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Items: 1 to 50 of 125


Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons.

Klein ME, Younts TJ, Cobo CF, Buxbaum AR, Aow J, Erdjument-Bromage H, Richard S, Malinow R, Neubert TA, Singer RH, Castillo PE, Jordan BA.

Cell Rep. 2019 Nov 12;29(7):1789-1799.e6. doi: 10.1016/j.celrep.2019.10.030.


Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import.

Malinow RA, Ying P, Koorman T, Boxem M, Jin Y, Kim KW.

Front Cell Neurosci. 2019 Jul 31;13:348. doi: 10.3389/fncel.2019.00348. eCollection 2019.


Stress transforms lateral habenula reward responses into punishment signals.

Shabel SJ, Wang C, Monk B, Aronson S, Malinow R.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12488-12493. doi: 10.1073/pnas.1903334116. Epub 2019 May 31.


The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

Sapkota K, Dore K, Tang K, Irvine M, Fang G, Burnell ES, Malinow R, Jane DE, Monaghan DT.

Biochem Pharmacol. 2019 Jan;159:140-153. doi: 10.1016/j.bcp.2018.11.018. Epub 2018 Nov 29.


NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice.

Müller MK, Jacobi E, Sakimura K, Malinow R, von Engelhardt J.

Acta Neuropathol Commun. 2018 Oct 23;6(1):110. doi: 10.1186/s40478-018-0611-4.


A neural pathway controlling motivation to exert effort.

Proulx CD, Aronson S, Milivojevic D, Molina C, Loi A, Monk B, Shabel SJ, Malinow R.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):5792-5797. doi: 10.1073/pnas.1801837115. Epub 2018 May 11.


A fluorescence assay for detecting amyloid-β using the cytomegalovirus enhancer/promoter.

Carrico ZM, Le G, Malinow R.

J Biol Methods. 2017;4(3). pii: e77. doi: 10.14440/jbm.2017.200. Epub 2017 Aug 7.


Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula.

Park H, Rhee J, Park K, Han JS, Malinow R, Chung C.

J Neurosci. 2017 Jun 21;37(25):6021-6030. doi: 10.1523/JNEUROSCI.2281-16.2017. Epub 2017 May 24.


Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3.

Reinders NR, Pao Y, Renner MC, da Silva-Matos CM, Lodder TR, Malinow R, Kessels HW.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6526-E6534. Epub 2016 Oct 5.


The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging.

Dore K, Aow J, Malinow R.

Front Synaptic Neurosci. 2016 Jul 28;8:20. doi: 10.3389/fnsyn.2016.00020. eCollection 2016. Review.


Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R.

Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209.


Depression: Ketamine steps out of the darkness.

Malinow R.

Nature. 2016 May 26;533(7604):477-8. doi: 10.1038/nature17897. Epub 2016 May 4. No abstract available.


Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice.

Landgraf D, Long JE, Proulx CD, Barandas R, Malinow R, Welsh DK.

Biol Psychiatry. 2016 Dec 1;80(11):827-835. doi: 10.1016/j.biopsych.2016.03.1050. Epub 2016 Mar 10.


Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow.

Dore K, Aow J, Malinow R.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14705-10. doi: 10.1073/pnas.1520023112. Epub 2015 Nov 9.


Conformational signaling required for synaptic plasticity by the NMDA receptor complex.

Aow J, Dore K, Malinow R.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14711-6. doi: 10.1073/pnas.1520029112. Epub 2015 Nov 9.


Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC.

J Biol Chem. 2015 Sep 4;290(36):21845-56. doi: 10.1074/jbc.M115.676221. Epub 2015 Jul 17.


Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.

Shabel SJ, Proulx CD, Piriz J, Malinow R.

Science. 2014 Sep 19;345(6203):1494-8. doi: 10.1126/science.1250469. Epub 2014 Sep 18.


Reward processing by the lateral habenula in normal and depressive behaviors.

Proulx CD, Hikosaka O, Malinow R.

Nat Neurosci. 2014 Sep;17(9):1146-52. doi: 10.1038/nn.3779. Review.


Engineering a memory with LTD and LTP.

Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R.

Nature. 2014 Jul 17;511(7509):348-52. doi: 10.1038/nature13294. Epub 2014 Jun 1.


Near-infrared-induced heating of confined water in polymeric particles for efficient payload release.

Viger ML, Sheng W, Doré K, Alhasan AH, Carling CJ, Lux J, de Gracia Lux C, Grossman M, Malinow R, Almutairi A.

ACS Nano. 2014 May 27;8(5):4815-26. doi: 10.1021/nn500702g. Epub 2014 Apr 10.


Synapto-depressive effects of amyloid beta require PICK1.

Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R.

Eur J Neurosci. 2014 Apr;39(7):1225-33. doi: 10.1111/ejn.12499.


Negative learning bias is associated with risk aversion in a genetic animal model of depression.

Shabel SJ, Murphy RT, Malinow R.

Front Hum Neurosci. 2014 Jan 16;8:1. doi: 10.3389/fnhum.2014.00001. eCollection 2014.


GluA1 trafficking and metabotropic NMDA: addressing results from other laboratories inconsistent with ours.

Nabavi S, Fox R, Alfonso S, Aow J, Malinow R.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130145. doi: 10.1098/rstb.2013.0145. Print 2014 Jan 5.


βCaMKII in lateral habenula mediates core symptoms of depression.

Li K, Zhou T, Liao L, Yang Z, Wong C, Henn F, Malinow R, Yates JR 3rd, Hu H.

Science. 2013 Aug 30;341(6149):1016-20. doi: 10.1126/science.1240729.


Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI).

Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY.

Neuron. 2013 Jul 24;79(2):241-53. doi: 10.1016/j.neuron.2013.05.022.


Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression.

Kessels HW, Nabavi S, Malinow R.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4033-8. doi: 10.1073/pnas.1219605110. Epub 2013 Feb 19.


Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.

Nabavi S, Kessels HW, Alfonso S, Aow J, Fox R, Malinow R.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4027-32. doi: 10.1073/pnas.1219454110. Epub 2013 Feb 19.


Neuroscience: Strength in numbers.

Sheng M, Malinow R, Huganir R.

Nature. 2013 Jan 24;493(7433):482-3. doi: 10.1038/493482a. No abstract available.


Disrupted cortical function underlies behavior dysfunction due to social isolation.

Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T.

J Clin Invest. 2012 Jul;122(7):2690-701. doi: 10.1172/JCI63060. Epub 2012 Jun 18. Erratum in: J Clin Invest. 2014 Jun 2;124(6):2807.


Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin.

Shabel SJ, Proulx CD, Trias A, Murphy RT, Malinow R.

Neuron. 2012 May 10;74(3):475-81. doi: 10.1016/j.neuron.2012.02.037.


Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory.

Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC.

J Biol Chem. 2012 Apr 13;287(16):12879-85. doi: 10.1074/jbc.M112.357244. Epub 2012 Feb 29.


Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex.

Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T.

Brain Res. 2012 Jan 30;1435:1-7. doi: 10.1016/j.brainres.2011.11.033. Epub 2011 Nov 19.


Compartmentalized versus global synaptic plasticity on dendrites controlled by experience.

Makino H, Malinow R.

Neuron. 2011 Dec 22;72(6):1001-11. doi: 10.1016/j.neuron.2011.09.036.


New developments on the role of NMDA receptors in Alzheimer's disease.

Malinow R.

Curr Opin Neurobiol. 2012 Jun;22(3):559-63. doi: 10.1016/j.conb.2011.09.001. Epub 2011 Sep 29. Review.


Synaptic potentiation onto habenula neurons in the learned helplessness model of depression.

Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, Henn F, Malinow R.

Nature. 2011 Feb 24;470(7335):535-9. doi: 10.1038/nature09742.


Alzheimer's disease: Recollection of lost memories.

Malenka RC, Malinow R.

Nature. 2011 Jan 6;469(7328):44-5. doi: 10.1038/469044a. No abstract available.


The prion protein as a receptor for amyloid-beta.

Kessels HW, Nguyen LN, Nabavi S, Malinow R.

Nature. 2010 Aug 12;466(7308):E3-4; discussion E4-5. doi: 10.1038/nature09217.


Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection.

Malinow R, Hayashi Y, Maletic-Savatic M, Zaman SH, Poncer JC, Shi SH, Esteban JA, Osten P, Seidenman K.

Cold Spring Harb Protoc. 2010 Apr;2010(4):pdb.prot5406. doi: 10.1101/pdb.prot5406.


Amyloid beta from axons and dendrites reduces local spine number and plasticity.

Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R.

Nat Neurosci. 2010 Feb;13(2):190-6. doi: 10.1038/nn.2476. Epub 2009 Dec 27.


AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis.

Makino H, Malinow R.

Neuron. 2009 Nov 12;64(3):381-90. doi: 10.1016/j.neuron.2009.08.035.


NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity.

Li B, Devidze N, Barengolts D, Prostak N, Sphicas E, Apicella AJ, Malinow R, Emamian ES.

J Neurosci. 2009 Sep 23;29(38):11965-72. doi: 10.1523/JNEUROSCI.2109-09.2009.


Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution.

Kessels HW, Kopec CD, Klein ME, Malinow R.

Nat Neurosci. 2009 Jul;12(7):888-96. doi: 10.1038/nn.2340. Epub 2009 Jun 21.


The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.

Nadif Kasri N, Nakano-Kobayashi A, Malinow R, Li B, Van Aelst L.

Genes Dev. 2009 Jun 1;23(11):1289-302. doi: 10.1101/gad.1783809.


Synaptic AMPA receptor plasticity and behavior.

Kessels HW, Malinow R.

Neuron. 2009 Feb 12;61(3):340-50. doi: 10.1016/j.neuron.2009.01.015. Review.


Cholinergic-mediated IP3-receptor activation induces long-lasting synaptic enhancement in CA1 pyramidal neurons.

Fernández de Sevilla D, Núñez A, Borde M, Malinow R, Buño W.

J Neurosci. 2008 Feb 6;28(6):1469-78. doi: 10.1523/JNEUROSCI.2723-07.2008.


GluR1 links structural and functional plasticity at excitatory synapses.

Kopec CD, Real E, Kessels HW, Malinow R.

J Neurosci. 2007 Dec 12;27(50):13706-18.


Beta-amyloid modulation of synaptic transmission and plasticity.

Venkitaramani DV, Chin J, Netzer WJ, Gouras GK, Lesne S, Malinow R, Lombroso PJ.

J Neurosci. 2007 Oct 31;27(44):11832-7. Review. No abstract available.


Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking.

Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL, Malinow R.

Cell. 2007 Oct 5;131(1):160-73.


PSD-95 is required for activity-driven synapse stabilization.

Ehrlich I, Klein M, Rumpel S, Malinow R.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4176-81. Epub 2007 Feb 27.

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