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Real-time hyperpolarized 13C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4-double knockout mouse livers.

Sharma G, Wu CY, Wynn RM, Gui W, Malloy CR, Sherry AD, Chuang DT, Khemtong C.

Sci Rep. 2019 Nov 11;9(1):16480. doi: 10.1038/s41598-019-52952-6.


Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats.

Lee MH, DeBerardinis RJ, Wen X, Corbin IR, Sherry AD, Malloy CR, Jin ES.

Metabolism. 2019 Dec;101:153993. doi: 10.1016/j.metabol.2019.153993. Epub 2019 Oct 28.


Remodeling of substrate consumption in the murine sTAC model of heart failure.

Turer A, Altamirano F, Schiattarella GG, May H, Gillette TG, Malloy CR, Merritt ME.

J Mol Cell Cardiol. 2019 Sep;134:144-153. doi: 10.1016/j.yjmcc.2019.07.007. Epub 2019 Jul 21.


A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.

Carreau AM, Jin ES, Garcia-Reyes Y, Rahat H, Nadeau KJ, Malloy CR, Cree-Green M.

Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R134-R142. doi: 10.1152/ajpregu.00047.2019. Epub 2019 May 1.


Metabolism of hyperpolarized 13 C-acetoacetate to β-hydroxybutyrate detects real-time mitochondrial redox state and dysfunction in heart tissue.

Chen W, Sharma G, Jiang W, Maptue NR, Malloy CR, Sherry AD, Khemtong C.

NMR Biomed. 2019 Jun;32(6):e4091. doi: 10.1002/nbm.4091. Epub 2019 Apr 10.


Assessing the pentose phosphate pathway using [2, 3-13 C2 ]glucose.

Lee MH, Malloy CR, Corbin IR, Li J, Jin ES.

NMR Biomed. 2019 Jun;32(6):e4096. doi: 10.1002/nbm.4096. Epub 2019 Mar 29.


Effects of deuteration on transamination and oxidation of hyperpolarized 13C-Pyruvate in the isolated heart.

Funk AM, Wen X, Hever T, Maptue NR, Khemtong C, Sherry AD, Malloy CR.

J Magn Reson. 2019 Apr;301:102-108. doi: 10.1016/j.jmr.2019.03.003. Epub 2019 Mar 4.


Modular 31 P wideband inversion transfer for integrative analysis of adenosine triphosphate metabolism, T1 relaxation and molecular dynamics in skeletal muscle at 7T.

Ren J, Sherry AD, Malloy CR.

Magn Reson Med. 2019 Jun;81(6):3440-3452. doi: 10.1002/mrm.27686. Epub 2019 Feb 22.


Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.

Jakkamsetti V, Marin-Valencia I, Ma Q, Good LB, Terrill T, Rajasekaran K, Pichumani K, Khemtong C, Hooshyar MA, Sundarrajan C, Patel MS, Bachoo RM, Malloy CR, Pascual JM.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaan0457. doi: 10.1126/scitranslmed.aan0457.


Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R.

Neoplasia. 2019 Jan;21(1):1-16. doi: 10.1016/j.neo.2018.09.006. Epub 2018 Nov 23. Review.


Esterase-Catalyzed Production of Hyperpolarized 13C-Enriched Carbon Dioxide in Tissues for Measuring pH.

Maptue N, Jiang W, Harrison C, Funk AM, Sharma G, Malloy CR, Sherry D, Khemtong C.

ACS Sens. 2018 Nov 26;3(11):2232-2236. doi: 10.1021/acssensors.8b01097. Epub 2018 Nov 9.


Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.

Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA.

Cell Metab. 2018 Nov 6;28(5):793-800.e2. doi: 10.1016/j.cmet.2018.07.020. Epub 2018 Aug 23.


Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans.

Jin ES, Browning JD, Murphy RE, Malloy CR.

J Lipid Res. 2018 Sep;59(9):1685-1694. doi: 10.1194/jlr.M086405. Epub 2018 Jul 27.


An Adjustable-Length Dipole Using Forced-Current Excitation for 7T MR.

Cui J, Dimitrov IE, Cheshkov S, Gu M, Malloy CR, Wright SM.

IEEE Trans Biomed Eng. 2018 Oct;65(10):2259-2266. doi: 10.1109/TBME.2017.2788864. Epub 2018 Jan 1.


MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation.

Makarewich CA, Baskin KK, Munir AZ, Bezprozvannaya S, Sharma G, Khemtong C, Shah AM, McAnally JR, Malloy CR, Szweda LI, Bassel-Duby R, Olson EN.

Cell Rep. 2018 Jun 26;23(13):3701-3709. doi: 10.1016/j.celrep.2018.05.058.


Unveiling a hidden 31 P signal coresonating with extracellular inorganic phosphate by outer-volume-suppression and localized 31 P MRS in the human brain at 7T.

Ren J, Shang T, Sherry AD, Malloy CR.

Magn Reson Med. 2018 Oct;80(4):1289-1297. doi: 10.1002/mrm.27121. Epub 2018 Feb 9.


Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver.

Jin ES, Lee MH, Murphy RE, Malloy CR.

Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E543-E551. doi: 10.1152/ajpendo.00342.2017. Epub 2018 Jan 9.


tcaSIM: A Simulation Program for Optimal Design of 13C Tracer Experiments for Analysis of Metabolic Flux by NMR and Mass Spectroscopy.

Alger JR, Sherry AD, Malloy CR.

Curr Metabolomics. 2018;6(3):176-187. doi: 10.2174/2213235X07666181219115856.


Lactate Metabolism in Human Lung Tumors.

Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ.

Cell. 2017 Oct 5;171(2):358-371.e9. doi: 10.1016/j.cell.2017.09.019.


The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose.

Funk AM, Anderson BL, Wen X, Hever T, Khemtong C, Kovacs Z, Sherry AD, Malloy CR.

J Magn Reson. 2017 Nov;284:86-93. doi: 10.1016/j.jmr.2017.09.007. Epub 2017 Sep 18.


Measurement of 13 C turnover into glutamate and glutamine pools in brain tumor patients.

Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA.

FEBS Lett. 2017 Nov;591(21):3548-3554. doi: 10.1002/1873-3468.12867. Epub 2017 Oct 27.


Automated modification and fusion of voxel models to construct body phantoms with heterogeneous breast tissue: Application to MRI simulations.

Rispoli JV, Wright SM, Malloy CR, McDougall MP.

J Biomed Graph Comput. 2017;7(1):1-7. doi: 10.5430/jbgc.v7n1p1. Epub 2017 Feb 26.


Intramyocellular lipid excess in the mitochondrial disorder MELAS: MRS determination at 7T.

Golla S, Ren J, Malloy CR, Pascual JM.

Neurol Genet. 2017 May 25;3(3):e160. doi: 10.1212/NXG.0000000000000160. eCollection 2017 Jun.


Hyperpolarized δ-[1-13 C]gluconolactone as a probe of the pentose phosphate pathway.

Moreno KX, Harrison CE, Merritt ME, Kovacs Z, Malloy CR, Sherry AD.

NMR Biomed. 2017 Jun;30(6). doi: 10.1002/nbm.3713. Epub 2017 Mar 8.


Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma.

Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA.

J Clin Oncol. 2016 Nov 20;34(33):4030-4039. doi: 10.1200/JCO.2016.67.1222. Epub 2016 Oct 31.


Oxidation of [U-13 C]glucose in the human brain at 7T under steady state conditions.

Cheshkov S, Dimitrov IE, Jakkamsetti V, Good L, Kelly D, Rajasekaran K, DeBerardinis RJ, Pascual JM, Sherry AD, Malloy CR.

Magn Reson Med. 2017 Dec;78(6):2065-2071. doi: 10.1002/mrm.26603. Epub 2017 Jan 23.


Effects of visceral adiposity on glycerol pathways in gluconeogenesis.

Neeland IJ, Hughes C, Ayers CR, Malloy CR, Jin ES.

Metabolism. 2017 Feb;67:80-89. doi: 10.1016/j.metabol.2016.11.008. Epub 2016 Nov 27.


Biochemical Specificity in Human Cardiac Imaging by 13C Magnetic Resonance Imaging.

Malloy CR, Sherry AD.

Circ Res. 2016 Nov 11;119(11):1146-1148. doi: 10.1161/CIRCRESAHA.116.310000. No abstract available.


Efficient 31 P band inversion transfer approach for measuring creatine kinase activity, ATP synthesis, and molecular dynamics in the human brain at 7 T.

Ren J, Sherry AD, Malloy CR.

Magn Reson Med. 2017 Nov;78(5):1657-1666. doi: 10.1002/mrm.26560. Epub 2016 Nov 20.


Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.

Wang JX, Merritt ME, Sherry AD, Malloy CR.

Magn Reson Med. 2016 Oct;76(4):1033-8. doi: 10.1002/mrm.26286. Epub 2016 Jul 4.


Band inversion amplifies 31 P-31 P nuclear overhauser effects: Relaxation mechanism and dynamic behavior of ATP in the human brain by 31 P MRS at 7 T.

Ren J, Sherry AD, Malloy CR.

Magn Reson Med. 2017 Apr;77(4):1409-1418. doi: 10.1002/mrm.26236. Epub 2016 Apr 8.


A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.

Wang JX, Merritt ME, Sherry D, Malloy CR.

Magn Reson Chem. 2016 Aug;54(8):665-73. doi: 10.1002/mrc.4435. Epub 2016 Apr 5.


Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2016 Apr 1;126(4):1605. doi: 10.1172/JCI86695. Epub 2016 Apr 1. No abstract available.


Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.

Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA.

Neurochem Int. 2016 Jul;97:133-6. doi: 10.1016/j.neuint.2016.03.015. Epub 2016 Mar 26.


Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24. Review. Erratum in: Circ Res. 2016 May 13;118(10):e35.


Metabolic Heterogeneity in Human Lung Tumors.

Hensley CT, Faubert B, Yuan Q, Lev-Cohain N, Jin E, Kim J, Jiang L, Ko B, Skelton R, Loudat L, Wodzak M, Klimko C, McMillan E, Butt Y, Ni M, Oliver D, Torrealba J, Malloy CR, Kernstine K, Lenkinski RE, DeBerardinis RJ.

Cell. 2016 Feb 11;164(4):681-94. doi: 10.1016/j.cell.2015.12.034. Epub 2016 Feb 4.


Metabolism of hyperpolarized [1-(13)C]pyruvate through alternate pathways in rat liver.

Jin ES, Moreno KX, Wang JX, Fidelino L, Merritt ME, Sherry AD, Malloy CR.

NMR Biomed. 2016 Apr;29(4):466-74. doi: 10.1002/nbm.3479. Epub 2016 Feb 2.


Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney.

Hato T, Friedman AN, Mang H, Plotkin Z, Dube S, Hutchins GD, Territo PR, McCarthy BP, Riley AA, Pichumani K, Malloy CR, Harris RA, Dagher PC, Sutton TA.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F717-F725. doi: 10.1152/ajprenal.00535.2015. Epub 2016 Jan 13.


Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2015 Dec;125(12):4447-62. doi: 10.1172/JCI82204. Epub 2015 Nov 16. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1605. Livingston, Kenneth [corrected to Livingston, Kenneth A].


Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.

Moreno KX, Moore CL, Burgess SC, Sherry AD, Malloy CR, Merritt ME.

Metabolomics. 2015 Oct;11(5):1144-1156. Epub 2015 Jan 9.


Lactate Contributes to Glyceroneogenesis and Glyconeogenesis in Skeletal Muscle by Reversal of Pyruvate Kinase.

Jin ES, Sherry AD, Malloy CR.

J Biol Chem. 2015 Dec 18;290(51):30486-97. doi: 10.1074/jbc.M115.689174. Epub 2015 Oct 21.


(31)P-MRS of healthy human brain: ATP synthesis, metabolite concentrations, pH, and T1 relaxation times.

Ren J, Sherry AD, Malloy CR.

NMR Biomed. 2015 Nov;28(11):1455-62. doi: 10.1002/nbm.3384. Epub 2015 Sep 24.


A simple approach to evaluate the kinetic rate constant for ATP synthesis in resting human skeletal muscle at 7 T.

Ren J, Sherry AD, Malloy CR.

NMR Biomed. 2016 Sep;29(9):1240-8. doi: 10.1002/nbm.3310. Epub 2015 May 6.


Conditions for (13)C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas.

Pichumani K, Mashimo T, Baek HM, Ratnakar J, Mickey B, DeBerardinis RJ, Maher EA, Bachoo RM, Malloy CR, Kovacs Z.

Anal Biochem. 2015 Jul 15;481:4-6. doi: 10.1016/j.ab.2015.04.017. Epub 2015 Apr 20.


Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.

Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR.

Nat Med. 2015 Feb;21(2):108-9. doi: 10.1038/nm.3789. No abstract available.


MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.

Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN.

EMBO Mol Med. 2014 Dec;6(12):1610-21. doi: 10.15252/emmm.201404218.


Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.

Moreno KX, Satapati S, DeBerardinis RJ, Burgess SC, Malloy CR, Merritt ME.

J Biol Chem. 2014 Dec 26;289(52):35859-67. doi: 10.1074/jbc.M114.613265. Epub 2014 Oct 28.


Propionate stimulates pyruvate oxidation in the presence of acetate.

Purmal C, Kucejova B, Sherry AD, Burgess SC, Malloy CR, Merritt ME.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1134-41. doi: 10.1152/ajpheart.00407.2014. Epub 2014 Aug 22.

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