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Items: 1 to 50 of 82

1.

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

Tsutsui K, Monfredi OJ, Sirenko-Tagirova SG, Maltseva LA, Bychkov R, Kim MS, Ziman BD, Tarasov KV, Tarasova YS, Zhang J, Wang M, Maltsev AV, Brennan JA, Efimov IR, Stern MD, Maltsev VA, Lakatta EG.

Sci Signal. 2018 Jun 12;11(534). pii: eaap7608. doi: 10.1126/scisignal.aap7608.

PMID:
29895616
2.

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

Lyashkov AE, Behar J, Lakatta EG, Yaniv Y, Maltsev VA.

Biophys J. 2018 Apr 24;114(8):2024. doi: 10.1016/j.bpj.2018.03.024. No abstract available.

3.

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

Lyashkov AE, Behar J, Lakatta EG, Yaniv Y, Maltsev VA.

Biophys J. 2018 Mar 13;114(5):1176-1189. doi: 10.1016/j.bpj.2017.12.043. Erratum in: Biophys J. 2018 Apr 24;114(8):2024.

PMID:
29539403
4.

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells.

Sirenko SG, Yang D, Maltseva LA, Kim MS, Lakatta EG, Maltsev VA.

PLoS One. 2017 Sep 25;12(9):e0185222. doi: 10.1371/journal.pone.0185222. eCollection 2017.

5.

Electrophysiological heterogeneity of pacemaker cells in the rabbit intercaval region, including the SA node: insights from recording multiple ion currents in each cell.

Monfredi O, Tsutsui K, Ziman B, Stern MD, Lakatta EG, Maltsev VA.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H403-H414. doi: 10.1152/ajpheart.00253.2016. Epub 2017 Sep 15.

PMID:
28916636
6.
7.

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells.

Maltsev AV, Parsons SP, Kim MS, Tsutsui K, Stern MD, Lakatta EG, Maltsev VA, Monfredi O.

PLoS One. 2017 Jul 6;12(7):e0179419. doi: 10.1371/journal.pone.0179419. eCollection 2017.

8.

Clusters of calcium release channels harness the Ising phase transition to confine their elementary intracellular signals.

Maltsev AV, Maltsev VA, Stern MD.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7525-7530. doi: 10.1073/pnas.1701409114. Epub 2017 Jul 3.

9.

Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.

Sirenko SG, Maltsev VA, Yaniv Y, Bychkov R, Yaeger D, Vinogradova T, Spurgeon HA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H251-67. doi: 10.1152/ajpheart.00667.2015. Epub 2016 May 20.

10.

Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.

Mishra S, Reznikov V, Maltsev VA, Undrovinas NA, Sabbah HN, Undrovinas A.

J Physiol. 2015 Mar 15;593(6):1409-27. doi: 10.1113/jphysiol.2014.278259. Epub 2014 Nov 17.

11.

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.

12.

From two competing oscillators to one coupled-clock pacemaker cell system.

Yaniv Y, Lakatta EG, Maltsev VA.

Front Physiol. 2015 Feb 13;6:28. doi: 10.3389/fphys.2015.00028. eCollection 2015. Review.

13.

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate.

Monfredi O, Lyashkov AE, Johnsen AB, Inada S, Schneider H, Wang R, Nirmalan M, Wisloff U, Maltsev VA, Lakatta EG, Zhang H, Boyett MR.

Hypertension. 2014 Dec;64(6):1334-43. doi: 10.1161/HYPERTENSIONAHA.114.03782. Epub 2014 Sep 15.

14.

Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.

Stern MD, Maltseva LA, Juhaszova M, Sollott SJ, Lakatta EG, Maltsev VA.

J Gen Physiol. 2014 May;143(5):577-604. doi: 10.1085/jgp.201311123.

15.

Modern perspectives on numerical modeling of cardiac pacemaker cell.

Maltsev VA, Yaniv Y, Maltsev AV, Stern MD, Lakatta EG.

J Pharmacol Sci. 2014;125(1):6-38. Epub 2014 Apr 19. Review.

16.

Numerical Modeling Calcium and CaMKII Effects in the SA Node.

Yaniv Y, Maltsev VA.

Front Pharmacol. 2014 Apr 1;5:58. doi: 10.3389/fphar.2014.00058. eCollection 2014. Review.

17.

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design.

Sirenko S, Maltsev VA, Maltseva LA, Yang D, Lukyanenko Y, Vinogradova TM, Jones LR, Lakatta EG.

J Mol Cell Cardiol. 2014 Jan;66:106-15. doi: 10.1016/j.yjmcc.2013.11.011. Epub 2013 Nov 22.

18.

RyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex.

Maltsev AV, Yaniv Y, Stern MD, Lakatta EG, Maltsev VA.

Circ Res. 2013 Oct 25;113(10):e94-e100. doi: 10.1161/CIRCRESAHA.113.302465.

19.

Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.

Yaniv Y, Stern MD, Lakatta EG, Maltsev VA.

Biophys J. 2013 Oct 1;105(7):1551-61. doi: 10.1016/j.bpj.2013.08.024.

20.

Life and death of a cardiac calcium spark.

Stern MD, Ríos E, Maltsev VA.

J Gen Physiol. 2013 Sep;142(3):257-74. doi: 10.1085/jgp.201311034. Erratum in: J Gen Physiol. 2013 Oct;142(4):477.

21.

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells.

Monfredi O, Maltseva LA, Spurgeon HA, Boyett MR, Lakatta EG, Maltsev VA.

PLoS One. 2013 Jun 27;8(6):e67247. doi: 10.1371/journal.pone.0067247. Print 2013.

22.

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

Yaniv Y, Sirenko S, Ziman BD, Spurgeon HA, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2013 Sep;62:80-9. doi: 10.1016/j.yjmcc.2013.04.026. Epub 2013 May 5.

23.

Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failure.

Undrovinas A, Maltsev VA, Sabbah HN.

PLoS One. 2013 Apr 15;8(4):e54436. doi: 10.1371/journal.pone.0054436. Print 2013.

24.
25.

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility".

Lakatta EG, Yaniv Y, Maltsev VA.

Am J Physiol Cell Physiol. 2013 May 15;304(10):C941-4. doi: 10.1152/ajpcell.00072.2013. Epub 2013 Mar 13. No abstract available.

26.

Modern concepts concerning the origin of the heartbeat.

Monfredi O, Maltsev VA, Lakatta EG.

Physiology (Bethesda). 2013 Mar;28(2):74-92. doi: 10.1152/physiol.00054.2012. Review.

27.

Reprogramming paces the heart.

Lakatta EG, Maltsev VA.

Nat Biotechnol. 2013 Jan;31(1):31-2. doi: 10.1038/nbt.2480. No abstract available.

28.

The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.

Yaniv Y, Maltsev VA, Ziman BD, Spurgeon HA, Lakatta EG.

Molecules. 2012 Jul 9;17(7):8241-54. doi: 10.3390/molecules17078241.

29.

Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.

Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, Lakatta EG.

PLoS One. 2012;7(5):e37582. doi: 10.1371/journal.pone.0037582. Epub 2012 May 29.

30.

Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

Yaniv Y, Maltsev VA, Escobar AL, Spurgeon HA, Ziman BD, Stern MD, Lakatta EG.

J Mol Cell Cardiol. 2011 Dec;51(6):902-5. doi: 10.1016/j.yjmcc.2011.08.029. Epub 2011 Sep 14.

31.

The funny current in the context of the coupled-clock pacemaker cell system.

Maltsev VA, Lakatta EG.

Heart Rhythm. 2012 Feb;9(2):302-7. doi: 10.1016/j.hrthm.2011.09.022. Epub 2011 Sep 16. No abstract available.

32.

Rebuttal: what I(f) the shoe doesn't fit? "The funny current has a major pacemaking role in the sinus node".

Lakatta EG, Maltsev VA.

Heart Rhythm. 2012 Mar;9(3):459-60. doi: 10.1016/j.hrthm.2011.09.024. Epub 2011 Sep 16. No abstract available.

33.

A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.

Liu J, Sirenko S, Juhaszova M, Ziman B, Shetty V, Rain S, Shukla S, Spurgeon HA, Vinogradova TM, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2011 Nov;51(5):730-9. doi: 10.1016/j.yjmcc.2011.07.028. Epub 2011 Aug 4.

34.

Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure.

Mishra S, Undrovinas NA, Maltsev VA, Reznikov V, Sabbah HN, Undrovinas A.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1596-605. doi: 10.1152/ajpheart.00948.2009. Epub 2011 Jun 24.

35.

Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".

Maltsev VA, Vinogradova TM, Stern MD, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2323-4; author reply H2325-6. doi: 10.1152/ajpheart.00110.2011. No abstract available.

36.

Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cells.

Maltsev AV, Maltsev VA, Mikheev M, Maltseva LA, Sirenko SG, Lakatta EG, Stern MD.

Biophys J. 2011 Jan 19;100(2):271-83. doi: 10.1016/j.bpj.2010.11.081.

37.

Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling.

Zahanich I, Sirenko SG, Maltseva LA, Tarasova YS, Spurgeon HA, Boheler KR, Stern MD, Lakatta EG, Maltsev VA.

J Mol Cell Cardiol. 2011 Jan;50(1):66-76. doi: 10.1016/j.yjmcc.2010.09.018. Epub 2010 Oct 15.

38.

Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure.

Undrovinas NA, Maltsev VA, Belardinelli L, Sabbah HN, Undrovinas A.

J Physiol Sci. 2010 Jul;60(4):245-57. doi: 10.1007/s12576-010-0092-0. Epub 2010 May 19.

39.

A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.

Maltsev VA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2010-23. doi: 10.1152/ajpheart.00783.2009. Epub 2010 Mar 12.

40.

A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

Lakatta EG, Maltsev VA, Vinogradova TM.

Circ Res. 2010 Mar 5;106(4):659-73. doi: 10.1161/CIRCRESAHA.109.206078. Review.

41.

Yin and yang of the cardiac pacemaker clock system in health and disease.

Maltsev VA, Lakatta EG.

Heart Rhythm. 2010 Jan;7(1):96-8. doi: 10.1016/j.hrthm.2009.11.001. Epub 2009 Nov 10. No abstract available.

42.

Funny current provides a relatively modest contribution to spontaneous beating rate regulation of human and rabbit sinoatrial node cells.

Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2010 Apr;48(4):804-6. doi: 10.1016/j.yjmcc.2009.12.009. Epub 2009 Dec 28. No abstract available.

43.

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

Lyashkov AE, Vinogradova TM, Zahanich I, Li Y, Younes A, Nuss HB, Spurgeon HA, Maltsev VA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H949-59. doi: 10.1152/ajpheart.01340.2008. Epub 2009 Jun 19.

44.

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.

Maltsev VA, Kyle JW, Undrovinas A.

J Physiol Sci. 2009 May;59(3):217-25. doi: 10.1007/s12576-009-0029-7. Epub 2009 Mar 3.

45.

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

Maltsev VA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H594-615. doi: 10.1152/ajpheart.01118.2008. Epub 2009 Jan 9.

46.

Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart.

Undrovinas A, Maltsev VA.

Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):348-59. Review.

47.

Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition.

Maltsev VA, Kyle JW, Mishra S, Undrovinas A.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H667-76. doi: 10.1152/ajpheart.00111.2008. Epub 2008 Jun 13.

48.

The missing link in the mystery of normal automaticity of cardiac pacemaker cells.

Lakatta EG, Vinogradova TM, Maltsev VA.

Ann N Y Acad Sci. 2008 Mar;1123:41-57. doi: 10.1196/annals.1420.006. Review.

PMID:
18375576
49.

Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences.

Maltsev VA, Reznikov V, Undrovinas NA, Sabbah HN, Undrovinas A.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1597-608. doi: 10.1152/ajpheart.00484.2007. Epub 2008 Jan 18.

50.

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