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Items: 39

1.

NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies.

Liguori A, Dello Iacono L, Maruggi G, Benucci B, Merola M, Lo Surdo P, López-Sagaseta J, Pizza M, Malito E, Bottomley MJ.

MBio. 2018 Oct 16;9(5). pii: e01914-18. doi: 10.1128/mBio.01914-18.

2.

Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.

Maritan M, Veggi D, Cozzi R, Dello Iacono L, Bartolini E, Lo Surdo P, Maruggi G, Spraggon G, Bottomley MJ, Malito E.

PLoS One. 2018 Aug 22;13(8):e0201922. doi: 10.1371/journal.pone.0201922. eCollection 2018.

3.

From recognition to execution-the HCMV Pentamer from receptor binding to fusion triggering.

Malito E, Chandramouli S, Carfi A.

Curr Opin Virol. 2018 Aug;31:43-51. doi: 10.1016/j.coviro.2018.05.004. Epub 2018 Jun 1. Review.

PMID:
29866439
4.

Structural basis for potent antibody-mediated neutralization of human cytomegalovirus.

Chandramouli S, Malito E, Nguyen T, Luisi K, Donnarumma D, Xing Y, Norais N, Yu D, Carfi A.

Sci Immunol. 2017 Jun 30;2(12). pii: eaan1457. doi: 10.1126/sciimmunol.aan1457.

PMID:
28783665
5.

Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA.

Maritan M, Cozzi R, Lo Surdo P, Veggi D, Bottomley MJ, Malito E.

Acta Crystallogr F Struct Biol Commun. 2017 Jun 1;73(Pt 6):305-314. doi: 10.1107/S2053230X17006021. Epub 2017 May 11.

6.

Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide.

Carboni F, Adamo R, Fabbrini M, De Ricco R, Cattaneo V, Brogioni B, Veggi D, Pinto V, Passalacqua I, Oldrini D, Rappuoli R, Malito E, Margarit IYR, Berti F.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):5017-5022. doi: 10.1073/pnas.1701885114. Epub 2017 Apr 24.

7.

Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy.

Malito E, Lo Surdo P, Veggi D, Santini L, Stefek H, Brunelli B, Luzzi E, Bottomley MJ, Beernink PT, Scarselli M.

Biochem J. 2016 Dec 15;473(24):4699-4713. Epub 2016 Oct 26.

8.

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA.

Liguori A, Malito E, Lo Surdo P, Fagnocchi L, Cantini F, Haag AF, Brier S, Pizza M, Delany I, Bottomley MJ.

PLoS Pathog. 2016 Apr 22;12(4):e1005557. doi: 10.1371/journal.ppat.1005557. eCollection 2016 Apr.

9.

Crystal structure of FhuD at 1.6 Å resolution: a ferrichrome-binding protein from the animal and human pathogen Staphylococcus pseudintermedius.

Abate F, Cozzi R, Maritan M, Lo Surdo P, Maione D, Malito E, Bottomley MJ.

Acta Crystallogr F Struct Biol Commun. 2016 Mar;72(Pt 3):214-9. doi: 10.1107/S2053230X16002272. Epub 2016 Feb 19.

10.

Self-assembling protein nanoparticles in the design of vaccines.

López-Sagaseta J, Malito E, Rappuoli R, Bottomley MJ.

Comput Struct Biotechnol J. 2015 Nov 26;14:58-68. doi: 10.1016/j.csbj.2015.11.001. eCollection 2016. Review.

11.

Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens.

Liljeroos L, Malito E, Ferlenghi I, Bottomley MJ.

J Immunol Res. 2015;2015:156241. doi: 10.1155/2015/156241. Epub 2015 Oct 7. Review.

12.

Noncanonical sortase-mediated assembly of pilus type 2b in group B Streptococcus.

Lazzarin M, Cozzi R, Malito E, Martinelli M, D'Onofrio M, Maione D, Margarit I, Rinaudo CD.

FASEB J. 2015 Nov;29(11):4629-40. doi: 10.1096/fj.15-272500. Epub 2015 Jul 22.

PMID:
26202865
13.

Protein Crystallography in Vaccine Research and Development.

Malito E, Carfi A, Bottomley MJ.

Int J Mol Sci. 2015 Jun 9;16(6):13106-40. doi: 10.3390/ijms160613106. Review.

14.

Structure and assembly of group B streptococcus pilus 2b backbone protein.

Cozzi R, Malito E, Lazzarin M, Nuccitelli A, Castagnetti A, Bottomley MJ, Margarit I, Maione D, Rinaudo CD.

PLoS One. 2015 May 5;10(5):e0125875. doi: 10.1371/journal.pone.0125875. eCollection 2015.

15.

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.

Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, Lo Surdo P, Veggi D, Liguori A, Santini L, Bertoldi I, Petracca R, Marchi S, Romagnoli G, Cartocci E, Vercellino I, Savino S, Spraggon G, Norais N, Pizza M, Rappuoli R, Masignani V, Bottomley MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17.

16.

Apo, Zn2+-bound and Mn2+-bound structures reveal ligand-binding properties of SitA from the pathogen Staphylococcus pseudintermedius.

Abate F, Malito E, Cozzi R, Lo Surdo P, Maione D, Bottomley MJ.

Biosci Rep. 2014 Nov 24;34(6):e00154. doi: 10.1042/BSR20140088.

17.

Finding epitopes with computers.

Malito E, Rappuoli R.

Chem Biol. 2013 Oct 24;20(10):1205-6. doi: 10.1016/j.chembiol.2013.10.002.

18.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SpyCEP, a candidate antigen for a vaccine against Streptococcus pyogenes.

Abate F, Malito E, Falugi F, Margarit Y Ros I, Bottomley MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1103-6. doi: 10.1107/S1744309113024871. Epub 2013 Sep 28.

19.

Comparison of CRM197, diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccines.

Tontini M, Berti F, Romano MR, Proietti D, Zambonelli C, Bottomley MJ, De Gregorio E, Del Giudice G, Rappuoli R, Costantino P; Study Group, Brogioni G, Balocchi C, Biancucci M, Malito E.

Vaccine. 2013 Oct 1;31(42):4827-33. doi: 10.1016/j.vaccine.2013.07.078. Epub 2013 Aug 17.

PMID:
23965218
20.

Mining the bacterial unknown proteome: identification and characterization of a novel family of highly conserved protective antigens in Staphylococcus aureus.

Schluepen C, Malito E, Marongiu A, Schirle M, McWhinnie E, Lo Surdo P, Biancucci M, Falugi F, Nardi-Dei V, Marchi S, Fontana MR, Lombardi B, De Falco MG, Rinaudo CD, Spraggon G, Nissum M, Bagnoli F, Grandi G, Bottomley MJ, Liberatori S.

Biochem J. 2013 Nov 1;455(3):273-84. doi: 10.1042/BJ20130540.

PMID:
23895222
21.

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3304-9. doi: 10.1073/pnas.1222845110. Epub 2013 Feb 8.

22.

Structural and functional characterization of the Staphylococcus aureus virulence factor and vaccine candidate FhuD2.

Mariotti P, Malito E, Biancucci M, Lo Surdo P, Mishra RP, Nardi-Dei V, Savino S, Nissum M, Spraggon G, Grandi G, Bagnoli F, Bottomley MJ.

Biochem J. 2013 Feb 1;449(3):683-93. doi: 10.1042/BJ20121426.

PMID:
23113737
23.

The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.

D'Urzo N, Malito E, Biancucci M, Bottomley MJ, Maione D, Scarselli M, Martinelli M.

FEBS J. 2012 Sep;279(17):3085-97. doi: 10.1111/j.1742-4658.2012.08688.x. Epub 2012 Jul 23.

24.

Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.

Malito E, Bursulaya B, Chen C, Lo Surdo P, Picchianti M, Balducci E, Biancucci M, Brock A, Berti F, Bottomley MJ, Nissum M, Costantino P, Rappuoli R, Spraggon G.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5229-34. doi: 10.1073/pnas.1201964109. Epub 2012 Mar 19.

25.

Rational design of a meningococcal antigen inducing broad protective immunity.

Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R.

Sci Transl Med. 2011 Jul 13;3(91):91ra62. doi: 10.1126/scitranslmed.3002234.

26.

Structure analysis and site-directed mutagenesis of defined key residues and motives for pilus-related sortase C1 in group B Streptococcus.

Cozzi R, Malito E, Nuccitelli A, D'Onofrio M, Martinelli M, Ferlenghi I, Grandi G, Telford JL, Maione D, Rinaudo CD.

FASEB J. 2011 Jun;25(6):1874-86. doi: 10.1096/fj.10-174797. Epub 2011 Feb 25.

PMID:
21357525
27.

Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus.

Spraggon G, Koesema E, Scarselli M, Malito E, Biagini M, Norais N, Emolo C, Barocchi MA, Giusti F, Hilleringmann M, Rappuoli R, Lesley S, Covacci A, Masignani V, Ferlenghi I.

PLoS One. 2010 Jun 15;5(6):e10919. doi: 10.1371/journal.pone.0010919.

28.

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ.

PLoS One. 2010 May 7;5(5):e10504. doi: 10.1371/journal.pone.0010504.

29.

Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.

Manolopoulou M, Guo Q, Malito E, Schilling AB, Tang WJ.

J Biol Chem. 2009 May 22;284(21):14177-88. doi: 10.1074/jbc.M900068200. Epub 2009 Mar 25.

30.

Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.

Bourdeau RW, Malito E, Chenal A, Bishop BL, Musch MW, Villereal ML, Chang EB, Mosser EM, Rest RF, Tang WJ.

J Biol Chem. 2009 May 22;284(21):14645-56. doi: 10.1074/jbc.M807631200. Epub 2009 Mar 23.

31.

Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ.

Biochemistry. 2008 Dec 2;47(48):12822-34. doi: 10.1021/bi801192h.

32.

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.

Malito E, Hulse RE, Tang WJ.

Cell Mol Life Sci. 2008 Aug;65(16):2574-85. doi: 10.1007/s00018-008-8112-4. Review.

33.

Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase.

Alfieri A, Malito E, Orru R, Fraaije MW, Mattevi A.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6572-7. doi: 10.1073/pnas.0800859105. Epub 2008 Apr 28.

34.

Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.

Johnson EC, Malito E, Shen Y, Pentelute B, Rich D, Florián J, Tang WJ, Kent SB.

J Mol Biol. 2007 Oct 26;373(3):573-86. Epub 2007 Aug 2.

35.

Modular total chemical synthesis of a human immunodeficiency virus type 1 protease.

Johnson EC, Malito E, Shen Y, Rich D, Tang WJ, Kent SB.

J Am Chem Soc. 2007 Sep 19;129(37):11480-90. Epub 2007 Aug 18.

PMID:
17705484
36.

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ.

J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5.

37.

Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.

Malito E, Sekulic N, Too WC, Konrad M, Lavie A.

J Mol Biol. 2006 Nov 24;364(2):136-51. Epub 2006 Sep 3.

38.

Crystal structure of a Baeyer-Villiger monooxygenase.

Malito E, Alfieri A, Fraaije MW, Mattevi A.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13157-62. Epub 2004 Aug 24.

39.

Structures of Michaelis and product complexes of plant cytokinin dehydrogenase: implications for flavoenzyme catalysis.

Malito E, Coda A, Bilyeu KD, Fraaije MW, Mattevi A.

J Mol Biol. 2004 Aug 27;341(5):1237-49.

PMID:
15321719

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