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Immunoproteasome activation enables human TRIM5α restriction of HIV-1.

Jimenez-Guardeño JM, Apolonia L, Betancor G, Malim MH.

Nat Microbiol. 2019 Jun;4(6):933-940. doi: 10.1038/s41564-019-0402-0. Epub 2019 Mar 18.


Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.

Skelton JK, Ortega-Prieto AM, Kaye S, Jimenez-Guardeño JM, Turner J, Malim MH, Towers GJ, Dorner M.

J Virol. 2019 May 15;93(11). pii: e02123-18. doi: 10.1128/JVI.02123-18. Print 2019 Jun 1.


Author Correction: The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry.

Doyle T, Moncorgé O, Bonaventure B, Pollpeter D, Lussignol M, Tauziet M, Apolonia L, Catanese MT, Goujon C, Malim MH.

Nat Microbiol. 2019 Mar;4(3):539. doi: 10.1038/s41564-019-0366-0.


Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases.

Ng JCF, Quist J, Grigoriadis A, Malim MH, Fraternali F.

Nucleic Acids Res. 2019 Feb 20;47(3):1178-1194. doi: 10.1093/nar/gky1316.


APOBEC restriction goes nuclear.

Malim MH, Pollpeter D.

Nat Microbiol. 2019 Jan;4(1):6-7. doi: 10.1038/s41564-018-0323-3. No abstract available.


Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction.

Dicks MDJ, Betancor G, Jimenez-Guardeño JM, Pessel-Vivares L, Apolonia L, Goujon C, Malim MH.

PLoS Pathog. 2018 Nov 29;14(11):e1007408. doi: 10.1371/journal.ppat.1007408. eCollection 2018 Nov.


The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry.

Doyle T, Moncorgé O, Bonaventure B, Pollpeter D, Lussignol M, Tauziet M, Apolonia L, Catanese MT, Goujon C, Malim MH.

Nat Microbiol. 2018 Dec;3(12):1369-1376. doi: 10.1038/s41564-018-0273-9. Epub 2018 Nov 26. Erratum in: Nat Microbiol. 2019 Mar;4(3):539.


Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.

Vantourout P, Laing A, Woodward MJ, Zlatareva I, Apolonia L, Jones AW, Snijders AP, Malim MH, Hayday AC.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1039-1044. doi: 10.1073/pnas.1701237115. Epub 2018 Jan 16.


Lorenzo-Redondo et al. reply.

Lorenzo-Redondo R, Fryer HR, Bedford T, Kim EY, Archer J, Pond SLK, Chung YS, Penugonda S, Chipman JG, Fletcher CV, Schacker TW, Malim MH, Rambaut A, Haase AT, McLean AR, Wolinsky SM.

Nature. 2017 Nov 22;551(7681):E10. doi: 10.1038/nature24635. No abstract available.


Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G.

Pollpeter D, Parsons M, Sobala AE, Coxhead S, Lang RD, Bruns AM, Papaioannou S, McDonnell JM, Apolonia L, Chowdhury JA, Horvath CM, Malim MH.

Nat Microbiol. 2018 Feb;3(2):220-233. doi: 10.1038/s41564-017-0063-9. Epub 2017 Nov 20.


Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.

Schaller T, Bulli L, Pollpeter D, Betancor G, Kutzner J, Apolonia L, Herold N, Burk R, Malim MH.

J Virol. 2017 Sep 12;91(19). pii: e00463-17. doi: 10.1128/JVI.00463-17. Print 2017 Oct 1.


Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors.

Bulli L, Apolonia L, Kutzner J, Pollpeter D, Goujon C, Herold N, Schwarz SM, Giernat Y, Keppler OT, Malim MH, Schaller T.

J Virol. 2016 Jul 27;90(16):7469-7480. doi: 10.1128/JVI.00458-16. Print 2016 Aug 15.


Corrigendum: Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Sobolev O, Binda E, O'Farrell S, Lorenc A, Pradines J, Huang Y, Duffner J, Schulz R, Cason J, Zambon M, Malim MH, Peakman M, Cope A, Capila I, Kaundinya GV, Hayday AC.

Nat Immunol. 2016 Apr;17(4):469. doi: 10.1038/ni0416-469b. No abstract available.


Persistent HIV-1 replication maintains the tissue reservoir during therapy.

Lorenzo-Redondo R, Fryer HR, Bedford T, Kim EY, Archer J, Pond SLK, Chung YS, Penugonda S, Chipman J, Fletcher CV, Schacker TW, Malim MH, Rambaut A, Haase AT, McLean AR, Wolinsky SM.

Nature. 2016 Feb 4;530(7588):51-56. doi: 10.1038/nature16933. Epub 2016 Jan 27.


Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Sobolev O, Binda E, O'Farrell S, Lorenc A, Pradines J, Huang Y, Duffner J, Schulz R, Cason J, Zambon M, Malim MH, Peakman M, Cope A, Capila I, Kaundinya GV, Hayday AC.

Nat Immunol. 2016 Feb;17(2):204-13. doi: 10.1038/ni.3328. Epub 2016 Jan 4. Erratum in: Nat Immunol. 2016 Apr;17(4):469.


Oligomerization Requirements for MX2-Mediated Suppression of HIV-1 Infection.

Dicks MD, Goujon C, Pollpeter D, Betancor G, Apolonia L, Bergeron JR, Malim MH.

J Virol. 2015 Oct 7;90(1):22-32. doi: 10.1128/JVI.02247-15. Print 2016 Jan 1.


HIV-1 and interferons: who's interfering with whom?

Doyle T, Goujon C, Malim MH.

Nat Rev Microbiol. 2015 Jul;13(7):403-13. doi: 10.1038/nrmicro3449. Epub 2015 Apr 27. Review.


Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection.

Mlcochova P, Apolonia L, Kluge SF, Sridharan A, Kirchhoff F, Malim MH, Sauter D, Gupta RK.

Virology. 2015 Aug;482:72-8. doi: 10.1016/j.virol.2015.03.015. Epub 2015 Mar 30.


A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2.

Goujon C, Greenbury RA, Papaioannou S, Doyle T, Malim MH.

J Virol. 2015 Apr;89(8):4676-80. doi: 10.1128/JVI.00169-15. Epub 2015 Feb 11.


Promiscuous RNA binding ensures effective encapsidation of APOBEC3 proteins by HIV-1.

Apolonia L, Schulz R, Curk T, Rocha P, Swanson CM, Schaller T, Ule J, Malim MH.

PLoS Pathog. 2015 Jan 15;11(1):e1004609. doi: 10.1371/journal.ppat.1004609. eCollection 2015 Jan.


Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism.

Aligeti M, Behrens RT, Pocock GM, Schindelin J, Dietz C, Eliceiri KW, Swanson CM, Malim MH, Ahlquist P, Sherer NM.

J Virol. 2014 Dec;88(24):14207-21. doi: 10.1128/JVI.01897-14. Epub 2014 Oct 1.


Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.

Kim EY, Lorenzo-Redondo R, Little SJ, Chung YS, Phalora PK, Maljkovic Berry I, Archer J, Penugonda S, Fischer W, Richman DD, Bhattacharya T, Malim MH, Wolinsky SM.

PLoS Pathog. 2014 Jul 31;10(7):e1004281. doi: 10.1371/journal.ppat.1004281. eCollection 2014 Jul.


Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor.

Goujon C, Moncorgé O, Bauby H, Doyle T, Barclay WS, Malim MH.

J Virol. 2014 Aug;88(16):9017-26. doi: 10.1128/JVI.01269-14. Epub 2014 Jun 4.


New insights into an X-traordinary viral protein.

Schaller T, Bauby H, Hué S, Malim MH, Goujon C.

Front Microbiol. 2014 Apr 8;5:126. doi: 10.3389/fmicb.2014.00126. eCollection 2014. Review.


HIV: Ringside views.

Malim MH.

Nature. 2014 Jan 9;505(7482):167-8. doi: 10.1038/505167a. No abstract available.


Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.

Lu Z, Bergeron JR, Atkinson RA, Schaller T, Veselkov DA, Oregioni A, Yang Y, Matthews SJ, Malim MH, Sanderson MR.

Open Biol. 2013 Nov 13;3(11):130100. doi: 10.1098/rsob.130100.


Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.

Goujon C, Moncorgé O, Bauby H, Doyle T, Ward CC, Schaller T, Hué S, Barclay WS, Schulz R, Malim MH.

Nature. 2013 Oct 24;502(7472):559-62. doi: 10.1038/nature12542. Epub 2013 Sep 18.


Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection.

Goujon C, Schaller T, Galão RP, Amie SM, Kim B, Olivieri K, Neil SJ, Malim MH.

Retrovirology. 2013 Feb 25;10:23. doi: 10.1186/1742-4690-10-23.


Suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4(+) T cells is associated with inhibition of processive reverse transcription as well as excessive cytidine deamination.

Gillick K, Pollpeter D, Phalora P, Kim EY, Wolinsky SM, Malim MH.

J Virol. 2013 Feb;87(3):1508-17. doi: 10.1128/JVI.02587-12. Epub 2012 Nov 14.


HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

Phalora PK, Sherer NM, Wolinsky SM, Swanson CM, Malim MH.

J Virol. 2012 Nov;86(21):11712-24. doi: 10.1128/JVI.00595-12. Epub 2012 Aug 22.


Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses.

Arjan-Odedra S, Swanson CM, Sherer NM, Wolinsky SM, Malim MH.

Retrovirology. 2012 Jun 22;9:53. doi: 10.1186/1742-4690-9-53.


HIV Restriction Factors and Mechanisms of Evasion.

Malim MH, Bieniasz PD.

Cold Spring Harb Perspect Med. 2012 May;2(5):a006940. doi: 10.1101/cshperspect.a006940. Review.


AIDS/HIV. HIV interplay with SAMHD1.

Schaller T, Goujon C, Malim MH.

Science. 2012 Mar 16;335(6074):1313-4. doi: 10.1126/science.1221057. No abstract available.


The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.

Fehrholz M, Kendl S, Prifert C, Weissbrich B, Lemon K, Rennick L, Duprex PW, Rima BK, Koning FA, Holmes RK, Malim MH, Schneider-Schaulies J.

J Gen Virol. 2012 Mar;93(Pt 3):565-76. doi: 10.1099/vir.0.038919-0. Epub 2011 Dec 14.


Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication.

Sherer NM, Swanson CM, Hué S, Roberts RG, Bergeron JR, Malim MH.

PLoS Pathog. 2011 Nov;7(11):e1002395. doi: 10.1371/journal.ppat.1002395. Epub 2011 Nov 17.


How Representative Are Research Tissue Biobanks of the Local Populations? Experience of the Infectious Diseases Biobank at King's College, London, UK.

Kozlakidis Z, Mant C, Peters B, Post F, Fox J, Philpott-Howard J, Tong WC, Edgeworth J, Peakman M, Malim M, Cason J.

Biopreserv Biobank. 2011 Sep;9(3):287-288.


Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.

Koning FA, Goujon C, Bauby H, Malim MH.

J Virol. 2011 Dec;85(24):13448-52. doi: 10.1128/JVI.00775-11. Epub 2011 Sep 28.


Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes.

Kim EY, Schulz R, Swantek P, Kunstman K, Malim MH, Wolinsky SM.

Gene Ther. 2012 Mar;19(3):347-53. doi: 10.1038/gt.2011.95. Epub 2011 Jun 23.


Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure.

Kim EY, Bhattacharya T, Kunstman K, Swantek P, Koning FA, Malim MH, Wolinsky SM.

J Virol. 2010 Oct;84(19):10402-5. doi: 10.1128/JVI.01223-10. Epub 2010 Jul 21.


Rationalisation of the differences between APOBEC3G structures from crystallography and NMR studies by molecular dynamics simulations.

Autore F, Bergeron JR, Malim MH, Fraternali F, Huthoff H.

PLoS One. 2010 Jul 12;5(7):e11515. doi: 10.1371/journal.pone.0011515.


Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells.

Goujon C, Malim MH.

J Virol. 2010 Sep;84(18):9254-66. doi: 10.1128/JVI.00854-10. Epub 2010 Jul 7.


The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.

Bergeron JR, Huthoff H, Veselkov DA, Beavil RL, Simpson PJ, Matthews SJ, Malim MH, Sanderson MR.

PLoS Pathog. 2010 Jun 3;6(6):e1000925. doi: 10.1371/journal.ppat.1000925.


SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA.

Swanson CM, Sherer NM, Malim MH.

J Virol. 2010 Jul;84(13):6748-59. doi: 10.1128/JVI.02526-09. Epub 2010 Apr 28.


Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.

Koning FA, Newman EN, Kim EY, Kunstman KJ, Wolinsky SM, Malim MH.

J Virol. 2009 Sep;83(18):9474-85. doi: 10.1128/JVI.01089-09. Epub 2009 Jul 8.


Matrix mediates the functional link between human immunodeficiency virus type 1 RNA nuclear export elements and the assembly competency of Gag in murine cells.

Sherer NM, Swanson CM, Papaioannou S, Malim MH.

J Virol. 2009 Sep;83(17):8525-35. doi: 10.1128/JVI.00699-09. Epub 2009 Jun 17.


RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.

Huthoff H, Autore F, Gallois-Montbrun S, Fraternali F, Malim MH.

PLoS Pathog. 2009 Mar;5(3):e1000330. doi: 10.1371/journal.ppat.1000330. Epub 2009 Mar 6.


Unsung hero Robert C. Gallo.

Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D.

Science. 2009 Jan 9;323(5911):206-7. doi: 10.1126/science.323.5911.206. No abstract available.


APOBEC3G inhibits elongation of HIV-1 reverse transcripts.

Bishop KN, Verma M, Kim EY, Wolinsky SM, Malim MH.

PLoS Pathog. 2008 Dec;4(12):e1000231. doi: 10.1371/journal.ppat.1000231. Epub 2008 Dec 5.

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