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Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.

Mammoto T, Torisawa YS, Muyleart M, Hendee K, Anugwom C, Gutterman D, Mammoto A.

Aging (Albany NY). 2019 Sep 5;11(17):7051-7069. doi: 10.18632/aging.102236. Epub 2019 Sep 5.


Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaau5898. doi: 10.1126/scitranslmed.aau5898.


LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung.

Mammoto A, Muyleart M, Mammoto T.

Aging (Albany NY). 2019 Jan 5;11(1):89-103. doi: 10.18632/aging.101722.


Endothelial YAP1 in Regenerative Lung Growth through the Angiopoietin-Tie2 Pathway.

Mammoto T, Muyleart M, Mammoto A.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):117-127. doi: 10.1165/rcmb.2018-0105OC.


YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α.

Mammoto A, Muyleart M, Kadlec A, Gutterman D, Mammoto T.

Microvasc Res. 2018 Sep;119:73-83. doi: 10.1016/j.mvr.2018.04.003. Epub 2018 Apr 20.


Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.

Musah S, Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, Ingber DE.

Nat Biomed Eng. 2017;1. pii: 0069. doi: 10.1038/s41551-017-0069. Epub 2017 May 10.


Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β-Smad Signaling.

Mammoto T, Muyleart M, Konduri GG, Mammoto A.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):194-207. doi: 10.1165/rcmb.2016-0323OC.


Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery.

Papa AL, Korin N, Kanapathipillai M, Mammoto A, Mammoto T, Jiang A, Mannix R, Uzun O, Johnson C, Bhatta D, Cuneo G, Ingber DE.

Biomaterials. 2017 Sep;139:187-194. doi: 10.1016/j.biomaterials.2017.06.003. Epub 2017 Jun 6.


Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail.

Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V, Evans PC.

Sci Rep. 2017 Jun 13;7(1):3375. doi: 10.1038/s41598-017-03532-z.


Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno MA, Louden CS, Hamilton GA, Flaumenhaft R, Ingber DE.

Clin Pharmacol Ther. 2018 Feb;103(2):332-340. doi: 10.1002/cpt.742. Epub 2017 Jul 14.


Role of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis.

Mammoto T, Jiang A, Jiang E, Mammoto A.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):633-644.


TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis.

Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R, Ariaans M, Francis SE, Weinberg PD, van der Heiden K, Jones EA, Chico TJ, Ridger V, Evans PC.

Circ Res. 2016 Jul 22;119(3):450-62. doi: 10.1161/CIRCRESAHA.116.308870. Epub 2016 May 31.


Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip.

Torisawa YS, Mammoto T, Jiang E, Jiang A, Mammoto A, Watters AL, Bahinski A, Ingber DE.

Tissue Eng Part C Methods. 2016 May;22(5):509-15. doi: 10.1089/ten.TEC.2015.0507. Epub 2016 Apr 20.


Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation.

Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ.

Nat Mater. 2015 Dec;14(12):1269-77. doi: 10.1038/nmat4407. Epub 2015 Sep 14.


VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.

Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK.

Biol Open. 2015 Jul 24;4(9):1063-76. doi: 10.1242/bio.010918.


Acceleration of Lung Regeneration by Platelet-Rich Plasma Extract through the Low-Density Lipoprotein Receptor-Related Protein 5-Tie2 Pathway.

Mammoto T, Chen Z, Jiang A, Jiang E, Ingber DE, Mammoto A.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):103-13. doi: 10.1165/rcmb.2015-0045OC.


Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation.

Mammoto T, Mammoto A, Jiang A, Jiang E, Hashmi B, Ingber DE.

Dev Dyn. 2015 Jun;244(6):713-23. doi: 10.1002/dvdy.24264. Epub 2015 Apr 24.


Implantation of fibrin gel on mouse lung to study lung-specific angiogenesis.

Mammoto T, Mammoto A.

J Vis Exp. 2014 Dec 21;(94). doi: 10.3791/52012.


Endothelial TWIST1 promotes pathological ocular angiogenesis.

Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J.

Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8267-77. doi: 10.1167/iovs.14-15623.


An extracorporeal blood-cleansing device for sepsis therapy.

Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ, Watters AL, Rottman M, Waterhouse A, Mammoto A, Gamini N, Rodas MJ, Kole A, Jiang A, Valentin TM, Diaz A, Takahashi K, Ingber DE.

Nat Med. 2014 Oct;20(10):1211-6. doi: 10.1038/nm.3640. Epub 2014 Sep 14.


Platelet-rich plasma extract prevents pulmonary edema through angiopoietin-Tie2 signaling.

Mammoto T, Jiang A, Jiang E, Mammoto A.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):56-64. doi: 10.1165/rcmb.2014-0076OC.


RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity.

Kawasaki J, Aegerter S, Fevurly RD, Mammoto A, Mammoto T, Sahin M, Mably JD, Fishman SJ, Chan J.

J Clin Invest. 2014 Jun;124(6):2774-84. doi: 10.1172/JCI67084. Epub 2014 May 16.


Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma.

Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, Klagsbrun M, Smith E.

Cancer Res. 2014 Jul 15;74(14):3716-26. doi: 10.1158/0008-5472.CAN-13-3116. Epub 2014 May 8.


Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.

Torisawa YS, Spina CS, Mammoto T, Mammoto A, Weaver JC, Tat T, Collins JJ, Ingber DE.

Nat Methods. 2014 Jun;11(6):663-9. doi: 10.1038/nmeth.2938. Epub 2014 May 4.


Mechanotransduction of fluid stresses governs 3D cell migration.

Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2447-52. doi: 10.1073/pnas.1316848111. Epub 2014 Feb 3.


Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.

Hashmi B, Zarzar LD, Mammoto T, Mammoto A, Jiang A, Aizenberg J, Ingber DE.

Adv Mater. 2014 May 28;26(20):3253-7. doi: 10.1002/adma.201304995. Epub 2014 Feb 18.


Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.

German AE, Mammoto T, Jiang E, Ingber DE, Mammoto A.

J Cell Sci. 2014 Apr 15;127(Pt 8):1672-83. doi: 10.1242/jcs.132316. Epub 2014 Feb 12.


Mechanobiology and developmental control.

Mammoto T, Mammoto A, Ingber DE.

Annu Rev Cell Dev Biol. 2013;29:27-61. doi: 10.1146/annurev-cellbio-101512-122340. Review.


Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression.

Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A.

PLoS One. 2013 Sep 2;8(9):e73407. doi: 10.1371/journal.pone.0073407. eCollection 2013.


Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.

Mammoto T, Jiang A, Jiang E, Panigrahy D, Kieran MW, Mammoto A.

Am J Pathol. 2013 Oct;183(4):1293-1305. doi: 10.1016/j.ajpath.2013.06.026. Epub 2013 Aug 5.


Epoxyeicosanoids promote organ and tissue regeneration.

Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13528-33. doi: 10.1073/pnas.1311565110. Epub 2013 Jul 29.


GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.

Coma S, Allard-Ratick M, Akino T, van Meeteren LA, Mammoto A, Klagsbrun M.

Angiogenesis. 2013 Oct;16(4):939-52. doi: 10.1007/s10456-013-9370-9. Epub 2013 Jul 28.


Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor-related protein 5/Tie2 signaling system.

Mammoto T, Jiang E, Jiang A, Mammoto A.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1009-18. doi: 10.1165/rcmb.2013-0147OC.


Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan.

Bischof AG, Yüksel D, Mammoto T, Mammoto A, Krause S, Ingber DE.

Integr Biol (Camb). 2013 Aug;5(8):1045-56. doi: 10.1039/c3ib40103k.


Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity.

Levesque BM, Kalish LA, Winston AB, Parad RB, Hernandez-Diaz S, Phillips M, Zolit A, Morey J, Gupta M, Mammoto A, Ingber DE, Van Marter LJ.

Neonatology. 2013;104(1):56-64. doi: 10.1159/000351040. Epub 2013 May 24.


Platelet rich plasma extract promotes angiogenesis through the angiopoietin1-Tie2 pathway.

Mammoto T, Jiang A, Jiang E, Mammoto A.

Microvasc Res. 2013 Sep;89:15-24. doi: 10.1016/j.mvr.2013.04.008. Epub 2013 May 6.


Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics.

Mammoto A, Mammoto T, Kanapathipillai M, Wing Yung C, Jiang E, Jiang A, Lofgren K, Gee EP, Ingber DE.

Nat Commun. 2013;4:1759. doi: 10.1038/ncomms2774.


Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.

Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M.

J Biol Chem. 2013 Jan 25;288(4):2210-22. doi: 10.1074/jbc.M112.397398. Epub 2012 Nov 29.


Paxillin controls directional cell motility in response to physical cues.

Sero JE, German AE, Mammoto A, Ingber DE.

Cell Adh Migr. 2012 Nov-Dec;6(6):502-8. doi: 10.4161/cam.21672. Epub 2012 Oct 17.


LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway.

Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A.

PLoS One. 2012;7(7):e41596. doi: 10.1371/journal.pone.0041596. Epub 2012 Jul 25.


Mechanosensitive mechanisms in transcriptional regulation.

Mammoto A, Mammoto T, Ingber DE.

J Cell Sci. 2012 Jul 1;125(Pt 13):3061-73. doi: 10.1242/jcs.093005. Epub 2012 Jul 13. Review.


Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix.

Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE.

Nano Lett. 2012 Jun 13;12(6):3213-7. doi: 10.1021/nl301206p. Epub 2012 May 10.


A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells.

Kang JH, Krause S, Tobin H, Mammoto A, Kanapathipillai M, Ingber DE.

Lab Chip. 2012 Jun 21;12(12):2175-81. doi: 10.1039/c2lc40072c. Epub 2012 Mar 28.


Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning.

Sero JE, Thodeti CK, Mammoto A, Bakal C, Thomas S, Ingber DE.

PLoS One. 2011;6(12):e28303. doi: 10.1371/journal.pone.0028303. Epub 2011 Dec 14.


Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.

Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC.

J Clin Invest. 2012 Jan;122(1):178-91. doi: 10.1172/JCI58128. Epub 2011 Dec 19.


Wnt signaling mediates pathological vascular growth in proliferative retinopathy.

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE.

Circulation. 2011 Oct 25;124(17):1871-81. doi: 10.1161/CIRCULATIONAHA.111.040337. Epub 2011 Oct 3.


Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.

Mammoto T, Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE.

Dev Cell. 2011 Oct 18;21(4):758-69. doi: 10.1016/j.devcel.2011.07.006. Epub 2011 Sep 15.


Multizone paper platform for 3D cell cultures.

Derda R, Tang SK, Laromaine A, Mosadegh B, Hong E, Mwangi M, Mammoto A, Ingber DE, Whitesides GM.

PLoS One. 2011 May 6;6(5):e18940. doi: 10.1371/journal.pone.0018940.


Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.

Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA.

J Exp Med. 2010 Oct 25;207(11):2421-37. doi: 10.1084/jem.20100433. Epub 2010 Oct 11.


Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins.

Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE.

Integr Biol (Camb). 2010 Sep;2(9):435-42. doi: 10.1039/c0ib00034e. Epub 2010 Aug 20.

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