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Items: 1 to 50 of 135

1.

The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.

Li L, Wei J, Li S, Jacko AM, Weathington NM, Mallampalli RK, Zhao J, Zhao Y.

EBioMedicine. 2019 Jun 13. pii: S2352-3964(19)30386-X. doi: 10.1016/j.ebiom.2019.06.011. [Epub ahead of print]

2.

TRIM21 mitigates human lung microvascular endothelial cells inflammatory responses to lipopolysaccharide.

Li L, Wei J, Mallampalli RK, Zhao Y, Zhao J.

Am J Respir Cell Mol Biol. 2019 Jun 11. doi: 10.1165/rcmb.2018-0366OC. [Epub ahead of print]

PMID:
31184939
3.

Redox (phospho)lipidomics of signaling in inflammation and programmed cell death.

Tyurina YY, St Croix CM, Watkins SC, Watson AM, Epperly MW, Anthonymuthu TS, Kisin ER, Vlasova II, Krysko O, Krysko DV, Kapralov AA, Dar HH, Tyurin VA, Amoscato AA, Popova EN, Bolevich SB, Timashev PS, Kellum JA, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Shvedova AA, Kagan VE.

J Leukoc Biol. 2019 Jul;106(1):57-81. doi: 10.1002/JLB.3MIR0119-004RR. Epub 2019 May 9. Review.

PMID:
31071242
4.

Update in Critical Care and Acute Respiratory Distress Syndrome 2018.

Douglas IS, Bednash JS, Fein DG, Mallampalli RK, Mansoori JN, Gershengorn HB.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1335-1343. doi: 10.1164/rccm.201903-0550UP. No abstract available.

PMID:
30958975
5.

Prolonged Cold-Ischemia Induces Necroptotic Cell Death in Ischemia Reperfusion Injury and Contributes to Primary Graft Dysfunction After Lung Transplantation.

Wang X, O'Brien ME, Yu J, Xu C, Zhang Q, Lu S, Liang L, An X, McDyer JF, Mallampalli RK.

Am J Respir Cell Mol Biol. 2019 Feb 11. doi: 10.1165/rcmb.2018-0207OC. [Epub ahead of print]

PMID:
30742487
6.

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.

Bain W, Olonisakin T, Yu M, Qu Y, Hulver M, Xiong Z, Li H, Pilewski J, Mallampalli RK, Nouraie M, Ray A, Ray P, Cheng Z, Shanks RMQ, St Croix C, Silverstein RL, Lee JS.

Blood Adv. 2019 Feb 12;3(3):432-445. doi: 10.1182/bloodadvances.2018026286.

7.

RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia.

Voic H, Li X, Jang JH, Zou C, Sundd P, Alder J, Rojas M, Chandra D, Randell S, Mallampalli RK, Tesfaigzi Y, Ryba T, Nyunoya T.

BMC Genomics. 2019 Jan 9;20(1):22. doi: 10.1186/s12864-018-5409-z.

8.

Retraction: Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD).

Lakshmi SP, Reddy AT, Zhang Y, Sciurba FC, Mallampalli RK, Duncan SR, Reddy RC.

J Biol Chem. 2019 Jan 4;294(1):69. doi: 10.1074/jbc.RX118.007042. No abstract available.

9.

The SCFFBXO3 ubiquitin E3 ligase regulates inflammation in atherosclerosis.

Chandra D, Londino J, Alexander S, Bednash JS, Zhang Y, Friedlander RM, Daskivich G, Carlisle DL, Lariviere WR, Nakassa ACI, Ross M, St Croix C, Nyunoya T, Sciurba F, Chen B, Mallampalli RK.

J Mol Cell Cardiol. 2019 Jan;126:50-59. doi: 10.1016/j.yjmcc.2018.11.006. Epub 2018 Nov 16.

PMID:
30448480
10.

FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells.

Suber TL, Nikolli I, O'Brien ME, Londino J, Zhao J, Chen K, Mallampalli RK, Zhao Y.

Respir Res. 2018 Oct 25;19(1):206. doi: 10.1186/s12931-018-0910-0.

11.

Ex vivo lung perfusion as a human platform for preclinical small molecule testing.

Weathington NM, Álvarez D, Sembrat J, Radder J, Cárdenes N, Noda K, Gong Q, Wong H, Kolls J, D'Cunha J, Mallampalli RK, Chen BB, Rojas M.

JCI Insight. 2018 Oct 4;3(19). pii: 95515. doi: 10.1172/jci.insight.95515.

12.

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.

Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE.

J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10.

13.

The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis.

Meiners S, Evankovich J, Mallampalli RK.

Transl Res. 2018 Aug;198:17-28. doi: 10.1016/j.trsl.2018.03.003. Epub 2018 Mar 29. Review.

PMID:
29702079
14.

ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis.

Bueno M, Brands J, Voltz L, Fiedler K, Mays B, St Croix C, Sembrat J, Mallampalli RK, Rojas M, Mora AL.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12720. Epub 2018 Jan 24.

15.

Targeting Deubiquitinases in Cancer.

Bednash JS, Mallampalli RK.

Methods Mol Biol. 2018;1731:295-305. doi: 10.1007/978-1-4939-7595-2_25.

PMID:
29318562
16.

An Emerging Role for Megalin as a Regulator of Protein Leak in Acute Lung Injury.

Suber T, Mallampalli RK.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):504-505. doi: 10.1165/rcmb.2017-0224ED. No abstract available.

PMID:
29090957
17.

Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

Wang D, Zhao J, Li S, Wei J, Nan L, Mallampalli RK, Weathington NM, Ma H, Zhao Y.

J Mol Cell Biol. 2018 Feb 1;10(1):60-73. doi: 10.1093/jmcb/mjx034.

18.

Post-translational modification of the interferon-gamma receptor alters its stability and signaling.

Londino JD, Gulick DL, Lear TB, Suber TL, Weathington NM, Masa LS, Chen BB, Mallampalli RK.

Biochem J. 2017 Oct 10;474(20):3543-3557. doi: 10.1042/BCJ20170548.

19.

"Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions.

Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE.

Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. Epub 2017 Oct 16.

PMID:
28835115
20.

Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation.

Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK.

Respir Res. 2017 Jun 28;18(1):131. doi: 10.1186/s12931-017-0608-8.

21.

Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.

Evankovich J, Lear T, Mckelvey A, Dunn S, Londino J, Liu Y, Chen BB, Mallampalli RK.

FASEB J. 2017 Sep;31(9):3894-3903. doi: 10.1096/fj.201700031R. Epub 2017 May 17.

22.

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.

Bednash JS, Weathington N, Londino J, Rojas M, Gulick DL, Fort R, Han S, McKelvey AC, Chen BB, Mallampalli RK.

Nat Commun. 2017 May 11;8:15203. doi: 10.1038/ncomms15203.

23.

IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling.

Weathington NM, Kanth SM, Gong Q, Londino J, Hoji A, Rojas M, Trudeau J, Wenzel S, Mallampalli RK.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):346-354. doi: 10.1165/rcmb.2016-0316OC.

24.

SCFFBXO17 E3 ligase modulates inflammation by regulating proteasomal degradation of glycogen synthase kinase-3β in lung epithelia.

Suber T, Wei J, Jacko AM, Nikolli I, Zhao Y, Zhao J, Mallampalli RK.

J Biol Chem. 2017 May 5;292(18):7452-7461. doi: 10.1074/jbc.M116.771667. Epub 2017 Mar 15.

25.

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia.

Chakraborty K, Raundhal M, Chen BB, Morse C, Tyurina YY, Khare A, Oriss TB, Huff R, Lee JS, St Croix CM, Watkins S, Mallampalli RK, Kagan VE, Ray A, Ray P.

Nat Commun. 2017 Jan 11;8:13944. doi: 10.1038/ncomms13944.

26.

Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination.

Han S, Jerome JA, Gregory AD, Mallampalli RK.

Respir Res. 2017 Jan 5;18(1):2. doi: 10.1186/s12931-016-0485-6.

27.

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H.

Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. Epub 2016 Nov 14.

28.

CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis.

Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS.

J Infect Dis. 2016 Dec 15;214(12):1865-1875. Epub 2016 Sep 28.

29.

Biosynthesis of oxidized lipid mediators via lipoprotein-associated phospholipase A2 hydrolysis of extracellular cardiolipin induces endothelial toxicity.

Buland JR, Wasserloos KJ, Tyurin VA, Tyurina YY, Amoscato AA, Mallampalli RK, Chen BB, Zhao J, Zhao Y, Ofori-Acquah S, Kagan VE, Pitt BR.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L303-16. doi: 10.1152/ajplung.00038.2016. Epub 2016 May 27.

30.

Regulation of inflammasomes by ubiquitination.

Bednash JS, Mallampalli RK.

Cell Mol Immunol. 2016 Nov;13(6):722-728. doi: 10.1038/cmi.2016.15. Epub 2016 Apr 11. Review.

31.

Crystal structure and interaction studies of the human FBxo3 ApaG domain.

Krzysiak TC, Chen BB, Lear T, Mallampalli RK, Gronenborn AM.

FEBS J. 2016 Jun;283(11):2091-101. doi: 10.1111/febs.13721. Epub 2016 Apr 22.

32.

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy.

Kagan VE, Jiang J, Huang Z, Tyurina YY, Desbourdes C, Cottet-Rousselle C, Dar HH, Verma M, Tyurin VA, Kapralov AA, Cheikhi A, Mao G, Stolz D, St Croix CM, Watkins S, Shen Z, Li Y, Greenberg ML, Tokarska-Schlattner M, Boissan M, Lacombe ML, Epand RM, Chu CT, Mallampalli RK, Bayır H, Schlattner U.

Cell Death Differ. 2016 Jul;23(7):1140-51. doi: 10.1038/cdd.2015.160. Epub 2016 Jan 8.

33.

LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.

Zou C, Synan MJ, Li J, Xiong S, Manni ML, Liu Y, Chen BB, Zhao Y, Shiva S, Tyurina YY, Jiang J, Lee JS, Das S, Ray A, Ray P, Kagan VE, Mallampalli RK.

J Cell Sci. 2016 Jan 1;129(1):51-64. doi: 10.1242/jcs.176701. Epub 2015 Nov 24.

34.

Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling.

Londino JD, Gulick D, Isenberg JS, Mallampalli RK.

J Biol Chem. 2015 Dec 25;290(52):31113-25. doi: 10.1074/jbc.M115.682914. Epub 2015 Nov 3.

35.

Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.

Zou C, Li J, Xiong S, Chen Y, Wu Q, Li X, Weathington NM, Han S, Snavely C, Chen BB, Mallampalli RK.

Sci Transl Med. 2015 Oct 28;7(311):311ra171. doi: 10.1126/scitranslmed.aac7793.

36.

Small molecule therapeutics targeting F-box proteins in cancer.

Liu Y, Mallampalli RK.

Semin Cancer Biol. 2016 Feb;36:105-19. doi: 10.1016/j.semcancer.2015.09.014. Epub 2015 Sep 30. Review.

37.

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity.

Balasubramanian K, Maeda A, Lee JS, Mohammadyani D, Dar HH, Jiang JF, St Croix CM, Watkins S, Tyurin VA, Tyurina YY, Klöditz K, Polimova A, Kapralova VI, Xiong Z, Ray P, Klein-Seetharaman J, Mallampalli RK, Bayir H, Fadeel B, Kagan VE.

Sci Signal. 2015 Sep 22;8(395):ra95. doi: 10.1126/scisignal.aaa6179.

38.

VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis.

Agassandian M, Tedrow JR, Sembrat J, Kass DJ, Zhang Y, Goncharova EA, Kaminski N, Mallampalli RK, Vuga LJ.

Cell Signal. 2015 Dec;27(12):2467-73. doi: 10.1016/j.cellsig.2015.09.003. Epub 2015 Sep 18.

39.

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.

Han S, Lear TB, Jerome JA, Rajbhandari S, Snavely CA, Gulick DL, Gibson KF, Zou C, Chen BB, Mallampalli RK.

J Biol Chem. 2015 Jul 17;290(29):18124-33. doi: 10.1074/jbc.M115.645549. Epub 2015 Jun 2.

40.

Correction: The acute respiratory distress syndrome: from mechanism to translation.

Han S, Mallampalli RK.

J Immunol. 2015 Jun 1;194(11):5569. doi: 10.4049/jimmunol.1500741. No abstract available.

41.

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, Jerome J, Chen BB, Mallampalli RK.

J Biol Chem. 2015 May 8;290(19):11843-52. doi: 10.1074/jbc.M114.629931. Epub 2015 Mar 16.

42.

The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections.

Han S, Mallampalli RK.

Ann Am Thorac Soc. 2015 May;12(5):765-74. doi: 10.1513/AnnalsATS.201411-507FR. Review.

43.

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.

Liu Y, Lear T, Zhao Y, Zhao J, Zou C, Chen BB, Mallampalli RK.

Cell Death Dis. 2015 Feb 5;6:e1630. doi: 10.1038/cddis.2014.585.

44.

The acute respiratory distress syndrome: from mechanism to translation.

Han S, Mallampalli RK.

J Immunol. 2015 Feb 1;194(3):855-60. doi: 10.4049/jimmunol.1402513. Review. Erratum in: J Immunol. 2015 Jun 1;194(11):5569.

45.

The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation.

Chen W, Xiong S, Li J, Li X, Liu Y, Zou C, Mallampalli RK.

Mol Cell Biol. 2015 Mar;35(6):1001-13. doi: 10.1128/MCB.01185-14. Epub 2015 Jan 12.

46.

Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation.

Kagan VE, Tyurina YY, Tyurin VA, Mohammadyani D, Angeli JP, Baranov SV, Klein-Seetharaman J, Friedlander RM, Mallampalli RK, Conrad M, Bayir H.

Antioxid Redox Signal. 2015 Jun 20;22(18):1667-80. doi: 10.1089/ars.2014.6219. Epub 2015 Mar 31. Review.

47.

Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.

Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS.

Mucosal Immunol. 2015 Jul;8(4):896-905. doi: 10.1038/mi.2014.120. Epub 2014 Dec 10.

48.

Decoding the growth advantage of hypoxia-sensitive lung cancer.

Liu Y, Mallampalli RK.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):603-5. doi: 10.1164/rccm.201408-1503ED. No abstract available.

49.

Sizing up surfactant synthesis.

Han S, Mallampalli RK.

Cell Metab. 2014 Aug 5;20(2):195-6. doi: 10.1016/j.cmet.2014.07.015.

50.

Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway.

Kagan VE, Kapralov AA, St Croix CM, Watkins SC, Kisin ER, Kotchey GP, Balasubramanian K, Vlasova II, Yu J, Kim K, Seo W, Mallampalli RK, Star A, Shvedova AA.

ACS Nano. 2014 Jun 24;8(6):5610-21. doi: 10.1021/nn406484b. Epub 2014 Jun 4.

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