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Items: 33


NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.

Miloudi K, Oubaha M, Ménard C, Dejda A, Guber V, Cagnone G, Wilson AM, Tétreault N, Mawambo G, Binet F, Chidiac R, Delisle C, Buscarlet M, Cerani A, Crespo-Garcia S, Bentley K, Rezende F, Joyal JS, Mallette FA, Gratton JP, Larrivée B, Sapieha P.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.


Targeting LINC00673 expression triggers cellular senescence in lung cancer.

Roth A, Boulay K, Groß M, Polycarpou-Schwarz M, Mallette FA, Regnier M, Bida O, Ginsberg D, Warth A, Schnabel PA, Muley T, Meister M, Zabeck H, Hoffmann H, Diederichs S.

RNA Biol. 2018;15(12):1499-1511. doi: 10.1080/15476286.2018.1553481. Epub 2018 Dec 7.


MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin.

Samba-Mondonga M, Calvé A, Mallette FA, Santos MM.

Front Cell Dev Biol. 2018 Aug 31;6:105. doi: 10.3389/fcell.2018.00105. eCollection 2018.


Translation Links Nutrient Availability with Inflammation.

Boulay K, Topisirovic I, Mallette FA.

Trends Biochem Sci. 2018 Nov;43(11):849-852. doi: 10.1016/j.tibs.2018.08.010. Epub 2018 Sep 14.


Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest.

Sapieha P, Mallette FA.

Trends Cell Biol. 2018 Aug;28(8):595-607. doi: 10.1016/j.tcb.2018.03.003. Epub 2018 Apr 25. Review.


Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S.

Cancer Cell. 2018 Apr 9;33(4):785. doi: 10.1016/j.ccell.2018.03.009. No abstract available.


Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S.

Cancer Cell. 2018 Feb 12;33(2):322-336.e8. doi: 10.1016/j.ccell.2018.01.002. Erratum in: Cancer Cell. 2018 Apr 9;33(4):785.


Molecular Regulation of Cellular Senescence by MicroRNAs: Implications in Cancer and Age-Related Diseases.

Neault M, Couteau F, Bonneau É, De Guire V, Mallette FA.

Int Rev Cell Mol Biol. 2017;334:27-98. doi: 10.1016/bs.ircmb.2017.04.001. Epub 2017 May 18. Review.


Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling.

M Gagné L, Boulay K, Topisirovic I, Huot MÉ, Mallette FA.

Trends Cell Biol. 2017 Oct;27(10):738-752. doi: 10.1016/j.tcb.2017.06.002. Epub 2017 Jul 12. Review.


The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma.

Fernández E, Mallette FA.

PLoS Genet. 2016 Nov 3;12(11):e1006344. doi: 10.1371/journal.pgen.1006344. eCollection 2016 Nov. No abstract available.


Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P.

Sci Transl Med. 2016 Oct 26;8(362):362ra144.


The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.

Carbonneau M, M Gagné L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot MÉ, Mallette FA.

Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700.


miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells.

Neault M, Mallette FA, Richard S.

Cell Rep. 2016 Mar 1;14(8):1966-78. doi: 10.1016/j.celrep.2016.01.068. Epub 2016 Feb 18.


The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.

Daou S, Hammond-Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono NV, Nkwe NS, Motorina A, Pak H, Yu H, Wurtele H, Milot E, Mallette FA, Carbone M, Affar el B.

J Biol Chem. 2015 Nov 27;290(48):28643-63. doi: 10.1074/jbc.M115.661553. Epub 2015 Sep 28.


Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.

Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V.

J Biol Chem. 2015 Jul 31;290(31):19044-54. doi: 10.1074/jbc.M115.637660. Epub 2015 Jun 12.


Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.

Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC.

Immunity. 2014 Mar 20;40(3):342-54. doi: 10.1016/j.immuni.2014.02.006.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.

Mallette FA, Richard S.

Cell Rep. 2012 Nov 29;2(5):1233-43. doi: 10.1016/j.celrep.2012.09.033. Epub 2012 Nov 15.


Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.

Neault M, Mallette FA, Vogel G, Michaud-Levesque J, Richard S.

Nucleic Acids Res. 2012 Oct;40(19):9513-21. doi: 10.1093/nar/gks764. Epub 2012 Aug 16.


K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites.

Mallette FA, Richard S.

Cell Res. 2012 Aug;22(8):1221-3. doi: 10.1038/cr.2012.58. Epub 2012 Apr 10.


The fight of the Tudor domain "Royal family" for a broken DNA throne.

Mallette FA, Richard S.

Cell Cycle. 2012 Apr 15;11(8):1483-4. doi: 10.4161/cc.20124. Epub 2012 Apr 15. No abstract available.


RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S.

EMBO J. 2012 Apr 18;31(8):1865-78. doi: 10.1038/emboj.2012.47. Epub 2012 Feb 28.


SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence.

Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G.

Aging (Albany NY). 2010 Jul;2(7):445-52.


Transcriptome analysis and tumor suppressor requirements of STAT5-induced senescence.

Mallette FA, Moiseeva O, Calabrese V, Mao B, Gaumont-Leclerc MF, Ferbeyre G.

Ann N Y Acad Sci. 2010 Jun;1197:142-51. doi: 10.1111/j.1749-6632.2010.05192.x.


Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells.

Voghel G, Thorin-Trescases N, Mamarbachi AM, Villeneuve L, Mallette FA, Ferbeyre G, Farhat N, Perrault LP, Carrier M, Thorin E.

Mech Ageing Dev. 2010 May;131(5):354-63. doi: 10.1016/j.mad.2010.04.004. Epub 2010 Apr 24. Erratum in: Mech Ageing Dev. 2010 Sep;131(9):599.


SOCS1 links cytokine signaling to p53 and senescence.

Calabrese V, Mallette FA, Deschênes-Simard X, Ramanathan S, Gagnon J, Moores A, Ilangumaran S, Ferbeyre G.

Mol Cell. 2009 Dec 11;36(5):754-67. doi: 10.1016/j.molcel.2009.09.044.


[The DNA damage response contributes to tumor suppression by sensing oncogenic activity].

Mallette FA, Ferbeyre G.

Med Sci (Paris). 2008 Jan;24(1):29-30. doi: 10.1051/medsci/200824129. French. No abstract available.


Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence.

Mallette FA, Gaumont-Leclerc MF, Huot G, Ferbeyre G.

J Biol Chem. 2007 Nov 30;282(48):34938-44. Epub 2007 Oct 3.


Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer.

Villiard E, Brinkmann H, Moiseeva O, Mallette FA, Ferbeyre G, Roy S.

BMC Evol Biol. 2007 Sep 28;7:180.


The DNA damage signaling pathway connects oncogenic stress to cellular senescence.

Mallette FA, Ferbeyre G.

Cell Cycle. 2007 Aug 1;6(15):1831-6. Epub 2007 May 24. Review.


The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

Mallette FA, Gaumont-Leclerc MF, Ferbeyre G.

Genes Dev. 2007 Jan 1;21(1):43-8.


DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation.

Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G.

Mol Biol Cell. 2006 Apr;17(4):1583-92. Epub 2006 Jan 25.


Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.

Mallette FA, Goumard S, Gaumont-Leclerc MF, Moiseeva O, Ferbeyre G.

Oncogene. 2004 Jan 8;23(1):91-9.


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