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Items: 1 to 20 of 48

1.

The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia.

Porter AP, White GRM, Mack NA, Malliri A.

J Cell Sci. 2019 Jul 15;132(14). pii: jcs230086. doi: 10.1242/jcs.230086.

2.

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.

Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A.

Nat Commun. 2018 May 29;9(1):2124. doi: 10.1038/s41467-018-04404-4.

3.

Compartmentalisation of RAC1 signalling.

Payapilly A, Malliri A.

Curr Opin Cell Biol. 2018 Oct;54:50-56. doi: 10.1016/j.ceb.2018.04.009. Epub 2018 Apr 30. Review.

PMID:
29723737
4.

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.

Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A.

Cancer Cell. 2017 May 8;31(5):621-634.e6. doi: 10.1016/j.ccell.2017.03.007. Epub 2017 Apr 13.

5.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ.

EMBO Mol Med. 2017 Feb;9(2):181-197. doi: 10.15252/emmm.201606684.

6.

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.

Marei H, Malliri A.

Small GTPases. 2017 Jul 3;8(3):139-163. doi: 10.1080/21541248.2016.1211398. Epub 2016 Jul 21. Review.

7.

GEFs: Dual regulation of Rac1 signaling.

Marei H, Malliri A.

Small GTPases. 2017 Apr 3;8(2):90-99. doi: 10.1080/21541248.2016.1202635. Epub 2016 Jun 17. Review.

8.

Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors.

Marei H, Carpy A, Macek B, Malliri A.

Cell Cycle. 2016 Aug 2;15(15):1961-74. doi: 10.1080/15384101.2016.1183852. Epub 2016 May 6.

9.

Deregulation of Rho GTPases in cancer.

Porter AP, Papaioannou A, Malliri A.

Small GTPases. 2016 Jul 2;7(3):123-38. doi: 10.1080/21541248.2016.1173767. Epub 2016 Apr 22. Review.

10.

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.

Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, Macek B, Malliri A.

Nat Commun. 2016 Feb 18;7:10664. doi: 10.1038/ncomms10664.

11.

Centrosome separation; a careful balancing act.

Whalley HJ, Malliri A.

Cell Cycle. 2015;14(19):3001-2. doi: 10.1080/15384101.2015.1080981. No abstract available.

12.

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.

Whalley HJ, Porter AP, Diamantopoulou Z, White GR, Castañeda-Saucedo E, Malliri A.

Nat Commun. 2015 Jun 16;6:7437. doi: 10.1038/ncomms8437.

13.

HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.

Vaughan L, Tan CT, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF, Malliri A.

Cell Rep. 2015 Jan 6;10(1):88-102. doi: 10.1016/j.celrep.2014.12.012. Epub 2014 Dec 24.

14.

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.

Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH.

Nat Commun. 2013;4:2180. doi: 10.1038/ncomms3180.

15.

Enhanced detection of ubiquitin isopeptides using reductive methylation.

Chicooree N, Connolly Y, Tan CT, Malliri A, Li Y, Smith DL, Griffiths JR.

J Am Soc Mass Spectrom. 2013 Mar;24(3):421-30. doi: 10.1007/s13361-012-0538-0. Epub 2013 Jan 30.

PMID:
23361369
16.

Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.

Dalton LE, Kamarashev J, Barinaga-Rementeria Ramirez I, White G, Malliri A, Hurlstone A.

J Invest Dermatol. 2013 Jun;133(6):1572-81. doi: 10.1038/jid.2013.23. Epub 2013 Jan 21.

17.

A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine.

Chicooree N, Griffiths JR, Connolly Y, Tan CT, Malliri A, Eyers CE, Smith DL.

Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):127-34. doi: 10.1002/rcm.6425.

PMID:
23239325
18.

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.

Mack NA, Porter AP, Whalley HJ, Schwarz JP, Jones RC, Khaja AS, Bjartell A, Anderson KI, Malliri A.

Nat Cell Biol. 2012 Nov;14(11):1169-80. doi: 10.1038/ncb2608. Epub 2012 Oct 28.

19.

The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.

Castillo-Lluva S, Tan CT, Daugaard M, Sorensen PH, Malliri A.

Oncogene. 2013 Mar 28;32(13):1735-42. doi: 10.1038/onc.2012.189. Epub 2012 May 21.

PMID:
22614015
20.

The diverse roles of Rac signaling in tumorigenesis.

Mack NA, Whalley HJ, Castillo-Lluva S, Malliri A.

Cell Cycle. 2011 May 15;10(10):1571-81. Epub 2011 May 15. Review.

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