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Items: 1 to 50 of 216

1.

The value of chest magnetic resonance imaging compared to chest radiographs with and without additional lung ultrasound in children with complicated pneumonia.

Konietzke P, Mueller J, Wuennemann F, Wagner WL, Schenk JP, Alrajab A, Kauczor HU, Stahl M, Mall MA, Wielpütz MO, Sommerburg O.

PLoS One. 2020 Mar 19;15(3):e0230252. doi: 10.1371/journal.pone.0230252. eCollection 2020.

2.

MRI Detects Chronic Rhinosinusitis in Infants and Preschool Children with Cystic Fibrosis.

Sommerburg O, Wielpütz MO, Trame JP, Wuennemann F, Optazaite E, Stahl M, Puderbach MU, Kopp-Schneider A, Fritzsching E, Kauczor HU, Baumann I, Mall MA, Eichinger M.

Ann Am Thorac Soc. 2020 Mar 6. doi: 10.1513/AnnalsATS.201910-777OC. [Epub ahead of print]

PMID:
32142375
3.

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA.

Eur Respir J. 2020 Mar 5. pii: 1902355. doi: 10.1183/13993003.02355-2019. [Epub ahead of print] No abstract available.

PMID:
32139467
4.

Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells.

Sörensen M, Kantorek J, Byrnes L, Boutin S, Mall MA, Lasitschka F, Zabeck H, Nguyen D, Dalpke AH.

Front Immunol. 2020 Feb 4;11:96. doi: 10.3389/fimmu.2020.00096. eCollection 2020.

5.

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.

Geurts MH, de Poel E, Amatngalim GD, Oka R, Meijers FM, Kruisselbrink E, van Mourik P, Berkers G, de Winter-de Groot KM, Michel S, Muilwijk D, Aalbers BL, Mullenders J, Boj SF, Suen SWF, Brunsveld JE, Janssens HM, Mall MA, Graeber SY, van Boxtel R, van der Ent CK, Beekman JM, Clevers H.

Cell Stem Cell. 2020 Feb 13. pii: S1934-5909(20)30019-9. doi: 10.1016/j.stem.2020.01.019. [Epub ahead of print]

PMID:
32084388
6.

At the forefront of cystic fibrosis Basic Science research: 16th ECFS Basic Science Conference.

Taggart CC, Weldon S, Mall MA.

J Cyst Fibros. 2020 Feb 13. pii: S1569-1993(20)30047-3. doi: 10.1016/j.jcf.2020.02.002. [Epub ahead of print] No abstract available.

PMID:
32063486
7.

Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease.

Giacalone VD, Margaroli C, Mall MA, Tirouvanziam R.

Int J Mol Sci. 2020 Jan 28;21(3). pii: E851. doi: 10.3390/ijms21030851. Review.

8.

Intravital microscopic optical coherence tomography imaging to assess mucus-mobilizing interventions for muco-obstructive lung disease in mice.

Pieper M, Schulz-Hildebrandt H, Mall MA, Hüttmann G, König P.

Am J Physiol Lung Cell Mol Physiol. 2020 Mar 1;318(3):L518-L524. doi: 10.1152/ajplung.00287.2019. Epub 2020 Jan 29.

9.

Normative data for multiple breath washout outcomes in school-aged Caucasian children.

Anagnostopoulou P, Latzin P, Jensen R, Stahl M, Harper A, Yammine S, Usemann J, Foong RE, Spycher B, Hall GL, Singer F, Stanojevic S, Mall M, Ratjen F, Ramsey KA.

Eur Respir J. 2019 Dec 20. pii: 1901302. doi: 10.1183/13993003.01302-2019. [Epub ahead of print]

PMID:
31862765
10.

Cystic Fibrosis: Emergence of Highly Effective Targeted Therapeutics and Potential Clinical Implications.

Mall MA, Mayer-Hamblett N, Rowe SM.

Am J Respir Crit Care Med. 2019 Dec 20. doi: 10.1164/rccm.201910-1943SO. [Epub ahead of print]

PMID:
31860331
11.

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

Balázs A, Mall MA.

Pediatr Pulmonol. 2019 Nov;54 Suppl 3:S5-S12. doi: 10.1002/ppul.24462. Review.

PMID:
31715090
12.

Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.

Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group.

N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31.

PMID:
31697873
13.

Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial.

Heijerman HGM, McKone EF, Downey DG, Van Braeckel E, Rowe SM, Tullis E, Mall MA, Welter JJ, Ramsey BW, McKee CM, Marigowda G, Moskowitz SM, Waltz D, Sosnay PR, Simard C, Ahluwalia N, Xuan F, Zhang Y, Taylor-Cousar JL, McCoy KS; VX17-445-103 Trial Group.

Lancet. 2019 Nov 23;394(10212):1940-1948. doi: 10.1016/S0140-6736(19)32597-8. Epub 2019 Oct 31.

PMID:
31679946
14.

Targeting Proteases in Cystic Fibrosis Lung Disease. Paradigms, Progress, and Potential.

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147. doi: 10.1164/rccm.201906-1190PP. No abstract available.

PMID:
31626562
15.

Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study.

Bélard S, Brand J, Schulze-Sturm U, Janda A, von Both U, Tacoli C, Alberer M, Kempf C, Stegemann MS, Krüger R, Varnholt V, Blohm M, Reiter K, Zoller T, Suttorp N, Mall M, von Bernuth H, Gratopp A, Hübner J, Hufnagel M, Kobbe R, Kurth F.

Pediatr Infect Dis J. 2019 Nov;38(11):e295-e300. doi: 10.1097/INF.0000000000002417.

PMID:
31626041
16.

The future of cystic fibrosis care: a global perspective.

Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castaños C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F.

Lancet Respir Med. 2020 Jan;8(1):65-124. doi: 10.1016/S2213-2600(19)30337-6. Epub 2019 Sep 27. Review. Erratum in: Lancet Respir Med. 2019 Dec;7(12):e40.

PMID:
31570318
17.

Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease.

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA.

Am J Respir Cell Mol Biol. 2020 Mar;62(3):300-309. doi: 10.1165/rcmb.2018-0359OC.

PMID:
31499011
18.

Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles.

Taylor-Cousar JL, Mall MA, Ramsey BW, McKone EF, Tullis E, Marigowda G, McKee CM, Waltz D, Moskowitz SM, Savage J, Xuan F, Rowe SM.

ERJ Open Res. 2019 Jun 17;5(2). pii: 00082-2019. doi: 10.1183/23120541.00082-2019. eCollection 2019 Apr.

19.

Ten years of chest MRI for patients with cystic fibrosis : Translation from the bench to clinical routine.

Leutz-Schmidt P, Eichinger M, Stahl M, Sommerburg O, Biederer J, Kauczor HU, Puderbach MU, Mall MA, Wielpütz MO.

Radiologe. 2019 Dec;59(Suppl 1):10-20. doi: 10.1007/s00117-019-0553-2. Review.

PMID:
31172247
20.

Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond.

Nair P, Mall M, Sharma P, Khan F, Nagegowda DA, Rout PK, Gupta MM, Pandey A, Shasany AK, Gupta AK, Shukla AK.

Plant Mol Biol. 2019 Jul;100(4-5):527-541. doi: 10.1007/s11103-019-00879-x. Epub 2019 May 15.

PMID:
31093899
21.

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry.

Guerra M, Frey D, Hagner M, Dittrich S, Paulsen M, Mall MA, Schultz C.

ACS Cent Sci. 2019 Mar 27;5(3):539-548. doi: 10.1021/acscentsci.8b00933. Epub 2019 Feb 19.

22.

Midterm Reproducibility of Chest Magnetic Resonance Imaging in Adults with Clinically Stable Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.

Wielpütz MO, Eichinger M, Wege S, Eberhardt R, Mall MA, Kauczor HU, Puderbach MU, Risse F, Heußel CP, Heußel G.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):103-107. doi: 10.1164/rccm.201812-2356LE. No abstract available.

PMID:
30875236
23.

Authors' response: Letter to the Editor 'Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis'.

Stahl M, Joachim C, Wielpütz MO, Mall MA.

J Cyst Fibros. 2019 May;18(3):e28-e29. doi: 10.1016/j.jcf.2019.01.016. Epub 2019 Feb 7. No abstract available.

PMID:
30738803
24.

Targeting of cathepsin S reduces cystic fibrosis-like lung disease.

Small DM, Brown RR, Doherty DF, Abladey A, Zhou-Suckow Z, Delaney RJ, Kerrigan L, Dougan CM, Borensztajn KS, Holsinger L, Booth R, Scott CJ, López-Campos G, Elborn JS, Mall MA, Weldon S, Taggart CC.

Eur Respir J. 2019 Mar 28;53(3). pii: 1801523. doi: 10.1183/13993003.01523-2018. Print 2019 Mar.

PMID:
30655278
25.

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons.

Luo C, Lee QY, Wapinski O, Castanon R, Nery JR, Mall M, Kareta MS, Cullen SM, Goodell MA, Chang HY, Wernig M, Ecker JR.

Elife. 2019 Jan 15;8. pii: e40197. doi: 10.7554/eLife.40197.

26.

Antisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosis.

Sermet-Gaudelus I, Clancy JP, Nichols DP, Nick JA, De Boeck K, Solomon GM, Mall MA, Bolognese J, Bouisset F, den Hollander W, Paquette-Lamontagne N, Tomkinson N, Henig N, Elborn JS, Rowe SM.

J Cyst Fibros. 2019 Jul;18(4):536-542. doi: 10.1016/j.jcf.2018.10.015. Epub 2018 Nov 19.

27.

Emerging Concepts and Therapies for Mucoobstructive Lung Disease.

Mall MA, Danahay H, Boucher RC.

Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S216-S226. doi: 10.1513/AnnalsATS.201806-368AW. Review.

28.

Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis.

Stahl M, Joachim C, Wielpütz MO, Mall MA.

J Cyst Fibros. 2019 May;18(3):399-406. doi: 10.1016/j.jcf.2018.11.001. Epub 2018 Nov 9.

PMID:
30420236
29.

Preventive Inhalation of Hypertonic Saline in Infants with Cystic Fibrosis (PRESIS). A Randomized, Double-Blind, Controlled Study.

Stahl M, Wielpütz MO, Ricklefs I, Dopfer C, Barth S, Schlegtendal A, Graeber SY, Sommerburg O, Diekmann G, Hüsing J, Koerner-Rettberg C, Nährlich L, Dittrich AM, Kopp MV, Mall MA.

Am J Respir Crit Care Med. 2019 May 15;199(10):1238-1248. doi: 10.1164/rccm.201807-1203OC.

PMID:
30409023
30.

VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

Davies JC, Moskowitz SM, Brown C, Horsley A, Mall MA, McKone EF, Plant BJ, Prais D, Ramsey BW, Taylor-Cousar JL, Tullis E, Uluer A, McKee CM, Robertson S, Shilling RA, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Rowe SM; VX16-659-101 Study Group.

N Engl J Med. 2018 Oct 25;379(17):1599-1611. doi: 10.1056/NEJMoa1807119. Epub 2018 Oct 18.

31.

VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

Keating D, Marigowda G, Burr L, Daines C, Mall MA, McKone EF, Ramsey BW, Rowe SM, Sass LA, Tullis E, McKee CM, Moskowitz SM, Robertson S, Savage J, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Taylor-Cousar JL; VX16-445-001 Study Group.

N Engl J Med. 2018 Oct 25;379(17):1612-1620. doi: 10.1056/NEJMoa1807120. Epub 2018 Oct 18.

32.

Role of the SLC26A9 Chloride Channel as Disease Modifier and Potential Therapeutic Target in Cystic Fibrosis.

Balázs A, Mall MA.

Front Pharmacol. 2018 Oct 1;9:1112. doi: 10.3389/fphar.2018.01112. eCollection 2018. Review.

33.

Assessment of Suspected Vascular Rings and Slings and/or Airway Pathologies Using Magnetic Resonance Imaging Rather Than Computed Tomography.

Sommburg O, Helling-Bakki A, Alrajab A, Schenk JP, Springer W, Mall MA, Loukanov T, Eichhorn JG.

Respiration. 2019;97(2):108-118. doi: 10.1159/000492080. Epub 2018 Oct 5.

PMID:
30293066
34.

Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis.

Margaroli C, Garratt LW, Horati H, Dittrich AS, Rosenow T, Montgomery ST, Frey DL, Brown MR, Schultz C, Guglani L, Kicic A, Peng L, Scholte BJ, Mall MA, Janssens HM, Stick SM, Tirouvanziam R.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):873-881. doi: 10.1164/rccm.201803-0442OC.

PMID:
30281324
35.

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis.

Balázs A, Balla Z, Kui B, Maléth J, Rakonczay Z Jr, Duerr J, Zhou-Suckow Z, Schatterny J, Sendler M, Mayerle J, Kühn JP, Tiszlavicz L, Mall MA, Hegyi P.

Front Physiol. 2018 May 29;9:632. doi: 10.3389/fphys.2018.00632. eCollection 2018.

36.

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis.

Montgomery ST, Dittrich AS, Garratt LW, Turkovic L, Frey DL, Stick SM, Mall MA, Kicic A; AREST CF.

J Cyst Fibros. 2018 Nov;17(6):715-722. doi: 10.1016/j.jcf.2018.05.006. Epub 2018 Jun 6.

PMID:
29884450
37.

Expression and function of Anoctamin 1/TMEM16A calcium-activated chloride channels in airways of in vivo mouse models for cystic fibrosis research.

Hahn A, Salomon JJ, Leitz D, Feigenbutz D, Korsch L, Lisewski I, Schrimpf K, Millar-Büchner P, Mall MA, Frings S, Möhrlen F.

Pflugers Arch. 2018 Sep;470(9):1335-1348. doi: 10.1007/s00424-018-2160-x. Epub 2018 Jun 2.

PMID:
29860639
38.

Multicentre standardisation of chest MRI as radiation-free outcome measure of lung disease in young children with cystic fibrosis.

Wielpütz MO, von Stackelberg O, Stahl M, Jobst BJ, Eichinger M, Puderbach MU, Nährlich L, Barth S, Schneider C, Kopp MV, Ricklefs I, Buchholz M, Tümmler B, Dopfer C, Vogel-Claussen J, Kauczor HU, Mall MA.

J Cyst Fibros. 2018 Jul;17(4):518-527. doi: 10.1016/j.jcf.2018.05.003. Epub 2018 May 25.

PMID:
29805050
39.

Ion Channel Modulators in Cystic Fibrosis.

Gentzsch M, Mall MA.

Chest. 2018 Aug;154(2):383-393. doi: 10.1016/j.chest.2018.04.036. Epub 2018 May 8. Review.

40.

Validation of automated lobe segmentation on paired inspiratory-expiratory chest CT in 8-14 year-old children with cystic fibrosis.

Konietzke P, Weinheimer O, Wielpütz MO, Savage D, Ziyeh T, Tu C, Newman B, Galbán CJ, Mall MA, Kauczor HU, Robinson TE.

PLoS One. 2018 Apr 9;13(4):e0194557. doi: 10.1371/journal.pone.0194557. eCollection 2018.

41.

Non-contrast enhanced magnetic resonance imaging detects mosaic signal intensity in early cystic fibrosis lung disease.

Leutz-Schmidt P, Stahl M, Sommerburg O, Eichinger M, Puderbach MU, Schenk JP, Alrajab A, Triphan SMF, Kauczor HU, Mall MA, Wielpütz MO.

Eur J Radiol. 2018 Apr;101:178-183. doi: 10.1016/j.ejrad.2018.02.023. Epub 2018 Feb 21.

PMID:
29571794
42.

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.

Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA.

Eur Respir J. 2018 Mar 29;51(3). pii: 1701910. doi: 10.1183/13993003.01910-2017. Print 2018 Mar.

43.

Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis.

Boutin S, Depner M, Stahl M, Graeber SY, Dittrich SA, Legatzki A, von Mutius E, Mall M, Dalpke AH.

Mediators Inflamm. 2017;2017:5047403. doi: 10.1155/2017/5047403. Epub 2017 Dec 27.

44.

One time quantitative PCR detection of Pseudomonas aeruginosa to discriminate intermittent from chronic infection in cystic fibrosis.

Boutin S, Weitnauer M, Hassel S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH.

J Cyst Fibros. 2018 May;17(3):348-355. doi: 10.1016/j.jcf.2017.12.007. Epub 2018 Jan 12.

PMID:
29336943
45.

Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis.

Graeber SY, Dopfer C, Naehrlich L, Gyulumyan L, Scheuermann H, Hirtz S, Wege S, Mairbäurl H, Dorda M, Hyde R, Bagheri-Hanson A, Rueckes-Nilges C, Fischer S, Mall MA, Tümmler B.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1433-1442. doi: 10.1164/rccm.201710-1983OC.

PMID:
29327948
46.

Mucopurulent Triggering of the Airway Epithelium. Implications in Health and Cystic Fibrosis.

Balázs A, Mall MA.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):418-420. doi: 10.1164/rccm.201712-2554ED. No abstract available.

PMID:
29298399
47.

An informative intragenic microsatellite marker suggests the IL-1 receptor as a genetic modifier in cystic fibrosis.

Stanke F, Hector A, Hedtfeld S, Hartl D, Griese M, Tümmler B, Mall MA.

Eur Respir J. 2017 Dec 28;50(6). pii: 1700426. doi: 10.1183/13993003.00426-2017. Print 2017 Dec. No abstract available.

48.

Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman's summary.

Mall MA, Hwang TC, Braakman I.

J Cyst Fibros. 2018 Mar;17(2S):S1-S4. doi: 10.1016/j.jcf.2017.11.008. Epub 2017 Dec 9. Review.

49.

Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways.

Livraghi-Butrico A, Wilkinson KJ, Volmer AS, Gilmore RC, Rogers TD, Caldwell RA, Burns KA, Esther CR Jr, Mall MA, Boucher RC, O'Neal WK, Grubb BR.

Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L318-L331. doi: 10.1152/ajplung.00382.2017. Epub 2017 Oct 26.

50.

Bypassing CFTR dysfunction in cystic fibrosis with alternative pathways for anion transport.

Li H, Salomon JJ, Sheppard DN, Mall MA, Galietta LJ.

Curr Opin Pharmacol. 2017 Jun;34:91-97. doi: 10.1016/j.coph.2017.10.002. Epub 2017 Oct 21. Review.

PMID:
29065356

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