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Process intensification for production of Streptococcus pneumoniae whole-cell vaccine.

Campos IB, Cardoso CP Jr, Fratelli F, Herd M, Moffitt KL, Lu YJ, Malley R, Leite LCC, Gonçalves VM.

Biotechnol Bioeng. 2020 Feb 18. doi: 10.1002/bit.27307. [Epub ahead of print]


A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults.

Keech CA, Morrison R, Anderson P, Tate A, Flores J, Goldblatt D, Briles D, Hural J, Malley R, Alderson MR.

Pediatr Infect Dis J. 2020 Apr;39(4):345-351. doi: 10.1097/INF.0000000000002567.


Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.

O'Hara JM, Redhu NS, Cheung E, Robertson NG, Patik I, Sayed SE, Thompson CM, Herd M, Lucas KB, Conaway E, Morton CC, Farber DL, Malley R, Horwitz BH.

Mucosal Immunol. 2020 Jan;13(1):172-182. doi: 10.1038/s41385-019-0218-5. Epub 2019 Oct 28.


Minimal effects of reduced teaching hours on undergraduate medical student learning outcomes and course evaluations.

Choi-Lundberg DL, Al-Aubaidy HA, Burgess JR, Clifford CA, Cuellar WA, Errey JA, Harper AJ, Malley RC, Ross RM, Williams AM, Hays R.

Med Teach. 2020 Jan;42(1):58-65. doi: 10.1080/0142159X.2019.1652258. Epub 2019 Aug 22.


Effect of a pneumococcal whole cell vaccine on influenza A-induced pneumococcal otitis media in infant mice.

Manning J, Dunne EM, Wang N, Pedersen JS, Ogier JM, Burt RA, Mulholland EK, Robins-Browne RM, Malley R, Wijburg OL, Satzke C.

Vaccine. 2019 Jun 6;37(26):3495-3504. doi: 10.1016/j.vaccine.2019.03.013. Epub 2019 May 15.


Pandoraea fibrosis sp. nov., a novel Pandoraea species isolated from clinical respiratory samples.

See-Too WS, Ambrose M, Malley R, Ee R, Mulcahy E, Manche E, Lazenby J, McEwan B, Pagnon J, Chen JW, Chan KG, Turnbull L, Whitchurch CB, Roddam LF.

Int J Syst Evol Microbiol. 2019 Mar;69(3):645-651. doi: 10.1099/ijsem.0.003147. Epub 2019 Jan 24.


Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination.

Campo JJ, Le TQ, Pablo JV, Hung C, Teng AA, Tettelin H, Tate A, Hanage WP, Alderson MR, Liang X, Malley R, Lipsitch M, Croucher NJ.

Elife. 2018 Dec 28;7. pii: e37015. doi: 10.7554/eLife.37015.


Protection against Staphylococcus aureus Colonization and Infection by B- and T-Cell-Mediated Mechanisms.

Zhang F, Ledue O, Jun M, Goulart C, Malley R, Lu YJ.

mBio. 2018 Oct 16;9(5). pii: e01949-18. doi: 10.1128/mBio.01949-18.


Th17 responses to pneumococcus in blood and adenoidal cells in children.

Oliver E, Pope C, Clarke E, Langton Hewer C, Ogunniyi AD, Paton JC, Mitchell T, Malley R, Finn A.

Clin Exp Immunol. 2019 Feb;195(2):213-225. doi: 10.1111/cei.13225. Epub 2018 Oct 31.


Introduction of New Journal Section-Translational Medicine.

Malley R.

Pediatr Infect Dis J. 2018 Nov;37(11):1175. doi: 10.1097/INF.0000000000002173. No abstract available.


Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses.

Lu YJ, Oliver E, Zhang F, Pope C, Finn A, Malley R.

Infect Immun. 2018 Oct 25;86(11). pii: e00490-18. doi: 10.1128/IAI.00490-18. Print 2018 Nov.


Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome.

Moffitt K, Cheung E, Manis J, Malley R.

Infect Immun. 2018 Apr 23;86(5). pii: e00024-18. doi: 10.1128/IAI.00024-18. Print 2018 May.


The immunological mechanisms that control pneumococcal carriage.

Jochems SP, Weiser JN, Malley R, Ferreira DM.

PLoS Pathog. 2017 Dec 21;13(12):e1006665. doi: 10.1371/journal.ppat.1006665. eCollection 2017 Dec. Review.


Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours.

FitzGerald LM, Raspin K, Marthick JR, Field MA, Malley RC, Thomson RJ, Blackburn NB, Banks A, Charlesworth JC, Donovan S, Dickinson JL.

Sci Rep. 2017 Dec 19;7(1):17778. doi: 10.1038/s41598-017-18217-w.


The Need for Early Referral: Characteristics of Children and Adolescents Who Are Overweight and Obese Attending a Multidisciplinary Weight Management Service.

Walker JL, Malley R, Littlewood R, Capra S.

Children (Basel). 2017 Oct 31;4(11). pii: E93. doi: 10.3390/children4110093.


A Combination of Recombinant Mycobacterium bovis BCG Strains Expressing Pneumococcal Proteins Induces Cellular and Humoral Immune Responses and Protects against Pneumococcal Colonization and Sepsis.

Goulart C, Rodriguez D, Kanno AI, Converso TR, Lu YJ, Malley R, Leite LCC.

Clin Vaccine Immunol. 2017 Oct 5;24(10). pii: e00133-17. doi: 10.1128/CVI.00133-17. Print 2017 Oct.


Antibody-mediated protection against Staphylococcus aureus dermonecrosis and sepsis by a whole cell vaccine.

Zhang F, Jun M, Ledue O, Herd M, Malley R, Lu YJ.

Vaccine. 2017 Jul 5;35(31):3834-3843. doi: 10.1016/j.vaccine.2017.05.085. Epub 2017 Jun 7.


Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia.

Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP.

Mucosal Immunol. 2018 Jan;11(1):220-235. doi: 10.1038/mi.2017.43. Epub 2017 May 17.


The Pneumococcal Type 1 Pilus Genes Are Thermoregulated and Are Repressed by a Member of the Snf2 Protein Family.

Basset A, Herd M, Daly R, Dove SL, Malley R.

J Bacteriol. 2017 Jul 11;199(15). pii: e00078-17. doi: 10.1128/JB.00078-17. Print 2017 Aug 1.


Immunotherapy with single agent nivolumab for advanced leiomyosarcoma of the uterus: Results of a phase 2 study.

Ben-Ami E, Barysauskas CM, Solomon S, Tahlil K, Malley R, Hohos M, Polson K, Loucks M, Severgnini M, Patel T, Cunningham A, Rodig SJ, Hodi FS, Morgan JA, Merriam P, Wagner AJ, Shapiro GI, George S.

Cancer. 2017 Sep 1;123(17):3285-3290. doi: 10.1002/cncr.30738. Epub 2017 Apr 25.


Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils.

Tovar C, Pye RJ, Kreiss A, Cheng Y, Brown GK, Darby J, Malley RC, Siddle HV, Skjødt K, Kaufman J, Silva A, Baz Morelli A, Papenfuss AT, Corcoran LM, Murphy JM, Pearse MJ, Belov K, Lyons AB, Woods GM.

Sci Rep. 2017 Mar 9;7:43827. doi: 10.1038/srep43827.


Recombinant BCG expressing a PspA-PdT fusion protein protects mice against pneumococcal lethal challenge in a prime-boost strategy.

Goulart C, Rodriguez D, Kanno AI, Lu YJ, Malley R, Leite LC.

Vaccine. 2017 Mar 23;35(13):1683-1691. doi: 10.1016/j.vaccine.2017.02.029. Epub 2017 Feb 24.


IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine.

Campos IB, Herd M, Moffitt KL, Lu YJ, Darrieux M, Malley R, Leite LC, Gonçalves VM.

Vaccine. 2017 Mar 1;35(9):1306-1315. doi: 10.1016/j.vaccine.2017.01.030. Epub 2017 Feb 1.


Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice.

Jabara HH, Lee JJ, Janssen E, Ullas S, Liadaki K, Garibyan L, Benson H, Sannikova T, Bram R, Hammarstrom L, Cruz AC, Siegel R, Manis J, Malley R, Geha RS.

J Allergy Clin Immunol. 2017 Apr;139(4):1293-1301.e4. doi: 10.1016/j.jaci.2016.07.028. Epub 2016 Sep 5.


Pandoraea pnomenusa Isolated from an Australian Patient with Cystic Fibrosis.

Ambrose M, Malley RC, Warren SJ, Beggs SA, Swallow OF, McEwan B, Stock D, Roddam LF.

Front Microbiol. 2016 May 11;7:692. doi: 10.3389/fmicb.2016.00692. eCollection 2016.


Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies.

Choi EH, Zhang F, Lu YJ, Malley R.

Clin Vaccine Immunol. 2015 Dec 16;23(2):162-7. doi: 10.1128/CVI.00591-15. Print 2016 Feb.


Rationale and prospects for novel pneumococcal vaccines.

Moffitt K, Malley R.

Hum Vaccin Immunother. 2016;12(2):383-92. doi: 10.1080/21645515.2015.1087625. Review.


Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model.

Trzciński K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M.

mBio. 2015 Sep 15;6(5):e00902-15. doi: 10.1128/mBio.00902-15.


T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins.

Moffitt K, Howard A, Martin S, Cheung E, Herd M, Basset A, Malley R.

Clin Vaccine Immunol. 2015 Aug;22(8):909-16. doi: 10.1128/CVI.00118-15. Epub 2015 Jun 3.


Effect of nonheme iron-containing ferritin Dpr in the stress response and virulence of pneumococci.

Hua CZ, Howard A, Malley R, Lu YJ.

Infect Immun. 2014 Sep;82(9):3939-47. doi: 10.1128/IAI.01829-14. Epub 2014 Jul 7.


The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.

van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V.

Cell Host Microbe. 2014 Jun 11;15(6):729-740. doi: 10.1016/j.chom.2014.05.009.


Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins.

Moffitt K, Skoberne M, Howard A, Gavrilescu LC, Gierahn T, Munzer S, Dixit B, Giannasca P, Flechtner JB, Malley R.

Infect Immun. 2014 May;82(5):2079-86. doi: 10.1128/IAI.01632-13. Epub 2014 Mar 10.


Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability.

Gonçalves VM, Dias WO, Campos IB, Liberman C, Sbrogio-Almeida ME, Silva EP, Cardoso CP Jr, Alderson M, Robertson G, Maisonneuve JF, Tate A, Anderson P, Malley R, Fratelli F, Leite LC.

Vaccine. 2014 Feb 19;32(9):1113-20. doi: 10.1016/j.vaccine.2013.10.091. Epub 2013 Dec 14.


Immunisation against meningococcus B.

Finn A, Malley R.

Lancet. 2013 Sep 7;382(9895):857. doi: 10.1016/S0140-6736(13)61860-7. No abstract available.


Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity.

Zhang F, Lu YJ, Malley R.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13564-9. doi: 10.1073/pnas.1307228110. Epub 2013 Jul 29.


Dietary vitamin D alters the response of the skin to UVB-irradiation depending on the genetic background of the mice.

Malley RC, Muller HK, Norval M, Woods GM.

Photochem Photobiol Sci. 2013 Mar;12(3):536-45. doi: 10.1039/c2pp25211b.


Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.

Basset A, Zhang F, Benes C, Sayeed S, Herd M, Thompson C, Golenbock DT, Camilli A, Malley R.

J Biol Chem. 2013 Jan 25;288(4):2665-75. doi: 10.1074/jbc.M112.398875. Epub 2012 Dec 11.


Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.

Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M.

PLoS Pathog. 2012;8(11):e1002989. doi: 10.1371/journal.ppat.1002989. Epub 2012 Nov 8.


Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine.

Moffitt KL, Malley R, Lu YJ.

PLoS One. 2012;7(8):e43445. doi: 10.1371/journal.pone.0043445. Epub 2012 Aug 14.


Meta-analysis of bacterial meningitis score validation studies.

Nigrovic LE, Malley R, Kuppermann N.

Arch Dis Child. 2012 Sep;97(9):799-805. doi: 10.1136/archdischild-2012-301798. Epub 2012 Jul 4. Review.


Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine.

Moffitt KL, Yadav P, Weinberger DM, Anderson PW, Malley R.

Vaccine. 2012 Jun 19;30(29):4316-22. doi: 10.1016/j.vaccine.2012.01.034.


Streptococcus pneumoniae carriage in the Gaza strip.

Regev-Yochay G, Abullaish I, Malley R, Shainberg B, Varon M, Roytman Y, Ziv A, Goral A, Elhamdany A, Rahav G, Raz M; Palestinian-Israeli Collaborative Research Study Group.

PLoS One. 2012;7(4):e35061. doi: 10.1371/journal.pone.0035061. Epub 2012 Apr 23.


Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country.

Lundgren A, Bhuiyan TR, Novak D, Kaim J, Reske A, Lu YJ, Qadri F, Malley R.

Vaccine. 2012 Jun 6;30(26):3897-907. doi: 10.1016/j.vaccine.2012.03.082. Epub 2012 Apr 12.


A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi.

Lu YJ, Zhang F, Sayeed S, Thompson CM, Szu S, Anderson PW, Malley R.

Vaccine. 2012 May 14;30(23):3405-12. doi: 10.1016/j.vaccine.2012.03.039. Epub 2012 Mar 29.


Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity.

Malley R, Anderson PW.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3623-7. doi: 10.1073/pnas.1121383109. Epub 2012 Feb 2. Review.


B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.

Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD.

Blood. 2012 Mar 22;119(12):2819-28. doi: 10.1182/blood-2011-09-379412. Epub 2012 Feb 1.


An epigenetic switch mediates bistable expression of the type 1 pilus genes in Streptococcus pneumoniae.

Basset A, Turner KH, Boush E, Sayeed S, Dove SL, Malley R.

J Bacteriol. 2012 Mar;194(5):1088-91. doi: 10.1128/JB.06078-11. Epub 2011 Dec 22.


Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization.

Zhang Q, Leong SC, McNamara PS, Mubarak A, Malley R, Finn A.

PLoS Pathog. 2011 Aug;7(8):e1002175. doi: 10.1371/journal.ppat.1002175. Epub 2011 Aug 11.


Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA.

Basset A, Turner KH, Boush E, Sayeed S, Dove SL, Malley R.

Infect Immun. 2011 Aug;79(8):2974-83. doi: 10.1128/IAI.05117-11. Epub 2011 May 16.


Next generation pneumococcal vaccines.

Moffitt KL, Malley R.

Curr Opin Immunol. 2011 Jun;23(3):407-13. doi: 10.1016/j.coi.2011.04.002. Epub 2011 Apr 21. Review.

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