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Items: 1 to 50 of 147

1.

Triterpenoids from stems of Kadsura heteroclita.

Cao L, Li B, Shehla N, Gong LM, Jian YQ, Peng CY, Sheng WB, Liu LP, Cai X, Man RY, Liao DF, Zhu XQ, Choudhary MI, Rahman AU, Wang W.

Fitoterapia. 2020 Jan;140:104441. doi: 10.1016/j.fitote.2019.104441. Epub 2019 Nov 26.

PMID:
31778760
2.

Flavonoids reduces lipopolysaccharide-induced release of inflammatory mediators in human bronchial epithelial cells: Structure-activity relationship.

Zhang P, Mak JC, Man RY, Leung SW.

Eur J Pharmacol. 2019 Dec 15;865:172731. doi: 10.1016/j.ejphar.2019.172731. Epub 2019 Oct 11.

PMID:
31610186
3.

L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta.

Wong ESW, Man RYK, Ng KFJ, Leung SWS, Vanhoutte PM.

Anesthesiology. 2018 Mar;128(3):564-573. doi: 10.1097/ALN.0000000000002032.

PMID:
29251642
4.

PPAR-α agonists acutely inhibit Ca2+-independent PLA2 to reduce H2O2-induced contractions in aortae of spontaneously hypertensive rats.

Chen H, Man RYK, Leung SWS.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H681-H691. doi: 10.1152/ajpheart.00314.2017. Epub 2017 Nov 10.

5.

Reduced activity of SKC a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats.

Kong BW, Man RY, Gao Y, Vanhoutte PM, Leung SW.

Pharmacol Res Perspect. 2015 Jun;3(3):e00150. doi: 10.1002/prp2.150. Epub 2015 May 20.

6.

17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice.

Kong BW, Vanhoutte PM, Man RY, Leung SW.

Vascul Pharmacol. 2015 Aug;71:166-73. doi: 10.1016/j.vph.2015.02.009. Epub 2015 Apr 11.

PMID:
25869512
7.

Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels.

Xu YC, Leung SW, Leung GP, Man RY.

Br J Pharmacol. 2015 Jun;172(12):3003-14. doi: 10.1111/bph.13108. Epub 2015 Mar 27.

8.

Induction of GADD45α protects M17 neuroblastoma cells against MPP*.

Wang XF, Zeng QG, Zeng Y, Man RY, Lu BX, Luo YF.

IUBMB Life. 2014 Nov;66(11):786-92. doi: 10.1002/iub.1327. Epub 2014 Dec 3.

9.

Upregulation of heme oxygenase-1 potentiates EDH-type relaxations in the mesenteric artery of the spontaneously hypertensive rat.

Li Z, Wang Y, Man RY, Vanhoutte PM.

Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1471-83. doi: 10.1152/ajpheart.00962.2012. Epub 2013 Sep 6.

10.

Differential ligand binding affinities of human estrogen receptor-α isoforms.

Lin AH, Li RW, Ho EY, Leung GP, Leung SW, Vanhoutte PM, Man RY.

PLoS One. 2013 Apr 30;8(4):e63199. doi: 10.1371/journal.pone.0063199. Print 2013.

11.

Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha.

Qu C, Leung SW, Vanhoutte PM, Man RY.

Eur J Pharmacol. 2012 Dec 5;696(1-3):101-10. doi: 10.1016/j.ejphar.2012.09.015. Epub 2012 Sep 26.

PMID:
23022336
12.

Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity.

Chan KH, Chan SC, Yeung SC, Man RY, Ip MS, Mak JC.

Free Radic Res. 2012 Sep;46(9):1123-9. doi: 10.3109/10715762.2012.692786. Epub 2012 Jun 8.

PMID:
22574903
13.

Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries.

Chan CK, Mak J, Gao Y, Man RY, Vanhoutte PM.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2313-21. doi: 10.1152/ajpheart.00258.2011. Epub 2011 Oct 7.

14.

Circulating sex hormones modulate vascular contractions and acute response to 17β-estradiol in rat mesenteric arteries.

Keung W, Man RY.

Pharmacology. 2011;88(1-2):55-64. doi: 10.1159/000329426. Epub 2011 Jul 25.

PMID:
21791946
15.

Non-genomic activation of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery.

Keung W, Chan ML, Ho EY, Vanhoutte PM, Man RY.

Pharmacol Res. 2011 Nov;64(5):509-16. doi: 10.1016/j.phrs.2011.05.010. Epub 2011 May 27.

PMID:
21641998
16.

Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide.

Zheng X, Ying L, Liu J, Dou D, He Q, Leung SW, Man RY, Vanhoutte PM, Gao Y.

Cardiovasc Res. 2011 Jun 1;90(3):565-72. doi: 10.1093/cvr/cvr016. Epub 2011 Jan 19.

PMID:
21248051
18.

Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.

Wong ES, Man RY, Vanhoutte PM, Ng KF.

J Pharmacol Exp Ther. 2010 Dec;335(3):659-64. doi: 10.1124/jpet.110.170688. Epub 2010 Sep 13.

PMID:
20837990
19.

Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.

Wong MS, Delansorne R, Man RY, Svenningsen P, Vanhoutte PM.

Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1226-34. doi: 10.1152/ajpheart.00288.2010. Epub 2010 Aug 6.

20.

Chronic inhibition of nitric-oxide synthase potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2.

Qu C, Leung SW, Vanhoutte PM, Man RY.

J Pharmacol Exp Ther. 2010 Aug;334(2):373-80. doi: 10.1124/jpet.110.167098. Epub 2010 May 5.

PMID:
20444882
21.

Endothelium-derived nitric oxide inhibits the relaxation of the porcine coronary artery to natriuretic peptides by desensitizing big conductance calcium-activated potassium channels of vascular smooth muscle.

Liang CF, Au AL, Leung SW, Ng KF, Félétou M, Kwan YW, Man RY, Vanhoutte PM.

J Pharmacol Exp Ther. 2010 Jul;334(1):223-31. doi: 10.1124/jpet.110.166652. Epub 2010 Mar 23.

PMID:
20332186
22.

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.

Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y.

Circ Res. 2010 Apr 30;106(8):1384-93. doi: 10.1161/CIRCRESAHA.109.215483. Epub 2010 Mar 4.

PMID:
20203304
23.

Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

Wong MS, Man RY, Vanhoutte PM.

Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1260-6. doi: 10.1152/ajpheart.01068.2009. Epub 2010 Jan 29.

24.

Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line.

Man RY, Onodera T, Komatsu E, Tsubata T.

PLoS One. 2010 Jan 21;5(1):e8815. doi: 10.1371/journal.pone.0008815.

25.

Effects of the aqueous extract of Salvia Miltiorrhiza (danshen) and its magnesium tanshinoate B-enriched form on blood pressure.

Leung SW, Zhu DY, Man RY.

Phytother Res. 2010 May;24(5):769-74. doi: 10.1002/ptr.3047.

PMID:
19943333
26.

Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats.

Chan KH, Ho SP, Yeung SC, So WH, Cho CH, Koo MW, Lam WK, Ip MS, Man RY, Mak JC.

Respir Med. 2009 Nov;103(11):1746-54. doi: 10.1016/j.rmed.2009.04.027. Epub 2009 May 31.

27.

Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.

Chan CK, Mak JC, Man RY, Vanhoutte PM.

J Pharmacol Exp Ther. 2009 May;329(2):820-6. doi: 10.1124/jpet.108.148247. Epub 2009 Feb 4.

PMID:
19193928
28.

Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries.

Teoh H, Quan A, Leung SW, Man RY.

Menopause. 2009 Jan-Feb;16(1):104-9. doi: 10.1097/gme.0b013e3181813346.

PMID:
19131845
29.

Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells.

Sy LK, Yan SC, Lok CN, Man RY, Che CM.

Cancer Res. 2008 Dec 15;68(24):10229-37. doi: 10.1158/0008-5472.CAN-08-1983.

30.

Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins.

Ng KF, Leung SW, Man RY, Vanhoutte PM.

Acta Pharmacol Sin. 2008 Dec;29(12):1419-24. doi: 10.1111/j.1745-7254.2008.00905.x.

31.

Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery.

Wan AK, Leung SW, Zhu DY, Man RY.

J Nat Prod. 2008 Nov;71(11):1825-8. doi: 10.1021/np800119k. Epub 2008 Oct 15.

PMID:
18855446
32.

Stimulation of ecto-5'-nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide.

Li RW, Man RY, Vanhoutte PM, Leung GP.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1177-H1181. doi: 10.1152/ajpheart.91513.2007. Epub 2008 Jul 18.

33.

Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat.

Michel FS, Man GS, Man RY, Vanhoutte PM.

Br J Pharmacol. 2008 Sep;155(2):217-26. doi: 10.1038/bjp.2008.256. Epub 2008 Jun 23.

34.

Kaempferol stimulates large conductance Ca2+ -activated K+ (BKCa) channels in human umbilical vein endothelial cells via a cAMP/PKA-dependent pathway.

Xu YC, Leung GP, Wong PY, Vanhoutte PM, Man RY.

Br J Pharmacol. 2008 Jul;154(6):1247-53. doi: 10.1038/bjp.2008.194. Epub 2008 May 19.

35.

Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.

Wong MS, Delansorne R, Man RY, Vanhoutte PM.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H289-96. doi: 10.1152/ajpheart.00116.2008. Epub 2008 May 16.

36.

Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats.

Shi Y, Man RY, Vanhoutte PM.

Acta Pharmacol Sin. 2008 Feb;29(2):185-92. doi: 10.1111/j.1745-7254.2008.00749.x.

37.

Genistein potentiates protein kinase A activity in porcine coronary artery.

Ng WW, Keung W, Xu YC, Ng KF, Leung GP, Vanhoutte PM, Choy PC, Man RY.

Mol Cell Biochem. 2008 Apr;311(1-2):37-44. doi: 10.1007/s11010-007-9691-3. Epub 2007 Dec 30.

PMID:
18165926
38.

The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.

Tang EH, Jensen BL, Skott O, Leung GP, Feletou M, Man RY, Vanhoutte PM.

Cardiovasc Res. 2008 Apr 1;78(1):130-8. Epub 2007 Dec 18.

PMID:
18093985
39.

Genomic changes in regenerated porcine coronary arterial endothelial cells.

Lee MY, Tse HF, Siu CW, Zhu SG, Man RY, Vanhoutte PM.

Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2443-9. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):e13.

PMID:
17942849
40.
41.

Non-genomic vascular actions of female sex hormones: physiological implications and signalling pathways.

Leung SW, Teoh H, Keung W, Man RY.

Clin Exp Pharmacol Physiol. 2007 Aug;34(8):822-6. Review.

PMID:
17600565
42.

Hormones and vascular function: introduction.

Man RY, Leung SW.

Clin Exp Pharmacol Physiol. 2007 Aug;34(8):799-800. No abstract available.

PMID:
17600561
43.

Increased spontaneous tone in renal arteries of spontaneously hypertensive rats.

Michel FS, Man RY, Vanhoutte PM.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1673-81. Epub 2007 Jun 8.

44.

Inhibition of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists.

Li RW, Tse CM, Man RY, Vanhoutte PM, Leung GP.

Eur J Pharmacol. 2007 Jul 30;568(1-3):75-82. Epub 2007 Apr 30.

PMID:
17512522
45.

Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery.

Xu YC, Leung SW, Yeung DK, Hu LH, Chen GH, Che CM, Man RY.

Phytochemistry. 2007 Apr;68(8):1179-88. Epub 2007 Mar 28.

PMID:
17395220
46.

Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor.

Tang EH, Leung FP, Huang Y, Feletou M, So KF, Man RY, Vanhoutte PM.

Br J Pharmacol. 2007 May;151(1):15-23. Epub 2007 Mar 12.

47.

The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes.

Shi Y, Feletou M, Ku DD, Man RY, Vanhoutte PM.

Br J Pharmacol. 2007 Mar;150(5):624-32. Epub 2007 Jan 22.

48.

Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast.

Ho YW, Yeung JS, Chiu PK, Tang WM, Lin ZB, Man RY, Lau CS.

Mol Cell Biochem. 2007 Jul;301(1-2):173-9. Epub 2007 Jan 12.

PMID:
17219061
49.

Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery.

Yeung DK, Leung SW, Xu YC, Vanhoutte PM, Man RY.

Eur J Pharmacol. 2006 Dec 15;552(1-3):105-11. Epub 2006 Sep 14.

PMID:
17027964
50.

Characterization of adenosine transport in H9c2 cardiomyoblasts.

Leung GP, Tse CM, Man RY.

Int J Cardiol. 2007 Mar 20;116(2):186-93. Epub 2006 Jul 5.

PMID:
16824629

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