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Items: 1 to 50 of 215

1.

Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock.

Tunctan B, Senol SP, Temiz-Resitoglu M, Guden DS, Sahan-Firat S, Falck JR, Malik KU.

Prostaglandins Other Lipid Mediat. 2019 Dec;145:106377. doi: 10.1016/j.prostaglandins.2019.106377. Epub 2019 Oct 3. Review.

PMID:
31586592
2.

Modulation of oxidative-nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia-reperfusion: the role of mammalian target of rapamycin.

Kocak Z, Temiz-Resitoglu M, Guden DS, Vezir O, Sucu N, Balcı S, Tamer-Gumus L, Tunctan B, Malik KU, Sahan-Firat S.

Can J Physiol Pharmacol. 2019 Dec;97(12):1193-1203. doi: 10.1139/cjpp-2019-0394. Epub 2019 Sep 10.

PMID:
31505123
3.

Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.

Mukherjee K, Song CY, Estes AM, Dhodi AN, Ormseth BH, Shin JS, Gonzalez FJ, Malik KU.

J Am Heart Assoc. 2018 Sep 18;7(18):e010065. doi: 10.1161/JAHA.118.010065.

4.

NF-κB activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock.

Sahan-Firat S, Temiz-Resitoglu M, Guden DS, Senol SP, Sari AN, Cil M, Unsal D, Korkmaz B, Tunctan B, Malik KU, Buharalioglu CK.

Clin Exp Pharmacol Physiol. 2019 Feb;46(2):173-182. doi: 10.1111/1440-1681.13045.

PMID:
30347478
5.

Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.

Zou Y, Chen Z, Jennings BL, Zhao G, Gu Q, Bhattacharya A, Cui Y, Yu B, Malik KU, Yue J.

Sci Rep. 2018 Jan 23;8(1):1468. doi: 10.1038/s41598-018-19660-z.

6.

Brain Cytosolic Phospholipase A2α Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice.

Song CY, Khan NS, Liao FF, Wang B, Shin JS, Bonventre JV, Malik KU.

Am J Hypertens. 2018 Apr 13;31(5):622-629. doi: 10.1093/ajh/hpy009.

7.

Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α/NF-κB Signalling Pathway.

Sahan-Firat S, Temiz-Resitoglu M, Guden DS, Kucukkavruk SP, Tunctan B, Sari AN, Kocak Z, Malik KU.

Inflammation. 2018 Feb;41(1):276-298. doi: 10.1007/s10753-017-0686-2.

PMID:
29110153
8.

The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock.

Unsal D, Kacan M, Temiz-Resitoglu M, Guden DS, Korkmaz B, Sari AN, Buharalioglu CK, Yildirim-Yaroglu H, Tamer-Gumus L, Tunctan B, Malik KU, Sahan-Firat S.

Clin Exp Pharmacol Physiol. 2018 Feb;45(2):155-165. doi: 10.1111/1440-1681.12864. Epub 2017 Nov 28.

PMID:
28949404
9.

Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae.

Michael CF, Waters CM, LeMessurier KS, Samarasinghe AE, Song CY, Malik KU, Lew DB.

J Immunol Res. 2017;2017:8903982. doi: 10.1155/2017/8903982. Epub 2017 Jul 9.

10.

2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.

Pingili AK, Davidge KN, Thirunavukkarasu S, Khan NS, Katsurada A, Majid DSA, Gonzalez FJ, Navar LG, Malik KU.

Hypertension. 2017 Jun;69(6):1104-1112. doi: 10.1161/HYPERTENSIONAHA.117.09175. Epub 2017 Apr 17.

11.

Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats.

Temiz-Resitoglu M, Kucukkavruk SP, Guden DS, Cecen P, Sari AN, Tunctan B, Gorur A, Tamer-Gumus L, Buharalioglu CK, Malik KU, Sahan-Firat S.

Eur J Pharmacol. 2017 May 5;802:7-19. doi: 10.1016/j.ejphar.2017.02.034. Epub 2017 Feb 20.

PMID:
28228357
12.

Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.

Thirunavukkarasu S, Khan NS, Song CY, Ghafoor HU, Brand DD, Gonzalez FJ, Malik KU.

Am J Pathol. 2016 Aug;186(8):2204-2219. doi: 10.1016/j.ajpath.2016.04.005. Epub 2016 Jun 11.

13.

6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.

Pingili AK, Thirunavukkarasu S, Kara M, Brand DD, Katsurada A, Majid DS, Navar LG, Gonzalez FJ, Malik KU.

Hypertension. 2016 May;67(5):916-26. doi: 10.1161/HYPERTENSIONAHA.115.06936. Epub 2016 Feb 29.

14.

Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.

Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B.

Inflamm Res. 2016 May;65(5):367-87. doi: 10.1007/s00011-016-0922-5. Epub 2016 Feb 13.

PMID:
26875149
15.

Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.

Song CY, Ghafoor K, Ghafoor HU, Khan NS, Thirunavukkarasu S, Jennings BL, Estes AM, Zaidi S, Bridges D, Tso P, Gonzalez FJ, Malik KU.

Hypertension. 2016 Jan;67(1):206-13. doi: 10.1161/HYPERTENSIONAHA.115.06427. Epub 2015 Nov 16.

16.

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment.

Tan XL, Xue YQ, Ma T, Wang X, Li JJ, Lan L, Malik KU, McDonald MP, Dopico AM, Liao FF.

Mol Neurodegener. 2015 Jun 24;10:24. doi: 10.1186/s13024-015-0020-0.

17.

Cytosolic Phospholipase A2α Is Essential for Renal Dysfunction and End-Organ Damage Associated With Angiotensin II-Induced Hypertension.

Khan NS, Song CY, Thirunavukkarasu S, Fang XR, Bonventre JV, Malik KU.

Am J Hypertens. 2016 Feb;29(2):258-65. doi: 10.1093/ajh/hpv083. Epub 2015 Jun 4.

18.

6β-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice.

Pingili AK, Kara M, Khan NS, Estes AM, Lin Z, Li W, Gonzalez FJ, Malik KU.

Hypertension. 2015 Jun;65(6):1279-87. doi: 10.1161/HYPERTENSIONAHA.115.05396. Epub 2015 Apr 13.

19.

Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice.

Jennings BL, Moore JA, Pingili AK, Estes AM, Fang XR, Kanu A, Gonzalez FJ, Malik KU.

Am J Physiol Renal Physiol. 2015 May 1;308(9):F981-92. doi: 10.1152/ajprenal.00597.2014. Epub 2015 Feb 18.

20.

Cytosolic phospholipase A2α is critical for angiotensin II-induced hypertension and associated cardiovascular pathophysiology.

Khan NS, Song CY, Jennings BL, Estes AM, Fang XR, Bonventre JV, Malik KU.

Hypertension. 2015 Apr;65(4):784-92. doi: 10.1161/HYPERTENSIONAHA.114.04803. Epub 2015 Feb 9.

21.

Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.

Sari AN, Korkmaz B, Serin MS, Kacan M, Unsal D, Buharalioglu CK, Sahan Firat S, Manthati VL, Falck JR, Malik KU, Tunctan B.

Inflamm Res. 2014 Sep;63(9):741-56. doi: 10.1007/s00011-014-0747-z. Epub 2014 Jun 12.

22.

Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice.

Jennings BL, George LW, Pingili AK, Khan NS, Estes AM, Fang XR, Gonzalez FJ, Malik KU.

Hypertension. 2014 Jul;64(1):134-40. doi: 10.1161/HYPERTENSIONAHA.114.03275. Epub 2014 Apr 28. Erratum in: Hypertension. 2014 Sep;64(3):e2. Dosage error in article text.

23.

Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.

Jennings BL, Montanez DE, May ME Jr, Estes AM, Fang XR, Yaghini FA, Kanu A, Malik KU.

Cardiovasc Drugs Ther. 2014 Apr;28(2):145-61. doi: 10.1007/s10557-014-6510-4.

24.

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z.

FASEB J. 2014 Feb;28(2):880-90. doi: 10.1096/fj.13-234997. Epub 2013 Nov 18.

25.

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU.

Nitric Oxide. 2013 Sep 1;33:18-41. doi: 10.1016/j.niox.2013.05.001. Epub 2013 May 14.

26.

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Falck JR, Malik KU.

Prostaglandins Other Lipid Mediat. 2013 Apr-May;102-103:31-41. doi: 10.1016/j.prostaglandins.2013.01.005. Epub 2013 Feb 27.

27.

Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice.

Jennings BL, Estes AM, Anderson LJ, Fang XR, Yaghini FA, Fan Z, Gonzalez FJ, Campbell WB, Malik KU.

Hypertension. 2012 Dec;60(6):1510-6. doi: 10.1161/HYPERTENSIONAHA.112.202606. Epub 2012 Oct 29.

28.

A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Schunck WH, Falck JR, Malik KU.

Antiinflamm Antiallergy Agents Med Chem. 2012;11(2):121-50. Review.

PMID:
23013331
29.

NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite.

Tunctan B, Sari AN, Kacan M, Unsal D, Buharalioglu CK, Sahan-Firat S, Korkmaz B, Falck JR, Malik KU.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:93-108. doi: 10.1016/j.prostaglandins.2012.08.007. Epub 2012 Sep 5.

30.

Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: a novel target for antihypertensive agents.

Malik KU, Jennings BL, Yaghini FA, Sahan-Firat S, Song CY, Estes AM, Fang XR.

Prostaglandins Other Lipid Mediat. 2012 Aug;98(3-4):69-74. doi: 10.1016/j.prostaglandins.2011.12.003. Epub 2011 Dec 20. Review.

31.

Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.

Jennings BL, Anderson LJ, Estes AM, Yaghini FA, Fang XR, Porter J, Gonzalez FJ, Campbell WB, Malik KU.

Hypertension. 2012 Feb;59(2):348-54. doi: 10.1161/HYPERTENSIONAHA.111.183301. Epub 2011 Dec 19.

32.

Involvement of cytochrome P-450 1B1 in renal dysfunction, injury, and inflammation associated with angiotensin II-induced hypertension in rats.

Jennings BL, Anderson LJ, Estes AM, Fang XR, Song CY, Campbell WB, Malik KU.

Am J Physiol Renal Physiol. 2012 Feb 15;302(4):F408-20. doi: 10.1152/ajprenal.00542.2011. Epub 2011 Nov 16.

33.

Stressor states and the cation crossroads.

Weber KT, Bhattacharya SK, Newman KP, Soberman JE, Ramanathan KB, McGee JE, Malik KU, Hickerson WL.

J Am Coll Nutr. 2010 Dec;29(6):563-74. Review.

PMID:
21677120
34.

Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation.

Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM, Malik KU.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1043-55. doi: 10.1152/ajpheart.01018.2010. Epub 2011 Jun 3.

35.

Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide.

Buharalioglu CK, Korkmaz B, Cuez T, Sahan-Firat S, Sari AN, Malik KU, Tunctan B.

Basic Clin Pharmacol Toxicol. 2011 Sep;109(3):186-94. doi: 10.1111/j.1742-7843.2011.00708.x. Epub 2011 May 6.

36.

Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.

Tunctan B, Korkmaz B, Cuez T, Kemal Buharalioglu C, Sahan-Firat S, Falck J, Malik KU.

Basic Clin Pharmacol Toxicol. 2010 Nov;107(5):877-82. doi: 10.1111/j.1742-7843.2010.00589.x.

37.

2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1.

Sahan-Firat S, Jennings BL, Yaghini FA, Song CY, Estes AM, Fang XR, Farjana N, Khan AI, Malik KU.

Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1891-901. doi: 10.1152/ajpheart.00655.2010. Epub 2010 Sep 17.

38.

Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology.

Jennings BL, Sahan-Firat S, Estes AM, Das K, Farjana N, Fang XR, Gonzalez FJ, Malik KU.

Hypertension. 2010 Oct;56(4):667-74. doi: 10.1161/HYPERTENSIONAHA.110.154518. Epub 2010 Aug 30.

39.

Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier.

Zhu L, Maruvada R, Sapirstein A, Malik KU, Peters-Golden M, Kim KS.

Infect Immun. 2010 Oct;78(10):4302-10. doi: 10.1128/IAI.00624-10. Epub 2010 Aug 9.

40.

Angiotensin II-induced vascular smooth muscle cell migration and growth are mediated by cytochrome P450 1B1-dependent superoxide generation.

Yaghini FA, Song CY, Lavrentyev EN, Ghafoor HU, Fang XR, Estes AM, Campbell WB, Malik KU.

Hypertension. 2010 Jun;55(6):1461-7. doi: 10.1161/HYPERTENSIONAHA.110.150029. Epub 2010 May 3.

41.

A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats.

Cuez T, Korkmaz B, Buharalioglu CK, Sahan-Firat S, Falck J, Malik KU, Tunctan B.

Basic Clin Pharmacol Toxicol. 2010 May;106(5):378-88. doi: 10.1111/j.1742-7843.2009.00501.x. Epub 2009 Dec 7.

42.

Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.

Mugabe BE, Yaghini FA, Song CY, Buharalioglu CK, Waters CM, Malik KU.

J Pharmacol Exp Ther. 2010 Jan;332(1):116-24. doi: 10.1124/jpet.109.157552. Epub 2009 Oct 1. Erratum in: J Pharmacol Exp Ther. 2010 Nov;335(2):516-7.

43.

High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs.

Lavrentyev EN, Malik KU.

Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H106-18. doi: 10.1152/ajpheart.00239.2008. Epub 2008 Oct 31.

44.

Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.

Tunctan B, Yaghini FA, Estes A, Malik KU.

Arch Pharm Res. 2008 Jul;31(7):856-65. doi: 10.1007/s12272-001-1238-x. Epub 2008 Aug 14.

45.

A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.

Tunctan B, Korkmaz B, Buharalioglu CK, Firat SS, Anjaiah S, Falck J, Roman RJ, Malik KU.

Shock. 2008 Sep;30(3):329-35. doi: 10.1097/SHK.0b013e31816471c6.

46.

cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells.

Pavicevic Z, Leslie CC, Malik KU.

J Lipid Res. 2008 Apr;49(4):724-37. doi: 10.1194/jlr.M700419-JLR200. Epub 2008 Jan 9.

47.

Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells.

Lavrentyev EN, Estes AM, Malik KU.

Circ Res. 2007 Aug 31;101(5):455-64. Epub 2007 Jul 12.

PMID:
17626897
48.
49.

Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury.

Parmentier JH, Zhang C, Estes A, Schaefer S, Malik KU.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1602-13. Epub 2006 May 5.

50.

Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.

Tunctan B, Yaghini FA, Estes A, Malik KU.

Nitric Oxide. 2006 Feb;14(1):51-7. Epub 2005 Nov 8.

PMID:
16288975

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