM, Ekpenyong A, Tourlomousis P, Achouri S, Cammarota E, Hughes K, Rizzo A, Ng G, Wright JA, Cicuta P, Guck JR, Bryant CE.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17588-93. doi: 10.1073/pnas.1419925111. Epub 2014 Nov 24.


Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.

Zhu Q, Man SM, Gurung P, Liu Z, Vogel P, Lamkanfi M, Kanneganti TD.

J Immunol. 2014 Nov 15;193(10):4779-82. doi: 10.4049/jimmunol.1402051. Epub 2014 Oct 15.


Role of emerging Campylobacter species in inflammatory bowel diseases.

Kaakoush NO, Mitchell HM, Man SM.

Inflamm Bowel Dis. 2014 Nov;20(11):2189-97. doi: 10.1097/MIB.0000000000000074. Review.


Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

Man SM, Hopkins LJ, Nugent E, Cox S, Glück IM, Tourlomousis P, Wright JA, Cicuta P, Monie TP, Bryant CE.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7403-8. doi: 10.1073/pnas.1402911111. Epub 2014 May 6.


Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.

Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):385-90. doi: 10.1073/pnas.1317643111. Epub 2013 Dec 17.


Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production.

Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE.

J Immunol. 2013 Nov 15;191(10):5239-46. doi: 10.4049/jimmunol.1301581. Epub 2013 Oct 11.


Functional relationship between Campylobacter concisus and the stomach ecosystem in health and disease.

Kaakoush NO, Man SM, Mitchell HM.

ISME J. 2013 Dec;7(12):2245-7. doi: 10.1038/ismej.2013.115. Epub 2013 Jul 4. No abstract available.


Individually addressable patterned multilayer microchambers for site-specific release-on-demand.

Kiryukhin MV, Gorelik SR, Man SM, Subramanian GS, Antipina MN, Low HY, Sukhorukov GB.

Macromol Rapid Commun. 2013 Jan 11;34(1):87-93. doi: 10.1002/marc.201200564. Epub 2012 Nov 6.


Bacterial infection of macrophages induces decrease in refractive index.

Ekpenyong AE, Man SM, Achouri S, Bryant CE, Guck J, Chalut KJ.

J Biophotonics. 2013 May;6(5):393-7. doi: 10.1002/jbio.201200113. Epub 2012 Aug 6.


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