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The pharmacogenomics of inhaled corticosteroids and lung function decline in COPD.

Obeidat M, Faiz A, Li X, van den Berge M, Hansel NN, Joubert P, Hao K, Brandsma CA, Rafaels N, Mathias R, Ruczinski I, Beaty TH, Barnes KC, Man SFP, Paré PD, Sin DD.

Eur Respir J. 2019 Dec 4;54(6). pii: 1900521. doi: 10.1183/13993003.00521-2019. Print 2019 Dec.


Sputum Microbiome Is Associated with 1-Year Mortality after Chronic Obstructive Pulmonary Disease Hospitalizations.

Leitao Filho FS, Alotaibi NM, Ngan D, Tam S, Yang J, Hollander Z, Chen V, FitzGerald JM, Nislow C, Leung JM, Man SFP, Sin DD.

Am J Respir Crit Care Med. 2019 May 15;199(10):1205-1213. doi: 10.1164/rccm.201806-1135OC.


Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD.

Jin M, Lee EC, Ra SW, Fishbane N, Tam S, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Aaron SD, Reed RM, Man SFP, Leung JM, Sin DD.

Chest. 2018 Aug;154(2):266-273. doi: 10.1016/j.chest.2018.05.022. Epub 2018 Jul 12.


Mortality among people living with HIV/AIDS with non-small-cell lung cancer in the modern HAART Era.

Smith DM, Salters KA, Eyawo O, Franco-Villalobos C, Jabbari S, Wiseman SM, Press N, Montaner JSG, Man SFP, Hull M, Hogg RS.

AIDS Care. 2018 Jul;30(7):936-942. doi: 10.1080/09540121.2018.1434120. Epub 2018 Feb 7.


Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori.

Ra SW, Sze MA, Lee EC, Tam S, Oh Y, Fishbane N, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Aaron SD, Reed RM, Man SFP, Sin DD; Canadian Respiratory Research Network.

Respir Res. 2017 May 30;18(1):109. doi: 10.1186/s12931-017-0594-x.


Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease.

Leitao Filho FS, Won Ra S, Mattman A, Schellenberg RS, Fishbane N, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Man SFP, Aaron SD, Reed RM, Sin DD.

J Allergy Clin Immunol. 2017 Oct;140(4):1164-1167.e6. doi: 10.1016/j.jaci.2017.01.046. Epub 2017 Apr 27. No abstract available.


Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion.

Leung JM, Fishbane N, Jones M, Morin A, Xu S, Liu JC, MacIsaac J, Milloy MJ, Hayashi K, Montaner J, Horvath S, Kobor M, Sin DD, Harrigan PR, Man SF.

Aging (Albany NY). 2017 Feb 23;9(3):687-705. doi: 10.18632/aging.101184.


Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection.

Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G.

PLoS One. 2016 Nov 30;11(11):e0167247. doi: 10.1371/journal.pone.0167247. eCollection 2016.


The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus.

Sze MA, Xu S, Leung JM, Vucic EA, Shaipanich T, Moghadam A, Harris M, Guillemi S, Sinha S, Nislow C, Murphy D, Hague C, Leipsic J, Lam S, Lam W, Montaner JS, Sin DD, Man SF.

BMC Pulm Med. 2016 Nov 9;16(1):142.


Sex-Related Differences in Pulmonary Function following 6 Months of Cigarette Exposure: Implications for Sexual Dimorphism in Mild COPD.

Tam A, Bates JH, Churg A, Wright JL, Man SF, Sin DD.

PLoS One. 2016 Oct 27;11(10):e0164835. doi: 10.1371/journal.pone.0164835. eCollection 2016.


Individualized prediction of lung-function decline in chronic obstructive pulmonary disease.

Zafari Z, Sin DD, Postma DS, Löfdahl CG, Vonk J, Bryan S, Lam S, Tammemagi CM, Khakban R, Man SFP, Tashkin D, Wise RA, Connett JE, McManus B, Ng R, Hollander Z, Sadatsafavi M.

CMAJ. 2016 Oct 4;188(14):1004-1011. doi: 10.1503/cmaj.151483. Epub 2016 Aug 2.


Lung exposure to lipopolysaccharide causes atherosclerotic plaque destabilisation.

Jaw JE, Tsuruta M, Oh Y, Schipilow J, Hirano Y, Ngan DA, Suda K, Li Y, Oh JY, Moritani K, Tam S, Ford N, van Eeden S, Wright JL, Man SF, Sin DD.

Eur Respir J. 2016 Jul;48(1):205-15. doi: 10.1183/13993003.00972-2015. Epub 2016 Mar 23.


Associations of interleukin-1 gene cluster polymorphisms with C-reactive protein concentration and lung function decline in smoking-induced chronic obstructive pulmonary disease.

Wang Y, Shumansky K, Sin DD, Man SF, Akhabir L, Connett JE, Anthonisen NR, Paré PD, Sandford AJ, He JQ.

Int J Clin Exp Pathol. 2015 Oct 1;8(10):13125-35. eCollection 2015.


Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease.

Tam A, Churg A, Wright JL, Zhou S, Kirby M, Coxson HO, Lam S, Man SF, Sin DD.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):825-34. doi: 10.1164/rccm.201503-0487OC.


Independent association of subclinical coronary artery disease and emphysema in HIV-infected patients.

Besutti G, Raggi P, Zona S, Scaglioni R, Santoro A, Orlando G, Ligabue G, Leipsic J, Sin DD, Man SF, Guaraldi G.

HIV Med. 2016 Mar;17(3):178-87. doi: 10.1111/hiv.12289. Epub 2015 Aug 13.


The relationship between Helicobacter pylori seropositivity and COPD.

Sze MA, Chen YW, Tam S, Tashkin D, Wise RA, Connett JE, Man SP, Sin DD.

Thorax. 2015 Oct;70(10):923-9. doi: 10.1136/thoraxjnl-2015-207059. Epub 2015 May 29.


Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease.

Liu JC, Leung JM, Ngan DA, Nashta NF, Guillemi S, Harris M, Lima VD, Um SJ, Li Y, Tam S, Shaipanich T, Raju R, Hague C, Leipsic JA, Bourbeau J, Tan WC, Harrigan PR, Sin DD, Montaner J, Man SF.

PLoS One. 2015 Apr 17;10(4):e0124426. doi: 10.1371/journal.pone.0124426. eCollection 2015.


Discovery of novel plasma protein biomarkers to predict imminent cystic fibrosis pulmonary exacerbations using multiple reaction monitoring mass spectrometry.

Quon BS, Dai DL, Hollander Z, Ng RT, Tebbutt SJ, Man SF, Wilcox PG, Sin DD.

Thorax. 2016 Mar;71(3):216-22. doi: 10.1136/thoraxjnl-2014-206710. Epub 2015 Mar 16.


Serum Bilirubin and Disease Progression in Mild COPD.

Apperley S, Park HY, Holmes DT, Man SFP, Tashkin D, Wise RA, Connett JE, Sin DD.

Chest. 2015 Jul;148(1):169-175. doi: 10.1378/chest.14-2150.


A sum greater than its parts.

Leung JM, Man SF.

Eur Respir J. 2014 Dec;44(6):1394-6. doi: 10.1183/09031936.00126514. No abstract available.


The burden of image based emphysema and bronchiolitis in HIV-infected individuals on antiretroviral therapy.

Guaraldi G, Besutti G, Scaglioni R, Santoro A, Zona S, Guido L, Marchioni A, Orlando G, Carli F, Beghe B, Fabbri L, Leipsic J, Sin DD, Man SF.

PLoS One. 2014 Oct 29;9(10):e109027. doi: 10.1371/journal.pone.0109027. eCollection 2014.


Changes in the bacterial microbiota in gut, blood, and lungs following acute LPS instillation into mice lungs.

Sze MA, Tsuruta M, Yang SW, Oh Y, Man SF, Hogg JC, Sin DD.

PLoS One. 2014 Oct 21;9(10):e111228. doi: 10.1371/journal.pone.0111228. eCollection 2014.


Estradiol increases mucus synthesis in bronchial epithelial cells.

Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD.

PLoS One. 2014 Jun 25;9(6):e100633. doi: 10.1371/journal.pone.0100633. eCollection 2014.


The determinants of poor respiratory health status in adults living with human immunodeficiency virus infection.

Leung JM, Liu JC, Mtambo A, Ngan D, Nashta N, Guillemi S, Harris M, Lima VD, Mattman A, Shaipanich T, Raju R, Hague C, Leipsic JA, Sin DD, Montaner JS, Man SF.

AIDS Patient Care STDS. 2014 May;28(5):240-7. doi: 10.1089/apc.2013.0373. Epub 2014 Apr 17.


Plasma sCD14 as a biomarker to predict pulmonary exacerbations in cystic fibrosis.

Quon BS, Ngan DA, Wilcox PG, Man SF, Sin DD.

PLoS One. 2014 Feb 20;9(2):e89341. doi: 10.1371/journal.pone.0089341. eCollection 2014.


Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients.

Um SJ, Lam S, Coxson H, Man SF, Sin DD.

PLoS One. 2013 Dec 26;8(12):e83881. doi: 10.1371/journal.pone.0083881. eCollection 2013.


Club cell protein 16 and disease progression in chronic obstructive pulmonary disease.

Park HY, Churg A, Wright JL, Li Y, Tam S, Man SF, Tashkin D, Wise RA, Connett JE, Sin DD.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1413-9. doi: 10.1164/rccm.201305-0892OC. Erratum in: Am J Respir Crit Care Med. 2014 Oct 1;190(7):843.


The relation of serum myeloperoxidase to disease progression and mortality in patients with chronic obstructive pulmonary disease (COPD).

Park HY, Man SF, Tashkin D, Wise RA, Connett JE, Anthonisen NA, Sin DD.

PLoS One. 2013 Apr 18;8(4):e61315. doi: 10.1371/journal.pone.0061315. Print 2013.


Reply: beneficial effects of angiotensin receptor blockade in chronic obstructive pulmonary disease.

Sin DD, Van Eeden S, Leipsic J, Man SF.

Am J Respir Crit Care Med. 2013 Feb 1;187(3):328. No abstract available.


Reply to letter from Mirrakhimov and Mirrakhimov.

Sin DD, van Eeden S, Man SF.

Can J Cardiol. 2013 May;29(5):639.e11. doi: 10.1016/j.cjca.2012.11.017. Epub 2013 Feb 11. No abstract available.


Epidemic of lung cancer in patients with HIV infection.

Winstone TA, Man SFP, Hull M, Montaner JS, Sin DD.

Chest. 2013 Feb 1;143(2):305-314. doi: 10.1378/chest.12-1699. Review.


Inhaled corticosteroids for chronic obstructive pulmonary disease.

Park HY, Man SF, Sin DD.

BMJ. 2012 Oct 25;345:e6843. doi: 10.1136/bmj.e6843. No abstract available.


Vascular risk in chronic obstructive pulmonary disease: role of inflammation and other mediators.

Man SF, Van Eeden S, Sin DD.

Can J Cardiol. 2012 Nov-Dec;28(6):653-61. doi: 10.1016/j.cjca.2012.06.013. Epub 2012 Aug 15. Review.


The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD).

Lee J, Sandford AJ, Connett JE, Yan J, Mui T, Li Y, Daley D, Anthonisen NR, Brooks-Wilson A, Man SF, Sin DD.

PLoS One. 2012;7(4):e35567. doi: 10.1371/journal.pone.0035567. Epub 2012 Apr 25.


The complex relationship between ischemic heart disease and COPD exacerbations.

Man JP, Sin DD, Ignaszewski A, Man SFP.

Chest. 2012 Apr;141(4):837-838. doi: 10.1378/chest.11-2483. No abstract available.


The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis.

Ngan DA, Wilcox PG, Aldaabil M, Li Y, Leipsic JA, Sin DD, Man SF.

BMC Pulm Med. 2012 Feb 14;12:3. doi: 10.1186/1471-2466-12-3.


The complex relationship of serum adiponectin to COPD outcomes COPD and adiponectin.

Yoon HI, Li Y, Man SFP, Tashkin D, Wise RA, Connett JE, Anthonisen NA, Churg A, Wright JL, Sin DD.

Chest. 2012 Oct;142(4):893-899. doi: 10.1378/chest.11-2173.


Is atherosclerotic heart disease in COPD a distinct phenotype?

Man SFP, Leipsic JA, Man JP, Sin DD.

Chest. 2011 Sep;140(3):569-571. doi: 10.1378/chest.11-0928. No abstract available.


Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality.

Hill J, Heslop C, Man SF, Frohlich J, Connett JE, Anthonisen NR, Wise RA, Tashkin DP, Sin DD.

Eur Heart J. 2011 Aug;32(15):1918-25. doi: 10.1093/eurheartj/ehr124. Epub 2011 Jun 8.


The role of female hormones on lung function in chronic lung diseases.

Tam A, Morrish D, Wadsworth S, Dorscheid D, Man SF, Sin DD.

BMC Womens Health. 2011 Jun 3;11:24. doi: 10.1186/1472-6874-11-24. Review.


CT in COPD: just a pretty picture or really worth a thousand words (or dollars)?

Sin DD, Leipsic J, Man SF.

Thorax. 2011 Sep;66(9):741-2. doi: 10.1136/thx.2011.161430. Epub 2011 May 14. No abstract available.


Sleep-disordered breathing and heart disease: is it one big, vicious loop?

Man SF, Sin DD.

Circulation. 2011 Mar 29;123(12):1265-6. doi: 10.1161/CIRCULATIONAHA.111.018945. Epub 2011 Mar 14. No abstract available.


The airway epithelium: more than just a structural barrier.

Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD.

Ther Adv Respir Dis. 2011 Aug;5(4):255-73. doi: 10.1177/1753465810396539. Epub 2011 Mar 3. Review.


Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease.

Sin DD, Miller BE, Duvoix A, Man SF, Zhang X, Silverman EK, Connett JE, Anthonisen NA, Wise RA, Tashkin D, Celli BR, Edwards LD, Locantore N, Macnee W, Tal-Singer R, Lomas DA; ECLIPSE Investigators.

Am J Respir Crit Care Med. 2011 May 1;183(9):1187-92. doi: 10.1164/rccm.201008-1220OC. Epub 2011 Jan 7.


Slaying the CVD dragon with steroids.

Sin DD, Van Eeden SF, Man SF.

Eur Respir J. 2010 Sep;36(3):466-8. doi: 10.1183/09031936.00082510. No abstract available.


A curious case of beta-blockers in chronic obstructive pulmonary disease.

Sin DD, Man SF.

Arch Intern Med. 2010 May 24;170(10):849-50. doi: 10.1001/archinternmed.2010.97. No abstract available.


Steroids in COPD: still up in the air?

Sin DD, Man SF.

Eur Respir J. 2010 May;35(5):949-51. doi: 10.1183/09031936.00006710. No abstract available.


Could oral hypoglycemics be the new therapeutic answer to chronic obstructive pulmonary disease?

Man SF, Sin DD.

Int J Tuberc Lung Dis. 2010 Mar;14(3):262. No abstract available.


Telomere length and chronic obstructive pulmonary disease: evidence of accelerated aging.

Mui TS, Man JM, McElhaney JE, Sandford AJ, Coxson HO, Birmingham CL, Li Y, Man SF, Sin DD.

J Am Geriatr Soc. 2009 Dec;57(12):2372-4. doi: 10.1111/j.1532-5415.2009.02589.x. No abstract available.


Thinning bone and inhaled corticosteroid in COPD: what to do until there is definitive proof?

Man SFP, Sin DD.

Chest. 2009 Dec;136(6):1448-1449. doi: 10.1378/chest.09-1787. No abstract available.


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