Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 171

1.

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.

Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V.

Cancer Discov. 2018 Jul;8(7):884-897. doi: 10.1158/2159-8290.CD-17-0912. Epub 2018 Jun 13.

PMID:
29899063
2.

RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas.

López-Nieva P, Fernández-Navarro P, Vaquero-Lorenzo C, Villa-Morales M, Graña-Castro O, Cobos-Fernández MÁ, López-Lorenzo JL, Llamas P, González-Sanchez L, Sastre I, Pollan M, Malumbres M, Santos J, Fernández-Piqueras J.

BMC Cancer. 2018 Apr 16;18(1):430. doi: 10.1186/s12885-018-4304-y.

3.

An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.

Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM.

Nucleic Acids Res. 2018 May 18;46(9):4546-4559. doi: 10.1093/nar/gky218.

4.

Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.

Álvarez-Fernández M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M.

Cell Death Differ. 2018 May;25(5):828-840. doi: 10.1038/s41418-017-0024-0. Epub 2017 Dec 11.

5.

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.

de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M.

Nat Med. 2017 Aug;23(8):964-974. doi: 10.1038/nm.4364. Epub 2017 Jul 10.

PMID:
28692064
6.

SnapShot: Phosphoregulation of Mitosis.

Burgess A, Vuong J, Rogers S, Malumbres M, O'Donoghue SI.

Cell. 2017 Jun 15;169(7):1358-1358.e1. doi: 10.1016/j.cell.2017.06.003.

7.

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.

Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P.

Nat Commun. 2017 Jun 12;8:15751. doi: 10.1038/ncomms15751.

8.

APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.

Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pendás AM, Malumbres M, Novák B, Herbert M, Nasmyth K.

Curr Biol. 2017 May 22;27(10):1462-1476.e5. doi: 10.1016/j.cub.2017.04.023. Epub 2017 May 11.

9.

Programmed mitophagy is essential for the glycolytic switch during cell differentiation.

Esteban-Martínez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P.

EMBO J. 2017 Jun 14;36(12):1688-1706. doi: 10.15252/embj.201695916. Epub 2017 May 2.

10.

Myelopathy secondary to copper deficiency: The great imitator.

Urtiaga S, Terrero R, Malumbres M, Pinel A.

Neurologia. 2018 May;33(4):278-281. doi: 10.1016/j.nrl.2017.02.009. Epub 2017 Apr 21. English, Spanish. No abstract available.

11.

Fueling the Cell Division Cycle.

Salazar-Roa M, Malumbres M.

Trends Cell Biol. 2017 Jan;27(1):69-81. doi: 10.1016/j.tcb.2016.08.009. Epub 2016 Oct 13. Review.

PMID:
27746095
12.

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V.

Cancer Cell. 2016 Aug 8;30(2):359-360. doi: 10.1016/j.ccell.2016.07.003. Epub 2016 Aug 8. No abstract available.

13.

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.

Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W.

Cell Discov. 2016 Feb 2;2:15044. doi: 10.1038/celldisc.2015.44. eCollection 2016.

14.

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.

Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L, Wei W, Zou W.

Cell Res. 2016 Jun;26(6):699-712. doi: 10.1038/cr.2016.51. Epub 2016 Apr 29.

15.

Aurora A drives early signalling and vesicle dynamics during T-cell activation.

Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F.

Nat Commun. 2016 Apr 19;7:11389. doi: 10.1038/ncomms11389.

16.

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression.

Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M.

Cancer Cell. 2016 Apr 11;29(4):607-608. doi: 10.1016/j.ccell.2016.03.013. No abstract available.

17.

Design of a Computerised Flight Mill Device to Measure the Flight Potential of Different Insects.

Martí-Campoy A, Ávalos JA, Soto A, Rodríguez-Ballester F, Martínez-Blay V, Malumbres MP.

Sensors (Basel). 2016 Apr 7;16(4). pii: E485. doi: 10.3390/s16040485.

18.

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.

Hydbring P, Malumbres M, Sicinski P.

Nat Rev Mol Cell Biol. 2016 May;17(5):280-92. doi: 10.1038/nrm.2016.27. Epub 2016 Apr 1. Review.

19.

CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER²⁺ Breast Cancer.

Malumbres M.

Cancer Cell. 2016 Mar 14;29(3):243-244. doi: 10.1016/j.ccell.2016.02.016.

20.

E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation.

Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM.

Nucleic Acids Res. 2016 Mar 9. pii: gkw146. [Epub ahead of print]

21.

The cell proliferation antigen Ki-67 organises heterochromatin.

Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, Eguren M, Birling MC, Urbach S, Hem S, Déjardin J, Malumbres M, Jay P, Dulic V, Lafontaine DLj, Feil R, Fisher D.

Elife. 2016 Mar 7;5:e13722. doi: 10.7554/eLife.13722.

22.

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia.

Correia NC, Melão A, Póvoa V, Sarmento L, Gómez de Cedrón M, Malumbres M, Enguita FJ, Barata JT.

Oncotarget. 2016 Feb 16;7(7):8268-81. doi: 10.18632/oncotarget.6987.

23.

Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.

Búa S, Sotiropoulou P, Sgarlata C, Borlado LR, Eguren M, Domínguez O, Ortega S, Malumbres M, Blanpain C, Méndez J.

Cell Cycle. 2015;14(24):3897-907. doi: 10.1080/15384101.2015.1120919.

24.

Keeping Order in Anaphase.

Malumbres M.

Dev Cell. 2015 Nov 23;35(4):403-4. doi: 10.1016/j.devcel.2015.11.011.

25.

Mitophagy in mitosis: More than a myth.

Esteban-Martínez L, Doménech E, Boya P, Salazar-Roa M, Malumbres M.

Autophagy. 2015;11(12):2379-80. doi: 10.1080/15548627.2015.1108509. Review. No abstract available.

26.

A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy.

Sánchez-Martínez R, Cruz-Gil S, Gómez de Cedrón M, Álvarez-Fernández M, Vargas T, Molina S, García B, Herranz J, Moreno-Rubio J, Reglero G, Pérez-Moreno M, Feliu J, Malumbres M, Ramírez de Molina A.

Oncotarget. 2015 Nov 17;6(36):38719-36. doi: 10.18632/oncotarget.5340.

27.

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.

Doménech E, Maestre C, Esteban-Martínez L, Partida D, Pascual R, Fernández-Miranda G, Seco E, Campos-Olivas R, Pérez M, Megias D, Allen K, López M, Saha AK, Velasco G, Rial E, Méndez R, Boya P, Salazar-Roa M, Malumbres M.

Nat Cell Biol. 2015 Oct;17(10):1304-16. doi: 10.1038/ncb3231. Epub 2015 Aug 31.

PMID:
26322680
28.

An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.

Quereda V, Porlan E, Cañamero M, Dubus P, Malumbres M.

Cell Death Differ. 2016 Mar;23(3):430-41. doi: 10.1038/cdd.2015.112. Epub 2015 Aug 21.

29.

Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.

González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez Á, de Cárcer G, Pérez de Castro I, Earnshaw WC, Malumbres M.

Mol Cell Biol. 2015 Oct;35(20):3566-78. doi: 10.1128/MCB.01286-14. Epub 2015 Aug 3.

30.

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.

Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

31.

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.

Trakala M, Partida D, Salazar-Roa M, Maroto M, Wachowicz P, de Cárcer G, Malumbres M.

Blood. 2015 Oct 1;126(14):1707-14. doi: 10.1182/blood-2015-03-634402. Epub 2015 Jul 16.

32.

An Atypical Oncogene Within the Atypical E2Fs.

Álvarez-Fernández M, Malumbres M.

J Natl Cancer Inst. 2015 Jun 18;107(9). pii: djv180. doi: 10.1093/jnci/djv180. Print 2015 Sep. No abstract available.

33.

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain.

Huang J, Ikeuchi Y, Malumbres M, Bonni A.

Neuron. 2015 May 6;86(3):726-39. doi: 10.1016/j.neuron.2015.03.049. Epub 2015 Apr 23.

34.

Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.

Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, Malumbres M, Roussel MF, Roush WR, Hatten ME, Ayad NG.

Cell Rep. 2015 Apr 14;11(2):249-60. doi: 10.1016/j.celrep.2015.03.016. Epub 2015 Apr 2.

35.

Functional reprogramming of polyploidization in megakaryocytes.

Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M.

Dev Cell. 2015 Jan 26;32(2):155-67. doi: 10.1016/j.devcel.2014.12.015.

36.

Cyclin C surprises in tumour suppression.

Trakala M, Malumbres M.

Nat Cell Biol. 2014 Nov;16(11):1031-3. doi: 10.1038/ncb3055.

PMID:
25358351
37.

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.

Scheicher R, Hoelbl-Kovacic A, Bellutti F, Tigan AS, Prchal-Murphy M, Heller G, Schneckenleithner C, Salazar-Roa M, Zöchbauer-Müller S, Zuber J, Malumbres M, Kollmann K, Sexl V.

Blood. 2015 Jan 1;125(1):90-101. doi: 10.1182/blood-2014-06-584417. Epub 2014 Oct 23.

38.

Splicing together sister chromatids.

Valcárcel J, Malumbres M.

EMBO J. 2014 Nov 18;33(22):2601-3. doi: 10.15252/embj.201489988. Epub 2014 Sep 29.

39.

Aurora kinase A inhibitors: promising agents in antitumoral therapy.

Malumbres M, Pérez de Castro I.

Expert Opin Ther Targets. 2014 Dec;18(12):1377-93. doi: 10.1517/14728222.2014.956085. Epub 2014 Sep 9. Review.

PMID:
25200357
40.

Cyclin-dependent kinases.

Malumbres M.

Genome Biol. 2014;15(6):122. Review.

41.

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.

Rodríguez-Díez E, Quereda V, Bellutti F, Prchal-Murphy M, Partida D, Eguren M, Kollmann K, Gómez de Cedrón M, Dubus P, Cañamero M, Martínez D, Sexl V, Malumbres M.

Blood. 2014 Oct 9;124(15):2380-90. doi: 10.1182/blood-2014-02-555292. Epub 2014 Aug 25.

42.

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

Piazzolla D, Palla AR, Pantoja C, Cañamero M, de Castro IP, Ortega S, Gómez-López G, Dominguez O, Megías D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sánchez-Carbayo M, García-Pedrero JM, Rodrigo JP, Malumbres M, Serrano M.

Nat Commun. 2014 Jun 30;5:4226. doi: 10.1038/ncomms5226.

PMID:
24979572
43.

The Greatwall-PP2A axis in cell cycle control.

Wang P, Malumbres M, Archambault V.

Methods Mol Biol. 2014;1170:99-111. doi: 10.1007/978-1-4939-0888-2_6.

PMID:
24906311
44.

Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry.

Alvarez-Fernández M, Malumbres M.

Bioessays. 2014 Aug;36(8):757-65. doi: 10.1002/bies.201400040. Epub 2014 May 30.

PMID:
24889070
45.

A centrosomal route for cancer genome instability.

de Cárcer G, Malumbres M.

Nat Cell Biol. 2014 Jun;16(6):504-6. doi: 10.1038/ncb2978.

PMID:
24875738
46.

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W.

Dev Cell. 2014 May 27;29(4):377-91. doi: 10.1016/j.devcel.2014.04.022.

47.

Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible.

Rattani A, Vinod PK, Godwin J, Tachibana-Konwalski K, Wolna M, Malumbres M, Novák B, Nasmyth K.

Curr Biol. 2014 Mar 17;24(6):630-7. doi: 10.1016/j.cub.2014.01.033. Epub 2014 Feb 27.

48.

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.

Eguren M, Álvarez-Fernández M, García F, López-Contreras AJ, Fujimitsu K, Yaguchi H, Luque-García JL, Fernández-Capetillo O, Muñoz J, Yamano H, Malumbres M.

Cell Rep. 2014 Feb 27;6(4):670-83. doi: 10.1016/j.celrep.2014.01.017. Epub 2014 Feb 6.

49.

The functional relevance of polyploidization in the skin.

Trakala M, Malumbres M.

Exp Dermatol. 2014 Feb;23(2):92-3. doi: 10.1111/exd.12305. Epub 2013 Dec 30.

PMID:
24330335
50.

The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.

Eguren M, Porlan E, Manchado E, García-Higuera I, Cañamero M, Fariñas I, Malumbres M.

Nat Commun. 2013;4:2880. doi: 10.1038/ncomms3880.

PMID:
24301385

Supplemental Content

Loading ...
Support Center