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Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated Pneumonia.

De Winter FHR, 's Jongers B, Bielen K, Mancuso D, Timbermont L, Lammens C, Van Averbeke V, Boddaert J, Ali O, Kluytmans J, Ruzin A, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S.

Int J Mol Sci. 2019 Oct 12;20(20). pii: E5072. doi: 10.3390/ijms20205072.


Optimization of an in vitro gut microbiome biotransformation platform with chlorogenic acid as model compound: From fecal sample to biotransformation product identification.

Mortelé O, Iturrospe E, Breynaert A, Verdickt E, Xavier BB, Lammens C, Malhotra-Kumar S, Jorens PG, Pieters L, van Nuijs ALN, Hermans N.

J Pharm Biomed Anal. 2019 Oct 25;175:112768. doi: 10.1016/j.jpba.2019.07.016. Epub 2019 Jul 10.


Estimating the association between antibiotic exposure and colonization with extended-spectrum β-lactamase-producing Gram-negative bacteria using machine learning methods: a multicentre, prospective cohort study.

Tacconelli E, Górska A, De Angelis G, Lammens C, Restuccia G, Schrenzel J, Huson DH, Carević B, Preoţescu L, Carmeli Y, Kazma M, Spanu T, Carrara E, Malhotra-Kumar S, Gladstone BP.

Clin Microbiol Infect. 2019 May 23. pii: S1198-743X(19)30247-2. doi: 10.1016/j.cmi.2019.05.013. [Epub ahead of print]


Remarkable Genome Stability among emm1 Group A Streptococcus in Belgium over 19 Years.

Coppens J, Xavier BB, Loens K, Lammens C, Ieven M, Matheeussen V, Goossens H, Malhotra-Kumar S.

Genome Biol Evol. 2019 May 1;11(5):1432-1439. doi: 10.1093/gbe/evz093.


Emergence of colistin resistance during treatment of recurrent pneumonia caused by carbapenemase producing Klebsiella pneumoniae.

Matheeussen V, Xavier BB, Mermans I, De Weerdt A, Lammens C, Goossens H, Jansens H, Malhotra-Kumar S.

Diagn Microbiol Infect Dis. 2019 Aug;94(4):407-409. doi: 10.1016/j.diagmicrobio.2019.02.014. Epub 2019 Feb 21.


Potential in vivo transfer of a blaCTX-M14-harbouring plasmid established by combining long- and short-read sequencing.

Xavier BB, Renzi G, Lammens C, Cherkaoui A, Goossens H, Schrenzel J, Harbarth S, Malhotra-Kumar S.

J Microbiol Methods. 2019 Apr;159:1-4. doi: 10.1016/j.mimet.2019.02.004. Epub 2019 Feb 7.


Follow-up of serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in child carriage after a PCV13-to-PCV10 vaccine switch in Belgium.

Wouters I, Desmet S, Van Heirstraeten L, Blaizot S, Verhaegen J, Van Damme P, Malhotra-Kumar S, Theeten H; NPcarriage Study Group.

Vaccine. 2019 Feb 14;37(8):1080-1086. doi: 10.1016/j.vaccine.2018.12.068. Epub 2019 Jan 19.


Comparison of GeneXpert MRSA/SA ETA assay with semi-quantitative and quantitative cultures and nuc gene-based qPCR for detection of Staphylococcus aureus in endotracheal aspirate samples.

Coppens J, Van Heirstraeten L, Ruzin A, Yu L, Timbermont L, Lammens C, Matheeussen V, McCarthy M, Jorens P, Ieven M, Kumar-Singh S, Goossens H, Malhotra-Kumar S.

Antimicrob Resist Infect Control. 2019 Jan 5;8:4. doi: 10.1186/s13756-018-0460-8. eCollection 2019.


Enzymes Catalyzing the TCA- and Urea Cycle Influence the Matrix Composition of Biofilms Formed by Methicillin-Resistant Staphylococcus aureus USA300.

De Backer S, Sabirova J, De Pauw I, De Greve H, Hernalsteens JP, Goossens H, Malhotra-Kumar S.

Microorganisms. 2018 Oct 29;6(4). pii: E113. doi: 10.3390/microorganisms6040113.


Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial.

Wittekamp BH, Plantinga NL, Cooper BS, Lopez-Contreras J, Coll P, Mancebo J, Wise MP, Morgan MPG, Depuydt P, Boelens J, Dugernier T, Verbelen V, Jorens PG, Verbrugghe W, Malhotra-Kumar S, Damas P, Meex C, Leleu K, van den Abeele AM, Gomes Pimenta de Matos AF, Fernández Méndez S, Vergara Gomez A, Tomic V, Sifrer F, Villarreal Tello E, Ruiz Ramos J, Aragao I, Santos C, Sperning RHM, Coppadoro P, Nardi G, Brun-Buisson C, Bonten MJM.

JAMA. 2018 Nov 27;320(20):2087-2098. doi: 10.1001/jama.2018.13765.


Novel composite SCCmec type III element in ST239 MRSA isolated from an Indian hospital.

Coppens J, Xavier BB, Vanjari L, De Backer S, Lammens C, Vemu L, Goossens H, Malhotra-Kumar S.

J Antimicrob Chemother. 2019 Jan 1;74(1):264-266. doi: 10.1093/jac/dky399. No abstract available.


Remarkable geographical variations between India and Europe in carriage of the staphylococcal surface protein-encoding sasX/sesI and in the population structure of methicillin-resistant Staphylococcus aureus belonging to clonal complex 8.

De Backer S, Xavier BB, Vanjari L, Coppens J, Lammens C, Vemu L, Carevic B, Hryniewicz W, Jorens P, Kumar-Singh S, Lee A, Harbarth S, Schrenzel J, Tacconelli E, Goossens H, Malhotra-Kumar S.

Clin Microbiol Infect. 2019 May;25(5):628.e1-628.e7. doi: 10.1016/j.cmi.2018.07.024. Epub 2018 Aug 2.


Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes.

Partridge SR, Di Pilato V, Doi Y, Feldgarden M, Haft DH, Klimke W, Kumar-Singh S, Liu JH, Malhotra-Kumar S, Prasad A, Rossolini GM, Schwarz S, Shen J, Walsh T, Wang Y, Xavier BB.

J Antimicrob Chemother. 2018 Oct 1;73(10):2625-2630. doi: 10.1093/jac/dky262.


Characterization of carbapenemase-producing Enterobacteriaceae from colonized patients in a university hospital in Madrid, Spain, during the R-GNOSIS project depicts increased clonal diversity over time with maintenance of high-risk clones.

Hernández-García M, Pérez-Viso B, Carmen Turrientes M, Díaz-Agero C, López-Fresneña N, Bonten M, Malhotra-Kumar S, Ruiz-Garbajosa P, Cantón R.

J Antimicrob Chemother. 2018 Nov 1;73(11):3039-3043. doi: 10.1093/jac/dky284.


Methicillin-resistant Staphylococcus aureus.

Lee AS, de Lencastre H, Garau J, Kluytmans J, Malhotra-Kumar S, Peschel A, Harbarth S.

Nat Rev Dis Primers. 2018 May 31;4:18033. doi: 10.1038/nrdp.2018.33. Review.


Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes.

Rebelo AR, Bortolaia V, Kjeldgaard JS, Pedersen SK, Leekitcharoenphon P, Hansen IM, Guerra B, Malorny B, Borowiak M, Hammerl JA, Battisti A, Franco A, Alba P, Perrin-Guyomard A, Granier SA, De Frutos Escobar C, Malhotra-Kumar S, Villa L, Carattoli A, Hendriksen RS.

Euro Surveill. 2018 Feb;23(6). doi: 10.2807/1560-7917.ES.2018.23.6.17-00672. Erratum in: Euro Surveill. 2018 Feb;23(7):.


Effect of outpatient antibiotics for urinary tract infections on antimicrobial resistance among commensal Enterobacteriaceae: a multinational prospective cohort study.

Stewardson AJ, Vervoort J, Adriaenssens N, Coenen S, Godycki-Cwirko M, Kowalczyk A, Huttner BD, Lammens C, Malhotra-Kumar S, Goossens H, Harbarth S; SATURN WP1 Study Group; SATURN WP3 Study Group.

Clin Microbiol Infect. 2018 Sep;24(9):972-979. doi: 10.1016/j.cmi.2017.12.026. Epub 2018 Jan 10.


Nasopharyngeal s. pneumoniae carriage and density in Belgian infants after 9 years of pneumococcal conjugate vaccine programme.

Wouters I, Van Heirstraeten L, Desmet S, Blaizot S, Verhaegen J, Goossens H, Van Damme P, Malhotra-Kumar S, Theeten H; NPcarriage Study Group.

Vaccine. 2018 Jan 2;36(1):15-22. doi: 10.1016/j.vaccine.2017.11.052. Epub 2017 Nov 24.


Evaluation of colistin stability in agar and comparison of four methods for MIC testing of colistin.

Turlej-Rogacka A, Xavier BB, Janssens L, Lammens C, Zarkotou O, Pournaras S, Goossens H, Malhotra-Kumar S.

Eur J Clin Microbiol Infect Dis. 2018 Feb;37(2):345-353. doi: 10.1007/s10096-017-3140-3. Epub 2017 Nov 25.


Mechanical Ventilation Induces Interleukin 4 Secretion in Lungs and Reduces the Phagocytic Capacity of Lung Macrophages.

Bielen K, 's Jongers B, Boddaert J, Lammens C, Jorens PG, Malhotra-Kumar S, Goossens H, Kumar-Singh S.

J Infect Dis. 2018 Apr 23;217(10):1645-1655. doi: 10.1093/infdis/jix573.


Rationale and design of ASPIRE-ICU: a prospective cohort study on the incidence and predictors of Staphylococcus aureus and Pseudomonas aeruginosa pneumonia in the ICU.

Paling FP, Troeman DPR, Wolkewitz M, Kalyani R, Prins DR, Weber S, Lammens C, Timbermont L, Goossens H, Malhotra-Kumar S, Sifakis F, Bonten MJM, Kluytmans JAJW.

BMC Infect Dis. 2017 Sep 25;17(1):643. doi: 10.1186/s12879-017-2739-4.


Biofilm-Induced Type 2 Innate Immunity in a Cystic Fibrosis Model of Pseudomonas aeruginosa.

Bielen K, 's Jongers B, Boddaert J, Raju TK, Lammens C, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S.

Front Cell Infect Microbiol. 2017 Jun 21;7:274. doi: 10.3389/fcimb.2017.00274. eCollection 2017.


Animal models of hospital-acquired pneumonia: current practices and future perspectives.

Bielen K, 's Jongers B, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S.

Ann Transl Med. 2017 Mar;5(6):132. doi: 10.21037/atm.2017.03.72. Review.


In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp.

Hotterbeekx A, Kumar-Singh S, Goossens H, Malhotra-Kumar S.

Front Cell Infect Microbiol. 2017 Apr 3;7:106. doi: 10.3389/fcimb.2017.00106. eCollection 2017. Review.


The endotracheal tube microbiome associated with Pseudomonas aeruginosa or Staphylococcus epidermidis.

Hotterbeekx A, Xavier BB, Bielen K, Lammens C, Moons P, Schepens T, Ieven M, Jorens PG, Goossens H, Kumar-Singh S, Malhotra-Kumar S.

Sci Rep. 2016 Nov 4;6:36507. doi: 10.1038/srep36507.


Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

Xavier BB, Lammens C, Ruhal R, Kumar-Singh S, Butaye P, Goossens H, Malhotra-Kumar S.

Euro Surveill. 2016 Jul 7;21(27). doi: 10.2807/1560-7917.ES.2016.21.27.30280. Erratum in: Euro Surveill. 2016 Jul 14;21(28):.


Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study.

Malhotra-Kumar S, Van Heirstraeten L, Coenen S, Lammens C, Adriaenssens N, Kowalczyk A, Godycki-Cwirko M, Bielicka Z, Hupkova H, Lannering C, Mölstad S, Fernandez-Vandellos P, Torres A, Parizel M, Ieven M, Butler CC, Verheij T, Little P, Goossens H; GRACE study group.

J Antimicrob Chemother. 2016 Nov;71(11):3258-3267. Epub 2016 Jun 26.


Complete sequence of an IncFII plasmid harbouring the colistin resistance gene mcr-1 isolated from Belgian pig farms.

Xavier BB, Lammens C, Butaye P, Goossens H, Malhotra-Kumar S.

J Antimicrob Chemother. 2016 Aug;71(8):2342-4. doi: 10.1093/jac/dkw191. Epub 2016 Jun 3. No abstract available.


Characterizing the in vitro biofilm phenotype of Staphylococcus epidermidis isolates from central venous catheters.

Van Kerckhoven M, Hotterbeekx A, Lanckacker E, Moons P, Lammens C, Kerstens M, Ieven M, Delputte P, Jorens PG, Malhotra-Kumar S, Goossens H, Maes L, Cos P.

J Microbiol Methods. 2016 Aug;127:95-101. doi: 10.1016/j.mimet.2016.05.009. Epub 2016 May 16.


Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup.

Nullens S, Staessens M, Peleman C, Plaeke P, Malhotra-Kumar S, Francque S, De Man JG, De Winter BY.

PLoS One. 2016 Apr 4;11(4):e0152914. doi: 10.1371/journal.pone.0152914. eCollection 2016.


Whole-genome typing and characterization of blaVIM19-harbouring ST383 Klebsiella pneumoniae by PFGE, whole-genome mapping and WGS.

Sabirova JS, Xavier BB, Coppens J, Zarkotou O, Lammens C, Janssens L, Burggrave R, Wagner T, Goossens H, Malhotra-Kumar S.

J Antimicrob Chemother. 2016 Jun;71(6):1501-9. doi: 10.1093/jac/dkw003. Epub 2016 Mar 10.


Faropenem Consumption is Increasing in India.

Gandra S, Klein EY, Pant S, Malhotra-Kumar S, Laxminarayan R.

Clin Infect Dis. 2016 Apr 15;62(8):1050-2. doi: 10.1093/cid/ciw055. Epub 2016 Feb 7. No abstract available. Erratum in: Clin Infect Dis. 2017 Aug 1;65(3):533.


Consolidating and Exploring Antibiotic Resistance Gene Data Resources.

Xavier BB, Das AJ, Cochrane G, De Ganck S, Kumar-Singh S, Aarestrup FM, Goossens H, Malhotra-Kumar S.

J Clin Microbiol. 2016 Apr;54(4):851-9. doi: 10.1128/JCM.02717-15. Epub 2016 Jan 27. Review.


Detection and characterization of two NDM-1-producing Klebsiella pneumoniae strains from Bulgaria.

Kostyanev T, Strateva T, Xavier BB, Marteva-Proevska Y, Lammens C, Markova B, Goossens H, Malhotra-Kumar S.

J Antimicrob Chemother. 2016 May;71(5):1428-30. doi: 10.1093/jac/dkv471. Epub 2016 Jan 26. No abstract available.


Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam.

Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Hoang HT, Pham NT, Goossens H.

Lancet Infect Dis. 2016 Mar;16(3):286-7. doi: 10.1016/S1473-3099(16)00014-1. Epub 2016 Jan 8. No abstract available.


Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid.

Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Butaye P, Goossens H.

Lancet Infect Dis. 2016 Mar;16(3):283-4. doi: 10.1016/S1473-3099(16)00012-8. Epub 2016 Jan 8. No abstract available. Erratum in: Lancet Infect Dis. 2016 Mar;16(3):279.


Colistin-Resistant Acinetobacter baumannii Clinical Strains with Deficient Biofilm Formation.

Dafopoulou K, Xavier BB, Hotterbeekx A, Janssens L, Lammens C, Dé E, Goossens H, Tsakris A, Malhotra-Kumar S, Pournaras S.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1892-5. doi: 10.1128/AAC.02518-15.



Nullens S, Staessens M, Peleman C, Schrijvers DM, Malhotra-Kumar S, Francque S, Matteoli G, Boeckxstaens GE, De Man JG, De Winter BY.

Shock. 2016 Apr;45(4):450-9. doi: 10.1097/SHK.0000000000000519.


Fatty acid kinase A is an important determinant of biofilm formation in Staphylococcus aureus USA300.

Sabirova JS, Hernalsteens JP, De Backer S, Xavier BB, Moons P, Turlej-Rogacka A, De Greve H, Goossens H, Malhotra-Kumar S.

BMC Genomics. 2015 Oct 26;16:861. doi: 10.1186/s12864-015-1956-8.


Metagenomic analysis of the impact of nitrofurantoin treatment on the human faecal microbiota.

Vervoort J, Xavier BB, Stewardson A, Coenen S, Godycki-Cwirko M, Adriaenssens N, Kowalczyk A, Lammens C, Harbarth S, Goossens H, Malhotra-Kumar S.

J Antimicrob Chemother. 2015 Jul;70(7):1989-92. doi: 10.1093/jac/dkv062. Epub 2015 Mar 12.


Collateral damage from oral ciprofloxacin versus nitrofurantoin in outpatients with urinary tract infections: a culture-free analysis of gut microbiota.

Stewardson AJ, Gaïa N, François P, Malhotra-Kumar S, Delémont C, Martinez de Tejada B, Schrenzel J, Harbarth S, Lazarevic V; SATURN WP1 and WP3 Study Groups.

Clin Microbiol Infect. 2015 Apr;21(4):344.e1-11. doi: 10.1016/j.cmi.2014.11.016. Epub 2014 Nov 25.


A longitudinal study of Staphylococcus aureus colonization in pigs in Ireland.

Burns A, Shore AC, Brennan GI, Coleman DC, Egan J, Fanning S, Galligan MC, Gibbons JF, Gutierrez M, Malhotra-Kumar S, Markey BK, Sabirova JS, Wang J, Leonard FC.

Vet Microbiol. 2014 Dec 5;174(3-4):504-513. doi: 10.1016/j.vetmic.2014.10.009. Epub 2014 Oct 25.


Whole genome mapping as a fast-track tool to assess genomic stability of sequenced Staphylococcus aureus strains.

Sabirova JS, Xavier BB, Ieven M, Goossens H, Malhotra-Kumar S.

BMC Res Notes. 2014 Oct 8;7:704. doi: 10.1186/1756-0500-7-704.


An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli.

Vervoort J, Xavier BB, Stewardson A, Coenen S, Godycki-Cwirko M, Adriaenssens N, Kowalczyk A, Lammens C, Harbarth S, Goossens H, Malhotra-Kumar S.

Antimicrob Agents Chemother. 2014 Dec;58(12):7225-33. doi: 10.1128/AAC.03952-14. Epub 2014 Sep 22.


Comparison of biofilm formation between major clonal lineages of methicillin resistant Staphylococcus aureus.

Vanhommerig E, Moons P, Pirici D, Lammens C, Hernalsteens JP, De Greve H, Kumar-Singh S, Goossens H, Malhotra-Kumar S.

PLoS One. 2014 Aug 8;9(8):e104561. doi: 10.1371/journal.pone.0104561. eCollection 2014.


Employing whole genome mapping for optimal de novo assembly of bacterial genomes.

Xavier BB, Sabirova J, Pieter M, Hernalsteens JP, de Greve H, Goossens H, Malhotra-Kumar S.

BMC Res Notes. 2014 Jul 30;7:484. doi: 10.1186/1756-0500-7-484.


High rates of intestinal colonisation with fluoroquinolone-resistant ESBL-harbouring Enterobacteriaceae in hospitalised patients with antibiotic-associated diarrhoea.

Vervoort J, Gazin M, Kazma M, Kotlovsky T, Lammens C, Carmeli Y, Goossens H, Malhotra-Kumar S; SATURN WP1 and MOSAR WP2 study groups.

Eur J Clin Microbiol Infect Dis. 2014 Dec;33(12):2215-21. doi: 10.1007/s10096-014-2193-9. Epub 2014 Jul 4.


Complete Genome Sequences of Two Prolific Biofilm-Forming Staphylococcus aureus Isolates Belonging to USA300 and EMRSA-15 Clonal Lineages.

Sabirova JS, Xavier BB, Hernalsteens JP, De Greve H, Ieven M, Goossens H, Malhotra-Kumar S.

Genome Announc. 2014 Jun 26;2(3). pii: e00610-14. doi: 10.1128/genomeA.00610-14.


Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains.

Xavier BB, Vervoort J, Stewardson A, Adriaenssens N, Coenen S, Harbarth S, Goossens H, Malhotra-Kumar S.

Genome Announc. 2014 Apr 10;2(2). pii: e00239-14. doi: 10.1128/genomeA.00239-14.


Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections.

Van Heirstraeten L, Spang P, Schwind C, Drese KS, Ritzi-Lehnert M, Nieto B, Camps M, Landgraf B, Guasch F, Corbera AH, Samitier J, Goossens H, Malhotra-Kumar S, Roeser T.

Lab Chip. 2014 May 7;14(9):1519-26. doi: 10.1039/c3lc51339d. Epub 2014 Mar 10.


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